What is the best erda dose?

[myxa8brah]

I am 15 years old and 5'7 tall; my target height is 5'8, so I plan to use erda with an aI or tamoxifen.

I am considering a standard 3 mg dose for a year maintaining phosphorus levels at 1200 without using lanthanum carbonate and keeping estradiol levels low but not zero to preserve natural pulsatile growth hormone secretion, since I won't be using gh to save money for some methyltren

Many people claim the optimal dose is 8 mg; however, the difference in FGFR3 and FGFR2 receptor inhibition between 4 mg and 8 mg is reportedly only 10%, even though the dose doubles and so do the side effects. Also, excessive FGFR2 inhibition probably isn't ideal. That said, if I did opt for 8 mg, I would only take it for 16 weeks; instead of AAS, I could add 50 mcg/kg of ghto the regimen.

Ultimately, I want to find the "best" dose for my current situation not one that would have been optimal a year or two ago because I don't have much growing time left.

 

[grymhackare]

5mg i think

 

[myxa8brah]

5mg i think

5mg i think

5mg isn't much different from 4mg; as I mentioned, 4mg inhibits 80% of FGFR2 and 75% of FGFR3, whereas 8mg inhibits 88% of FGFR2 and 85% of FGFR3. The difference is minimal, yet the side effects are greater, so I don't get why 8mg is so overhyped—which is why I'm making this post. On the other hand, 2mg inhibits 50% of both, but—as I said—it's probably better not to completely block FGFR2 for the sake of bone growth, right? Meanwhile, 3mg yields 65% inhibition for FGFR2 and 60% for FGFR3, and it can be run for a year alongside a low-dose AI and a SERM. So, I have a choice between 3mg, 4mg, and 8mg (plus GH), but I'm unsure if—even with a low-dose AI and 3mg for a year—the growth plates might still close halfway through anyway.

 

[grymhackare]

well i dnr

 

[myxa8brah]

I am 15 years old and 5'7 tall; my target height is 5'8, so I plan to use erda with an aI or tamoxifen.

I am considering a standard 3 mg dose for a year maintaining phosphorus levels at 1200 without using lanthanum carbonate and keeping estradiol levels low but not zero to preserve natural pulsatile growth hormone secretion, since I won't be using gh to save money for some methyltren

Many people claim the optimal dose is 8 mg; however, the difference in FGFR3 and FGFR2 receptor inhibition between 4 mg and 8 mg is reportedly only 10%, even though the dose doubles and so do the side effects. Also, excessive FGFR2 inhibition probably isn't ideal. That said, if I did opt for 8 mg, I would only take it for 16 weeks; instead of AAS, I could add 50 mcg/kg of ghto the regimen.

Ultimately, I want to find the "best" dose for my current situation not one that would have been optimal a year or two ago because I don't have much growing time left.

bump

 

[myxa8brah]

I am 15 years old and 5'7 tall; my target height is 5'8, so I plan to use erda with an aI or tamoxifen.

I am considering a standard 3 mg dose for a year maintaining phosphorus levels at 1200 without using lanthanum carbonate and keeping estradiol levels low but not zero to preserve natural pulsatile growth hormone secretion, since I won't be using gh to save money for some methyltren

Many people claim the optimal dose is 8 mg; however, the difference in FGFR3 and FGFR2 receptor inhibition between 4 mg and 8 mg is reportedly only 10%, even though the dose doubles and so do the side effects. Also, excessive FGFR2 inhibition probably isn't ideal. That said, if I did opt for 8 mg, I would only take it for 16 weeks; instead of AAS, I could add 50 mcg/kg of ghto the regimen.

Ultimately, I want to find the "best" dose for my current situation not one that would have been optimal a year or two ago because I don't have much growing time left.

bump