What is the best AI?

[Itneverleaves]

Exemestane, anastrozole or letrozole?

 

[urs]

anastrozole (arimidex) mogs.

Exemestane, anastrozole or letrozole?

 

[Zagro]

anastrozole (arimidex) mogs.

Most useless out of the three

 

[BR32]

Aromasin by far

 

[BR32]

anastrozole (arimidex) mogs.

you don't know shit, suicidal AIs mog

 

[urs]

you don't know shit, suicidal AIs mog

nigga its not fucking optimal for kids who just wanna grow taller

 

[urs]

Most useless out of the three

any studies to backup what u gotta say?

 

[Datto29]

grok ai clears

 

[Zagro]

any studies to backup what u gotta say?

I said its the most useless out of the three i wont bother to give you studies on all of them just so your ass can learn

 

[BR32]

nigga its not fucking optimal for kids who just wanna grow taller

AIs aren't optimal if you wanna get taller what are you talking about.

 

[mememanw24]

Exemestane, anastrozole or letrozole?

Letrozole

 

[urs]

AIs aren't optimal if you wanna get taller what are you talking about.

nigga did u just say ai isnt optimal for getting taller during puberty?

 

[BR32]

nigga did u just say ai isnt optimal for getting taller during puberty?

I did

go read the data

 

[urs]

I said its the most useless out of the three i wont bother to give you studies on all of them just so your ass can learn

yea no ur just saying shit out your ass nigger

 

[urs]

I did

go read the data

send it

 

[BR32]

send it

bro im not gonna dig through the threads I wrote just go on pubmed and read

also mechanistically taking an AI doesn't make any sense because growth plates respond to long term estrogen exposure so randomly nuking it won't help. also you can't permenatnly lower your E2 during puberty or you will just fuck your health

 

[Zagro]

yea no ur just saying shit out your ass nigger

You haven’t read a singular study on it and are this cocky that’s fucking hilarious bro will all 2026cels be like this

Letro is the most potent out of the three the other ones barely work, aromasin even shows 30% suppression of serum E2 in some studies and no you cant just dose it higher cause it plateaus at 25mg and the suppression rate increases by like 2% at 50mg and anastrozole is simply just less potent then letrozole by 10-20% and has zero unique properties.

If you even want to heightmax with aromatase inhibitors keep in mind that they literally wont grow you, only could help avoid premature fusion if your serum E2 is higher than like 20pg, you can even push to 10pg but thats where the growth plate biology is only partially active. It doesn’t even matter if your baseline isn’t high because it cant inhibit locally synthesized E2 in the growth plates meaning it wont do shit

Aromasin has an androgenic metabolite called 17-hydroexemestane that increases glucuronidation which is essentially your body getting rid of in this case androgens, you will excrete androgens more through urine and make them less bioavailable, its only a half decent choice if you’re natty

Now go fucking hang yourself you piece of shit delete your account

 

[notagreycell]

Exemestane, anastrozole or letrozole?

Exemestane because it doesn't have a strong estrogen rebound like the other ais its more stable and doesn't completely crush your hormones or estrogen aromasin is also good and similar

 

[urs]

You haven’t read a singular study on it and are this cocky that’s fucking hilarious bro will all 2026cels be like this

Letro is the most potent out of the three the other ones barely work, aromasin even shows 30% suppression of serum E2 in some studies and no you cant just dose it higher cause it plateaus at 25mg and the suppression rate increases by like 2% at 50mg and anastrozole is simply just less potent then letrozole by 10-20% and has zero unique properties.

If you even want to heightmax with aromatase inhibitors keep in mind that they literally wont grow you, only could help avoid premature fusion if your serum E2 is higher than like 20pg, you can even push to 10pg but thats where the growth plate biology is only partially active. It doesn’t even matter if your baseline isn’t high because it cant inhibit locally synthesized E2 in the growth plates meaning it wont do shit

Aromasin has an androgenic metabolite called 17-hydroexemestane that increases glucuronidation which is essentially your body getting rid of in this case androgens, you will excrete androgens more through urine and make them less bioavailable, its only a half decent choice if you’re natty

Now go fucking hang yourself you piece of shit delete your account

nigga send me a single study u can type all this shit out but cant send a single study faggot retard

 

[Zagro]

nigga send me a single study u can type all this shit out but cant send a single study faggot retard

These are what the studies say you fucking moron

 

[maxlokks]

Bhai js stfu, and accept ure a faggot

 

[Zagro]

nigga send me a single study u can type all this shit out but cant send a single study faggot retard

Exemestane and Its Active Metabolite 17-Hydroexemestane Induce UDP-Glucuronosyltransferase (UGT) 2B17 Expression in Breast Cancer Cells

Exemestane (EXE) is an aromatase inhibitor indicated for endocrine therapy of breast cancer in postmenopausal women. The primary active metabolite of …

www.sciencedirect.com

Pharmacokinetics and dose finding of a potent aromatase inhibitor, aromasin (exemestane), in young males - PubMed

Suppression of estrogen, via estrogen receptor or aromatase blockade, is being investigated in the treatment of different conditions. Exemestane (Aromasin) is a potent and selective irreversible aromatase inhibitor. To characterize its suppression of estrogen and its pharmacokinetic (PK)...

pubmed.ncbi.nlm.nih.gov

https://onlinelibrary.wiley.com/doi/10.1111/andr.13185

First study talks about the 17-hydroexemestane metabolite and its detrimental actions, second study shows how weak exemestance can be showing 30% supression "Exemestane suppressed plasma estradiol comparably with either dose [25 mg, 38% (P <or= 0.002); 50 mg, 32% (P <or= 0.008)]" and third study shows how strong letrozole is "decreased E2 levels (SMD: −3.67; 95% CI: −5.24 to −2.09; p = 0.001)".

Please kill yourself

Bhai js stfu, and accept ure a faggot

 

[urs]

Exemestane and Its Active Metabolite 17-Hydroexemestane Induce UDP-Glucuronosyltransferase (UGT) 2B17 Expression in Breast Cancer Cells

Exemestane (EXE) is an aromatase inhibitor indicated for endocrine therapy of breast cancer in postmenopausal women. The primary active metabolite of …

www.sciencedirect.com

Pharmacokinetics and dose finding of a potent aromatase inhibitor, aromasin (exemestane), in young males - PubMed

Suppression of estrogen, via estrogen receptor or aromatase blockade, is being investigated in the treatment of different conditions. Exemestane (Aromasin) is a potent and selective irreversible aromatase inhibitor. To characterize its suppression of estrogen and its pharmacokinetic (PK)...

pubmed.ncbi.nlm.nih.gov

https://onlinelibrary.wiley.com/doi/10.1111/andr.13185

First study talks about the 17-hydroexemestane metabolite and its detrimental actions, second study shows how weak exemestance can be showing 30% supression "Exemestane suppressed plasma estradiol comparably with either dose [25 mg, 38% (P <or= 0.002); 50 mg, 32% (P <or= 0.008)]" and third study shows how strong letrozole is "decreased E2 levels (SMD: −3.67; 95% CI: −5.24 to −2.09; p = 0.001)".

Please kill yourself


View attachment 4502478

nigga my fucking argument isnt about exemestane being fucking weak?? iqlet

 

[Swarthy Knight]

Was boutta say Chatgpt until I realized this a thread for roid-heads

 

[Zagro]

nigga my fucking argument isnt about exemestane being fucking weak?? iqlet

Did you even read any of my posts? What a fucking retarded human being you are I swear to god you vanishing off of the surface of earth would increase the average iq globally

I said that arimidex is the worst out of the three, you wanted studies, I provided studies and why. Exemestane has unique properties thus why its better than anastrozole, and letrozole is simply stronger than arimidex at suppressing serum E2 so why would you use the less potent compound Do you know the reason why people even use aromatase inhibitors

Both aromasin and letro are better than arimidex and that was my point which you wanted studies for please for the love of god kill yourself please please please

 

[urs]

and whatever you fucking quoted you fucking cherry picked, the 32-38% supression was on young males with low baseline e2 nigga, and in normal/higher e2 like boys in puberty exemestane supresses 60-80% at 25mg

letrozole might be more potent on e2, but this https://pmc.ncbi.nlm.nih.gov/articles/PMC11388000/ shows that (direct 3y comparasion) showed no fucking difference in final PAH, both minimal ass gains, 1.7cm anastrozole 0.8cm letrozole, anastrozole had better early PAH and less deviations.

Exemestane and Its Active Metabolite 17-Hydroexemestane Induce UDP-Glucuronosyltransferase (UGT) 2B17 Expression in Breast Cancer Cells

Exemestane (EXE) is an aromatase inhibitor indicated for endocrine therapy of breast cancer in postmenopausal women. The primary active metabolite of …

www.sciencedirect.com

Pharmacokinetics and dose finding of a potent aromatase inhibitor, aromasin (exemestane), in young males - PubMed

Suppression of estrogen, via estrogen receptor or aromatase blockade, is being investigated in the treatment of different conditions. Exemestane (Aromasin) is a potent and selective irreversible aromatase inhibitor. To characterize its suppression of estrogen and its pharmacokinetic (PK)...

pubmed.ncbi.nlm.nih.gov

https://onlinelibrary.wiley.com/doi/10.1111/andr.13185

First study talks about the 17-hydroexemestane metabolite and its detrimental actions, second study shows how weak exemestance can be showing 30% supression "Exemestane suppressed plasma estradiol comparably with either dose [25 mg, 38% (P <or= 0.002); 50 mg, 32% (P <or= 0.008)]" and third study shows how strong letrozole is "decreased E2 levels (SMD: −3.67; 95% CI: −5.24 to −2.09; p = 0.001)".

Please kill yourself


View attachment 4502478

 

[Zagro]

and whatever you fucking quoted you fucking cherry picked, the 32-38% supression was on young males with low baseline e2 nigga, and in normal/higher e2 like boys in puberty exemestane supresses 60-80% at 25mg

letrozole might be more potent on e2, but this https://pmc.ncbi.nlm.nih.gov/articles/PMC11388000/ shows that (direct 3y comparasion) showed no fucking difference in final PAH, both minimal ass gains, 1.7cm anastrozole 0.8cm letrozole, anastrozole had better early PAH and less deviations.

Aromasin E2 supression is 30-50% you cant prove me otherwise (the reason for it having a range is because of individual response to the drug, an exact amount cant be given), its the shittiest compound for lowering serum E2, give a single study for your claim, your claims are based on postmenopausal women.

Low baseline E2 doesn't matter if what you're seeking is the percentage for the serum E2 suppression

You fucking idiot you cant ever base this on a group of 80 people, do you know how many other factors there are? Nigga thinks 80 pubertal males with the bone age of under 10 years will work the same on normal health adolescents, no placebo control aswell. Prediced adult height is a wrecked idea itself you cant predict your final adults height and even if you do the margin of error is already like 4cms so this means absolutely nothing

And you just said yourself AIs don't work bud

 

[urs]

Aromasin E2 supression is 30-50% you cant prove me otherwise (the reason for it having a range is because of individual response to the drug, an exact amount cant be given), its the shittiest compound for lowering serum E2, how does low baseline E2 matter if what we're seeking is the serum E2 suppression, give a single study for your claim, your claims are based on postmenopausal women.

You fucking idiot you cant ever base this on a group of 80 people, do you know how many other factors there are? Nigga thinks 80 pubertal males with the bone age of under 10 years will work the same on normal health adolescents, no placebo control aswell. Prediced adult height is a wrecked idea itself you cant predict your final adults height and even if you do the margin of error is already like 4cms so this means absolutely nothing

And you just said yourself AIs don't work bud

im basing this on actual studies not fucking postmenopausal women

first off your 30-50% claim is wrong u jeet, the 2003 study your quoted (Pharmacokinetics) shows maximal e2 supression 62 + 14% at 25mg, not 30-38%, also low baseline E2 matters because percentage suppression is relative in pubertal boys with higher baseline e2 (20-40pg) its 60-80% for exemestane similar to anastrozole https://pubmed.ncbi.nlm.nih.gov/14671195/



letrozole is more potent on e2 but clearly shows no difference in final pah and even gets out performed by anastrozole in the first year 4.2cm vs 1.4cm and even fewer deviations, also 80 is a normal sample size nigga most medical trials have smaller, https://pmc.ncbi.nlm.nih.gov/articles/PMC11388000/

(letro has more potency with more deviations and imbalances, below it shows that anastrozole 1mg gave better results with adult height than letrozole 2.5mg (173.2 cm vs 171.8 cm) anastrozole was preferred for overall balance study below:

Aromatase inhibitor plus rhGH improves adult height for boys with idiopathic short stature | medwireNewsFocus | Paediatric Endocrinology

For teenage boys with idiopathic short stature (ISS), combining a third-generation aromatase inhibitor (AI) with recombinant human growth hormone (rhGH) therapy can significantly improve adult height, suggest study findings published in the Journal of Clinical Endocrinology & Metabolism.

paediatric-endocrinology.medwirenews.com

and no anastrozole is not the worst fucking ai retard, its the most studied and most tolerable ai for height augmentation in pubertal boys, with even comparable or superior outcomes in direct comparisons, letros more potency comes with more side effects and no proven edge in final height while aromasin (exemes) has no fucking studies done in adolescent males for height where


summary

anastrozole isnt the worst, it has the most direct evidence in pubertal boys (e.g mauras showed better outcome in gh combo: https://pmc.ncbi.nlm.nih.gov/articles/PMC5155684/) letrozoles potency caused more fucking deviations without any extra fucking height niggerjeet

 

[Zagro]

im basing this on actual studies not fucking postmenopausal women

first off your 30-50% claim is wrong u jeet, the 2003 study your quoted (Pharmacokinetics) shows maximal e2 supression 62 + 14% at 25mg, not 30-38%, also low baseline E2 matters because percentage suppression is relative in pubertal boys with higher baseline e2 (20-40pg) its 60-80% for exemestane similar to anastrozole https://pubmed.ncbi.nlm.nih.gov/14671195/



letrozole is more potent on e2 but clearly shows no difference in final pah and even gets out performed by anastrozole in the first year 4.2cm vs 1.4cm and even fewer deviations, also 80 is a normal sample size nigga most medical trials have smaller, https://pmc.ncbi.nlm.nih.gov/articles/PMC11388000/

(letro has more potency with more deviations and imbalances, below it shows that anastrozole 1mg gave better results with adult height than letrozole 2.5mg (173.2 cm vs 171.8 cm) anastrozole was preferred for overall balance study below:

Aromatase inhibitor plus rhGH improves adult height for boys with idiopathic short stature | medwireNewsFocus | Paediatric Endocrinology

For teenage boys with idiopathic short stature (ISS), combining a third-generation aromatase inhibitor (AI) with recombinant human growth hormone (rhGH) therapy can significantly improve adult height, suggest study findings published in the Journal of Clinical Endocrinology & Metabolism.

paediatric-endocrinology.medwirenews.com

and no anastrozole is not the worst fucking ai retard, its the most studied and most tolerable ai for height augmentation in pubertal boys, with even comparable or superior outcomes in direct comparisons, letros more potency comes with more side effects and no proven edge in final height while aromasin (exemes) has no fucking studies done in adolescent males for height where


summary

anastrozole isnt the worst, it has the most direct evidence in pubertal boys (e.g mauras showed better outcome in gh combo: https://pmc.ncbi.nlm.nih.gov/articles/PMC5155684/) letrozoles potency caused more fucking deviations without any extra fucking height niggerjeet

Without even opening the study i have read all of this stop changing what the study says its not 62% +14 its either 48% or 76% or inbetween and this changes as I have said per individual, the E2 suppression is 30-50% and your study proves my point, also you cant just make this claim with a singular study you need to review many.

Not sure if i even wanna waste my time and read your GPT responses and studies cause you cant even comprehend the basics of heightmaxxing and don't even know why aromatase inhibitors are used, may respond later if I feel like it till then smd

 

[urs]

Without even opening the study i have read all of this stop changing what the study says its not 62% +14 its either 48% or 76% or inbetween and this changes as I have said per individual, the E2 suppression is 30-50% and your study proves my point, also you cant just make this claim with a singular study you need to review many.

Not sure if i even wanna waste my time and read your GPT responses and studies cause you cant even comprehend the basics of heightmaxxing and don't even know why aromatase inhibitors are used, may respond later if I feel like it till then smd

LOL yea fuck off cause u cant counter my claims, i dont care about aromasin its shit and has no studies on it, over all arimidex is the jack of all trades

 

[Zagro]

LOL yea fuck off cause u cant counter my claims

Oh yeah and do you know that exemestane is progressive lol? The maximal suppression was 62 +/- 14% and the suppression in E2 was 30%, you don't know how to read studies, the 60% range comes from the highest reached E2 suppression which was at the 12 hour mark and that wasn't consistent

Its like saying a 12 unit natural GH pulse is better than 12 unit continuous

You cant even make a point to begin with nor can you read studies lol

 

[Mess]

Was boutta say Chatgpt until I realized this a thread for roid-heads

Same, I always have to do a double-take before I start talking about some Grok shit.

 

[urs]

Oh yeah and do you know that exemestane is progressive lol? The maximal suppression was 62 +/- 14% and the suppression in E2 was 30%, you don't know how to read studies, the 60% range comes from the highest reached E2 suppression which was at the 12 hour mark and that wasn't consistent

You cant even make a point to begin with nor can you read studies lol

the 2003 study (pharmacokinetics) shows the maximal e2 suppresion was 62 + 14% (range 38–78%) at 25mg, that's the overall max from baseline, not just a 12-hour peak, steady state was lower ~38% but in normal pubertal boys with higher baseline e2 exemestane suppresses 60–80% consistently (no progressive bullshit) its dose dependant like the other ais


also thats not my point im not here to argue about exmestane and how much you put up your ass , my point is that anastrozole is better than letro and exmes. lmao

 

[Zagro]

im basing this on actual studies not fucking postmenopausal women

first off your 30-50% claim is wrong u jeet, the 2003 study your quoted (Pharmacokinetics) shows maximal e2 supression 62 + 14% at 25mg, not 30-38%, also low baseline E2 matters because percentage suppression is relative in pubertal boys with higher baseline e2 (20-40pg) its 60-80% for exemestane similar to anastrozole https://pubmed.ncbi.nlm.nih.gov/14671195/



letrozole is more potent on e2 but clearly shows no difference in final pah and even gets out performed by anastrozole in the first year 4.2cm vs 1.4cm and even fewer deviations, also 80 is a normal sample size nigga most medical trials have smaller, https://pmc.ncbi.nlm.nih.gov/articles/PMC11388000/

(letro has more potency with more deviations and imbalances, below it shows that anastrozole 1mg gave better results with adult height than letrozole 2.5mg (173.2 cm vs 171.8 cm) anastrozole was preferred for overall balance study below:

Aromatase inhibitor plus rhGH improves adult height for boys with idiopathic short stature | medwireNewsFocus | Paediatric Endocrinology

For teenage boys with idiopathic short stature (ISS), combining a third-generation aromatase inhibitor (AI) with recombinant human growth hormone (rhGH) therapy can significantly improve adult height, suggest study findings published in the Journal of Clinical Endocrinology & Metabolism.

paediatric-endocrinology.medwirenews.com

and no anastrozole is not the worst fucking ai retard, its the most studied and most tolerable ai for height augmentation in pubertal boys, with even comparable or superior outcomes in direct comparisons, letros more potency comes with more side effects and no proven edge in final height while aromasin (exemes) has no fucking studies done in adolescent males for height where


summary

anastrozole isnt the worst, it has the most direct evidence in pubertal boys (e.g mauras showed better outcome in gh combo: https://pmc.ncbi.nlm.nih.gov/articles/PMC5155684/) letrozoles potency caused more fucking deviations without any extra fucking height niggerjeet

Muhh more tolerable are you fucking retarded lol? Is using GH secretagogues better than rhGH? No, but are they more tolerable? Yes

Do you even understand the basics of heightmaxxing, do you know what 17 beta estradiol does? Do you know why aromatase inhibitors are used? You don't, and you also cant comprehend that a non-placebo controlled, small test group and >10 BA study doesn't mean nothing there are like a 1000 other factors for growth and individual response differs.

Anastrozole is the worst AI

 

[urs]

Muhh more tolerable are you fucking retarded lol? Is using GH secretagogues better than rhGH? No, but are they more tolerable? Yes

Do you even understand the basics of heightmaxxing, do you know what 17 beta estradiol does? Do you know why aromatase inhibitors are used? You don't, and you also cant comprehend that a non-placebo controlled, small test group and >10 BA study doesn't mean nothing there are like a 1000 other factors for growth and individual response differs.

Anastrozole is the worst AI

looks like your just getting emotional and just hating on arimidex without a brain, every study aginst letro vs anastrozole, it had lower deviations and a higher pah nigga so just stop crying on the forum and get a job peanut brain

 

[Zagro]

the 2003 study (pharmacokinetics) shows the maximal e2 suppresion was 62 + 14% (range 38–78%) at 25mg, that's the overall max from baseline, not just a 12-hour peak, steady state was lower ~38% but in normal pubertal boys with higher baseline e2 exemestane suppresses 60–80% consistently (no progressive bullshit) its dose dependant like the other ais


also thats not my point im not here to argue about exmestane and how much you put up your ass , my point is that anastrozole is better than letro and exmes. lmao

This fucking 2026cel grey bro lollll

"62 +/- 14%" doesn't mean +14 if you want to play with that logic it also means 48% and that you're proving my point retard. You're so fucking clueless its hilarious, it was JUST a 12 hour peak as stated in the study which you haven't read of course because you cant even fucking understand anything

It literally says that the suppression is 32 and 38 percent right there you retard.

Do you know that every AI plateaus at a given dose? What do you mean no progressive bullshit That's how the drug works you retard

Arimidex is shit you've lost every argument and keep repeating the same shit

 

[Zagro]

looks like your just getting emotional and just hating on arimidex without a brain, every study aginst letro vs anastrozole, it had lower deviations and a higher pah nigga so just stop crying on the forum and get a job peanut brain

"You fucking idiot you cant ever base this on a group of 80 people, do you know how many other factors there are? Nigga thinks 80 pubertal males with the bone age of under 10 years will work the same on normal health adolescents, no placebo control aswell. Prediced adult height is a wrecked idea itself you cant predict your final adults height and even if you do the margin of error is already like 4cms so this means absolutely nothing "

You don't know how to read studies nor to make a consensus regarding a topic like this, what a fucking pseudo intellect

Niggas counter-argument is "stop crying peanut brain get a job"

 

[urs]

read the study again retard, it says maximal estradiol suppression of 62 + 14% was observed at 12 h, thats the literal peak suppression from baseline across subjects range (38–78%) not just a 12 hr peak tht wasnt consistent, steady state was 38% on avg

im not gonna waste my time arguing about some exmestane study, my clear point is arimidex is the jack of all trades when it comes to arim, letro, exmes

your just hating on arimidex with your pitchfork brain when it outperforms your little letro

This fucking 2026cel grey bro lollll

"62 +/- 14%" doesn't mean +14 if you want to play with that logic it also means 48% and that you're proving my point retard. You're so fucking clueless its hilarious, it was JUST a 12 hour peak as stated in the study which you haven't read of course because you cant even fucking understand anything

It literally says that the suppression is 32 and 38 percent right there you retard.

Do you know that every AI plateaus at a given dose? What do you mean no progressive bullshit That's how the drug works you retard

Arimidex is shit you've lost every argument and keep repeating the same shit

 

[Zagro]

read the study again retard, it says maximal estradiol suppression of 62 + 14% was observed at 12 h, thats the literal peak suppression from baseline across subjects range (38–78%) not just a 12 hr peak tht wasnt consistent, steady state was 38% on avg

im not gonna waste my time arguing about some exmestane study, my clear point is arimidex is the jack of all trades when it comes to arim, letro, exmes

your just hating on arimidex with your pitchfork brain when it outperforms your little letro

Nigga literally agreed to what I said

The maximal estradiol suppression was at 12h and the steady serum E2 suppression was 38-32%

Yes bro the less potent zero unique property aromatase inhibitor mogs you're right I'm trolling, its almost as if its more tolerable because its less potent at doing it's job

I literally wont endorse aromatase inhibitors for height if you don't meet the requirements/have high baseline e2, it doesn't do shit which you keep contradicting yourself with aswell lol