Deleted member 6403
Made It Out The Hood
- Joined
- Apr 14, 2020
- Posts
- 56,224
- Reputation
- 96,760
This was a short-term human study, which makes it particularly interesting to athletes and people with hypothyroidism. When Ray was asked about declining health in an aging male, his response was:
"...Thyroid deficiency in men typically causes a high ratio of cortisol to testosterone, with a tendency to convert testosterone to estrogen. Thyroid, pregnenolone, aspirin, and a diet that includes liver about once a week, help to improve the ratios."
Now, this study confirms that aspirin may be able to achieve the improvement in cortisol/testosterone ratio, while also opposing estrogen. The doses was 800mg twice a day (1,600mg total) for 10 days.
It is also worth noting, that in 4 of the 12 subjects (33%) plasma testosterone concentrations went above the upper limit of the normal range defined by the lab.
Do non-steroidal anti-inflammatory drugs influence the steroid hormone milieu in male athletes? - PubMed - NCBI
"...The main result of this study is that in our group of moderately trained athletes, a short-term ASA treatment compared to placebo was associated to significantly reduced after-treatment morning plasma F (cortisol) absolute concentrations (Fig. 1). Also, significant differences in the absolute and percentage of variation for F, T, and T/F ratio were observed. In particular, F concentration showed a significantly greater decrease and T concentration a significantly greater increase after ASA treatment, with respect to placebo treatment."
"...In fact, after ASA treatment, four volunteers showed individual plasma T concentrations slightly higher than the upper level of the reference range for their age (e.g., 30.67, 30.81, 35.15, and 39.48 nmol/L, respectively) (Fig. 3). On these bases, the observed higher mean plasma T concentration after ASA treatment, although above the limits of statistical significance (p = 0.052), has to be considered of clinical relevance."
"...Thyroid deficiency in men typically causes a high ratio of cortisol to testosterone, with a tendency to convert testosterone to estrogen. Thyroid, pregnenolone, aspirin, and a diet that includes liver about once a week, help to improve the ratios."
Now, this study confirms that aspirin may be able to achieve the improvement in cortisol/testosterone ratio, while also opposing estrogen. The doses was 800mg twice a day (1,600mg total) for 10 days.
It is also worth noting, that in 4 of the 12 subjects (33%) plasma testosterone concentrations went above the upper limit of the normal range defined by the lab.
Do non-steroidal anti-inflammatory drugs influence the steroid hormone milieu in male athletes? - PubMed - NCBI
"...The main result of this study is that in our group of moderately trained athletes, a short-term ASA treatment compared to placebo was associated to significantly reduced after-treatment morning plasma F (cortisol) absolute concentrations (Fig. 1). Also, significant differences in the absolute and percentage of variation for F, T, and T/F ratio were observed. In particular, F concentration showed a significantly greater decrease and T concentration a significantly greater increase after ASA treatment, with respect to placebo treatment."
"...In fact, after ASA treatment, four volunteers showed individual plasma T concentrations slightly higher than the upper level of the reference range for their age (e.g., 30.67, 30.81, 35.15, and 39.48 nmol/L, respectively) (Fig. 3). On these bases, the observed higher mean plasma T concentration after ASA treatment, although above the limits of statistical significance (p = 0.052), has to be considered of clinical relevance."
