1xc6
height is life
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low estrogen is often emphasized for delaying growth plate fusion and mistaken to “allow growth” but this only creates the potential for growth it doesn’t drive it. The real determining factor is DNA methylation which is an epigenetic process that controls whether growth-related genes are expressed. Key genes like the OBVIOUS and well known IGF-1 (responsible for bone elongation), as well RUNX2 (ossification), and COL2A1 (cartilage growth) all rely on proper methylation to function. Without it, these genes can be silenced, stalling growth even if the plates remain open. Unlike low estrogen, which passively delays plate closure, DNA methylation is an active mechanism that directly determines whether the body uses the growth window effectively. This makes methylation more critical than low estrogen in unlocking height potential.
So how can we improve dna methylation ?
This is really a key factor that questions if heightmaxxing is cope or not as improving dna methylations for height is kinda hard ….
However there are theoretical methods which may or may not work (theoretical) :
-Histone Deacetylase (HDAC) Inhibitors
-S-adenosylmethionine (SAMe) Enhancers
-5-Azacytidine and Decitabine
studies :
openarchive.ki.se
www.nature.com
clinicalepigeneticsjournal.biomedcentral.com
www.medrxiv.org
So how can we improve dna methylation ?
This is really a key factor that questions if heightmaxxing is cope or not as improving dna methylations for height is kinda hard ….
However there are theoretical methods which may or may not work (theoretical) :
-Histone Deacetylase (HDAC) Inhibitors
-S-adenosylmethionine (SAMe) Enhancers
-5-Azacytidine and Decitabine
studies :
The role of estrogen in growth plate chondrogenesis
Overall body proportion is determined by the size of the skeleton, which in turn is determined by the rate and duration of longitudinal bone growth. Longitudinal bone growth occurs at the growth plate and is regulated by a variety of hormones and growth factors. During puberty, estrogen...
openarchive.ki.se
DNA methylation at the suppressor of cytokine signaling 3 (SOCS3) gene influences height in childhood - Nature Communications
Here the authors identify an association between methylation of the suppressor of cytokine signaling 3 (SOCS3) and height in children from India, Gambia and the UK.
www.nature.com
Abnormal DNA methylation within genes of the steroidogenesis pathway two years after paediatric critical illness and association with stunted growth in height further in time - Clinical Epigenetics
Background Former critically ill children show an epigenetic age deceleration 2 years after paediatric intensive care unit (PICU) admission as compared with normally developing healthy children, with stunted growth in height 2 years further in time as physical correlate. This was particularly...
clinicalepigeneticsjournal.biomedcentral.com
Childhood growth and development and DNA methylation age in mid-life
Background In the first study of its kind, we examine the association between growth and development in early life and DNAm age biomarkers in mid-life. Methods Participants were from the Medical Research Council National Survey of Health and Development(n=1,376). Four DNAm age...
