Kojo
18 | 160mg Isotret | 500mg Test
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Low effort Clickbait Shitpost, but Aromatase inhibitors are shit as a monotherapy for height increase and could actually work against you (though unlikely). STILL USE AI'S. CHECK "SOLUTION" AT THE BOTTOM OF THIS THREAD
If you don't know by now, basics of knowing/discussing or theorising about any hormone altering compounds is that feedack loops exist. You should also understand the concept of Ligands and receptors, binding(Binding affinity included) and competitive binding.
Ligands/Substrate are any molecule that binds to a binding site, Like enzymes or receptors which are proteins. Compounds you take into your system usually bind to the receptor it's designated to. Aromatase Inhibitors have to bind to aromatase and either deactivate it or kill it which comes under the umbrella term of "Antagonism".
Competitive binding is the process by which different ligands have to compete for the same binding site, only one thing can bind the site at once. The ligand that wins typically wins through having a higher binding affinity which is the strength at which it binds and takes over the binding site.
HOWEVER another factor matters like it's concentration, For example Endoxifen and 4-Hydroxytamoxifen have the same binding affinity, yet Endoxifen wins the binding race to estrogen receptors becaue it's concentration is much higher.
The relevance of all this is that testosterone and aromatase inhibitors exhibit the same effect as they both want to bind to aromatase, Testosterone wants to convert into E2 and AI's want to deactivate it. Now normally, AI's rape testosterone on binding affinity for this exact reason.
The Nuance comes in when you factor in the fact that Aromatase inhibitors like letrozole can give you disgusting surges of testosterone by 300% due to the negative feedback loop of the pituitary triggering more testosterone synthesis as the brain thinks estrogen is too low so it also thinks testosterone is too low.
This saturates the Aromatase Enzyme which leads to testosterone breaking through and outcompeting Letrozole for aromatase. This is why aromatase inhibitors as a monotherapy are dogshit for height and often do not produce any FAH additions, this also explains why we see insane growth velocity upregulations in kids using it.
JUST TO BE CLEAR, I LOVE AROMATASE INHIBITORS (FUCK ANASTROZOLE, LETROZOLE SUPREMACY OVER BOTH OTHERS) BUT JUST DON'T USE IT ON IT'S OWN. ADD IN GROWTH BOOSTING COMPOUNDS WHILST DOING WHAT I SAID IN THE SOLUTION BELOW AND YOU HAVE YOUR IDEAL HEIGHT STACK.
@Niebvll @Paul.jnxy @AtrophicPyra @avgsub5human @flowiza
If you don't know by now, basics of knowing/discussing or theorising about any hormone altering compounds is that feedack loops exist. You should also understand the concept of Ligands and receptors, binding(Binding affinity included) and competitive binding.
Ligands/Substrate are any molecule that binds to a binding site, Like enzymes or receptors which are proteins. Compounds you take into your system usually bind to the receptor it's designated to. Aromatase Inhibitors have to bind to aromatase and either deactivate it or kill it which comes under the umbrella term of "Antagonism".
Competitive binding is the process by which different ligands have to compete for the same binding site, only one thing can bind the site at once. The ligand that wins typically wins through having a higher binding affinity which is the strength at which it binds and takes over the binding site.
HOWEVER another factor matters like it's concentration, For example Endoxifen and 4-Hydroxytamoxifen have the same binding affinity, yet Endoxifen wins the binding race to estrogen receptors becaue it's concentration is much higher.
The relevance of all this is that testosterone and aromatase inhibitors exhibit the same effect as they both want to bind to aromatase, Testosterone wants to convert into E2 and AI's want to deactivate it. Now normally, AI's rape testosterone on binding affinity for this exact reason.
The Nuance comes in when you factor in the fact that Aromatase inhibitors like letrozole can give you disgusting surges of testosterone by 300% due to the negative feedback loop of the pituitary triggering more testosterone synthesis as the brain thinks estrogen is too low so it also thinks testosterone is too low.
This saturates the Aromatase Enzyme which leads to testosterone breaking through and outcompeting Letrozole for aromatase. This is why aromatase inhibitors as a monotherapy are dogshit for height and often do not produce any FAH additions, this also explains why we see insane growth velocity upregulations in kids using it.
JUST TO BE CLEAR, I LOVE AROMATASE INHIBITORS (FUCK ANASTROZOLE, LETROZOLE SUPREMACY OVER BOTH OTHERS) BUT JUST DON'T USE IT ON IT'S OWN. ADD IN GROWTH BOOSTING COMPOUNDS WHILST DOING WHAT I SAID IN THE SOLUTION BELOW AND YOU HAVE YOUR IDEAL HEIGHT STACK.
Shut off the HPG-Axis
@Niebvll @Paul.jnxy @AtrophicPyra @avgsub5human @flowiza
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