AllOrNothing
fallen, not finished
- Joined
- Jan 21, 2026
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Done some research but want real-world experiences before even considering MK-677.
Main reason I’m looking at it is to increase appetite and gain weight (22M, 6ft, 46kg).
I’ve already tried increasing calories and using calorie-dense foods, so I’m mainly interested in experiences with MK-677 rather than general “just eat more” advice.
From what I understand so far:
Risks:
Mitigation (from what I’ve seen):
Bloods I’d check:
Dosing I’ve seen:
What I want to know:
Main reason I’m looking at it is to increase appetite and gain weight (22M, 6ft, 46kg).
I’ve already tried increasing calories and using calorie-dense foods, so I’m mainly interested in experiences with MK-677 rather than general “just eat more” advice.
From what I understand so far:
Risks:
- Water retention (can affect blood pressure)
- Insulin resistance / blood sugar issues
- Fatigue, libido and mood changes
- Acne / oiliness
- Carpal tunnel symptoms (tingling/pins & needles)
- Possible prolactin/cortisol changes
- Potential impact on lipids
- Can stimulate existing abnormal cell growth
- Unknown long-term effects
- Can improve sleep (but mixed reports)
- May improve skin/hair for some (not guaranteed)
- A lot of the “full” look may just be water retention
Mitigation (from what I’ve seen):
- Eating clean
- Using berberine for blood sugar (not a fix, just support)
- Staying hydrated
- Monitoring blood pressure + bloodwork
Bloods I’d check:
- Fasting glucose
- HbA1c
- Fasting insulin
- Lipids
- IGF-1
Dosing I’ve seen:
- 10–25 mg/day
What I want to know:
- Anything important I’m missing?
- How do you actually cycle it (what worked for you)?
- What actually changed for you?
- How did you mitigate side effects?
- Your experience overall

you got it

