alfej
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Adrenergic receptors are receptors for adrenergic substances. All adrenoreceptors are GPCR. They respond to adrenaline and noradrenaline. There are several groups of receptors that differ in the effects they mediate, localization, and affinity for various substances: α1-, α2-, β1-, β2, β3-adrenoreceptors. (https://ru.wikipedia.org/wiki/Адренорецепторы)
Adrenergic receptor agonists are used mainly to relieve problems with blood pressure, impotence, depression, muscle hypertonicity, ischemia, etc.
As a result of studying the effect of adrenergic receptors on GH, it was found that agonism of a2-adrenergic receptors stimulates an increase in GH through inhibition of somatostatin (https://pubmed.ncbi.nlm.nih.gov/1977761/). It is also worth adding that the main effect on GH is exerted by the a2-adrenergic receptor, while the a1 receptor agonist did not cause a response from GH, and the b1-adrenergic receptor, on the contrary, inhibited the release of GH (https://www.sciencedirect.com/science/article/abs/pii/S0006322397000140). Elimination of the effect of the b1-adrenergic receptor, on the contrary, increased GH. In studies, in addition to inhibiting somatostatin, a2-adrenergic receptor agonists lowered blood pressure and caused drowsiness, so people with cardiovascular diseases and problems with blood pressure should refrain from taking a2-adrenergic receptor agonists.
The a2-adrenergic receptor gives a very large response to GH, comparable to the effect of already known drugs for increasing GH, including ibutamoren.
a2-adrenergic receptor agonists also synergize very favorably with growth hormone secretagogues, due to the inhibition of somatostatin. But the synergy with nicotinic receptor agonists is especially notable (https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/j.1365-2125.1984.tb02547.x).
in studies clonidine is cited, you can use sirdalud instead
Я использую переводчик, за качество не ручаюсь.
Adrenergic receptor agonists are used mainly to relieve problems with blood pressure, impotence, depression, muscle hypertonicity, ischemia, etc.
As a result of studying the effect of adrenergic receptors on GH, it was found that agonism of a2-adrenergic receptors stimulates an increase in GH through inhibition of somatostatin (https://pubmed.ncbi.nlm.nih.gov/1977761/). It is also worth adding that the main effect on GH is exerted by the a2-adrenergic receptor, while the a1 receptor agonist did not cause a response from GH, and the b1-adrenergic receptor, on the contrary, inhibited the release of GH (https://www.sciencedirect.com/science/article/abs/pii/S0006322397000140). Elimination of the effect of the b1-adrenergic receptor, on the contrary, increased GH. In studies, in addition to inhibiting somatostatin, a2-adrenergic receptor agonists lowered blood pressure and caused drowsiness, so people with cardiovascular diseases and problems with blood pressure should refrain from taking a2-adrenergic receptor agonists.
The a2-adrenergic receptor gives a very large response to GH, comparable to the effect of already known drugs for increasing GH, including ibutamoren.
a2-adrenergic receptor agonists also synergize very favorably with growth hormone secretagogues, due to the inhibition of somatostatin. But the synergy with nicotinic receptor agonists is especially notable (https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/j.1365-2125.1984.tb02547.x).
in studies clonidine is cited, you can use sirdalud instead
Я использую переводчик, за качество не ручаюсь.
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