Anxiolytics: Alternatives to Common Social Anxiety Medications like Baclofen & Pregabalin(MENTALCELS GTFINH)

[Shirobon]

Notes:​

Desktop Site on mobile or zoom out Use Darkmode: Click Here Recently a thought came to me about the extensive use of Pregabalin and SSRI's to treat Social anxiety and things related, and wondered why there was so few options on the market to help people who struggle with anxiety. In this small low effort guide ill tell you some interesting options instead of abusing pregabalin and others (those who are wondering no this is not the guide i told u im working on)​

Spoiler: Thread Song:

Fasedienol(PH94B):​

Fasedional is a Anxiolytic compound designed to stimulate the vomeronasal organ(chemical receptor in nose) which is thought to increases excretion of the enzyme named Carbonic Anhydrase II, this in-turn modulates the amgydala's olfactory pathways of Fear and anxiety making you more calm and collected during otherwise stress inducing situations. The method of administration used is Intra-nasal, or in other words its a nasal spray. In trials it was taken 15 minutes from social interactions and in under ten showed effects already, providing an acute fast acting medication. Moreover, Fasedienol has shown no withdraw symptoms, and good tolerability according to studies. Currently it is processing through Trials III and if passed will hit the market, but for now you must formulate yourself.​ Implications:​ Fasedienol Formulation:​ Evidence:​ ☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲​ 100 mL Batch(16 month supply)​ Ingredients:​ Concentrations:​ Fasedienol / PH94B 16 µg/mL Phosphate buffer solution, pH 7 8.6% v/v Polysorbate 80 (Tween 80) 8.6% v/v Propylene glycol 2.0% v/v Ethanol 3.0% v/v Benzalkonium chloride 0.01% w/v final Sterile water for injection q.s. to volume Proceed with caustion i have not verified seller authenticity can get cheaper prices off b2b sites like Echemi​ “Vistagen Therapuetics Patent Application WIPO.” Edited by Stephen C Bellum, Google, World Intellecutal Property Organization, 25 Nov. 2021, docs.google.com/viewer?url=patentimages.storage.googleapis.com%2Fpdfs%2FUS20150161458.pdf.​ Fasedienol significantly increased EGNR amplitude (males: 5.0 vs. 0.6 mV, p < 0.001; females:5.7 vs. 0.6 mV, p < 0.001), and rapidly reduced respiratory rate (p < 0.05), heart rate (p < 0.01), and electrodermal activity (p< 0.05) versus control. EGNR and ANS responses after steroidal hormone administration were similar to control. 81% reported feeling less tense/more relaxed after receiving fasedienol, but not after receiving either control or steroidal hormones.​ TL;DR: Intranasal fasedienol, but not control or steroidal hormones, activated EGNR and rapidly reduced ANS responses, consistent with sympatholytic effects. Combined with subjective reports, results suggest fasedienol may provide acute relief in anxiety conditions.​ Monti, Louis. “Effect of FASEDIENOL (PH94B) Pherine Nasal Spray and Steroidal Hormones on Electrogram Responses and Autonomic Nervous System Activity in Healthy Adult Volunteers - Monti - 2024 - Human Psychopharmacology: Clinical and Experimental - Wiley Online Library.” Wiley Online Library, Jan. 2024, onlinelibrary.wiley.com/doi/full/10.1002/hup.2892.​

Soclenicant(BNC210):​

Soclenicant is a Pharmaceutical Modulator of the alpha-7 nicotinic acetylcholine receptor, in studies it has shown to have Anxiolytic effects without known side effects from other common Anxiolytic compounds, i.e mood/emotional stability, narcotic effects, withdraw/addictive nature. This makes it another great alternative along with Fasedienol, that should be used instead of spamming Baclofen and Pregabalin everytime you go out. The method of administration is Orally activated by ingesting through aqueous suspension(drinking it in water), the only issue is the two available formulas differ greatly, for this guide since none of you have laboratory equipment(i think), we will be forced to use the one with less solubility; combat this by taking Soclenicant with food.​ Implications:​ Soclenicant Formulation:​ Evidence:​ ☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲​ 100 mL Batch(16 month supply)​ Ingredients:​ Concentrations:​ Soclenicant / BNC210 300 mg Hydroxypropyl methylcellulose 500 mg Solutol 100 mg Benzyl alcohol 0.5 mL Water No Fixed amount(cup of water likely) Proceed with caustion i have not verified seller authenticity can get cheaper prices off b2b sites like Echemi​ Rolan, Paul. “The Pathway to Proof-of-Concept for BNC210, a Negative Allosteric Modulator of the Alpha-7 Nicotinic Acetylcholine Receptor (nAChR), for Treatment of Psychiatric Disease.” Wiley Online Library, 27 Sept. 2025, accp1.onlinelibrary.wiley.com/doi/full/10.1002/cpdd.1609.​ BNC210 demonstrated anti-panic activity among the 15 evaluable participants who responded to the CCK-4 challenge in trial BNC210.004. Pairwise analyses showed that at 10 min post CCK-4 injection, participants treated with BNC210 2000 mg had a significant reduction in the Total Symptom score (total number of symptoms, P < 0.048) and in the Sum Intensity score (P < 0.041) on the PSS versus placebo-treated participants (Figure 4). The eVAS was used to subjectively assess recovery to emotional stability following CCK-4 injection, and among the 15 participants there was a trend (P = 0.104) toward improved emotional stability at 5 min post CCK-4 injection with BNC210 compared to placebo (Figure 5).​ TL;DR: BNC210 demonstrated improvement in panic-like symptoms in a cholecystokinin tetrapeptide panic model. Initial clinical trials used an aqueous suspension formulation of BNC210 to cover a wide dosage range; however, its pharmacokinetic parameters were consistent with solubility-limited absorption and a significant food effect. A dispersible tablet formulation was then developed with improved bioavailability and is being used in Phases 2 and 3 clinical trials. Collectively, the Phase 1 data demonstrated desired properties of BNC210 supporting proof-of-concept clinical trials. BNC210 is currently being developed for acute, as-needed treatment of social anxiety disorder and chronic treatment of post-traumatic stress disorder.​ Rolan, Paul. “The Pathway to Proof-of-Concept for BNC210, a Negative Allosteric Modulator of the Alpha-7 Nicotinic Acetylcholine Receptor (nAChR), for Treatment of Psychiatric Disease.” Wiley Online Library, 27 Sept. 2025, accp1.onlinelibrary.wiley.com/doi/full/10.1002/cpdd.1609.​

(There are a couple other known Pharmaceuticals(non ssris&snris) that help with Social Anxiety, but their method of doing so is usually as a byproduct of their main purpose)

Conclusion:​

Fasedienol, and Soclenicant offer great alternatives to those who struggle with social anxiety(Soclenicant kinda expensive doe), hope someone can use this guide and benefit from it i myself struggle with social anxiety so i know how it feels sometimes dreading public interaction. anyway thx for reading ​

Spoiler: Follower Tags:

@shedontluv-U @Askinov @Scarlet @Sayori @filthycurrycel @Lemic @negative @Regret @Paul.jnxy @Thatsall101 @anondude @lowdimotrucel

 

[Askinov]

Notes:​

Recently a thought came to me about the extensive use of Pregabalin and SSRI's to treat Social anxiety and things related, and wondered why there was so few options on the market to help people who struggle with anxiety. In this small low effort guide ill tell you some interesting options instead of abusing pregabalin and others (those who are wondering no this is not the guide i told u im working on)​

Spoiler: Thread Song:

Fasedienol(PH94B):​

Fasedional is a Anxiolytic compound designed to stimulate the vomeronasal organ(chemical receptor in nose) which is thought to increases excretion of the enzyme named Carbonic Anhydrase II, this in-turn modulates the amgydala's olfactory pathways of Fear and anxiety making you more calm and collected during otherwise stress inducing situations. The method of administration used is Intra-nasal, or in other words its a nasal spray. In trials it was taken 15 minutes from social interactions and in under ten showed effects already, providing an acute fast acting medication. Moreover, Fasedienol has shown no withdraw symptoms, and good tolerability according to studies. Currently it is processing through Trials III and if passed will hit the market, but for now you must formulate yourself.​ Implications:​ Fasedienol Formulation:​ Evidence:​ ☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲​ 100 mL Batch(16 month supply)​ Ingredients:​ Concentrations:​ Fasedienol / PH94B 16 µg/mL Phosphate buffer solution, pH 7 8.6% v/v Polysorbate 80 (Tween 80) 8.6% v/v Propylene glycol 2.0% v/v Ethanol 3.0% v/v Benzalkonium chloride 0.01% w/v final Sterile water for injection q.s. to volume Proceed with caustion i have not verified seller authenticity can get cheaper prices off b2b sites like Echemi​ “Vistagen Therapuetics Patent Application WIPO.” Edited by Stephen C Bellum, Google, World Intellecutal Property Organization, 25 Nov. 2021, docs.google.com/viewer?url=patentimages.storage.googleapis.com%2Fpdfs%2FUS20150161458.pdf.​ Fasedienol significantly increased EGNR amplitude (males: 5.0 vs. 0.6 mV, p < 0.001; females:5.7 vs. 0.6 mV, p < 0.001), and rapidly reduced respiratory rate (p < 0.05), heart rate (p < 0.01), and electrodermal activity (p< 0.05) versus control. EGNR and ANS responses after steroidal hormone administration were similar to control. 81% reported feeling less tense/more relaxed after receiving fasedienol, but not after receiving either control or steroidal hormones.​ TL;DR: Intranasal fasedienol, but not control or steroidal hormones, activated EGNR and rapidly reduced ANS responses, consistent with sympatholytic effects. Combined with subjective reports, results suggest fasedienol may provide acute relief in anxiety conditions.​ Monti, Louis. “Effect of FASEDIENOL (PH94B) Pherine Nasal Spray and Steroidal Hormones on Electrogram Responses and Autonomic Nervous System Activity in Healthy Adult Volunteers - Monti - 2024 - Human Psychopharmacology: Clinical and Experimental - Wiley Online Library.” Wiley Online Library, Jan. 2024, onlinelibrary.wiley.com/doi/full/10.1002/hup.2892.​

Soclenicant(BNC210):​

Soclenicant is a Pharmaceutical Modulator of the alpha-7 nicotinic acetylcholine receptor, in studies it has shown to have Anxiolytic effects without known side effects from other common Anxiolytic compounds, i.e mood/emotional stability, narcotic effects, withdraw/addictive nature. This makes it another great alternative along with Fasedienol, that should be used instead of spamming Baclofen and Pregabalin everytime you go out. The method of administration is Orally activated by ingesting through aqueous suspension(drinking it in water), the only issue is the two available formulas differ greatly, for this guide since none of you have laboratory equipment(i think), we will be forced to use the one with less solubility; combat this by taking Soclenicant with food.​ Implications:​ Soclenicant Formulation:​ Evidence:​ ☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲​ 100 mL Batch(16 month supply)​ Ingredients:​ Concentrations:​ Soclenicant / BNC210 300 mg Hydroxypropyl methylcellulose 500 mg Solutol 100 mg Benzyl alcohol 0.5 mL Water No Fixed amount(cup of water likely) Proceed with caustion i have not verified seller authenticity can get cheaper prices off b2b sites like Echemi​ Rolan, Paul. “The Pathway to Proof-of-Concept for BNC210, a Negative Allosteric Modulator of the Alpha-7 Nicotinic Acetylcholine Receptor (nAChR), for Treatment of Psychiatric Disease.” Wiley Online Library, 27 Sept. 2025, accp1.onlinelibrary.wiley.com/doi/full/10.1002/cpdd.1609.​ BNC210 demonstrated anti-panic activity among the 15 evaluable participants who responded to the CCK-4 challenge in trial BNC210.004. Pairwise analyses showed that at 10 min post CCK-4 injection, participants treated with BNC210 2000 mg had a significant reduction in the Total Symptom score (total number of symptoms, P < 0.048) and in the Sum Intensity score (P < 0.041) on the PSS versus placebo-treated participants (Figure 4). The eVAS was used to subjectively assess recovery to emotional stability following CCK-4 injection, and among the 15 participants there was a trend (P = 0.104) toward improved emotional stability at 5 min post CCK-4 injection with BNC210 compared to placebo (Figure 5).​ TL;DR: BNC210 demonstrated improvement in panic-like symptoms in a cholecystokinin tetrapeptide panic model. Initial clinical trials used an aqueous suspension formulation of BNC210 to cover a wide dosage range; however, its pharmacokinetic parameters were consistent with solubility-limited absorption and a significant food effect. A dispersible tablet formulation was then developed with improved bioavailability and is being used in Phases 2 and 3 clinical trials. Collectively, the Phase 1 data demonstrated desired properties of BNC210 supporting proof-of-concept clinical trials. BNC210 is currently being developed for acute, as-needed treatment of social anxiety disorder and chronic treatment of post-traumatic stress disorder.​ Rolan, Paul. “The Pathway to Proof-of-Concept for BNC210, a Negative Allosteric Modulator of the Alpha-7 Nicotinic Acetylcholine Receptor (nAChR), for Treatment of Psychiatric Disease.” Wiley Online Library, 27 Sept. 2025, accp1.onlinelibrary.wiley.com/doi/full/10.1002/cpdd.1609.​

(There are a couple other known Pharmaceuticals(non ssris&snris) that help with Social Anxiety, but their method of doing so is usually as a byproduct of their main purpose)

Conclusion:​

Fasedienol, and Soclenicant offer great alternatives to those who struggle with social anxiety(Soclenicant kinda expensive doe), hope someone can use this guide and benefit from it i myself struggle with social anxiety so i know how it feels sometimes dreading public interaction. anyway thx for reading ​

Spoiler: Follower Tags:

@shedontluv-U @Askinov @Scarlet @Sayori @filthycurrycel @Lemic @negative @Regret @Paul.jnxy @Thatsall101 @anondude @lowdimotrucel

how i feel after seeing this thread

 

[Askinov]

good use of wiki bro mirin

 

[Shirobon]

good use of wiki bro mirin

wikipedia godsend for buying chemicals yo

 

[Askinov]

wikipedia godsend for buying chemicals yo

ohhh

 

[smegor]

also i take prozac and its so good for social life

 

[Shirobon]

ohhh

if only it were that ez for finding sellers

 

[Shirobon]

how i feel after seeing this thread

in short
take these if u dont wanna use pregab

 

[Askinov]

in short
take these if u dont wanna use pregab

in short i just iam not going to use any shit i just book mark this for knowledge

 

[jf8]

bump

 

[Shirobon]

in short i just iam not going to use any shit i just book mark this for knowledge

 

[Sayori]

Notes:​

Desktop Site on mobile or zoom out Use Darkmode: Click Here Recently a thought came to me about the extensive use of Pregabalin and SSRI's to treat Social anxiety and things related, and wondered why there was so few options on the market to help people who struggle with anxiety. In this small low effort guide ill tell you some interesting options instead of abusing pregabalin and others (those who are wondering no this is not the guide i told u im working on)​

Spoiler: Thread Song:

Fasedienol(PH94B):​

Fasedional is a Anxiolytic compound designed to stimulate the vomeronasal organ(chemical receptor in nose) which is thought to increases excretion of the enzyme named Carbonic Anhydrase II, this in-turn modulates the amgydala's olfactory pathways of Fear and anxiety making you more calm and collected during otherwise stress inducing situations. The method of administration used is Intra-nasal, or in other words its a nasal spray. In trials it was taken 15 minutes from social interactions and in under ten showed effects already, providing an acute fast acting medication. Moreover, Fasedienol has shown no withdraw symptoms, and good tolerability according to studies. Currently it is processing through Trials III and if passed will hit the market, but for now you must formulate yourself.​ Implications:​ Fasedienol Formulation:​ Evidence:​ ☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲​ 100 mL Batch(16 month supply)​ Ingredients:​ Concentrations:​ Fasedienol / PH94B 16 µg/mL Phosphate buffer solution, pH 7 8.6% v/v Polysorbate 80 (Tween 80) 8.6% v/v Propylene glycol 2.0% v/v Ethanol 3.0% v/v Benzalkonium chloride 0.01% w/v final Sterile water for injection q.s. to volume Proceed with caustion i have not verified seller authenticity can get cheaper prices off b2b sites like Echemi​ “Vistagen Therapuetics Patent Application WIPO.” Edited by Stephen C Bellum, Google, World Intellecutal Property Organization, 25 Nov. 2021, docs.google.com/viewer?url=patentimages.storage.googleapis.com%2Fpdfs%2FUS20150161458.pdf.​ Fasedienol significantly increased EGNR amplitude (males: 5.0 vs. 0.6 mV, p < 0.001; females:5.7 vs. 0.6 mV, p < 0.001), and rapidly reduced respiratory rate (p < 0.05), heart rate (p < 0.01), and electrodermal activity (p< 0.05) versus control. EGNR and ANS responses after steroidal hormone administration were similar to control. 81% reported feeling less tense/more relaxed after receiving fasedienol, but not after receiving either control or steroidal hormones.​ TL;DR: Intranasal fasedienol, but not control or steroidal hormones, activated EGNR and rapidly reduced ANS responses, consistent with sympatholytic effects. Combined with subjective reports, results suggest fasedienol may provide acute relief in anxiety conditions.​ Monti, Louis. “Effect of FASEDIENOL (PH94B) Pherine Nasal Spray and Steroidal Hormones on Electrogram Responses and Autonomic Nervous System Activity in Healthy Adult Volunteers - Monti - 2024 - Human Psychopharmacology: Clinical and Experimental - Wiley Online Library.” Wiley Online Library, Jan. 2024, onlinelibrary.wiley.com/doi/full/10.1002/hup.2892.​

Soclenicant(BNC210):​

Soclenicant is a Pharmaceutical Modulator of the alpha-7 nicotinic acetylcholine receptor, in studies it has shown to have Anxiolytic effects without known side effects from other common Anxiolytic compounds, i.e mood/emotional stability, narcotic effects, withdraw/addictive nature. This makes it another great alternative along with Fasedienol, that should be used instead of spamming Baclofen and Pregabalin everytime you go out. The method of administration is Orally activated by ingesting through aqueous suspension(drinking it in water), the only issue is the two available formulas differ greatly, for this guide since none of you have laboratory equipment(i think), we will be forced to use the one with less solubility; combat this by taking Soclenicant with food.​ Implications:​ Soclenicant Formulation:​ Evidence:​ ☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲​ 100 mL Batch(16 month supply)​ Ingredients:​ Concentrations:​ Soclenicant / BNC210 300 mg Hydroxypropyl methylcellulose 500 mg Solutol 100 mg Benzyl alcohol 0.5 mL Water No Fixed amount(cup of water likely) Proceed with caustion i have not verified seller authenticity can get cheaper prices off b2b sites like Echemi​ Rolan, Paul. “The Pathway to Proof-of-Concept for BNC210, a Negative Allosteric Modulator of the Alpha-7 Nicotinic Acetylcholine Receptor (nAChR), for Treatment of Psychiatric Disease.” Wiley Online Library, 27 Sept. 2025, accp1.onlinelibrary.wiley.com/doi/full/10.1002/cpdd.1609.​ BNC210 demonstrated anti-panic activity among the 15 evaluable participants who responded to the CCK-4 challenge in trial BNC210.004. Pairwise analyses showed that at 10 min post CCK-4 injection, participants treated with BNC210 2000 mg had a significant reduction in the Total Symptom score (total number of symptoms, P < 0.048) and in the Sum Intensity score (P < 0.041) on the PSS versus placebo-treated participants (Figure 4). The eVAS was used to subjectively assess recovery to emotional stability following CCK-4 injection, and among the 15 participants there was a trend (P = 0.104) toward improved emotional stability at 5 min post CCK-4 injection with BNC210 compared to placebo (Figure 5).​ TL;DR: BNC210 demonstrated improvement in panic-like symptoms in a cholecystokinin tetrapeptide panic model. Initial clinical trials used an aqueous suspension formulation of BNC210 to cover a wide dosage range; however, its pharmacokinetic parameters were consistent with solubility-limited absorption and a significant food effect. A dispersible tablet formulation was then developed with improved bioavailability and is being used in Phases 2 and 3 clinical trials. Collectively, the Phase 1 data demonstrated desired properties of BNC210 supporting proof-of-concept clinical trials. BNC210 is currently being developed for acute, as-needed treatment of social anxiety disorder and chronic treatment of post-traumatic stress disorder.​ Rolan, Paul. “The Pathway to Proof-of-Concept for BNC210, a Negative Allosteric Modulator of the Alpha-7 Nicotinic Acetylcholine Receptor (nAChR), for Treatment of Psychiatric Disease.” Wiley Online Library, 27 Sept. 2025, accp1.onlinelibrary.wiley.com/doi/full/10.1002/cpdd.1609.​

(There are a couple other known Pharmaceuticals(non ssris&snris) that help with Social Anxiety, but their method of doing so is usually as a byproduct of their main purpose)

Conclusion:​

Fasedienol, and Soclenicant offer great alternatives to those who struggle with social anxiety(Soclenicant kinda expensive doe), hope someone can use this guide and benefit from it i myself struggle with social anxiety so i know how it feels sometimes dreading public interaction. anyway thx for reading ​

Spoiler: Follower Tags:

@shedontluv-U @Askinov @Scarlet @Sayori @filthycurrycel @Lemic @negative @Regret @Paul.jnxy @Thatsall101 @anondude @lowdimotrucel

Goated btw, I did not expect a useful thread rn

Amazing

 

[Shirobon]

Goated btw, I did not expect a useful thread rn

Amazing

np bhai check out my other guide if u find it useful

 

[fantamaxxer]

bump

 

[Mr. Squarepants]

Bump

 

[shedontluv-U]

MIRIN

 

[Shirobon]

MIRIN

thx

 

[thaum]

Notes:​

Desktop Site on mobile or zoom out Use Darkmode: Click Here Recently a thought came to me about the extensive use of Pregabalin and SSRI's to treat Social anxiety and things related, and wondered why there was so few options on the market to help people who struggle with anxiety. In this small low effort guide ill tell you some interesting options instead of abusing pregabalin and others (those who are wondering no this is not the guide i told u im working on)​

Spoiler: Thread Song:

Fasedienol(PH94B):​

Fasedional is a Anxiolytic compound designed to stimulate the vomeronasal organ(chemical receptor in nose) which is thought to increases excretion of the enzyme named Carbonic Anhydrase II, this in-turn modulates the amgydala's olfactory pathways of Fear and anxiety making you more calm and collected during otherwise stress inducing situations. The method of administration used is Intra-nasal, or in other words its a nasal spray. In trials it was taken 15 minutes from social interactions and in under ten showed effects already, providing an acute fast acting medication. Moreover, Fasedienol has shown no withdraw symptoms, and good tolerability according to studies. Currently it is processing through Trials III and if passed will hit the market, but for now you must formulate yourself.​ Implications:​ Fasedienol Formulation:​ Evidence:​ ☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲​ 100 mL Batch(16 month supply)​ Ingredients:​ Concentrations:​ Fasedienol / PH94B 16 µg/mL Phosphate buffer solution, pH 7 8.6% v/v Polysorbate 80 (Tween 80) 8.6% v/v Propylene glycol 2.0% v/v Ethanol 3.0% v/v Benzalkonium chloride 0.01% w/v final Sterile water for injection q.s. to volume Proceed with caustion i have not verified seller authenticity can get cheaper prices off b2b sites like Echemi​ “Vistagen Therapuetics Patent Application WIPO.” Edited by Stephen C Bellum, Google, World Intellecutal Property Organization, 25 Nov. 2021, docs.google.com/viewer?url=patentimages.storage.googleapis.com%2Fpdfs%2FUS20150161458.pdf.​ Fasedienol significantly increased EGNR amplitude (males: 5.0 vs. 0.6 mV, p < 0.001; females:5.7 vs. 0.6 mV, p < 0.001), and rapidly reduced respiratory rate (p < 0.05), heart rate (p < 0.01), and electrodermal activity (p< 0.05) versus control. EGNR and ANS responses after steroidal hormone administration were similar to control. 81% reported feeling less tense/more relaxed after receiving fasedienol, but not after receiving either control or steroidal hormones.​ TL;DR: Intranasal fasedienol, but not control or steroidal hormones, activated EGNR and rapidly reduced ANS responses, consistent with sympatholytic effects. Combined with subjective reports, results suggest fasedienol may provide acute relief in anxiety conditions.​ Monti, Louis. “Effect of FASEDIENOL (PH94B) Pherine Nasal Spray and Steroidal Hormones on Electrogram Responses and Autonomic Nervous System Activity in Healthy Adult Volunteers - Monti - 2024 - Human Psychopharmacology: Clinical and Experimental - Wiley Online Library.” Wiley Online Library, Jan. 2024, onlinelibrary.wiley.com/doi/full/10.1002/hup.2892.​

Soclenicant(BNC210):​

Soclenicant is a Pharmaceutical Modulator of the alpha-7 nicotinic acetylcholine receptor, in studies it has shown to have Anxiolytic effects without known side effects from other common Anxiolytic compounds, i.e mood/emotional stability, narcotic effects, withdraw/addictive nature. This makes it another great alternative along with Fasedienol, that should be used instead of spamming Baclofen and Pregabalin everytime you go out. The method of administration is Orally activated by ingesting through aqueous suspension(drinking it in water), the only issue is the two available formulas differ greatly, for this guide since none of you have laboratory equipment(i think), we will be forced to use the one with less solubility; combat this by taking Soclenicant with food.​ Implications:​ Soclenicant Formulation:​ Evidence:​ ☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲​ 100 mL Batch(16 month supply)​ Ingredients:​ Concentrations:​ Soclenicant / BNC210 300 mg Hydroxypropyl methylcellulose 500 mg Solutol 100 mg Benzyl alcohol 0.5 mL Water No Fixed amount(cup of water likely) Proceed with caustion i have not verified seller authenticity can get cheaper prices off b2b sites like Echemi​ Rolan, Paul. “The Pathway to Proof-of-Concept for BNC210, a Negative Allosteric Modulator of the Alpha-7 Nicotinic Acetylcholine Receptor (nAChR), for Treatment of Psychiatric Disease.” Wiley Online Library, 27 Sept. 2025, accp1.onlinelibrary.wiley.com/doi/full/10.1002/cpdd.1609.​ BNC210 demonstrated anti-panic activity among the 15 evaluable participants who responded to the CCK-4 challenge in trial BNC210.004. Pairwise analyses showed that at 10 min post CCK-4 injection, participants treated with BNC210 2000 mg had a significant reduction in the Total Symptom score (total number of symptoms, P < 0.048) and in the Sum Intensity score (P < 0.041) on the PSS versus placebo-treated participants (Figure 4). The eVAS was used to subjectively assess recovery to emotional stability following CCK-4 injection, and among the 15 participants there was a trend (P = 0.104) toward improved emotional stability at 5 min post CCK-4 injection with BNC210 compared to placebo (Figure 5).​ TL;DR: BNC210 demonstrated improvement in panic-like symptoms in a cholecystokinin tetrapeptide panic model. Initial clinical trials used an aqueous suspension formulation of BNC210 to cover a wide dosage range; however, its pharmacokinetic parameters were consistent with solubility-limited absorption and a significant food effect. A dispersible tablet formulation was then developed with improved bioavailability and is being used in Phases 2 and 3 clinical trials. Collectively, the Phase 1 data demonstrated desired properties of BNC210 supporting proof-of-concept clinical trials. BNC210 is currently being developed for acute, as-needed treatment of social anxiety disorder and chronic treatment of post-traumatic stress disorder.​ Rolan, Paul. “The Pathway to Proof-of-Concept for BNC210, a Negative Allosteric Modulator of the Alpha-7 Nicotinic Acetylcholine Receptor (nAChR), for Treatment of Psychiatric Disease.” Wiley Online Library, 27 Sept. 2025, accp1.onlinelibrary.wiley.com/doi/full/10.1002/cpdd.1609.​

(There are a couple other known Pharmaceuticals(non ssris&snris) that help with Social Anxiety, but their method of doing so is usually as a byproduct of their main purpose)

Conclusion:​

Fasedienol, and Soclenicant offer great alternatives to those who struggle with social anxiety(Soclenicant kinda expensive doe), hope someone can use this guide and benefit from it i myself struggle with social anxiety so i know how it feels sometimes dreading public interaction. anyway thx for reading ​

Spoiler: Follower Tags:

@shedontluv-U @Askinov @Scarlet @Sayori @filthycurrycel @Lemic @negative @Regret @Paul.jnxy @Thatsall101 @anondude @lowdimotrucel

mirin post

good thread

 

[Shirobon]

b

 

[mendeds]

beautiful formatting

 

[shedontluv-U]

@Avocet @Brava @DrMd @Fynn @Tesarossa

NONE of you can tell what this guide is about

 

[Shirobon]

@Avocet @Brava @DrMd @Fynn @Tesarossa

NONE of you can tell what this guide is about

is it rlly that hard to understand

 

[shedontluv-U]

is it rlly that hard to understand

no they just dont understand very well shiro

 

[Fynn]

very nice guide

 

[Shirobon]

no they just dont understand very well shiro

oh ok

 

[Fynn]

@Avocet @Brava @DrMd @Fynn @Tesarossa

NONE of you can tell what this guide is about

its obv about how to get a sharp jaw line duh

 

[Organ]

Notes:​

Desktop Site on mobile or zoom out Use Darkmode: Click Here Recently a thought came to me about the extensive use of Pregabalin and SSRI's to treat Social anxiety and things related, and wondered why there was so few options on the market to help people who struggle with anxiety. In this small low effort guide ill tell you some interesting options instead of abusing pregabalin and others (those who are wondering no this is not the guide i told u im working on)​

Spoiler: Thread Song:

Fasedienol(PH94B):​

Fasedional is a Anxiolytic compound designed to stimulate the vomeronasal organ(chemical receptor in nose) which is thought to increases excretion of the enzyme named Carbonic Anhydrase II, this in-turn modulates the amgydala's olfactory pathways of Fear and anxiety making you more calm and collected during otherwise stress inducing situations. The method of administration used is Intra-nasal, or in other words its a nasal spray. In trials it was taken 15 minutes from social interactions and in under ten showed effects already, providing an acute fast acting medication. Moreover, Fasedienol has shown no withdraw symptoms, and good tolerability according to studies. Currently it is processing through Trials III and if passed will hit the market, but for now you must formulate yourself.​ Implications:​ Fasedienol Formulation:​ Evidence:​ ☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲​ 100 mL Batch(16 month supply)​ Ingredients:​ Concentrations:​ Fasedienol / PH94B 16 µg/mL Phosphate buffer solution, pH 7 8.6% v/v Polysorbate 80 (Tween 80) 8.6% v/v Propylene glycol 2.0% v/v Ethanol 3.0% v/v Benzalkonium chloride 0.01% w/v final Sterile water for injection q.s. to volume Proceed with caustion i have not verified seller authenticity can get cheaper prices off b2b sites like Echemi​ “Vistagen Therapuetics Patent Application WIPO.” Edited by Stephen C Bellum, Google, World Intellecutal Property Organization, 25 Nov. 2021, docs.google.com/viewer?url=patentimages.storage.googleapis.com%2Fpdfs%2FUS20150161458.pdf.​ Fasedienol significantly increased EGNR amplitude (males: 5.0 vs. 0.6 mV, p < 0.001; females:5.7 vs. 0.6 mV, p < 0.001), and rapidly reduced respiratory rate (p < 0.05), heart rate (p < 0.01), and electrodermal activity (p< 0.05) versus control. EGNR and ANS responses after steroidal hormone administration were similar to control. 81% reported feeling less tense/more relaxed after receiving fasedienol, but not after receiving either control or steroidal hormones.​ TL;DR: Intranasal fasedienol, but not control or steroidal hormones, activated EGNR and rapidly reduced ANS responses, consistent with sympatholytic effects. Combined with subjective reports, results suggest fasedienol may provide acute relief in anxiety conditions.​ Monti, Louis. “Effect of FASEDIENOL (PH94B) Pherine Nasal Spray and Steroidal Hormones on Electrogram Responses and Autonomic Nervous System Activity in Healthy Adult Volunteers - Monti - 2024 - Human Psychopharmacology: Clinical and Experimental - Wiley Online Library.” Wiley Online Library, Jan. 2024, onlinelibrary.wiley.com/doi/full/10.1002/hup.2892.​

Soclenicant(BNC210):​

Soclenicant is a Pharmaceutical Modulator of the alpha-7 nicotinic acetylcholine receptor, in studies it has shown to have Anxiolytic effects without known side effects from other common Anxiolytic compounds, i.e mood/emotional stability, narcotic effects, withdraw/addictive nature. This makes it another great alternative along with Fasedienol, that should be used instead of spamming Baclofen and Pregabalin everytime you go out. The method of administration is Orally activated by ingesting through aqueous suspension(drinking it in water), the only issue is the two available formulas differ greatly, for this guide since none of you have laboratory equipment(i think), we will be forced to use the one with less solubility; combat this by taking Soclenicant with food.​ Implications:​ Soclenicant Formulation:​ Evidence:​ ☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲​ 100 mL Batch(16 month supply)​ Ingredients:​ Concentrations:​ Soclenicant / BNC210 300 mg Hydroxypropyl methylcellulose 500 mg Solutol 100 mg Benzyl alcohol 0.5 mL Water No Fixed amount(cup of water likely) Proceed with caustion i have not verified seller authenticity can get cheaper prices off b2b sites like Echemi​ Rolan, Paul. “The Pathway to Proof-of-Concept for BNC210, a Negative Allosteric Modulator of the Alpha-7 Nicotinic Acetylcholine Receptor (nAChR), for Treatment of Psychiatric Disease.” Wiley Online Library, 27 Sept. 2025, accp1.onlinelibrary.wiley.com/doi/full/10.1002/cpdd.1609.​ BNC210 demonstrated anti-panic activity among the 15 evaluable participants who responded to the CCK-4 challenge in trial BNC210.004. Pairwise analyses showed that at 10 min post CCK-4 injection, participants treated with BNC210 2000 mg had a significant reduction in the Total Symptom score (total number of symptoms, P < 0.048) and in the Sum Intensity score (P < 0.041) on the PSS versus placebo-treated participants (Figure 4). The eVAS was used to subjectively assess recovery to emotional stability following CCK-4 injection, and among the 15 participants there was a trend (P = 0.104) toward improved emotional stability at 5 min post CCK-4 injection with BNC210 compared to placebo (Figure 5).​ TL;DR: BNC210 demonstrated improvement in panic-like symptoms in a cholecystokinin tetrapeptide panic model. Initial clinical trials used an aqueous suspension formulation of BNC210 to cover a wide dosage range; however, its pharmacokinetic parameters were consistent with solubility-limited absorption and a significant food effect. A dispersible tablet formulation was then developed with improved bioavailability and is being used in Phases 2 and 3 clinical trials. Collectively, the Phase 1 data demonstrated desired properties of BNC210 supporting proof-of-concept clinical trials. BNC210 is currently being developed for acute, as-needed treatment of social anxiety disorder and chronic treatment of post-traumatic stress disorder.​ Rolan, Paul. “The Pathway to Proof-of-Concept for BNC210, a Negative Allosteric Modulator of the Alpha-7 Nicotinic Acetylcholine Receptor (nAChR), for Treatment of Psychiatric Disease.” Wiley Online Library, 27 Sept. 2025, accp1.onlinelibrary.wiley.com/doi/full/10.1002/cpdd.1609.​

(There are a couple other known Pharmaceuticals(non ssris&snris) that help with Social Anxiety, but their method of doing so is usually as a byproduct of their main purpose)

Conclusion:​

Fasedienol, and Soclenicant offer great alternatives to those who struggle with social anxiety(Soclenicant kinda expensive doe), hope someone can use this guide and benefit from it i myself struggle with social anxiety so i know how it feels sometimes dreading public interaction. anyway thx for reading ​

Spoiler: Follower Tags:

@shedontluv-U @Askinov @Scarlet @Sayori @filthycurrycel @Lemic @negative @Regret @Paul.jnxy @Thatsall101 @anondude @lowdimotrucel

Mirin effort.

I bought a years worth of pregab and bac from pharmacies when I was traveling overseas.

 

[Shirobon]

Mirin effort.

was low effort literally made in 3 hours

I bought a years worth of pregab and bac from pharmacies when I was traveling overseas.

wild if u got money to do that maybe try some of the stuff i talked about in here

 

[filthycurrycel]

Notes:​

Desktop Site on mobile or zoom out Use Darkmode: Click Here Recently a thought came to me about the extensive use of Pregabalin and SSRI's to treat Social anxiety and things related, and wondered why there was so few options on the market to help people who struggle with anxiety. In this small low effort guide ill tell you some interesting options instead of abusing pregabalin and others (those who are wondering no this is not the guide i told u im working on)​

Spoiler: Thread Song:

Fasedienol(PH94B):​

Fasedional is a Anxiolytic compound designed to stimulate the vomeronasal organ(chemical receptor in nose) which is thought to increases excretion of the enzyme named Carbonic Anhydrase II, this in-turn modulates the amgydala's olfactory pathways of Fear and anxiety making you more calm and collected during otherwise stress inducing situations. The method of administration used is Intra-nasal, or in other words its a nasal spray. In trials it was taken 15 minutes from social interactions and in under ten showed effects already, providing an acute fast acting medication. Moreover, Fasedienol has shown no withdraw symptoms, and good tolerability according to studies. Currently it is processing through Trials III and if passed will hit the market, but for now you must formulate yourself.​ Implications:​ Fasedienol Formulation:​ Evidence:​ ☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲​ 100 mL Batch(16 month supply)​ Ingredients:​ Concentrations:​ Fasedienol / PH94B 16 µg/mL Phosphate buffer solution, pH 7 8.6% v/v Polysorbate 80 (Tween 80) 8.6% v/v Propylene glycol 2.0% v/v Ethanol 3.0% v/v Benzalkonium chloride 0.01% w/v final Sterile water for injection q.s. to volume Proceed with caustion i have not verified seller authenticity can get cheaper prices off b2b sites like Echemi​ “Vistagen Therapuetics Patent Application WIPO.” Edited by Stephen C Bellum, Google, World Intellecutal Property Organization, 25 Nov. 2021, docs.google.com/viewer?url=patentimages.storage.googleapis.com%2Fpdfs%2FUS20150161458.pdf.​ Fasedienol significantly increased EGNR amplitude (males: 5.0 vs. 0.6 mV, p < 0.001; females:5.7 vs. 0.6 mV, p < 0.001), and rapidly reduced respiratory rate (p < 0.05), heart rate (p < 0.01), and electrodermal activity (p< 0.05) versus control. EGNR and ANS responses after steroidal hormone administration were similar to control. 81% reported feeling less tense/more relaxed after receiving fasedienol, but not after receiving either control or steroidal hormones.​ TL;DR: Intranasal fasedienol, but not control or steroidal hormones, activated EGNR and rapidly reduced ANS responses, consistent with sympatholytic effects. Combined with subjective reports, results suggest fasedienol may provide acute relief in anxiety conditions.​ Monti, Louis. “Effect of FASEDIENOL (PH94B) Pherine Nasal Spray and Steroidal Hormones on Electrogram Responses and Autonomic Nervous System Activity in Healthy Adult Volunteers - Monti - 2024 - Human Psychopharmacology: Clinical and Experimental - Wiley Online Library.” Wiley Online Library, Jan. 2024, onlinelibrary.wiley.com/doi/full/10.1002/hup.2892.​

Soclenicant(BNC210):​

Soclenicant is a Pharmaceutical Modulator of the alpha-7 nicotinic acetylcholine receptor, in studies it has shown to have Anxiolytic effects without known side effects from other common Anxiolytic compounds, i.e mood/emotional stability, narcotic effects, withdraw/addictive nature. This makes it another great alternative along with Fasedienol, that should be used instead of spamming Baclofen and Pregabalin everytime you go out. The method of administration is Orally activated by ingesting through aqueous suspension(drinking it in water), the only issue is the two available formulas differ greatly, for this guide since none of you have laboratory equipment(i think), we will be forced to use the one with less solubility; combat this by taking Soclenicant with food.​ Implications:​ Soclenicant Formulation:​ Evidence:​ ☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲☲​ 100 mL Batch(16 month supply)​ Ingredients:​ Concentrations:​ Soclenicant / BNC210 300 mg Hydroxypropyl methylcellulose 500 mg Solutol 100 mg Benzyl alcohol 0.5 mL Water No Fixed amount(cup of water likely) Proceed with caustion i have not verified seller authenticity can get cheaper prices off b2b sites like Echemi​ Rolan, Paul. “The Pathway to Proof-of-Concept for BNC210, a Negative Allosteric Modulator of the Alpha-7 Nicotinic Acetylcholine Receptor (nAChR), for Treatment of Psychiatric Disease.” Wiley Online Library, 27 Sept. 2025, accp1.onlinelibrary.wiley.com/doi/full/10.1002/cpdd.1609.​ BNC210 demonstrated anti-panic activity among the 15 evaluable participants who responded to the CCK-4 challenge in trial BNC210.004. Pairwise analyses showed that at 10 min post CCK-4 injection, participants treated with BNC210 2000 mg had a significant reduction in the Total Symptom score (total number of symptoms, P < 0.048) and in the Sum Intensity score (P < 0.041) on the PSS versus placebo-treated participants (Figure 4). The eVAS was used to subjectively assess recovery to emotional stability following CCK-4 injection, and among the 15 participants there was a trend (P = 0.104) toward improved emotional stability at 5 min post CCK-4 injection with BNC210 compared to placebo (Figure 5).​ TL;DR: BNC210 demonstrated improvement in panic-like symptoms in a cholecystokinin tetrapeptide panic model. Initial clinical trials used an aqueous suspension formulation of BNC210 to cover a wide dosage range; however, its pharmacokinetic parameters were consistent with solubility-limited absorption and a significant food effect. A dispersible tablet formulation was then developed with improved bioavailability and is being used in Phases 2 and 3 clinical trials. Collectively, the Phase 1 data demonstrated desired properties of BNC210 supporting proof-of-concept clinical trials. BNC210 is currently being developed for acute, as-needed treatment of social anxiety disorder and chronic treatment of post-traumatic stress disorder.​ Rolan, Paul. “The Pathway to Proof-of-Concept for BNC210, a Negative Allosteric Modulator of the Alpha-7 Nicotinic Acetylcholine Receptor (nAChR), for Treatment of Psychiatric Disease.” Wiley Online Library, 27 Sept. 2025, accp1.onlinelibrary.wiley.com/doi/full/10.1002/cpdd.1609.​

(There are a couple other known Pharmaceuticals(non ssris&snris) that help with Social Anxiety, but their method of doing so is usually as a byproduct of their main purpose)

Conclusion:​

Fasedienol, and Soclenicant offer great alternatives to those who struggle with social anxiety(Soclenicant kinda expensive doe), hope someone can use this guide and benefit from it i myself struggle with social anxiety so i know how it feels sometimes dreading public interaction. anyway thx for reading ​

Spoiler: Follower Tags:

@shedontluv-U @Askinov @Scarlet @Sayori @filthycurrycel @Lemic @negative @Regret @Paul.jnxy @Thatsall101 @anondude @lowdimotrucel

MIRIN

 

[DrMd]

@Avocet @Brava @DrMd @Fynn @Tesarossa

NONE of you can tell what this guide is about

its for high inhib ppl bro

 

[shedontluv-U]

hwo you did for the first gif