30yr old redditor on tretinoin for 2yrs. Glowing skin.

[Deusmaximus]

 

[Deleted member 17829]

wait what does this tret shit do? something to do with collagen?

 

[MrRubiks]

wait what does this tret shit do? something to do with collagen?

It increases cell turnover, reducing fine lines and redness.

 

[dough]

he looks gay

 

[Slob]

looks like a weak low t pussy 18 year old

 

[chigoha]

we need to see his before to judge

 

[Deleted member 17829]

It increases cell turnover, reducing fine lines and redness.

basically chemotherapy on your face then

 

[Ken]

It increases cell turnover, reducing fine lines and redness.

It also causes facial fat loss

 

[Deleted member 16834]

basically chemotherapy on your face then

You’re extremely smart if you didn’t look that up.
Retinoic acid is literally used as a chemotherapy treatment.

 

[goldensoul]

It increases cell turnover, reducing fine lines and redness.

so does it affect your skin's ability to regenerate in the long run ?

 

[MrRubiks]

so does it affect your skin's ability to regenerate in the long run ?

Are you referring to telomere shortening? As far as I'm aware, tretinoin has only shown to have positive effects over time, but if telomere shortening is a concern, there are now supplements that can restore telomere length, supplements like epitalon, TAM818, and TA-65 to name a few.

 

[MrRubiks]

basically chemotherapy on your face then

Well chemotherapy affects tissues with a faster turnover rate, which is why skin, hair, and mucosa are especially affected. I don't think it's the same thing.

 

[goldensoul]

Are you referring to telomere shortening? As far as I'm aware, tretinoin has only shown to have positive effects over time, but if telomere shortening is a concern, there are now supplements that can restore telomere length, supplements like epitalon, TAM818, and TA-65 to name a few.

I just heard a long time ago that your skin's ability to regenerate itself is not unlimited, that's why it's better to start chemical skincare later in life, but I never heard about telomere i have to check this.

 

[MrRubiks]

I just heard a long time ago that your skin's ability to regenerate itself is not unlimited, that's why it's better to start chemical skincare later in life, but I never heard about telomere i have to check this.

No tissue can proliferate indefinitely (without intervention). it's called the Hayflick limit.

 

[Deleted member 16834]

Well chemotherapy affects tissues with a faster turnover rate, which is why skin, hair, and mucosa are especially affected. I don't think it's the same thing.

I just heard a long time ago that your skin's ability to regenerate itself is not unlimited, that's why it's better to start chemical skincare later in life, but I never heard about telomere i have to check this.

Retinoic acid aka tretinoin/accutane is a active form of vitamin A.

 

[Deleted member 16834]

No tissue can proliferate indefinitely (without intervention). it's called the Hayflick limit.

Accutane and retin a are both active forms of vitamin a. Retin a at 0.1% (assuming the absorption rate is bw 1-8% like the studies) will show all signs of hypervitaminosis a just like accutane but at a rate of about ~12x slower.

 

[Deleted member 16834]

It increases cell turnover, reducing fine lines and redness.

It increases redness and causes sun sensitivity. Sorry I just hate misinformation

 

[goldensoul]

Retinoic acid aka tretinoin/accutane is a active form of vitamin A.

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are they talking about tropical use ? that's crasy. well everything that works comes with serious risks

 

[Deleted member 16834]

are they talking about tropical use ? that's crasy. well everything that works comes with serious risks

There’s talking about hypervitaminosis a. It’s induced by accutane more strongly than retin a bc accutane is ingested. But studies have shown that even retin a has a absorption rate of 1-8%. Meaning retin a will cause the same sides as accutane but 12 times slower.

So if a person noticed hypervitaminosis a from accutane after 2 years, he/she will notices the same effects from retin-a after 24 years of usage.

Essentially buying time b4 your liver is full and ready to fuck up your body.

Also vitamin a is fat soluble so there is no escape. You have to bear the side effects

 

[MrRubiks]

It increases redness and causes sun sensitivity. Sorry I just hate misinformation

That's not misinformation.

 

[lonelycurry]

Fag

 

[lonelycurry]

Retinoic acid aka tretinoin/accutane is a active form of vitamin A.

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Why are you going schizo over a topical acne medication. Your nuts man It doesn’t do anything

 

[poopmaster22]

Insane he looks like a ten year old. I’ve tried tret but it makes me dry and redness irritated. I must have shitty skin because I have never met anyone this happens too.

 

[Deleted member 16834]

Why are you going schizo over a topical acne medication. Your nuts man It doesn’t do anything

Cognitive dissonance.

Sorry for destroying your next cope

 

[AscendingHero]

There’s talking about hypervitaminosis a. It’s induced by accutane more strongly than retin a bc accutane is ingested. But studies have shown that even retin a has a absorption rate of 1-8%. Meaning retin a will cause the same sides as accutane but 12 times slower.

So if a person noticed hypervitaminosis a from accutane after 2 years, he/she will notices the same effects from retin-a after 24 years of usage.

Essentially buying time b4 your liver is full and ready to fuck up your body.

Also vitamin a is fat soluble so there is no escape. You have to bear the side effects

I'll just use retin a sporadically and only on important occassions and i'll discontinue in a few yrs when i find and/or better collagen maxxing protocls are available

money opens door buyos

 

[MrRubiks]

So if a person noticed hypervitaminosis a from accutane after 2 years, he/she will notices the same effects from retin-a after 24 years of usage.

Essentially buying time b4 your liver is full and ready to fuck up your body.

You're using faulty logic. If you have toxicity at a certain dose and a therapeutic effect at, say, 1/4 that dose, it doesn't mean that toxicity is just delayed 4x as long. There's also an output rate, and it's possible to achieve a steady state.

 

[Deleted member 16834]

You're using faulty logic. If you have toxicity at a certain dose and a therapeutic effect at, say, 1/4 that dose, it doesn't mean that toxicity is just delayed 4x as long. There's also an output rate, and it's possible to achieve a steady state.

False. Vitamin a is fat soluble. It BUILDS up to toxic amounts bc the liver STORES it. It’s a liver toxin after a certain point.

Your claim presupposes that there is a built in detoxing mechanism that would prevent from side effects. You claiming that it’s possible to achieve a therapeutic effect completely ignores countless research I posted which explains the entire mechanism being identical to that of chemotherapy drugs. ALL vitamin a ends up in the liver where’s it stored b4 further usage. Toxic levels wreak havoc on the body as the liver has no further need for said vitamin. This is why accutane side effects range from ALL across the body. Hypervitaminosis a attacks the entire metabolism and wrecks havoc on multiple systems (skeletal, nervous etc.)

Therapeutic levels or micro dosing or using retin a as a spot treatment would then negate the purpose of my original argument which was that this is not for everyday usage.

 

[Baldingman1998]

Retinoic acid aka tretinoin/accutane is a active form of vitamin A.

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Just use it twice or 3 times week. To give your body time to get rid of excess vit a in the long term

 

[Deleted member 16834]

Just use it twice or 3 times week. To give your body time to get rid of excess vit a in the long term

Indeed retin a was initially designed for spot treatment sparingly (upon notice of a acne breakout for example)

For people with cognitive dissonance I suggest using twice a weak at the weakest strength (.25%) and searching for a healthier alternative (glycolic acid, bakuchiol)

 

[Tobias Fünke]

Indeed retin a was initially designed for spot treatment sparingly (upon notice of a acne breakout for example)

For people with cognitive dissonance I suggest using twice a weak at the weakest strength (.25%) and searching for a healthier alternative (glycolic acid, bakuchiol)

Would it make sense to go slightly under the RDA of vitamin A from diet (to let's say 70%) in order to reduce the stress on liver if tret is being used?

 

[Deleted member 16834]

Would it make sense to go slightly under the RDA of vitamin A from diet (to let's say 70%) in order to reduce the stress on liver if tret is being used?

Yes most certainly. Food has retinol which gets converted to retinoic acid by the body. So using accutane/retin a AND having a diet high in retinol consumption (fortified milk, tons of eggs etc) is a recipe for disaster (long term)

 

[BoneDensity]

False. Vitamin a is fat soluble. It BUILDS up to toxic amounts bc the liver STORES it. It’s a liver toxin after a certain point.

Your claim presupposes that there is a built in detoxing mechanism that would prevent from side effects. You claiming that it’s possible to achieve a therapeutic effect completely ignores countless research I posted which explains the entire mechanism being identical to that of chemotherapy drugs. ALL vitamin a ends up in the liver where’s it stored b4 further usage. Toxic levels wreak havoc on the body as the liver has no further need for said vitamin. This is why accutane side effects range from ALL across the body. Hypervitaminosis a attacks the entire metabolism and wrecks havoc on multiple systems (skeletal, nervous etc.)

Therapeutic levels or micro dosing or using retin a as a spot treatment would then negate the purpose of my original argument which was that this is not for everyday usage.

Does this mean megadoising beta catotene will cause hypervitaminosis? >50k IU a day

 

[Deleted member 16834]

Does this mean megadoising beta catotene will cause hypervitaminosis? >50k IU a day

Retinol and beta carotene are different forms of vitamin a

Beta carotene will lead to skin color changes but have a less likelihood off triggering hypervitaminosis a

 

[BoneDensity]

Does this mean megadoising beta catotene will cause hypervitaminosis? >50k IU a day

Never mind just read that cartenoids don't cause thisb

 

[fauxfox]

Retinol and beta carotene are different forms of vitamin a

Beta carotene will lead to skin color changes but have a less likelihood off triggering hypervitaminosis a

You seem knowledgeable about Accutane. I took it for 6 months at 16 and didn't grow a single inch after/fell into deep depression. I feel like if I never took this shit I'd reach my genetic potential, legit lost the spark in me. Plus I have osteopenia now as a 21 yr old JFL likely due to accutane.

 

[Deleted member 16834]

You seem knowledgeable about Accutane. I took it for 6 months at 16 and didn't grow a single inch after/fell into deep depression. I feel like if I never took this shit I'd reach my genetic potential, legit lost the spark in me. Plus I have osteopenia now as a 21 yr old JFL likely due to accutane.

All sides of hypervitaminosis A.

What you can do is go on a low vitamin a diet. No eggs, No milk (substitute with calcium carbonate or get the calcium from sardines etc).

This is how I reversed all side effects that I personally experienced.

Also since you have osteopenia you need to optimize calcium metabolism.

Calcium metabolism is: having enough vitamin d, vitamin k2, phosphorous and magnesium (as all these minerals and vitamin aid in metabolizing and making use of calcium).


Just dropping the eggs and milk by itself would be huge (I wouldn’t advise this extreme of a measure to anyone but since your problems are 100% in sync with Retinoic acid toxicity you need to detox all vitamin a rich foods even if some of them are healthy).

 

[Deleted member 16834]

@fauxfox

 

[MrRubiks]

Retinoic acid aka tretinoin/accutane is a active form of vitamin A.

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Could you provide a link to the full article? Earlier you extrapolated based off a linear change, but there are problems with that logic. I understand obviously that fat-soluble vitamins are much more likely to cause hypervitaminosis than those that are water soluble, but it still seems likely that the body could achieve a steady state, thus avoiding toxicity.

Even one of the pictures you posted included a part where the side effects resolved quickly after discontinuing treatment. It seems like the body has a decent elimination rate.

 

[fauxfox]

All sides of hypervitaminosis A.

What you can do is go on a low vitamin a diet. No eggs, No milk (substitute with calcium carbonate or get the calcium from sardines etc).

View attachment 1635637

This is how I reversed all side effects that I personally experienced.

Also since you have osteopenia you need to optimize calcium metabolism.

Calcium metabolism is: having enough vitamin d, vitamin k2, phosphorous and magnesium (as all these minerals and vitamin aid in metabolizing and making use of calcium).


Just dropping the eggs and milk by itself would be huge (I wouldn’t advise this extreme of a measure to anyone but since your problems are 100% in sync with Retinoic acid toxicity you need to detox all vitamin a rich foods even if some of them are healthy).

Just to let you know I'm 21 now so it's been 5 years since then, not sure if that's enough time to recover. I already don't drink milk even though I'm lactose tolerant, I'll start avoiding eggs from now on though. I supplement 2100 IU vitamin D a day and 200mg magnesium a day. I'll look into the other 2 supplements you mentioned.

 

[Deleted member 16834]

Could you provide a link to the full article? Earlier you extrapolated based off a linear change, but there are problems with that logic. I understand obviously that fat-soluble vitamins are much more likely to cause hypervitaminosis than those that are water soluble, but it still seems likely that the body could achieve a steady state, thus avoiding toxicity.

Which one specifically these are different research papers complied into one post.

 

[Deleted member 16834]

Just to let you know I'm 21 now so it's been 5 years since then, not sure if that's enough time to recover. I already don't drink milk even though I'm lactose tolerant, I'll start avoiding eggs from now on though. I supplement 2100 IU vitamin D a day and 200mg magnesium a day. I'll look into the other 2 supplements you mentioned.

Good .
Optimal vitamin d supplementation
For magnesium the best one is magnesium chloride. It had practically cured all teeth sensitivity that I experienced with hypervitaminosis a.

For phosphorus you get it pretty much every source. So no need to supplement

And lastly for k2 avocados are a great source!

 

[closedplatecel]

Indeed retin a was initially designed for spot treatment sparingly (upon notice of a acne breakout for example)

For people with cognitive dissonance I suggest using twice a weak at the weakest strength (.25%) and searching for a healthier alternative (glycolic acid, bakuchiol)

How about every other day at 0.1?

And cycle 2 months on 1 month off

 

[Deleted member 16834]

How about every other day at 0.1?

And cycle 2 months on 1 month off

Would not recommend, twice a week at the lowest dosage 0.25% (with your cycle) seems better since people I’m sure already have a high retinol diet (lots of milk and eggs etc)

 

[Mysticcc]

I got to use 1% aswell but it makes my skin so fucking irritated

 

[Deleted member 16834]

Could you provide a link to the full article? Earlier you extrapolated based off a linear change, but there are problems with that logic. I understand obviously that fat-soluble vitamins are much more likely to cause hypervitaminosis than those that are water soluble, but it still seems likely that the body could achieve a steady state, thus avoiding toxicity.

Even one of the pictures you posted included a part where the side effects resolved quickly after discontinuing treatment. It seems like the body has a decent elimination rate.

I saw that you edited your post so I want to answer your second paragraph.

Retinoic acid cessation would obviously result in lowered side effects as the overall metabolism is under less pressure to detox. Less havoc. Signs of heavy detox include orange stools and metallic smelling sweat etc.
The younger/healthier you are the higher the rate of said detox. Still the host is under unnecessary burden. Not to even mention the telomere shortening angle.

Also,

All to have skin that looks baby smooth? Ha the lengths people go to justify certain extremely horrible habits

 

[Mayorga2.0]

Accutane and retin a are both active forms of vitamin a. Retin a at 0.1% (assuming the absorption rate is bw 1-8% like the studies) will show all signs of hypervitaminosis a just like accutane but at a rate of about ~12x slower.

Are you confusing tissue absorption with systemic absorption? Do you have a source on isotret/tret going systemic in any significant quantity, because the only studies I can find show that using 10g (yes, ten fucking grams) of 0.1% isotret cream did not increase the plasma concentration of related metabolites above the 2SD.

 

[Deleted member 14077]

Are you referring to telomere shortening? As far as I'm aware, tretinoin has only shown to have positive effects over time, but if telomere shortening is a concern, there are now supplements that can restore telomere length, supplements like epitalon, TAM818, and TA-65 to name a few.

You are 1000iq cel

 

[Deleted member 16834]

Are you confusing tissue absorption with systemic absorption? Do you have a source on isotret/tret going systemic in any significant quantity, because the only studies I can find show that using 10g (yes, ten fucking grams) of 0.1% isotret cream did not increase the plasma concentration of related metabolites above the 2SD.

 

[Soalian]

I'm about to order some Tret again (am 29, did one tub Retin-A when I was 27),

and try to get my skin back from the Abyss somehow, cuz I fucked it up with a 4-week corticosteroid topical course for four weeks on noae area last for nose skin thinning.

I think I'm one of the lowest-inhib guys on this forum when it comes to trying shit out, unfortunately I'm also stupid af smh, so all in all very dangerous combination lol

 

[MrRubiks]

I saw that you edited your post so I want to answer your second paragraph.

Retinoic acid cessation would obviously result in lowered side effects as the overall metabolism is under less pressure to detox. Less havoc. Signs of heavy detox include orange stools and metallic smelling sweat etc.
The younger/healthier you are the higher the rate of said detox. Still the host is under unnecessary burden. Not to even mention the telomere shortening angle.

Also,

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All to have skin that looks baby smooth? Ha the lengths people go to justify certain extremely horrible habits

I'm going to have to do more research. The effects that you've included in your post--are those from topical use? That's definitely concerning. I'm always open to having my mind changed.

*edit* Okay, it looks like there's a systemic absorption rate from topical use. I see.

*edit again* At the very least, for now I'm going to reduce my use to select areas of my face, like around the eyes. That alone would drastically reduce absorption.