Why HGH is cope and will NOT work for you!!!! (HGH USERS GTFIH!!!)

A lot of People continue to believe that healthy children who lack growth hormone deficiency will experience height increases through HGH injections.

It won’t.

Why?

Let’s get into this


1. How Growth Hormone Actually Works

Human growth hormone (HGH), also called somatotropin, is a hormone that the pituitary gland, which is about the size of a pea and found at the base of your brain, makes and releases

Its main job?

Human growth hormone triggers growth in almost every tissue and organ in your body. It’s mostly known for its growth-promoting effect on cartilage and bone, especially in puberty. Cells in cartilage called chondrocytes and cells in bones called osteoblasts, receive signals from HGH to increase replication and thus allow for growth in size.


2. What the Studies ACTUALLY Show

People often cite studies claiming “HGH increases height.” Let’s clarify what these studies actually studied.

Most research involves children who are GH-deficient children who cannot produce normal levels of GH due to medical conditions. Examples:




VERY Important: These studies are on children who are medically short due to GH deficiency, and do NOT produce enough HGH not normal kids. The effect is correcting a deficiency, not surpassing genetic potential.



Some other studies explore ISS (Idiopathic Short Stature):


B-B-But ISS Children Grew Taller why can’t i?

Let’s clarify: ISS children are not short simply because of genetics. ISS is defined as short stature without a known cause, that INCLUDES GENETICS and many children diagnosed as having ISS have partial GH insensitivity (Evidence: Idiopathic short stature)

Bottom line: if you are within normal growth ranges and are not diagnosed as ISS, these studies do NOT apply to you.


3. Why HGH does NOT work for healthy normal children with PROOF

For children with normal growth hormone (GH) levels, exogenous GH administration cannot increase final adult height. Here’s why:



  • GH does not create new growth potential.
    The growth plates in long bones experience linear growth through their epiphyseal plates. The genetic code determines both number and proliferative capacity of chondrocytes present at these growth plates. GH promotes the growth of chondrocytes and their development into mature cells, yet it cannot boost these cells' genetic-based growth capacity beyond their existing limits.
  • GH cannot override genetic determinants of stature.
    Height is a polygenic trait which multiple genetic loci control its development. The treatment of GH-sufficient children with GH therapy does not affect their gene expression or the genetic skeletal structure which their genome contains.
  • Endocrine feedback loops limit excessive growth signaling.
    The GH–IGF-1 axis is tightly regulated:
    • Elevated serum IGF-1 inhibits hypothalamic GHRH secretion and stimulates somatostatin release, reducing endogenous GH production.
    • Peripheral tissues exhibit receptor-mediated resistance to supra-physiologic GH and IGF-1 concentrations, limiting further cellular proliferation.
  • Physiologic ceiling effect.
    In GH-sufficient children, endogenous GH already saturates IGF-1 production and downstream growth plate signaling. Exogenous GH cannot enhance this process; the system is operating at maximal physiological capacity. Clinical evidence and studies supports these claims: children with normal GH levels do not achieve increased adult height despite high-dose GH administration
EVIDENCE AND STUDIES ON NORMAL KIDS:

Final height after growth hormone therapy in non-growth-hormone-deficient children with short stature - PubMed

No Improvement of Adult Height in Non-growth Hormone (GH) Deficient Short Children with GH Treatment - PMC

https://www.sciencedirect.com/science/article/abs/pii/S002234769470192X

No Improvement of Adult Height in Non-growth Hormone (GH) Deficient Short Children with GH Treatment - PubMed



Analogy (for conceptual clarity): Imagine a plant with genetically fixed maximum height. Adequate water and nutrients allow it to reach its potential. Adding more water beyond what it can physiologically use does not make it grow taller; it may even disrupt normal growth processes.

Summary: GH in healthy, non-deficient children simply optimizes a process that is already at capacity. There is no latent or “hidden” height to unlock the endocrine system and growth plates are already functioning at their maximum biological limits.


4. Why people think it works!!!!!!

This is where most people get fooled and start to think it’s working.

HGH can TEMPORARILY increase growth rate (as seen in the studies). You grow faster for a period, but it does NOT increase final adult height. Your genetic height ceiling remains THE SAME. In the end you will grow the same without HGH.


5. What you actually get and are paying for: Side Effects

Injecting ratpiss HGH from Chinese labs is retarded and will NOT work all you are paying for are potential risks including:

  • Insulin resistance
  • Increased risk of type 2 diabetes
  • Fluid retention and edema
  • Joint pain
  • Carpal tunnel syndrome
  • Hip growth plate injury
  • Benign intracranial hypertension (severe headaches and vision changes)
  • Abnormal IGF‑1 elevations
  • Theoretical increased cancer risk due to chronic IGF‑1 stimulation
​

6. Summary

HGH only works in:

  • Documented GH deficiency
  • Select ISS cases


HGH does NOT:

  • Make normal kids taller than their genetics allow
  • Extend growth plates
  • Increase final adult height
  • Create height out of nowhere
If you do not have a diagnosed condition, you will not gain any adult height you will only get side effects.

The truth?: There is no hack around genetics. Injecting Chinese ratpiss HGH is expensive, unnecessary, and retarded.



Biology does not care about your retarded cope.
 
Last edited:
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This will be the biggest debunk I've ever done its fun when greys like you claim random shit
 
  • +1
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Ahmed88 said:
Thats 6ius/day for a 80kg and they also used 1iu/kg a week which would be 12iu/day which is double or 3x more, what some people inject. Both of them did not show an increase in adult height
Click to expand...
Did the patients have igf receptor issues?
 
  • Hmm...
Reactions: Ahmed88
the alternative is doing nothing 🥀

Unless u actually loaded and can afford the stem cell method
 
  • +1
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Some people say estrogen plays a role in closing the growth plates
Would blocking estrogen during puberty increase potential for height, despite obvious risks that would come with that
 
r4pid said:
Some people say estrogen plays a role in closing the growth plates
Would blocking estrogen during puberty increase potential for height, despite obvious risks that would come with that
Click to expand...
Aromatase inhibitors extend the duration of epiphyseal closure because they decrease estrogen levels, yet estrogen remains vital for chondrocyte development and growth together with the control of essential genes which include CTX5, Sox9, Runx2, and extracellular matrix modulators. Blocking estrogen disrupts these gene networks and cartilage maturation, blocking these would at best lead to minimal gains at height and the side effects wouldn't outweigh the benefits
 
  • +1
Reactions: r4pid
So there is pretty much nothing you can do?
 
Ahmed88 said:
A lot of People continue to believe that healthy children who lack growth hormone deficiency will experience height increases through HGH injections.

It won’t.

Why?

Let’s get into this


1. How Growth Hormone Actually Works

Human growth hormone (HGH), also called somatotropin, is a hormone that the pituitary gland, which is about the size of a pea and found at the base of your brain, makes and releases

Its main job?

Human growth hormone triggers growth in almost every tissue and organ in your body. It’s mostly known for its growth-promoting effect on cartilage and bone, especially in puberty. Cells in cartilage called chondrocytes and cells in bones called osteoblasts, receive signals from HGH to increase replication and thus allow for growth in size.


2. What the Studies ACTUALLY Show

People often cite studies claiming “HGH increases height.” Let’s clarify what these studies actually studied.

Most research involves children who are GH-deficient children who cannot produce normal levels of GH due to medical conditions. Examples:




VERY Important: These studies are on children who are medically short due to GH deficiency, and do NOT produce enough HGH not normal kids. The effect is correcting a deficiency, not surpassing genetic potential.



Some other studies explore ISS (Idiopathic Short Stature):


B-B-But ISS Children Grew Taller why can’t i?

Let’s clarify: ISS children are not short simply because of genetics. ISS is defined as short stature without a known cause, that INCLUDES GENETICS and many children diagnosed as having ISS have partial GH insensitivity (Evidence: Idiopathic short stature)

Bottom line: if you are within normal growth ranges and are not diagnosed as ISS, these studies do NOT apply to you.


3. Why HGH does NOT work for healthy normal children with PROOF

For children with normal growth hormone (GH) levels, exogenous GH administration cannot increase final adult height. Here’s why:



  • GH does not create new growth potential.
    The growth plates in long bones experience linear growth through their epiphyseal plates. The genetic code determines both number and proliferative capacity of chondrocytes present at these growth plates. GH promotes the growth of chondrocytes and their development into mature cells, yet it cannot boost these cells' genetic-based growth capacity beyond their existing limits.
  • GH cannot override genetic determinants of stature.
    Height is a polygenic trait which multiple genetic loci control its development. The treatment of GH-sufficient children with GH therapy does not affect their gene expression or the genetic skeletal structure which their genome contains.
  • Endocrine feedback loops limit excessive growth signaling.
    The GH–IGF-1 axis is tightly regulated:
    • Elevated serum IGF-1 inhibits hypothalamic GHRH secretion and stimulates somatostatin release, reducing endogenous GH production.
    • Peripheral tissues exhibit receptor-mediated resistance to supra-physiologic GH and IGF-1 concentrations, limiting further cellular proliferation.
  • Physiologic ceiling effect.
    In GH-sufficient children, endogenous GH already saturates IGF-1 production and downstream growth plate signaling. Exogenous GH cannot enhance this process; the system is operating at maximal physiological capacity. Clinical evidence and studies supports these claims: children with normal GH levels do not achieve increased adult height despite high-dose GH administration
EVIDENCE AND STUDIES ON NORMAL KIDS:

Final height after growth hormone therapy in non-growth-hormone-deficient children with short stature - PubMed

No Improvement of Adult Height in Non-growth Hormone (GH) Deficient Short Children with GH Treatment - PMC

https://www.sciencedirect.com/science/article/abs/pii/S002234769470192X

No Improvement of Adult Height in Non-growth Hormone (GH) Deficient Short Children with GH Treatment - PubMed



Analogy (for conceptual clarity): Imagine a plant with genetically fixed maximum height. Adequate water and nutrients allow it to reach its potential. Adding more water beyond what it can physiologically use does not make it grow taller; it may even disrupt normal growth processes.

Summary: GH in healthy, non-deficient children simply optimizes a process that is already at capacity. There is no latent or “hidden” height to unlock the endocrine system and growth plates are already functioning at their maximum biological limits.


4. Why people think it works!!!!!!

This is where most people get fooled and start to think it’s working.

HGH can TEMPORARILY increase growth rate (as seen in the studies). You grow faster for a period, but it does NOT increase final adult height. Your genetic height ceiling remains THE SAME. In the end you will grow the same without HGH.


5. What you actually get and are paying for: Side Effects

Injecting ratpiss HGH from Chinese labs is retarded and will NOT work all you are paying for are potential risks including:

  • Insulin resistance
  • Increased risk of type 2 diabetes
  • Fluid retention and edema
  • Joint pain
  • Carpal tunnel syndrome
  • Hip growth plate injury
  • Benign intracranial hypertension (severe headaches and vision changes)
  • Abnormal IGF‑1 elevations
  • Theoretical increased cancer risk due to chronic IGF‑1 stimulation
​

6. Summary

HGH only works in:

  • Documented GH deficiency
  • Select ISS cases


HGH does NOT:

  • Make normal kids taller than their genetics allow
  • Extend growth plates
  • Increase final adult height
  • Create height out of nowhere
If you do not have a diagnosed condition, you will not gain any adult height you will only get side effects.

The truth?: There is no hack around genetics. Injecting Chinese ratpiss HGH is expensive, unnecessary, and retarded.



Biology does not care about your retarded cope.
Click to expand...
why do acromegaly patients grow to 7 foot if genetics are the limit and its only for "deficiency". i guarantee u their genetics capped them at 5'11 but the excess hgh made them a foot taller, fucking jfl:lul:
 
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Reactions: JohnSynder and briiiancoma
r4pid said:
So there is pretty much nothing you can do?
Click to expand...
dont listen to this guy human "GROWTH" hormone works. just take ais bec it can prematurely close ur growth plates from the estrogen.
 
Ahmed88 said:
Thanks, Surpassing your genetic limit is biologically impossible no amount of hgh and ai can surpass it andwe need e2 for growth since it enhances hgh and igf1 signaling in growth plates and supports chondrocyte , supressing e2 would likely have negative effects on your health and height
Click to expand...
genetics are the blueprint not the ceiling jfl, why do u call every real method cope its misleading
 
AtrophicPyra said:
why do acromegaly patients grow to 7 foot if genetics are the limit and its only for "deficiency". i guarantee u their genetics capped them at 5'11 but the excess hgh made them a foot taller, fucking jfl:lul:
Click to expand...
is that the best argument? Why a person with a tumor in their pituitary gland grows but we dont? I refuted this multiple times jfl u might be worse then the zagro guy
 
r4pid said:
So there is pretty much nothing you can do?
Click to expand...
Pretty much yes, retards on these forums promote hgh, so they can sell their overpriced hgh to little kids, in the end its your choice to choose if you wanna believe literal studies or some random guy on org promoting chinese hgh
 
Biggest moron on this forum
 
Ahmed88 said:
is that the best argument? Why a person with a tumor in their pituitary gland grows but we dont? I refuted this multiple times jfl u might be worse then the zagro guy
Click to expand...
tryna be diff for no reason
 
Ahmed88 said:
A lot of People continue to believe that healthy children who lack growth hormone deficiency will experience height increases through HGH injections.

It won’t.

Why?

Let’s get into this


1. How Growth Hormone Actually Works

Human growth hormone (HGH), also called somatotropin, is a hormone that the pituitary gland, which is about the size of a pea and found at the base of your brain, makes and releases

Its main job?

Human growth hormone triggers growth in almost every tissue and organ in your body. It’s mostly known for its growth-promoting effect on cartilage and bone, especially in puberty. Cells in cartilage called chondrocytes and cells in bones called osteoblasts, receive signals from HGH to increase replication and thus allow for growth in size.


2. What the Studies ACTUALLY Show

People often cite studies claiming “HGH increases height.” Let’s clarify what these studies actually studied.

Most research involves children who are GH-deficient children who cannot produce normal levels of GH due to medical conditions. Examples:




VERY Important: These studies are on children who are medically short due to GH deficiency, and do NOT produce enough HGH not normal kids. The effect is correcting a deficiency, not surpassing genetic potential.



Some other studies explore ISS (Idiopathic Short Stature):


B-B-But ISS Children Grew Taller why can’t i?

Let’s clarify: ISS children are not short simply because of genetics. ISS is defined as short stature without a known cause, that INCLUDES GENETICS and many children diagnosed as having ISS have partial GH insensitivity (Evidence: Idiopathic short stature)

Bottom line: if you are within normal growth ranges and are not diagnosed as ISS, these studies do NOT apply to you.


3. Why HGH does NOT work for healthy normal children with PROOF

For children with normal growth hormone (GH) levels, exogenous GH administration cannot increase final adult height. Here’s why:



  • GH does not create new growth potential.
    The growth plates in long bones experience linear growth through their epiphyseal plates. The genetic code determines both number and proliferative capacity of chondrocytes present at these growth plates. GH promotes the growth of chondrocytes and their development into mature cells, yet it cannot boost these cells' genetic-based growth capacity beyond their existing limits.
  • GH cannot override genetic determinants of stature.
    Height is a polygenic trait which multiple genetic loci control its development. The treatment of GH-sufficient children with GH therapy does not affect their gene expression or the genetic skeletal structure which their genome contains.
  • Endocrine feedback loops limit excessive growth signaling.
    The GH–IGF-1 axis is tightly regulated:
    • Elevated serum IGF-1 inhibits hypothalamic GHRH secretion and stimulates somatostatin release, reducing endogenous GH production.
    • Peripheral tissues exhibit receptor-mediated resistance to supra-physiologic GH and IGF-1 concentrations, limiting further cellular proliferation.
  • Physiologic ceiling effect.
    In GH-sufficient children, endogenous GH already saturates IGF-1 production and downstream growth plate signaling. Exogenous GH cannot enhance this process; the system is operating at maximal physiological capacity. Clinical evidence and studies supports these claims: children with normal GH levels do not achieve increased adult height despite high-dose GH administration
EVIDENCE AND STUDIES ON NORMAL KIDS:

Final height after growth hormone therapy in non-growth-hormone-deficient children with short stature - PubMed

No Improvement of Adult Height in Non-growth Hormone (GH) Deficient Short Children with GH Treatment - PMC

https://www.sciencedirect.com/science/article/abs/pii/S002234769470192X

No Improvement of Adult Height in Non-growth Hormone (GH) Deficient Short Children with GH Treatment - PubMed



Analogy (for conceptual clarity): Imagine a plant with genetically fixed maximum height. Adequate water and nutrients allow it to reach its potential. Adding more water beyond what it can physiologically use does not make it grow taller; it may even disrupt normal growth processes.

Summary: GH in healthy, non-deficient children simply optimizes a process that is already at capacity. There is no latent or “hidden” height to unlock the endocrine system and growth plates are already functioning at their maximum biological limits.


4. Why people think it works!!!!!!

This is where most people get fooled and start to think it’s working.

HGH can TEMPORARILY increase growth rate (as seen in the studies). You grow faster for a period, but it does NOT increase final adult height. Your genetic height ceiling remains THE SAME. In the end you will grow the same without HGH.


5. What you actually get and are paying for: Side Effects

Injecting ratpiss HGH from Chinese labs is retarded and will NOT work all you are paying for are potential risks including:

  • Insulin resistance
  • Increased risk of type 2 diabetes
  • Fluid retention and edema
  • Joint pain
  • Carpal tunnel syndrome
  • Hip growth plate injury
  • Benign intracranial hypertension (severe headaches and vision changes)
  • Abnormal IGF‑1 elevations
  • Theoretical increased cancer risk due to chronic IGF‑1 stimulation
​

6. Summary

HGH only works in:

  • Documented GH deficiency
  • Select ISS cases


HGH does NOT:

  • Make normal kids taller than their genetics allow
  • Extend growth plates
  • Increase final adult height
  • Create height out of nowhere
If you do not have a diagnosed condition, you will not gain any adult height you will only get side effects.

The truth?: There is no hack around genetics. Injecting Chinese ratpiss HGH is expensive, unnecessary, and retarded.



Biology does not care about your retarded cope.
Click to expand...
FINALLY someone that says it. So many people think hgh will ascend them; not only heightwise but also facewise. SOLEY hgh. Stupid tiktokcels smh. gh is good, but not when youre on only hgh. Its good in roid cycles or when you combine it with other compounds to actually atleast grow a bit more
 
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Ahmed88 said:
Thats 6ius/day for a 80kg and they also used 1iu/kg a week which would be 12iu/day which is double or 3x more, what some people inject. Both of them did not show an increase in adult height
Click to expand...
There is a study where they use 0.3mg/kg/week on 13.8yo children
That's 7.75iu for a 60kg boy
They grew 2inches taller than prediction
n>1000
 
tomahawk said:
There is a study where they use 0.3mg/kg/week on 13.8yo children
That's 7.75iu for a 60kg boy
They grew 2inches taller than prediction
n>1000
Click to expand...
On non ghd and non iss children?
 
tomahawk said:
Iss
Click to expand...
Yes the thing most niggas fail to understand is that we are not iss children, they are short without a reason (that includes genetics), most of the people here blast hgh because they are short DUE to genetics
 
Ahmed88 said:
Yes the thing most niggas fail to understand is that we are not iss children, they are short without a reason (that includes genetics), most of the people here blast hgh because they are short DUE to genetics
Click to expand...
Iss children are just children with shit genetics so what they work the same way
 
  • +1
  • JFL
Reactions: JohnSynder and Ahmed88
tomahawk said:
Iss children are just children with shit genetics so what they work the same way
Click to expand...
No, they are children who are short without a identifiable reason, that includes genetics
 
  • JFL
Reactions: tomahawk
Ahmed88 said:
A lot of People continue to believe that healthy children who lack growth hormone deficiency will experience height increases through HGH injections.

It won’t.

Why?

Let’s get into this


1. How Growth Hormone Actually Works

Human growth hormone (HGH), also called somatotropin, is a hormone that the pituitary gland, which is about the size of a pea and found at the base of your brain, makes and releases

Its main job?

Human growth hormone triggers growth in almost every tissue and organ in your body. It’s mostly known for its growth-promoting effect on cartilage and bone, especially in puberty. Cells in cartilage called chondrocytes and cells in bones called osteoblasts, receive signals from HGH to increase replication and thus allow for growth in size.


2. What the Studies ACTUALLY Show

People often cite studies claiming “HGH increases height.” Let’s clarify what these studies actually studied.

Most research involves children who are GH-deficient children who cannot produce normal levels of GH due to medical conditions. Examples:




VERY Important: These studies are on children who are medically short due to GH deficiency, and do NOT produce enough HGH not normal kids. The effect is correcting a deficiency, not surpassing genetic potential.



Some other studies explore ISS (Idiopathic Short Stature):


B-B-But ISS Children Grew Taller why can’t i?

Let’s clarify: ISS children are not short simply because of genetics. ISS is defined as short stature without a known cause, that INCLUDES GENETICS and many children diagnosed as having ISS have partial GH insensitivity (Evidence: Idiopathic short stature)

Bottom line: if you are within normal growth ranges and are not diagnosed as ISS, these studies do NOT apply to you.


3. Why HGH does NOT work for healthy normal children with PROOF

For children with normal growth hormone (GH) levels, exogenous GH administration cannot increase final adult height. Here’s why:



  • GH does not create new growth potential.
    The growth plates in long bones experience linear growth through their epiphyseal plates. The genetic code determines both number and proliferative capacity of chondrocytes present at these growth plates. GH promotes the growth of chondrocytes and their development into mature cells, yet it cannot boost these cells' genetic-based growth capacity beyond their existing limits.
  • GH cannot override genetic determinants of stature.
    Height is a polygenic trait which multiple genetic loci control its development. The treatment of GH-sufficient children with GH therapy does not affect their gene expression or the genetic skeletal structure which their genome contains.
  • Endocrine feedback loops limit excessive growth signaling.
    The GH–IGF-1 axis is tightly regulated:
    • Elevated serum IGF-1 inhibits hypothalamic GHRH secretion and stimulates somatostatin release, reducing endogenous GH production.
    • Peripheral tissues exhibit receptor-mediated resistance to supra-physiologic GH and IGF-1 concentrations, limiting further cellular proliferation.
  • Physiologic ceiling effect.
    In GH-sufficient children, endogenous GH already saturates IGF-1 production and downstream growth plate signaling. Exogenous GH cannot enhance this process; the system is operating at maximal physiological capacity. Clinical evidence and studies supports these claims: children with normal GH levels do not achieve increased adult height despite high-dose GH administration
EVIDENCE AND STUDIES ON NORMAL KIDS:

Final height after growth hormone therapy in non-growth-hormone-deficient children with short stature - PubMed

No Improvement of Adult Height in Non-growth Hormone (GH) Deficient Short Children with GH Treatment - PMC

https://www.sciencedirect.com/science/article/abs/pii/S002234769470192X

No Improvement of Adult Height in Non-growth Hormone (GH) Deficient Short Children with GH Treatment - PubMed



Analogy (for conceptual clarity): Imagine a plant with genetically fixed maximum height. Adequate water and nutrients allow it to reach its potential. Adding more water beyond what it can physiologically use does not make it grow taller; it may even disrupt normal growth processes.

Summary: GH in healthy, non-deficient children simply optimizes a process that is already at capacity. There is no latent or “hidden” height to unlock the endocrine system and growth plates are already functioning at their maximum biological limits.


4. Why people think it works!!!!!!

This is where most people get fooled and start to think it’s working.

HGH can TEMPORARILY increase growth rate (as seen in the studies). You grow faster for a period, but it does NOT increase final adult height. Your genetic height ceiling remains THE SAME. In the end you will grow the same without HGH.


5. What you actually get and are paying for: Side Effects

Injecting ratpiss HGH from Chinese labs is retarded and will NOT work all you are paying for are potential risks including:

  • Insulin resistance
  • Increased risk of type 2 diabetes
  • Fluid retention and edema
  • Joint pain
  • Carpal tunnel syndrome
  • Hip growth plate injury
  • Benign intracranial hypertension (severe headaches and vision changes)
  • Abnormal IGF‑1 elevations
  • Theoretical increased cancer risk due to chronic IGF‑1 stimulation
​

6. Summary

HGH only works in:

  • Documented GH deficiency
  • Select ISS cases


HGH does NOT:

  • Make normal kids taller than their genetics allow
  • Extend growth plates
  • Increase final adult height
  • Create height out of nowhere
If you do not have a diagnosed condition, you will not gain any adult height you will only get side effects.

The truth?: There is no hack around genetics. Injecting Chinese ratpiss HGH is expensive, unnecessary, and retarded.



Biology does not care about your retarded cope.
Click to expand...
but if you are a late bloomer just pin hgh and get your max height earlier???????
 
makka27141 said:
but if you are a late bloomer just pin hgh and get your max height earlier???????
Click to expand...
So get side effects and waste money, to get your already future planned height 2 years sooner?
 
will still buy and cope
 
  • +1
Reactions: JohnSynder and Ahmed88
dnr nigger
 
  • So Sad
Reactions: Ahmed88
gigantism lit proves it works for height?
 
Ahmed88 said:
A lot of People continue to believe that healthy children who lack growth hormone deficiency will experience height increases through HGH injections.

It won’t.

Why?

Let’s get into this


1. How Growth Hormone Actually Works

Human growth hormone (HGH), also called somatotropin, is a hormone that the pituitary gland, which is about the size of a pea and found at the base of your brain, makes and releases

Its main job?

Human growth hormone triggers growth in almost every tissue and organ in your body. It’s mostly known for its growth-promoting effect on cartilage and bone, especially in puberty. Cells in cartilage called chondrocytes and cells in bones called osteoblasts, receive signals from HGH to increase replication and thus allow for growth in size.


2. What the Studies ACTUALLY Show

People often cite studies claiming “HGH increases height.” Let’s clarify what these studies actually studied.

Most research involves children who are GH-deficient children who cannot produce normal levels of GH due to medical conditions. Examples:




VERY Important: These studies are on children who are medically short due to GH deficiency, and do NOT produce enough HGH not normal kids. The effect is correcting a deficiency, not surpassing genetic potential.



Some other studies explore ISS (Idiopathic Short Stature):


B-B-But ISS Children Grew Taller why can’t i?

Let’s clarify: ISS children are not short simply because of genetics. ISS is defined as short stature without a known cause, that INCLUDES GENETICS and many children diagnosed as having ISS have partial GH insensitivity (Evidence: Idiopathic short stature)

Bottom line: if you are within normal growth ranges and are not diagnosed as ISS, these studies do NOT apply to you.


3. Why HGH does NOT work for healthy normal children with PROOF

For children with normal growth hormone (GH) levels, exogenous GH administration cannot increase final adult height. Here’s why:



  • GH does not create new growth potential.
    The growth plates in long bones experience linear growth through their epiphyseal plates. The genetic code determines both number and proliferative capacity of chondrocytes present at these growth plates. GH promotes the growth of chondrocytes and their development into mature cells, yet it cannot boost these cells' genetic-based growth capacity beyond their existing limits.
  • GH cannot override genetic determinants of stature.
    Height is a polygenic trait which multiple genetic loci control its development. The treatment of GH-sufficient children with GH therapy does not affect their gene expression or the genetic skeletal structure which their genome contains.
  • Endocrine feedback loops limit excessive growth signaling.
    The GH–IGF-1 axis is tightly regulated:
    • Elevated serum IGF-1 inhibits hypothalamic GHRH secretion and stimulates somatostatin release, reducing endogenous GH production.
    • Peripheral tissues exhibit receptor-mediated resistance to supra-physiologic GH and IGF-1 concentrations, limiting further cellular proliferation.
  • Physiologic ceiling effect.
    In GH-sufficient children, endogenous GH already saturates IGF-1 production and downstream growth plate signaling. Exogenous GH cannot enhance this process; the system is operating at maximal physiological capacity. Clinical evidence and studies supports these claims: children with normal GH levels do not achieve increased adult height despite high-dose GH administration
EVIDENCE AND STUDIES ON NORMAL KIDS:

Final height after growth hormone therapy in non-growth-hormone-deficient children with short stature - PubMed

No Improvement of Adult Height in Non-growth Hormone (GH) Deficient Short Children with GH Treatment - PMC

https://www.sciencedirect.com/science/article/abs/pii/S002234769470192X

No Improvement of Adult Height in Non-growth Hormone (GH) Deficient Short Children with GH Treatment - PubMed



Analogy (for conceptual clarity): Imagine a plant with genetically fixed maximum height. Adequate water and nutrients allow it to reach its potential. Adding more water beyond what it can physiologically use does not make it grow taller; it may even disrupt normal growth processes.

Summary: GH in healthy, non-deficient children simply optimizes a process that is already at capacity. There is no latent or “hidden” height to unlock the endocrine system and growth plates are already functioning at their maximum biological limits.


4. Why people think it works!!!!!!

This is where most people get fooled and start to think it’s working.

HGH can TEMPORARILY increase growth rate (as seen in the studies). You grow faster for a period, but it does NOT increase final adult height. Your genetic height ceiling remains THE SAME. In the end you will grow the same without HGH.


5. What you actually get and are paying for: Side Effects

Injecting ratpiss HGH from Chinese labs is retarded and will NOT work all you are paying for are potential risks including:

  • Insulin resistance
  • Increased risk of type 2 diabetes
  • Fluid retention and edema
  • Joint pain
  • Carpal tunnel syndrome
  • Hip growth plate injury
  • Benign intracranial hypertension (severe headaches and vision changes)
  • Abnormal IGF‑1 elevations
  • Theoretical increased cancer risk due to chronic IGF‑1 stimulation
​

6. Summary

HGH only works in:

  • Documented GH deficiency
  • Select ISS cases


HGH does NOT:

  • Make normal kids taller than their genetics allow
  • Extend growth plates
  • Increase final adult height
  • Create height out of nowhere
If you do not have a diagnosed condition, you will not gain any adult height you will only get side effects.

The truth?: There is no hack around genetics. Injecting Chinese ratpiss HGH is expensive, unnecessary, and retarded.



Biology does not care about your retarded cope.
Click to expand...
So thankful someone made this post too much hgh snake oil cope is being sold in this community now and its legit just tt content creators and retards who follow trends on here pushing it with no info on study content and how gene coding or height actually works jfl
 
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Ergogenic said:
Growth hormone certainly will increase final height growth if the doses are high enough. Look at the case of Robert Wadlow.

You could just inject 10 to 30 international units of growth hormone per day to see noticeable results. This only is a good idea if you have enough money. 1 international unit of growth hormone is 0.33 milligrams. 1 milligram of growth hormone is equal to 3 international units.

There is also no way to know if you have growth hormone deficiency for any reason until you get tested. Any child and teenager that is not sleeping enough per day (8 hours) is certainly underproducing growth hormone, and that will result in earlier maturation of the epiphyseal plates, so it will not be a bad idea to take advantage of this.
Click to expand...
This is such a bad faith retarded response and is shifting the quantifier of what he's saying lol, sure most kids who aren't sleeping 8 hours are underproducing to some degree but that doesn't mean functional deficiency hence the fact things like ranges exist and not a bang on number. So if we said for example 1 person sleeps 9 hours and one person sleeps 6, the 9 guy gets 50gh and the 6 guy gets 30gh with normal ranges being 10-50 then the 6 guy is still fine but is simultaneously "underperforming" jfl
 
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Ergogenic said:
I already had. I actively read through your whole post.

I am not a scientist, so I have no studies or counter points, but I do care about the difference between what is written on paper, and what happens in the real world.

Estrogen is mainly responsible for epiphyseal plates to fuse. This is why growth hormone is to be used with aromatase inhibitors unless estrogen is already naturally low. The point is to keep estrogen low but not crash it because estrogen is also essential for good bone and cardiovascular health.

How could the case of Robert Wadlow or any other individual with gigantism be possible according to your post?
Click to expand...
Well at some degree it becomes overloaded, you can't use robert wadlow because he quite literally had a pituitary tumour which messes with the entire endocrine system and is a crazy outlier from someone just using boosted hgh levels jfl his cxxc5 activity was probably fucked up alongside it, I'm sure there's more scientific analysis on his body
 
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Last edited:
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fractual said:
Genes determine the number of chondrocytes in the growth plates, how fast they divide, how long plates stay open, sensitivity to gh, and timing of puberty. So that means a maximum height is genetically limited.
You can still absolutely optimize conditions so those condrocytes divide longer, more efficiently, and delay exhaustion and growth plate closure. Things that affect these condrocytes are gh and igf-1 levels, estrogen exposure, nutrition,sleep and overall health.
When people talk about growing taller with hgh here some retards think blastin that shit while being like 5’6 at 16 will magically growth them to 6ft, which is not what happens. The studies you cited weren’t even using enough gh and likely wasn’t implementing aromaste inhibitors which is needed to keep the growth plates open while you actually grow faster. Reasonably there’s a bone age limit where no sort of peptide will seriously help with height but it’s not impossible to say with a good hgh+ai cycle you can’t squeeze in some extra cm. Like let’s say you start gh at 15 sharp and you’re 5’7, you’ll probably be 5’9-5’11 no intervention but gh can realistically push that up to 5’10-6’1. Of course this is assuming optimal conditions and blood tests. Most dumbasses here won’t reap any benefit from pinning hgh. A real cycle that would help would be very expensive for the avg highschooler

Mirin thread tho
Click to expand...
Still disagree w this, plate proliferation being catalysed by estradiol doesn't ignore the fact that genes still control to activity and rate, so even if you inhibit a large portion of your estradiol (which if you don't know what you're doing or what your levels are you could cause hormonal balance which does the exact opposite of growing you anyways) your cxxc5 and wnt/b-catenin pathways are still active. There's no evidence suggesting that these pathways or gene expressions decline with estradiol blockage jfl
 
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cometohaunted said:
gigantism is caused by pituitary tumours that is a stupid response lmfao
Click to expand...
and that pituitary tumor releases a lot of gh? sure it could affect some other hormones but in a lot of gigantism cases it only affects gh and has no supression or releasing effect or at least to a noticable degree on other pituitary hormones. and all of that is easily replicated by using exogenous gh to get similar gh levels? it cannot be hard to understand
 
cometohaunted said:
Well at some degree it becomes overloaded, you can't use robert wadlow because he quite literally had a pituitary tumour which messes with the entire endocrine system and is a crazy outlier from someone just using boosted hgh levels jfl his cxxc5 activity was probably fucked up alongside it, I'm sure there's more scientific analysis on his body
Click to expand...
https://pmc.ncbi.nlm.nih.gov/articles/PMC6533620/. in a lot of gigantism cases theres no noticable difference in pubertal delay and no noticable difference on other pituitary axes, ur talking about cxxc5 only because u think u have a lot of knowledge after finding ky19382 or read abt it on tiktok, ur speaking and providing no value in basically all of ur replies
 
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megapro981 said:
and that pituitary tumor releases a lot of gh? sure it could affect some other hormones but in a lot of gigantism cases it only affects gh and has no supression or releasing effect or at least to a noticable degree on other pituitary hormones. and all of that is easily replicated by using exogenous gh to get similar gh levels? it cannot be hard to understand
Click to expand...
That's not all pituitary tumors do that's the entire point.. Jesus Christ, a pituitary tumor wouldn't ONLY affect gh as pituitary issues would give you issues with all hormones and feedback since it's the master gland that controls the entire endocrine system.. read op again he already refuted this jfl
 
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megapro981 said:
https://pmc.ncbi.nlm.nih.gov/articles/PMC6533620/. in a lot of gigantism cases theres no noticable difference in pubertal delay and no noticable difference on other pituitary axes, ur talking about cxxc5 only because u think u have a lot of knowledge after finding ky19382 or read abt it on tiktok, ur speaking and providing no value in basically all of ur replies
Click to expand...
I didn't even read about cxxc5 on tiktok don't make assumptions u retarded iqlet LMAO also I said nothing about puberty shift, dnr this retarded fallacy machine dont strawman
 
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Ahmed88 said:
A lot of People continue to believe that healthy children who lack growth hormone deficiency will experience height increases through HGH injections.

It won’t.

Why?

Let’s get into this


1. How Growth Hormone Actually Works

Human growth hormone (HGH), also called somatotropin, is a hormone that the pituitary gland, which is about the size of a pea and found at the base of your brain, makes and releases

Its main job?

Human growth hormone triggers growth in almost every tissue and organ in your body. It’s mostly known for its growth-promoting effect on cartilage and bone, especially in puberty. Cells in cartilage called chondrocytes and cells in bones called osteoblasts, receive signals from HGH to increase replication and thus allow for growth in size.


2. What the Studies ACTUALLY Show

People often cite studies claiming “HGH increases height.” Let’s clarify what these studies actually studied.

Most research involves children who are GH-deficient children who cannot produce normal levels of GH due to medical conditions. Examples:




VERY Important: These studies are on children who are medically short due to GH deficiency, and do NOT produce enough HGH not normal kids. The effect is correcting a deficiency, not surpassing genetic potential.



Some other studies explore ISS (Idiopathic Short Stature):


B-B-But ISS Children Grew Taller why can’t i?

Let’s clarify: ISS children are not short simply because of genetics. ISS is defined as short stature without a known cause, that INCLUDES GENETICS and many children diagnosed as having ISS have partial GH insensitivity (Evidence: Idiopathic short stature)

Bottom line: if you are within normal growth ranges and are not diagnosed as ISS, these studies do NOT apply to you.


3. Why HGH does NOT work for healthy normal children with PROOF

For children with normal growth hormone (GH) levels, exogenous GH administration cannot increase final adult height. Here’s why:



  • GH does not create new growth potential.
    The growth plates in long bones experience linear growth through their epiphyseal plates. The genetic code determines both number and proliferative capacity of chondrocytes present at these growth plates. GH promotes the growth of chondrocytes and their development into mature cells, yet it cannot boost these cells' genetic-based growth capacity beyond their existing limits.
  • GH cannot override genetic determinants of stature.
    Height is a polygenic trait which multiple genetic loci control its development. The treatment of GH-sufficient children with GH therapy does not affect their gene expression or the genetic skeletal structure which their genome contains.
  • Endocrine feedback loops limit excessive growth signaling.
    The GH–IGF-1 axis is tightly regulated:
    • Elevated serum IGF-1 inhibits hypothalamic GHRH secretion and stimulates somatostatin release, reducing endogenous GH production.
    • Peripheral tissues exhibit receptor-mediated resistance to supra-physiologic GH and IGF-1 concentrations, limiting further cellular proliferation.
  • Physiologic ceiling effect.
    In GH-sufficient children, endogenous GH already saturates IGF-1 production and downstream growth plate signaling. Exogenous GH cannot enhance this process; the system is operating at maximal physiological capacity. Clinical evidence and studies supports these claims: children with normal GH levels do not achieve increased adult height despite high-dose GH administration
EVIDENCE AND STUDIES ON NORMAL KIDS:

Final height after growth hormone therapy in non-growth-hormone-deficient children with short stature - PubMed

No Improvement of Adult Height in Non-growth Hormone (GH) Deficient Short Children with GH Treatment - PMC

https://www.sciencedirect.com/science/article/abs/pii/S002234769470192X

No Improvement of Adult Height in Non-growth Hormone (GH) Deficient Short Children with GH Treatment - PubMed



Analogy (for conceptual clarity): Imagine a plant with genetically fixed maximum height. Adequate water and nutrients allow it to reach its potential. Adding more water beyond what it can physiologically use does not make it grow taller; it may even disrupt normal growth processes.

Summary: GH in healthy, non-deficient children simply optimizes a process that is already at capacity. There is no latent or “hidden” height to unlock the endocrine system and growth plates are already functioning at their maximum biological limits.


4. Why people think it works!!!!!!

This is where most people get fooled and start to think it’s working.

HGH can TEMPORARILY increase growth rate (as seen in the studies). You grow faster for a period, but it does NOT increase final adult height. Your genetic height ceiling remains THE SAME. In the end you will grow the same without HGH.


5. What you actually get and are paying for: Side Effects

Injecting ratpiss HGH from Chinese labs is retarded and will NOT work all you are paying for are potential risks including:

  • Insulin resistance
  • Increased risk of type 2 diabetes
  • Fluid retention and edema
  • Joint pain
  • Carpal tunnel syndrome
  • Hip growth plate injury
  • Benign intracranial hypertension (severe headaches and vision changes)
  • Abnormal IGF‑1 elevations
  • Theoretical increased cancer risk due to chronic IGF‑1 stimulation
​

6. Summary

HGH only works in:

  • Documented GH deficiency
  • Select ISS cases


HGH does NOT:

  • Make normal kids taller than their genetics allow
  • Extend growth plates
  • Increase final adult height
  • Create height out of nowhere
If you do not have a diagnosed condition, you will not gain any adult height you will only get side effects.

The truth?: There is no hack around genetics. Injecting Chinese ratpiss HGH is expensive, unnecessary, and retarded.



Biology does not care about your retarded cope.
Click to expand...
dnr
 
cometohaunted said:
That's not all pituitary tumors do that's the entire point.. Jesus Christ, a pituitary tumor wouldn't ONLY affect gh as pituitary issues would give you issues with all hormones and feedback since it's the master gland that controls the entire endocrine system.. read op again he already refuted this jfl
Click to expand...
op refuted this with garbage arguments that hold no value, he said:
Robert wadlow had a tumour, we do not, his tumour supressed his natural feedback system extremely, exogenous hgh does not, ais do not reliably increase your height there are multiple threads on this, all my claims are backed by studies what most people say here is a theory on paper with no evidence
Click to expand...
when talking about the natural feedback system i assume hes talking about exogenous gh reducing endogenous gh production a lot, ofc we dont need to rely on endogenous gh production if we use exogenous? and otherwise maybe hes talking about the ghr feedback in peripheral tissues leading to less igf1 produced from the gh, this feedback system wouldnt be impacted in a pituitary tumor and this feedback would be as strong in both pituitary tumors secreting gh and exogenously injected gh


also just debunked this in my other reply, in a lot of cases only gh is affected, sure some gh secreting tumors affect other axes but not all
 
Last edited:
cometohaunted said:
I didn't even read about cxxc5 on tiktok don't make assumptions u retarded iqlet LMAO also I said nothing about puberty shift, dnr this retarded fallacy machine dont strawman
Click to expand...
holy ego, u mentioned the pituitary tumor affecting other axes, and in a lot of cases people mean the hpt and hpg axes when talking about growth, but i mentioned all the axes not only those, ad hom ad hom ad hom ad hom classic
 
megapro981 said:
op refuted this with garbage arguments that hold no value, also just debunked this in my other reply, in a lot of cases only gh is affected, sure some gh secreting tumors affect other axes but not all
Click to expand...
u could make a simple logical deduction to disprove the idiocy of the statement about gh using philo jfl, if gh is what would grow you beyond potential or normal means, then it would also be the case that height is fully accounted for with gh secretion as its primary factor. If that is the case, it would logically entail that people with higher gh levels than others would analytically have to be taller as it's established in the 2nd condition that it's the main cause of height which CLEARLY is not true, taller people do not necessarily have more gh secretion than shorter people as that's environmental lmfao. using modus tollens you could also counteract the argument to display the retarded logic you use by saying, if you agree hgh is NOT the determining factor to height having it in excessive amounts isn't going to give you excessive height because there's something above it that does the primary determination of this phenomena. also this isn't just about other pituitary axes, op also said there's reduced proliferation feedback.
 
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cometohaunted said:
u could make a simple logical deduction to disprove the idiocy of the statement about gh using philo jfl, if gh is what would grow you beyond potential or normal means, then it would also be the case that height is fully accounted for with gh secretion as its primary factor. If that is the case, it would logically entail that people with higher gh levels than others would analytically have to be taller as it's established in the 2nd condition that it's the main cause of height which CLEARLY is not true, taller people do not necessarily have more gh secretion than shorter people as that's environmental lmfao. using modus tollens you could also counteract the argument to display the retarded logic you use by saying, if you agree hgh is NOT the determining factor to height having it in excessive amounts isn't going to give you excessive height because there's something above it that does the primary determination of this phenomena. also this isn't just about other pituitary axes, op also said there's reduced proliferation feedback.
Click to expand...
its insane how people with this level of critical thinking have the same right to vote as me, sure its fine if ur wrong about some things but the fact that ur this confident is very wrong.

of course gh isnt the sole factor of final growth? i didnt claim anything close to that. theres a lot of factors and even factors like genetic sensetivity and density of ghr and igf1r, these are just two factors with a shit ton of other factors both genetic and environmental affecting just those two, and we havent even spoken about all the other factors, theres a shit ton of factors at play. this should be enough for u but i doubt u will understand from even this. in gigantism the gh levels are usually extremely elevated and doesnt follow normal feedback, leading to constant levels that doesnt respond like normal to usual signals that should suppress gh release. the nature of the gh released is different and the gh levels are a lot higher, which makes the other genetic and environmental factors not matter as much in the big picture.

and i debunked the reduced profileration feedback in my other reply, the reduced wouldnt completely block it when it reached a certain amount of profileration signal it would obviously only reduce it, and that feedback in peripheral tissues isnt affected by a tumor in the pituitary gland.
 
Last edited:
megapro981 said:
its insane how people with this level of critical thinking have the same right to vote as me, sure its fine if ur wrong about some things but the fact that ur this confident is very wrong.

of course gh isnt the sole factor of final growth? i didnt claim anything close to that. theres a lot of factors and even factors like genetic sensetivity and density of ghr and igf1r, these are just two factors with a shit ton of other factors both genetic and environmental affecting just those two, and we havent even spoken about all the other factors, theres a shit ton of factors at play. this should be enough for u but i doubt u will understand from even this. in gigantism the gh levels are usually extremely elevated and doesnt follow normal feedback, leading to constant levels that doesnt respond like normal to usual signals that should suppress gh release. the nature of the gh released is different and the gh levels are a lot higher, which makes the other genetic and environmental factors not matter as much in the big picture.

and i debunked the reduced profileration feedback in my other reply, the reduced wouldnt completely block it when it reached a certain amount of profileration signal it would obviously only reduce it, and that feedback in peripheral tissues isnt affected by a tumor in the pituitary gland.
Click to expand...
I honestly can't believe you are this confident whilst actively strawmanning the claim posited on my end, I proposed that you claimed gh is the sole factor of growth you can't even read and you have the genuine audacity to talk about my critical thinking skills when it's being based on literal formal logic principles like deductive syllogisms☠️I said hgh is the prime determiner, obviously there's other factors that's a vacuous statement to make, you could say something like even being alive is "a factor" for growth. Don't act stupid to defend your stupid point, i said prime determiner meaning it matters most to determine stature, if it doesn't and there's a different prime factor then you're conceding hgh doesn't do anything for you so you're stuck in a dilemma of choosing whether hgh is or isnt (both destroy your position.

also I'm still not seeing the good argumentation to support that you can even equivocate gigantism with exogenous hgh usage, if exogenous hgh usage cant be equivocated to cases of gigantism. pituitary tumors are consistently producing really high amounts of gh without any feedback responses and it's continuously happening from young ages. this is not the same as someone using exogenous hgh at much lower levels for a much shorter period of time especially at a specific time nightly and is also susceptible to igf1 levels/sensitivity. with pituitary tumors this is NOT the case, natural and synthetically induced gh levels always have peaks and dips whereas it isnt the same for gigantism Once again displaying that my original point about something being **too** much at SOME point being true because sure you can fuck yourself with a bunch of hgh and live for 10 more years for 3-5 inches of height or u can cope and take the normal safe ranges and gain almost nothing or just not take it and live life jfl
 
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Ahmed88 said:
A lot of People continue to believe that healthy children who lack growth hormone deficiency will experience height increases through HGH injections.

It won’t.

Why?

Let’s get into this


1. How Growth Hormone Actually Works

Human growth hormone (HGH), also called somatotropin, is a hormone that the pituitary gland, which is about the size of a pea and found at the base of your brain, makes and releases

Its main job?

Human growth hormone triggers growth in almost every tissue and organ in your body. It’s mostly known for its growth-promoting effect on cartilage and bone, especially in puberty. Cells in cartilage called chondrocytes and cells in bones called osteoblasts, receive signals from HGH to increase replication and thus allow for growth in size.


2. What the Studies ACTUALLY Show

People often cite studies claiming “HGH increases height.” Let’s clarify what these studies actually studied.

Most research involves children who are GH-deficient children who cannot produce normal levels of GH due to medical conditions. Examples:




VERY Important: These studies are on children who are medically short due to GH deficiency, and do NOT produce enough HGH not normal kids. The effect is correcting a deficiency, not surpassing genetic potential.



Some other studies explore ISS (Idiopathic Short Stature):


B-B-But ISS Children Grew Taller why can’t i?

Let’s clarify: ISS children are not short simply because of genetics. ISS is defined as short stature without a known cause, that INCLUDES GENETICS and many children diagnosed as having ISS have partial GH insensitivity (Evidence: Idiopathic short stature)

Bottom line: if you are within normal growth ranges and are not diagnosed as ISS, these studies do NOT apply to you.


3. Why HGH does NOT work for healthy normal children with PROOF

For children with normal growth hormone (GH) levels, exogenous GH administration cannot increase final adult height. Here’s why:



  • GH does not create new growth potential.
    The growth plates in long bones experience linear growth through their epiphyseal plates. The genetic code determines both number and proliferative capacity of chondrocytes present at these growth plates. GH promotes the growth of chondrocytes and their development into mature cells, yet it cannot boost these cells' genetic-based growth capacity beyond their existing limits.
  • GH cannot override genetic determinants of stature.
    Height is a polygenic trait which multiple genetic loci control its development. The treatment of GH-sufficient children with GH therapy does not affect their gene expression or the genetic skeletal structure which their genome contains.
  • Endocrine feedback loops limit excessive growth signaling.
    The GH–IGF-1 axis is tightly regulated:
    • Elevated serum IGF-1 inhibits hypothalamic GHRH secretion and stimulates somatostatin release, reducing endogenous GH production.
    • Peripheral tissues exhibit receptor-mediated resistance to supra-physiologic GH and IGF-1 concentrations, limiting further cellular proliferation.
  • Physiologic ceiling effect.
    In GH-sufficient children, endogenous GH already saturates IGF-1 production and downstream growth plate signaling. Exogenous GH cannot enhance this process; the system is operating at maximal physiological capacity. Clinical evidence and studies supports these claims: children with normal GH levels do not achieve increased adult height despite high-dose GH administration
EVIDENCE AND STUDIES ON NORMAL KIDS:

Final height after growth hormone therapy in non-growth-hormone-deficient children with short stature - PubMed

No Improvement of Adult Height in Non-growth Hormone (GH) Deficient Short Children with GH Treatment - PMC

https://www.sciencedirect.com/science/article/abs/pii/S002234769470192X

No Improvement of Adult Height in Non-growth Hormone (GH) Deficient Short Children with GH Treatment - PubMed



Analogy (for conceptual clarity): Imagine a plant with genetically fixed maximum height. Adequate water and nutrients allow it to reach its potential. Adding more water beyond what it can physiologically use does not make it grow taller; it may even disrupt normal growth processes.

Summary: GH in healthy, non-deficient children simply optimizes a process that is already at capacity. There is no latent or “hidden” height to unlock the endocrine system and growth plates are already functioning at their maximum biological limits.


4. Why people think it works!!!!!!

This is where most people get fooled and start to think it’s working.

HGH can TEMPORARILY increase growth rate (as seen in the studies). You grow faster for a period, but it does NOT increase final adult height. Your genetic height ceiling remains THE SAME. In the end you will grow the same without HGH.


5. What you actually get and are paying for: Side Effects

Injecting ratpiss HGH from Chinese labs is retarded and will NOT work all you are paying for are potential risks including:

  • Insulin resistance
  • Increased risk of type 2 diabetes
  • Fluid retention and edema
  • Joint pain
  • Carpal tunnel syndrome
  • Hip growth plate injury
  • Benign intracranial hypertension (severe headaches and vision changes)
  • Abnormal IGF‑1 elevations
  • Theoretical increased cancer risk due to chronic IGF‑1 stimulation
​

6. Summary

HGH only works in:

  • Documented GH deficiency
  • Select ISS cases


HGH does NOT:

  • Make normal kids taller than their genetics allow
  • Extend growth plates
  • Increase final adult height
  • Create height out of nowhere
If you do not have a diagnosed condition, you will not gain any adult height you will only get side effects.

The truth?: There is no hack around genetics. Injecting Chinese ratpiss HGH is expensive, unnecessary, and retarded.



Biology does not care about your retarded cope.
Click to expand...
2hollis is on 20iu of hgh
 
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cometohaunted said:
I honestly can't believe you are this confident whilst actively strawmanning the claim posited on my end, I proposed that you claimed gh is the sole factor of growth you can't even read and you have the genuine audacity to talk about my critical thinking skills when it's being based on literal formal logic principles like deductive syllogisms☠️I said hgh is the prime determiner, obviously there's other factors that's a vacuous statement to make, you could say something like even being alive is "a factor" for growth. Don't act stupid to defend your stupid point, i said prime determiner meaning it matters most to determine stature, if it doesn't and there's a different prime factor then you're conceding hgh doesn't do anything for you so you're stuck in a dilemma of choosing whether hgh is or isnt (both destroy your position.

also I'm still not seeing the good argumentation to support that you can even equivocate gigantism with exogenous hgh usage, if exogenous hgh usage cant be equivocated to cases of gigantism. pituitary tumors are consistently producing really high amounts of gh without any feedback responses and it's continuously happening from young ages. this is not the same as someone using exogenous hgh at much lower levels for a much shorter period of time especially at a specific time nightly and is also susceptible to igf1 levels/sensitivity. with pituitary tumors this is NOT the case, natural and synthetically induced gh levels always have peaks and dips whereas it isnt the same for gigantism Once again displaying that my original point about something being **too** much at SOME point being true because sure you can fuck yourself with a bunch of hgh and live for 10 more years for 3-5 inches of height or u can cope and take the normal safe ranges and gain almost nothing or just not take it and live life jfl
Click to expand...
i didnt claim that u claimed that hgh is the sole factor, u argumented that because of my arguments i claimed something like that, u said that if i claim rhgh would have a big impact like in gigantism then it must be a very very important or the sole factor in height, but no, i acknowledged that its not at all, sure its one of the primary ones but not the sole one. whats ur primary language? u keep saying that i misunderstand ur words but i dont think so at all, i even asked other people and ai and they all said this thinking was correct from what u wrote. i think ur misunderstanding me or were both doing it. gh is an extremely important factor for height but what i acknowledged was that its far from the only factor, theres a lot of minor and theres some also other big factors and how someone responds to gh and the other factors is also very very individual. gh not being the sole or the very main factor doesnt automatically mean that high gh cant cause increased height?

i didnt say anything about the rhgh dosage nor did i say anything about when they start taking gh or how often, i simply said exogenous rhgh can increase height similar to gigantism cases. gigantism doesnt mean that the tumor develops during birth or right after it just means that the tumor is there releasing loads of gh for a time long enough for growth plates to react assuming theyre open, so u cannot argue that rhgh wouldnt work since its usually added later, someone can start exogenous hgh at 12, 14, 16 or 18+ if their plates are open ofc and they can grow more than expected depending on several factors. and u also cant also argue that it doesnt work because gh levels are very high in gigantism, just take a high rhgh dose then? from ugl its not even that expensive. and u also cant argue that when taking rhgh its pulsatile, it leads to one big spike and then a big trail of continued high gh levels in blood due to flip flop kinetics. a singular high subq rhgh dosed injection before bed would cause elevated gh levels for almost the entire next 24 hours, and if thats an issue then simply divide dosage into 2-4 injections daily or more. some even argue that prolonged elevated gh is detrimental to height due to socs and other feedback mechanisms, which i doubt is a very strong argument since it shows clearly in gigantism that the feedback clearly isnt strong enough to stop height growth enough.

first picture shows estimated gh levels in blood after rhgh subq injections in a human model in a 72 hour timeframe, graph made quickly w chatgpt, it used the official genotropin information to create the graph along with other studies to estimate the levels, keep in mind how sharp the peak and how prolonged the elevated levels as well as how much gets absorbed is individual and relies on other factors like depth and site of injection, second picture simply shows again gh levels in blood following a rhgh subq injection, its clearly in both elevated highly for a long time, and the levels are enough to cause gigantism levels of igf1 and therefore likely growth.
1772156780781
1772156805296


i didnt talk about any final choices of taking and likely losing some healthiness or not taking and ending up slightly shorter, obviously thats up to the person and not a part of this argument at all, im simple trying to prove it most likely works very well if u know what u do and make people stop spewing words about stuff they dont know.
 
This is where most people get fooled and start to think it’s working.

HGH can TEMPORARILY increase growth rate (as seen in the studies). You grow faster for a period, but it does NOT increase final adult height. Your genetic height ceiling remains THE SAME. In the end you will grow the same without HGH.

^ if thats true (according to you) if your pairing it with an ai theres no doubt your gonna grow taller
 
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youre a retard trying to farm rep from other tards :lul::lul::lul:
 
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