doidfestroyer
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People beleive that HGH is cope because they beleive that it increases your growth velocity for a short period of time
when you take it, however you end up with the same adult height that you originally would have had if you didnt take HGH (AKA you'll hit your genetic limit regardless.)
this idea comes from real biology, growth plates are finite tissues, chondrocytes do senesce over time, and puberty accelerates epiphyseal maturation. The problem with that is
when you take it, however you end up with the same adult height that you originally would have had if you didnt take HGH (AKA you'll hit your genetic limit regardless.)
this idea comes from real biology, growth plates are finite tissues, chondrocytes do senesce over time, and puberty accelerates epiphyseal maturation. The problem with that is
This argument is wrong because it asssumes an equal trade off in which faster growth equals proportionately faster plate exhaustion. height is not something that just gets used up at a fixed rateit is regulated by multiple interacting systems such as, GH/IGF-1 signaling, estrogen-mediated maturation, local growth plate stem cell dynamics, receptor sensitivity and saturation and these systems do not scale proportionately with dose or velocity.
and developmental timing (“bone age” progression)
and developmental timing (“bone age” progression)
There isnt a thing such as a genetic limit. There is no encoded number in your dna that just stops you from growing above a certain height. There is also no way to find out the genetic ceiling of someone obviously. most "genetic ceilings" are just estimates based on growth patters, parental height, etc. So for example if someone takes compounds to reach 6ft when their predicted height was 5'10 then the 'genetic limit' says that you were always predetermined to reach 6ft. but this cannot be proven because you cannot run the same individual twice, once naturally and once with intervention, meaning the untreated counterfactual does not exist and the claim is not experimentally verifiable at the individual level.
Also, if you are able to go past your genetic limit with compounds like fgfr3 inhibitors or hdac esers (FGFR3 and HDAC are considered some of the factors that put a genetic limit on your height growth), then it further proves that genetic llimit is not a thing, as if there was one it would not be able to be influenced.
Also, if you are able to go past your genetic limit with compounds like fgfr3 inhibitors or hdac esers (FGFR3 and HDAC are considered some of the factors that put a genetic limit on your height growth), then it further proves that genetic llimit is not a thing, as if there was one it would not be able to be influenced.
GH and IGF-1 signaling are not binary; more GH generally increases IGF-1 production, chondrocyte proliferation, and growth velocity, which is basic endocrinology, and higher signaling changes growth plate activity, meaning the idea that HGH does nothing in GH-sufficient individuals is objectively false because the pathway is dose responsive, even if the magnitude of final adult height change is variable and not linearly proportional to dose.
if increased GH signaling could never substantially alter final adult height because growth ossify faster,' then gigantism would not exist, but gigantism does exist, people with pituitary GH excess before epiphyseal fusion can reach extreme heights way above population averages and their parents height, showing their bodies do not relate back to a predicted genetic outcome, which directly contradicts the strongest deterministic version of the claim that everyone ends at the same height regardless of GH exposure.
rep pls took me a while
