extraorbitals
Iron
- Joined
- Mar 9, 2026
- Posts
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DISCLAIMER: This is my first post and just my thoughts, not proffesional opinion, let me know what i should talk about next / what to do different. leave some feedback 
We all know that stimulants like adderal, ritalin, vyvanse/medikinet and others have been prescribed by doctors for years, but stimulants only provide short term relief as oversignalling the AKT pathways in the motor cortex / amygdala lead to heightened symptoms of ADHD, because higher amygdala acitivity leads to changes in the prefrontal cortex, which results in an increase in impulsivity, anxiety, hyperactivity and an increase in restlessness. Unregulated dopamine is a symptom of deeper issues that cant be resolved due to adding more with stimulants.
Thats why i think peptides such as Dihexa are so important. Its an orally active brain penetrating peptide that provides significantly more neuroplasticity, which could potentially be up to 10,000,000x more potent than natural brain derived neurotrophic factor (BDNF) in stimulating synapse formation. it enhances cognitive function by boosting neurogenisis, synaptic connectivity and neuronal survival.
ADHD is a decrease and increase in: (MTOR) (WNT/MTOR) Pathways, IGF2, FGF and GDNF. This largely results in overdevelopment of motor cortex and amygdala and an underdevelopment of the hippocampus and prefrontal cortex.
Dihexa provides cognitive repairment and recovers memory in some studies in the APP/PS1 Mouse via the PI3K/AKT signalling pathway. It binds with hepatocyte growth factor (HGF) and induces C-MET phosphorylation. It provides an increase in neuronal cells and the expansion of SYP protein in APP/PS1 (reduced neuron loss and improved cognition). It also increases expression of P13K and phosphorylated AKT (P-AKT). The only downside is due to increased cell growth activity, theres a chance that malignant/benign tumors could begin to grow. This is a large issue with dihexa, but its an extremely small chance and not something most should worry about.
Dopaminergic neurons need to be developed through the HGF (preferrably using Dihexa) so that the ADHD brain becomes beter at directing the artificial dopamine to the prefrontal cortex longterm. This is why i believe dihexa has such massive possibility.
Ok thats all byebye
We all know that stimulants like adderal, ritalin, vyvanse/medikinet and others have been prescribed by doctors for years, but stimulants only provide short term relief as oversignalling the AKT pathways in the motor cortex / amygdala lead to heightened symptoms of ADHD, because higher amygdala acitivity leads to changes in the prefrontal cortex, which results in an increase in impulsivity, anxiety, hyperactivity and an increase in restlessness. Unregulated dopamine is a symptom of deeper issues that cant be resolved due to adding more with stimulants.
Thats why i think peptides such as Dihexa are so important. Its an orally active brain penetrating peptide that provides significantly more neuroplasticity, which could potentially be up to 10,000,000x more potent than natural brain derived neurotrophic factor (BDNF) in stimulating synapse formation. it enhances cognitive function by boosting neurogenisis, synaptic connectivity and neuronal survival.
ADHD is a decrease and increase in: (MTOR) (WNT/MTOR) Pathways, IGF2, FGF and GDNF. This largely results in overdevelopment of motor cortex and amygdala and an underdevelopment of the hippocampus and prefrontal cortex.
Dihexa provides cognitive repairment and recovers memory in some studies in the APP/PS1 Mouse via the PI3K/AKT signalling pathway. It binds with hepatocyte growth factor (HGF) and induces C-MET phosphorylation. It provides an increase in neuronal cells and the expansion of SYP protein in APP/PS1 (reduced neuron loss and improved cognition). It also increases expression of P13K and phosphorylated AKT (P-AKT). The only downside is due to increased cell growth activity, theres a chance that malignant/benign tumors could begin to grow. This is a large issue with dihexa, but its an extremely small chance and not something most should worry about.
Dopaminergic neurons need to be developed through the HGF (preferrably using Dihexa) so that the ADHD brain becomes beter at directing the artificial dopamine to the prefrontal cortex longterm. This is why i believe dihexa has such massive possibility.
Ok thats all byebye
