D
Deleted member 3990
Kraken
- Joined
- Nov 19, 2019
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Introduction
Anti-Cortisol - lower Inhibition, lower stress, lower inhib, lower muscle catabolism
Anti-Prolactin - shorter break between orgasm, lower anxiety, anti-depressiva
Anti-Aromatase - lower Estrogen
Highly Androgenic - Dimorphism, masculinity, maybe anabolic (unlikely at the common dosages), lower inhibition, higher libido, more energy, Androgenic growth
Anti-Serotonin - Anti-Depressiva, more T production
Not Suppressive (in moderate doses) - No need for PCT etc.
11-keto DHT, also known as 11-ketoandrostanolone, is a keto-steroid present naturally in small amounts in a mammals body. Its physiological role in mammals is currently unknown, however, in fish 11-keto DHT is the primary androgen driving the male phenotype. In vitro research suggests that 11-keto DHT binds to and activates the androgen receptor with the same potency / affinity as the mammalian androgen DHT.
Abstract
5α-dihydro-11-keto Testosterone (11KDHT) ...
- is a full androgen receptor agonist comparable to dihydrotestosterone (DHT)
-resulted in significant increase in androgenic activity at a physiologically relevant concentration.
-might be implicated in driving castration-resistant prostate cancer (CRPC) in the absence of testicular T
- represented a novel androgen which may play an important role in driving AR-mediated gene expression
-11KT and 11KDHT induce androgen dependent cellular proliferation
-11KDHT is a potent androgen with a high AR-agonist activity, it also regulates the expression of more AR-regulated proteins than DHT
-11KDHT and 11KT have a longer half-life than DHT and T due to the slower metabolism. The half life of 11-KDHT is 36 hours.
DHT was completely eleminated from the body in 48 hours, while 21% of 11-KDHT remained after 72 hours
-DHT and its related steroids like 11-keto DHT all stimulate 5-AR and as such create a positive loopback cycle
Anecdotes:
Noticed the following changes:
+ Erections basically all night (or whenever he wakes up)
+ Increased libido
+ Significantly less body odor on 1 day where he applied 2 doses about 8hrs apart
+ Larger flacid hang
+ Harder erections
+ Much harder muscles
+ Increased appetite
+ Improved sleep quality
Topical Application
Could decrease fat on topical administration
Could increase bodyhair
Helps bone metabolism (Could grow clavicle for example or jaw)
Could increase dimorphic traits (I will try this for voice on throat)
Could also be used on dick combined with PEGym
Summary
11KDHT does the following:
-Increase NT
-lower inhibition
-Increase aggression
-lower stress
-enhance sexual experience
-decrease refractory period (time it take for a male to recover after orgasm.)
-Decrease estrogen
-could help muscle building (proven to improve fast twitch muscles)
-Burn fat
-Increase height in open platecels
-doesn't need AI
-Increase energy
-Eliminate bloat
-Decrease fatigue (or even increase it due to drop of stress hormones in the first few days of taking)
-better dreams
-clearer mind
-lower Depression
For Aspies:
A report documenting on which Proteins are stimulated by 11-KDHT (at the Androgen receptor)
Sources
raypeatforum.com
www.ncbi.nlm.nih.gov
www.bioanalysis-zone.com
www.ncbi.nlm.nih.gov
www.ncbi.nlm.nih.gov
www.ncbi.nlm.nih.gov
academic.oup.com
www.apexbt.com
Warning!
This is not a holy grail, but can really be considered as a legit help and supplement
I dont think 11-KDHT itself could cause hairloss, but it indeed stimulates more synthesis of 5AR, thus could increase DHT
But I still think that DHT (Androgens in general) are NOT causative in terms of hairloss. At the very least, they accelerate, but only because your health is already endangered.
I will soon (in 1-3 days) take 11-KDHT myself, combined with DHEA and Pregnenolone and I am prone to hairloss
I will report back in this thread again
Besides that, I would like to plead @forwardgrowth to shortly summarize his experience with 11-KDHT (with DHEA and Pregnenolone) so far
Anti-Cortisol - lower Inhibition, lower stress, lower inhib, lower muscle catabolism
Anti-Prolactin - shorter break between orgasm, lower anxiety, anti-depressiva
Anti-Aromatase - lower Estrogen
Highly Androgenic - Dimorphism, masculinity, maybe anabolic (unlikely at the common dosages), lower inhibition, higher libido, more energy, Androgenic growth
Anti-Serotonin - Anti-Depressiva, more T production
Not Suppressive (in moderate doses) - No need for PCT etc.
11-keto DHT, also known as 11-ketoandrostanolone, is a keto-steroid present naturally in small amounts in a mammals body. Its physiological role in mammals is currently unknown, however, in fish 11-keto DHT is the primary androgen driving the male phenotype. In vitro research suggests that 11-keto DHT binds to and activates the androgen receptor with the same potency / affinity as the mammalian androgen DHT.
Abstract
5α-dihydro-11-keto Testosterone (11KDHT) ...
- is a full androgen receptor agonist comparable to dihydrotestosterone (DHT)
-resulted in significant increase in androgenic activity at a physiologically relevant concentration.
-might be implicated in driving castration-resistant prostate cancer (CRPC) in the absence of testicular T
- represented a novel androgen which may play an important role in driving AR-mediated gene expression
-11KT and 11KDHT induce androgen dependent cellular proliferation
-11KDHT is a potent androgen with a high AR-agonist activity, it also regulates the expression of more AR-regulated proteins than DHT
-11KDHT and 11KT have a longer half-life than DHT and T due to the slower metabolism. The half life of 11-KDHT is 36 hours.
DHT was completely eleminated from the body in 48 hours, while 21% of 11-KDHT remained after 72 hours
-DHT and its related steroids like 11-keto DHT all stimulate 5-AR and as such create a positive loopback cycle
Anecdotes:
noticed vivid dreams and Morning wood. Good so far after 5 days.
I've had crazy vivid dreams as well
11-keto DHT, Ritanserin, and candy before bed. Lab rat awoke to extremely vivid dreams. Female life mate barely had a chance to compose herself.
Since starting the keto DHT I have the feeling my t3 supplement works much better. I used to take 50mcg per day and i didnt feel much from it. Now im sleeping 10h+ a day and i have diarrhea.
The dreams on this stuff are out of this world! I'm waking up from my dreams within my dreams, and I'm not even asleep yet! That's with 4 drops in the morning.
Also noticed more assertiveness at work.
Improvement in mood, better performance in weight/resistance training, more interesting and memorable dreams, and seemed to get some more female attention. All seeming very positive, and in a very short period of time. Especially so seeing as Ratt has been under a significant amount of stress, and tested very low in serum androgens, and high in estrone right before the supplementation started.
More bodyhair and beard
I've had crazy vivid dreams as well
11-keto DHT, Ritanserin, and candy before bed. Lab rat awoke to extremely vivid dreams. Female life mate barely had a chance to compose herself.
Since starting the keto DHT I have the feeling my t3 supplement works much better. I used to take 50mcg per day and i didnt feel much from it. Now im sleeping 10h+ a day and i have diarrhea.
The dreams on this stuff are out of this world! I'm waking up from my dreams within my dreams, and I'm not even asleep yet! That's with 4 drops in the morning.
Also noticed more assertiveness at work.
Improvement in mood, better performance in weight/resistance training, more interesting and memorable dreams, and seemed to get some more female attention. All seeming very positive, and in a very short period of time. Especially so seeing as Ratt has been under a significant amount of stress, and tested very low in serum androgens, and high in estrone right before the supplementation started.
More bodyhair and beard
Noticed the following changes:
+ Erections basically all night (or whenever he wakes up)
+ Increased libido
+ Significantly less body odor on 1 day where he applied 2 doses about 8hrs apart
+ Larger flacid hang
+ Harder erections
+ Much harder muscles
+ Increased appetite
+ Improved sleep quality
Could decrease fat on topical administration
Could increase bodyhair
Helps bone metabolism (Could grow clavicle for example or jaw)
Could increase dimorphic traits (I will try this for voice on throat)
Could also be used on dick combined with PEGym
11KDHT does the following:
-Increase NT
-lower inhibition
-Increase aggression
-lower stress
-enhance sexual experience
-decrease refractory period (time it take for a male to recover after orgasm.)
-Decrease estrogen
-could help muscle building (proven to improve fast twitch muscles)
-Burn fat
-Increase height in open platecels
-doesn't need AI
-Increase energy
-Eliminate bloat
-Decrease fatigue (or even increase it due to drop of stress hormones in the first few days of taking)
-better dreams
-clearer mind
-lower Depression
For Aspies:
A report documenting on which Proteins are stimulated by 11-KDHT (at the Androgen receptor)
Sources
11-keto DHT - Adrenosterone Derivative For Lab/R&D Use
As promised, I am releasing a steroid that may be of interest to some people on the forum. It is a variation of the well-known steroid DHT that Peat has written about and I have also posted quite a few studies on. The steroid belongs to the group of the so-called keto-steroids and AFAIK this is...
11β-Hydroxydihydrotestosterone and 11-ketodihydrotestosterone, novel C19 steroids with androgenic activity: a putative role in castration resistant prostate cancer? - PubMed
Adrenal C19 steroids, dehydroepiandrostenedione (DHEA(S)) and androstenedione (A4), play a critical role in castration resistant prostate cancer (CRPC) as they are metabolised to dihydrotestosterone (DHT), via testosterone (T), or via the alternate 5α-dione pathway, bypassing T. Adrenal 11OHA4...
www.ncbi.nlm.nih.gov
2016 New Investigator: Karl Storbeck
We introduce the nominees for this year's New Investigator Award. Here we feature Karl Storbeck.
Antagonism of estrogen-induced prolactin release by dihydrotestosterone - PubMed
Previous work from our laboratory has demonstrated that progesterone can inhibit estrogen-induced prolactin release in female rats. Since androgens have been reported to mimic progesterone actions in certain systems, and to antagonize estrogen action in rat uteri, the purpose of this study was...
www.ncbi.nlm.nih.gov
Low Preoperative Prolactin Levels Predict Non-Organ Confined Prostate Cancer in Clinically Localized Disease - PubMed
Low preoperative PRL levels predict the risk of non-organ confined PCa in clinically localized disease.
www.ncbi.nlm.nih.gov
Evaluation of androgen antagonism of estrogen effect by dihydrotestosterone - PubMed
The antagonism of estrogen effect on the immature rat uterus by dihydrotestosterone (DHT) was evaluated in vivo. One-hundred micrograms of DHT which has been shown by previous workers [4] to saturate the androgen receptor but not bind or translocate estrogen receptor was injected daily into...
www.ncbi.nlm.nih.gov
11-Ketotestosterone Is a Major Androgen Produced in Human Gonads
Context:. 11-ketotestosterone (11-KT) is a novel class of active androgen. However, the detail of its synthesis remains unknown for humans.Objective:. The
academic.oup.com
5α-dihydro-11-keto Testosterone
5α-dihydro-11-keto Testosterone (11KDHT) is a full androgen receptor agonist comparable to dihydrotestosterone (DHT) [1][2][3]. Androgen receptor is a nuclear receptor that is activated by the androgenic hormones, testosterone, or dihydrotestosterone in
Warning!
This is not a holy grail, but can really be considered as a legit help and supplement
I dont think 11-KDHT itself could cause hairloss, but it indeed stimulates more synthesis of 5AR, thus could increase DHT
But I still think that DHT (Androgens in general) are NOT causative in terms of hairloss. At the very least, they accelerate, but only because your health is already endangered.
I will soon (in 1-3 days) take 11-KDHT myself, combined with DHEA and Pregnenolone and I am prone to hairloss
I will report back in this thread again
Besides that, I would like to plead @forwardgrowth to shortly summarize his experience with 11-KDHT (with DHEA and Pregnenolone) so far
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