lilcrodyshe
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Pls someone high iq answer
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Of course:U sure? Explain
epiphyseal fusion is driven by E2 almost exclusively.Pls someone high iq answer
U sure? Explainepiphyseal fusion is driven by E2 almost exclusively.
Of course:U sure? Explain
if you want more responses take a look into this thread where me and other guys discuss itU sure? Explain
Ty tyOf course:
Tuesday at 11:20 PM
for anyone who thinks androgens would close growth plates, regardless ERa signalling, i ask to take a look at this
[https://www.nejm.org/doi/full/10.1056/NEJM199707103370204]
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[https://pubmed.ncbi.nlm.nih.gov/8090165/
![]()
{https://pubmed.ncbi.nlm.nih.gov/37373981/}
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{https://pubmed.ncbi.nlm.nih.gov/40048086/}
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~Elevated levels of androgens in their body, yet undectetable levels of E2. Results? Still growing till 31 years old~
Mirin high iq answerOf course:
Tuesday at 11:20 PM
for anyone who thinks androgens would close growth plates, regardless ERa signalling, i ask to take a look at this
[https://www.nejm.org/doi/full/10.1056/NEJM199707103370204]
![]()
[https://pubmed.ncbi.nlm.nih.gov/8090165/
![]()
{https://pubmed.ncbi.nlm.nih.gov/37373981/}
![]()
{https://pubmed.ncbi.nlm.nih.gov/40048086/}
![]()
~Elevated levels of androgens in their body, yet undectetable levels of E2. Results? Still growing till 31 years old~
I also want an aromatase enzyme deficiencyOf course:
Tuesday at 11:20 PM
for anyone who thinks androgens would close growth plates, regardless ERa signalling, i ask to take a look at this
[https://www.nejm.org/doi/full/10.1056/NEJM199707103370204]
![]()
[https://pubmed.ncbi.nlm.nih.gov/8090165/
![]()
{https://pubmed.ncbi.nlm.nih.gov/37373981/}
![]()
{https://pubmed.ncbi.nlm.nih.gov/40048086/}
![]()
~Elevated levels of androgens in their body, yet undectetable levels of E2. Results? Still growing till 31 years old~
Yes, he have a special condition, cyp19a1/aromatese deficiency, undetectable levels of E2 in his body and very elevated levels of FSH, LSH and testoterone, yet no epiphyseal fusion at 31 yo. they attempted to finish his growth with testoterone treatment(failed), and would still be growing if they don't introduce exo E2 into his body.Mirin high iq answer
So if I have decent reading and comprehension skills the guy in the first 2 sources wanted to purposefully close his plates??? Does he have a certain condition
Do you know how the study ended??? I suposse the testosterone treatment failed due to the deficiency in the aromatase which is kind of obvious??Yes, he have a special condition, cyp19a1/aromatese deficiency, undetectable levels of E2 in his body and very elevated levels of FSH, LSH and testoterone, yet no epiphyseal fusion at 31 yo. they attempted to finish his growth with testoterone treatment(failed), and would still be growing if they don't introduce exo E2 into his body.
Do you know how the study ended??? I suposse the testosterone treatment failed due to the deficiency in the aromatase which is kind of obvious??
How big was that guy those hands look huge
His genes traded his fertility for being a 100kg 187 unit I guess