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Sertraline - Wikipedia
it has been suggested that clinically it may weakly inhibit the reuptake of dopamine,[115] particularly at high dosages.[116] For this reason, sertraline has sometimes been described as a serotonin–dopamine reuptake inhibitor (SDRI).[1
Tatsumi et al. (1997) found Ki values of sertraline at the human SERT, DAT, and NET of 0.29, 25, and 420 nM, respectively.[102] The selectivity of sertraline for the SERT over the DAT was 86-fold.[102] In any case, of the wide assortment of antidepressants assessed in the study, sertraline showed the highest affinity of them all for the DAT, even higher than the norepinephrine–dopamine reuptake inhibitors (NDRIs) nomifensine (Ki = 56 nM) and bupropion (Ki = 520 nM).[102][113] Sertraline also has similar affinity for the DAT as the NDRI methylphenidate (Ki = 24 nM).[102][113] Tametraline (CP-24,441), a very close analogue of sertraline and the compound from which sertraline was originally derived, is an NDRI that was never marketed.[118]