
ReverseNorwoodPill
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sounds solid, i will reply tomorrowBut what if you think about my reverse theory here?
Prolonged cortisol = lower cortisol sensitivity in vascular tissues. Cortisol is extremely diurnal as I claimed before, varying up to 300%. It seems that constant cortisol levels produces the least cortisol effect in the long-term in vascular tissues.
So cushing's is actually low cortisol effect in vascular tissues, but it will still continue to have effect in peripheral tissues because the cortisol sensitivity there doesn't vary much as there is mega-load of receptors everywhere that just regenerate faster than the cortisol can desensitize them.
So in peripheral there is a lot of cortisol effect going on such as bone and muscle wasting, but in vascular the opposite is happening with low cortisol effect. Cortisol is protein wasting, so it makes sense that it on it's own can cause hair thinning and hair loss. But of course high cortisol will crash hormone levels as well, which means even more hair thinning as E1 and E2 are lowered.
Either way I think having lower E is worse than benefits of having lower DHT for hair loss, E stimulates hair growth a lot.