Why dna methylation is more important than low estrogen for heightmaxxing (must read!!!)

[1xc6]

low estrogen is often emphasized for delaying growth plate fusion and mistaken to “allow growth” but this only creates the potential for growth it doesn’t drive it. The real determining factor is DNA methylation which is an epigenetic process that controls whether growth-related genes are expressed. Key genes like the OBVIOUS and well known IGF-1 (responsible for bone elongation), as well RUNX2 (ossification), and COL2A1 (cartilage growth) all rely on proper methylation to function. Without it, these genes can be silenced, stalling growth even if the plates remain open. Unlike low estrogen, which passively delays plate closure, DNA methylation is an active mechanism that directly determines whether the body uses the growth window effectively. This makes methylation more critical than low estrogen in unlocking height potential.

So how can we improve dna methylation ?
This is really a key factor that questions if heightmaxxing is cope or not as improving dna methylations for height is kinda hard ….
However there are theoretical methods which may or may not work (theoretical) :
-Histone Deacetylase (HDAC) Inhibitors
-S-adenosylmethionine (SAMe) Enhancers
-5-Azacytidine and Decitabine


studies :

The role of estrogen in growth plate chondrogenesis

Overall body proportion is determined by the size of the skeleton, which in turn is determined by the rate and duration of longitudinal bone growth. Longitudinal bone growth occurs at the growth plate and is regulated by a variety of hormones and growth factors. During puberty, estrogen...

openarchive.ki.se

Associations between epigenome-wide DNA methylation and height-related traits among Sub-Saharan Africans: the RODAM study | Journal of Developmental Origins of Health and Disease | Cambridge Core

Associations between epigenome-wide DNA methylation and height-related traits among Sub-Saharan Africans: the RODAM study - Volume 14 Issue 5

www.cambridge.org

DNA methylation at the suppressor of cytokine signaling 3 (SOCS3) gene influences height in childhood - Nature Communications

Here the authors identify an association between methylation of the suppressor of cytokine signaling 3 (SOCS3) and height in children from India, Gambia and the UK.

www.nature.com

Abnormal DNA methylation within genes of the steroidogenesis pathway two years after paediatric critical illness and association with stunted growth in height further in time - Clinical Epigenetics

Background Former critically ill children show an epigenetic age deceleration 2 years after paediatric intensive care unit (PICU) admission as compared with normally developing healthy children, with stunted growth in height 2 years further in time as physical correlate. This was particularly...

clinicalepigeneticsjournal.biomedcentral.com

Childhood growth and development and DNA methylation age in mid-life

Background In the first study of its kind, we examine the association between growth and development in early life and DNAm age biomarkers in mid-life. Methods Participants were from the Medical Research Council National Survey of Health and Development(n=1,376). Four DNAm age...

www.medrxiv.org

 

[1xc6]

ungrateful forum

 

[DR. NICKGA]

This medicine that you mentioned, are they studies that show that it increase height growth?

 

[1xc6]

@mydream

This medicine that you mentioned, are they studies that show that it increase height growth?

I don’t think u understand the point of this thread . anyways yes supposedly they can support height growth

 

[Cyrus]

@mydream

I don’t think u understand the point of this thread . anyways yes supposedly they can support height growth

link

 

[1xc6]

ungrateful forum

 

[Cyrus]

anyways yes supposedly they can support height growth

@1xc6 link it bro

 

[Cyrus]

ungrateful forum

what would be ur ideal stack for dna methylation

 

[wastedspermcel]

OP forgot the children in the study are like 6 fucking years old. Forget about heightmaxxing and gaining more than an inch if you're over the age of 12. If you're over 16 then just rope

 

[1xc6]

read it i wrote it niger

@1xc6 link it bro

 

[Sachlichkeit]

low estrogen is often emphasized for delaying growth plate fusion and mistaken to “allow growth” but this only creates the potential for growth it doesn’t drive it. The real determining factor is DNA methylation which is an epigenetic process that controls whether growth-related genes are expressed. Key genes like the OBVIOUS and well known IGF-1 (responsible for bone elongation), as well RUNX2 (ossification), and COL2A1 (cartilage growth) all rely on proper methylation to function. Without it, these genes can be silenced, stalling growth even if the plates remain open. Unlike low estrogen, which passively delays plate closure, DNA methylation is an active mechanism that directly determines whether the body uses the growth window effectively. This makes methylation more critical than low estrogen in unlocking height potential.

So how can we improve dna methylation ?
This is really a key factor that questions if heightmaxxing is cope or not as improving dna methylations for height is kinda hard ….
However there are theoretical methods which may or may not work (theoretical) :
-Histone Deacetylase (HDAC) Inhibitors
-S-adenosylmethionine (SAMe) Enhancers
-5-Azacytidine and Decitabine


studies :

The role of estrogen in growth plate chondrogenesis

Overall body proportion is determined by the size of the skeleton, which in turn is determined by the rate and duration of longitudinal bone growth. Longitudinal bone growth occurs at the growth plate and is regulated by a variety of hormones and growth factors. During puberty, estrogen...

openarchive.ki.se

Associations between epigenome-wide DNA methylation and height-related traits among Sub-Saharan Africans: the RODAM study | Journal of Developmental Origins of Health and Disease | Cambridge Core

Associations between epigenome-wide DNA methylation and height-related traits among Sub-Saharan Africans: the RODAM study - Volume 14 Issue 5

www.cambridge.org

DNA methylation at the suppressor of cytokine signaling 3 (SOCS3) gene influences height in childhood - Nature Communications

Here the authors identify an association between methylation of the suppressor of cytokine signaling 3 (SOCS3) and height in children from India, Gambia and the UK.

www.nature.com

Abnormal DNA methylation within genes of the steroidogenesis pathway two years after paediatric critical illness and association with stunted growth in height further in time - Clinical Epigenetics

Background Former critically ill children show an epigenetic age deceleration 2 years after paediatric intensive care unit (PICU) admission as compared with normally developing healthy children, with stunted growth in height 2 years further in time as physical correlate. This was particularly...

clinicalepigeneticsjournal.biomedcentral.com

Childhood growth and development and DNA methylation age in mid-life

Background In the first study of its kind, we examine the association between growth and development in early life and DNAm age biomarkers in mid-life. Methods Participants were from the Medical Research Council National Survey of Health and Development(n=1,376). Four DNAm age...

www.medrxiv.org

You are right.

Mechanism	Study	Efficacy Metric	Estimated Growth Impact
Anastrozole	Mauras et al., 2004	+6.7 cm predicted height	~15–20% increase in growth outcome
Letrozole	Wickman et al., 2001	+10 cm predicted height	~25–30% potential in youth
EZH2 Inhibitor (Tazemetostat)	Dudakovic et al., 2015	↑ osteoblast markers, ↑ mineralization	~30–40% more bone formation
HDAC Inhibitor (Vorinostat)	Lee et al., 2009	↑ BMP2/Runx2 gene expression	2–4x osteogenic lineage bias
Decitabine (DNMT Inhibitor)	Beerman et al., 2013	Reversal of stem cell aging via demethylation	Epigenetic “reset” of potential

Efficacy of epigenetic drugs on height I would say is somewhere between 40-60%, estrogen control 10-30%

 

[Dex1310]

You are right.

Mechanism	Study	Efficacy Metric	Estimated Growth Impact
Anastrozole	Mauras et al., 2004	+6.7 cm predicted height	~15–20% increase in growth outcome
Letrozole	Wickman et al., 2001	+10 cm predicted height	~25–30% potential in youth
EZH2 Inhibitor (Tazemetostat)	Dudakovic et al., 2015	↑ osteoblast markers, ↑ mineralization	~30–40% more bone formation
HDAC Inhibitor (Vorinostat)	Lee et al., 2009	↑ BMP2/Runx2 gene expression	2–4x osteogenic lineage bias
Decitabine (DNMT Inhibitor)	Beerman et al., 2013	Reversal of stem cell aging via demethylation	Epigenetic “reset” of potential

Efficacy of epigenetic drugs on height I would say is somewhere between 40-60%, estrogen control 10-30%

which of these 3 drugs would you take for height not talking about ai