Where’s the evidence that local e2 cant be inhibited?

[Zagro]

It’s like everytime retards on tiktok make a claim it spreads everywhere

Yes local e2 exists and there’s also estrogen biosynthesis in the chondrocytes locally but where does it say that we cant inhibit it?

Local e2 partly depends on your systemic/serum e2, and even when dosing test high you can take potent aromatase inhibitors which are known to work insanely good intracellulary.

So someone tell me how it cant be blocked

 

[PharmaPhaggot]

The evidence is retards shouting it, an even better piece of evidence that it can be inhibited is the brain as that can be looked at more easily, if ai's were not able to do this they also wouldnt make you retarded when used in high doses as the hypocampus mainly uses local e2 yet they time and time again reduce ltp, memory etc and same with the amygdala but with anxiety and such we can also se lower e2 levels locally when tedted

 

[Zagro]

The evidence is retards shouting it, an even better piece of evidence that it can be inhibited is the brain as that can be looked at more easily, if ai's were not able to do this they also wouldnt make you retarded when used in high doses as the hypocampus mainly uses local e2 yet they time and time again reduce ltp, memory etc and same with the amygdala but with anxiety and such we can also se lower e2 levels locally when tedted

B-but fletchzilla on tiktok said it’ll stunt my growth

Yeah decent comparison and we literally have studies where letrozole is used on pubertal boys and it slows down bone age maturation rate compared to the control group, although their t levels are exceptionally high because of the letro so with their logic it should stunt growth cus muhh substrates

@birthdefect

 

[birthdefect]

B-but fletchzilla on tiktok said it’ll stunt my growth

Yeah decent comparison and we literally have studies where letrozole is used on pubertal boys and it slows down bone age maturation rate compared to the control group, although their t levels are exceptionally high because of the letro so with their logic it should stunt growth cus muhh substrates

@birthdefect

exactly
infact letrozole is best for this purpose as its shown to decrease intracellular and peripheral aromatisation, likely why it causes a surge in test so much higher than arimidex
saying this tho, this doesnt even get into the best drug for e2 but i doubt many are sourcing it, a serd

 

[CertifiedGoy]

I used to say it couldn’t until I looked further into it and low and behold aromatase inhibitors will work in every tissue including bone