ZerefDragnee1l
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Analysis of the effects of isotretinoin on the premature epiphyseal closure in pediatric populations: a literature review
Context Oral isotretinoin, a systemic retinoid and a vitamin A derivative, has been widely utilized to treat acne in both adult and pediatric populations. Additionally, systemic retinoids have also been utilized to treat neuroblastoma in pediatric patients. Common side effects associated with...
Premature epiphyseal growth plate arrest after isotretinoin therapy for high-risk neuroblastoma: A case series and review of the literature - PubMed
Bone toxicity associated with isotretinoin exposure is a concern. Growth plate arrest is a serious adverse effect that is attributable to isotretinoin therapy. Our findings suggest the prepubescent growth plate may be most at risk, and we recommend special attention to this population.
pubmed.ncbi.nlm.nih.gov
A double-blind, randomized, Phase III, multicenter study in 358 pediatric subjects receiving isotretinoin therapy demonstrates no effect on pediatric bone mineral density - PubMed
There is no difference in the effect of two formulations of isotretinoin on spine bone density after 6 months of treatment. BMD increased and the small change in spine Z-score over treatment disappeared after height adjustment. Mean positive Z-scores and HAZ in the study were likely due to the...
pubmed.ncbi.nlm.nih.gov
Bone densities in patients receiving isotretinoin for cystic acne - PubMed
A loss of bone density occurring in the absence of measurable alterations of calcium metabolism is likely to be a direct effect of retinoids on bone. Further study of retinoid-induced osteoporosis in humans and of bone density in patients with cystic acne is needed.
pubmed.ncbi.nlm.nih.gov
Potential Effects of Oral Isotretinoin on Growth Plate and Height
Longitudinal growth and puberty are the result of a complex interaction of genetic, hormonal, nutritional, and environmental factors. Acne vulgaris is a chronic disease of the pilosebaceous unit that affects 85% of adolescents worldwide. Isotretinoin is a synthetic vitamin A derivative drug...
www.mdpi.com
Isotretinoin Shows No Effect on Final Adult Height
A population-based cohort study found that that isotretinoin slows adolescent height velocity but is not associated with shorter final adult height.
www.medscape.com
The Effect of Isotretinoin Treatment for Acne Vulgaris on Height in Adolescents: A Retrospective Cohort Study Using the Rochester Epidemiology Project - PubMed
While isotretinoin may reduce height velocity, it is not associated with negative effects on final adult height among adolescents treated for acne.
pubmed.ncbi.nlm.nih.gov
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