elkkkk
Actual Ted Kaczynski btw
- Joined
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Hello
Im interested in why mk-677 is so hated on this forum even tho there is definitly research to support its use:
First how does mk-677 even work?
MK-677 (Ibutamoren) is an oral ghrelin receptor agonist that stimulates the pituitary gland to release more growth hormone (GH). This increase in GH also boosts insulin-like growth factor 1 (IGF-1), promoting muscle growth, fat loss, and potentially bone development.
Effects of mk-677 on muscle mass
Effects of mk-677 on Hgh and IGF-1 + Cholesterol
Receptor desensitivation
Even afer 24 months of mk-677 use studies showed that IGF-1 levels were still nearly as elevated as in the first weeks after starting the threatment
-> mk-677 can be taken longterm even tho not recommended because of the possible insulin resistance
Side Effects of mk-677
So why is mk-677 so hated on here when it literally has postive effects on muscle mass recovery bone density, mineralization and bone volume
while having slight side effects which can be medigated if u dont act like a moron
This Thread was high effort so rep it
Im interested in why mk-677 is so hated on this forum even tho there is definitly research to support its use:
First how does mk-677 even work?
MK-677 (Ibutamoren) is an oral ghrelin receptor agonist that stimulates the pituitary gland to release more growth hormone (GH). This increase in GH also boosts insulin-like growth factor 1 (IGF-1), promoting muscle growth, fat loss, and potentially bone development.
Effects of mk-677 on muscle mass
- Increased gain of lean mass
- Weight gain through the grehlin stimulation
- Possible positive effects on strength
- Better and deeper Sleep resulting in a better recovery
Effects of mk-677 on Hgh and IGF-1 + Cholesterol
- In a human study on mk-677 Hgh increased by about 100% (25mg taken daily)
- In the study a increase of IGF-1 Levels (after 4 weeks on norm young adults) of about 90 % percent was recorded
- Studies showed a slight decrease in LDL Cholesterol
Receptor desensitivation
Even afer 24 months of mk-677 use studies showed that IGF-1 levels were still nearly as elevated as in the first weeks after starting the threatment
-> mk-677 can be taken longterm even tho not recommended because of the possible insulin resistance
Side Effects of mk-677
- Possible Insulin resistance -> can be medigated through berberine and cycling + not taking dumb doses + having a look on your diet
- Bloating caused by the increased water retention -> can be bettered by low sodium intake and high water intake
- slight prolactin increase -> only sight not really relevant enough to be actually harmful
- increased appetite through the ghrelin stimulation -> can be medigated a bit through taking it before going to sleep
- Musle and joint pain ->( rare and generally mild )
- Anecdotic but not study proven possible short term insomnia after stopping to take mk-677 -> not proven by science only anecdotic
So why is mk-677 so hated on here when it literally has postive effects on muscle mass recovery bone density, mineralization and bone volume
while having slight side effects which can be medigated if u dont act like a moron
This Thread was high effort so rep it
[
pubmed.ncbi.nlm.nih.gov
pmc.ncbi.nlm.nih.gov
pmc.ncbi.nlm.nih.gov
pubmed.ncbi.nlm.nih.gov
]
Two-month treatment of obese subjects with the oral growth hormone (GH) secretagogue MK-677 increases GH secretion, fat-free mass, and energy expenditure - PubMed
Obesity is associated with blunted GH secretion, unfavorable body composition, and increased cardiovascular mortality. The objective of this study was to investigate the effects of oral treatment with the GH secretagogue MK-677 on GH secretion and body composition in otherwise healthy obese...
pubmed.ncbi.nlm.nih.gov
Effects of an Oral Ghrelin Mimetic on Body Composition and Clinical Outcomes in Healthy Older Adults: A Randomized, Controlled Trial - PMC
Growth hormone (GH) secretion and muscle mass decline from mid-puberty throughout life culminating in sarcopenia, frailty, decreased function and loss of independence. Determine if an oral ghrelin mimetic (MK-677) would enhance GH secretion into the ...
pmc.ncbi.nlm.nih.gov
Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males - PMC
Male hypogonadism is an increasingly prevalent clinical condition that affects patients’ quality of life and overall health. Obesity and metabolic syndrome can both cause and result from hypogonadism. Although testosterone remains the gold standard ...
pmc.ncbi.nlm.nih.gov
Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of a GH secretogogue (MK-677) in healthy elderly subjects - PubMed
Aging is associated with declining activity of the GH axis, possibly contributing to adverse body composition changes and increased incidence of cardiovascular disease. The stimulatory effects on the GH-insulin-like growth factor I (IGF-I) axis of orally administered MK-677, a GH-releasing...
pubmed.ncbi.nlm.nih.gov
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