Atz_foidslayer
hey I like maths and gym !
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It is important to separate the Insulin and
IGF-1. However, IGF-1's role in muscle growth might be overhyped. Here's why:
IGF-1 = muscle growth driver: Circulating IGF-1 doesn't strongly correlate With muscle growth from resistance training in humans.
Local IGF-1 action: Muscle cells (myofibres) might not produce as much IGF-1 as thought ; other cells like fibroblasts in muscle tissue might be key IGF-1 producers. Old studies said muscle fibers produce their own IGF-1 to grow bigger = "autocrine" function. Like the muscle talks to itself. But now we think mature muscle fibers actually make less IGF-1 than we originally believed.
Cell line studies skew perception: A lot of the hype came from studies on lab-grown muscle cells like C2C12 or L6. Those are immature muscle cells in a netri dish. Real
muscle in your pody benaves ditterently.
Other cells make IGF-1 too , it’s not just muscle fibers. Fibroblasts and other cells living inside your muscle tissue also rrated produce IGF-1. So when you measure IGF-1 in muscle, you can'trassume it's coming from the muscle tibers rowth... themselves.
Overall, just because IGF-1 goes up in your blood after training doesn't mean it's causing growth. And just because IGF-1 is present in muscle doesn't mean the muscle fibers are using it to grow.
Bottom line: Don't count on acute IGF-1 spikes for muscle gain!
IGF-1. However, IGF-1's role in muscle growth might be overhyped. Here's why:
IGF-1 = muscle growth driver: Circulating IGF-1 doesn't strongly correlate With muscle growth from resistance training in humans.
Local IGF-1 action: Muscle cells (myofibres) might not produce as much IGF-1 as thought ; other cells like fibroblasts in muscle tissue might be key IGF-1 producers. Old studies said muscle fibers produce their own IGF-1 to grow bigger = "autocrine" function. Like the muscle talks to itself. But now we think mature muscle fibers actually make less IGF-1 than we originally believed.
Cell line studies skew perception: A lot of the hype came from studies on lab-grown muscle cells like C2C12 or L6. Those are immature muscle cells in a netri dish. Real
muscle in your pody benaves ditterently.
Other cells make IGF-1 too , it’s not just muscle fibers. Fibroblasts and other cells living inside your muscle tissue also rrated produce IGF-1. So when you measure IGF-1 in muscle, you can'trassume it's coming from the muscle tibers rowth... themselves.
Overall, just because IGF-1 goes up in your blood after training doesn't mean it's causing growth. And just because IGF-1 is present in muscle doesn't mean the muscle fibers are using it to grow.
Bottom line: Don't count on acute IGF-1 spikes for muscle gain!
