Where is facial fat loss good?

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As we've all heard, tretinoin may burn fat locally. So what parts of the face is that a good thing, and where is it a disaster?
 
Bad=upper eyelid and undereye area
Good=everywhere else
 
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Where does the under eye area stop exactly?
Wherever dark circles are. Low body fat makes them more visible.
1636487721428
 
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loss of facial fat in certain places will create naso folds + undereye creases

loss of facial fat is basically looking less youthful, thats a given
 
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loss of facial fat in certain places will create naso folds + undereye creases

loss of facial fat is basically looking less youthful, thats a given
Where would you avoid applying Tret to minimize nasiolabal folds? Literally just over the folds?
 
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Where would you avoid applying Tret to minimize nasiolabal folds? Literally just over the folds?
not sure it works that way
even if you spread o certain areas its gonna spear near around it

also I dont quite understand the mechanism behind the fat loss
 

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