Working on a exogenous gh + gh secretagogues guide. Any specific questions yall want me to answer ?

[exyonf]

Title.

 

[Lemur]

dont bother

no one even reads guides anymore unless u have a colourful name and you have a group of people to tag

also theres plenty of gh threads alreadey

 

[fraudster#1]

pulsatile gh those who know

 

[exyonf]

pulsatile gh those who know

Mentioning that in the guide

 

[buccalfatremoval]

Title.

Gonna agree with lemur here but have fun making it
Tag me I’ll give it a read young shonen, I was 14 pinning in the gym lockers once too

 

[exyonf]

dont bother

no one even reads guides anymore unless u have a colourful name and you have a group of people to tag

also theres plenty of gh threads alreadey

True, still it's good eitherway. Win/win

 

[ghost!]

check pms i got a question to ask u

 

[fraudster#1]

Mentioning that in the guide

i spoke of this here one time


may you guys here should learn somethings about pulsatile hgh

gh administration lower endogenous production dose-dependitly via increasing circularting IGF-1 which in turn promotes more Somastostatin that directly affects Somatotrophes in the pituary. However, GHRELIN via GHS-R1A activation locally antagonizes Somastostatin in the pituary.

Additionally, it is common knowledge that GHRPs and GHRHs produce synergistic GH increases through different protein kinase pathways, but GHRH also decreases GHS-R1A desensitization.
Moreover, GHS-R1A and GHRH-R are present in muscle, bone and cartilage and have GH-R and IGF-1/2R sensitizing properties. GHRH-R also decreases the STAT5/3 transcription ratio in the liver which can keep syst. IGF-1 in the high phys/ low supra range even on high dose rHGH (anecdotally).
Therefore, not only is Somatostatin very effectively inhibited, but also disproportionally lower than with GH only which further spirals the cascade upwards because the GHS yield even more GH -> perpetuum mobile

1. The Synergistic Effect (1+1=3) (AI cover)
GHRPs (Growth Hormone Releasing Peptides) and GHRHs (Growth Hormone Releasing Hormones) work on different receptors in the pituitary gland.

• GHRH initiates the "pulse" of Growth Hormone.
• GHRP amplifies that pulse and inhibits Somatostatin (the hormone that tells your body to stop producing GH).
  By using both, you are simultaneously pressing the gas pedal and cutting the brake lines.

2. Preventing Desensitization
Usually, when you overstimulate a receptor, the body shuts it down to protect itself (desensitization). The text claims that GHRH actually helps keep the GHS-R1A receptors sensitive, meaning the drugs continue to work effectively for longer periods without needing higher doses.

3. Local Sensitivity in Tissues
The text mentions that these receptors are present directly in muscle, bone, and cartilage. This suggests that the substances don't just work through the liver; they make the target tissues themselves more "hungry" or sensitive to the IGF-1 and GH circulating in the blood.

4. The "Perpetuum Mobile" Cascade
By lowering Somatostatin levels disproportionately compared to using exogenous GH alone, the body stays in a state where it is constantly primed to release more of its own hormone. This creates a feedback loop (the "cascade") that keeps IGF-1 levels at the high end of the physiological range or even slightly above (supraphysiological), maximizing recovery and growth.

With regards to PK: In rat studies, pulsatile GH administration was superior (3-5x IGF-1mRNA). However, in human administration and pathophysiology (acromegaly), even physiological amounts of continuous GH yield higher hepatic and local IGF-1mRNA. My hypothesis is that ID8835 is a species-specific AUC integrater; in rats time-weighed (extended STAT5B is more detrimental than Cmax) and in humans amplitude-weighed, making the exactly opposite signaling patterns optimal for each species


As already implied, the goal is to create an insane AUC of GH with extremely potent, self-potentiating local IGF-1 signaling:

• rHGH >= 0,07 mg/kg/day (if allometrically scaled x<1; 80 kg bw -> 16,8 IU/day) showed statistically significant increases in under a year of administration of Tanner 3+ boys (Rothenbuhler et al 2015.). May be titrated to or over 0,1 mg/kg/day (e.g. 80 kg bw -> 24 IU/day)"

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ignore this retard
why would you take a GH releasing peptide, then inject GH?
the amount of retards on the forum nowadays

explain

DISCUSS WITH A WALL AND YES IT AI ASSISTED

 

[exyonf]

dont bother

no one even reads guides anymore unless u have a colourful name and you have a group of people to tag

also theres plenty of gh threads alreadey

I am sorry I formulated the title wrong here. This guide will talk about exogenous gh. Pulsatile gh. And exogenous paired with gh sercretagogues.

 

[Lemur]

I am sorry I formulated the title wrong here. This guide will talk about exogenous gh. Pulsatile gh. And exogenous paired with gh sercretagogues.

interesting, tag me in the thread.

ill tag the groups that im part of as well

 

[exyonf]

interesting, tag me in the thread.

ill tag the groups that im part of as well

Glad to hear that. It will take me some time to get the grammar and formatting in. I will try my best bhai.

 

[exyonf]

interesting, tag me in the thread.

ill tag the groups that im part of as well

currently have 3000 words done, not even half-way there.

 

[itsalwaysmyheight]

Explain dosing of ghrps ghs and especially administration timing of say exo gh, cjc, mk and ghrp2 in order to first inhibit somatostatin then begin the secretion