What is the best aromatase inhibitor to take in puberty for growth plates?

[manuel355335]

Im 15 and my plates are still open I am on hgh already but I need an ai so my bones dont age faster which ai is the best in your opinion because too low estrogen or zero estrogen is also bad and what ai lowers it but not too low?

 

[Sayan.xdd]

this isn't clear evidence
Estrogen being the main driver of fusion does not prove anything about androgens
In the 2nd picture, it also never talks about the effect of androgens. Even though they reached average female height., this doesnt prove anything with androgens, since these people have the estrogens of a woman.I mean, you cant give an androgen to a woman and expect same effects with men...
Additionally, the third example is too nuanced... The aromatase deficient people already have very elevated levels of T, this doesn't apply to us

dodged, no response to anything ive said

 

[i cant lie cant lie]

dodged, no response to anything ive said

?

If you're gonna say that at least elaborate dodged? you won the argument man!

 

[Sayan.xdd]

?

If you're gonna say that at least elaborate dodged? you won the argument man!

the point isn't winning the argument. you're not engaging with the substance im bringing up

 

[Sayan.xdd]

?

If you're gonna say that at least elaborate dodged? you won the argument man!

prove to me that androgens have the properties to age bones by themselves. explain it mechanistically. i dont care about one shitty google search which isn't even backed by the consensus of modern endocrinology.

 

[i cant lie cant lie]

prove to me that androgens have the properties to age bones by themselves. explain it mechanistically. i dont care about one shitty google search which isn't even backed by the consensus of modern endocrinology.

There are AR [androgen receptors] in the growth plates, which speed up maturation... Hence androgens play a role in skeletal maturation.


Similar to how ER [estrogen receptors] in the growth plates also speed up maturation

 

[Sayan.xdd]

There are AR [androgen receptors] in the growth plates, which speed up maturation... Hence androgens play a role in skeletal maturation.


Similar to how ER [estrogen receptors] in the growth plates also speed up maturation

non sequitur. the presence of ARs in growth plates doesnt mechanistically demonstrate that androgens alone can induce skeletal maturation. on what deductive basis do you reach that conclusion?

 

[12thdisciple]

Endoxifen is the only good option, its a SERM which antagonizes estrogen at the growth plates. Supressing estrogen in your whole body is far from optimal

 

[i cant lie cant lie]

non sequitur. the presence of ARs in growth plates doesnt mechanistically demonstrate that androgens alone can induce skeletal maturation. on what deductive basis do you reach that conclusion?

Androgens and Bone - PMC

Testosterone is the major gonadal sex steroid produced by the testes in men. Testosterone is also produced in smaller amounts by the ovaries in women. The adrenal glands produce the weaker androgens dehydroepiandrosterone, dehydroepiandrosterone ...

pmc.ncbi.nlm.nih.gov

This chunk really says most of it for you, I copied link to highlight

 

[Sayan.xdd]

Androgens and Bone - PMC

Testosterone is the major gonadal sex steroid produced by the testes in men. Testosterone is also produced in smaller amounts by the ovaries in women. The adrenal glands produce the weaker androgens dehydroepiandrosterone, dehydroepiandrosterone ...

pmc.ncbi.nlm.nih.gov

This chunk really says most of it for you, I copied link to highlight

i know, ive read that study. it doesn't even prove your point. it literally says that any effect on epiphyseal fusion may be indirect via aromatization to estrogen. it doesn't prove that androgens by themselves can age bones.

 

[i cant lie cant lie]

i know, ive read that study. it doesn't even prove your point. it literally says that any effect on epiphyseal fusion may be indirect via aromatization to estrogen. it doesn't prove that androgens by themselves can age bones.

right....