seimakkak
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- Feb 24, 2020
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Atrogin-1 Affects Muscle Protein Synthesis and Degradation When Energy Metabolism Is Impaired by the Antidiabetes Drug Berberine
Defects in insulin/IGF-1 signaling stimulate muscle protein loss by suppressing protein synthesis and increasing protein degradation. Since an herbal compound, berberine, lowers blood levels of glucose and lipids, we proposed that it would improve insulin/IGF-1 ...
www.ncbi.nlm.nih.gov
people take this shit often with mk677 and other shit to lower blood sugar levels but it weakens growth inducing compounds at the same time.
"Besides accelerated protein degradation causing muscle atrophy, a decrease in protein synthesis will cause loss of muscle protein. Mechanisms changing protein synthesis include impaired insulin/IGF-1 signaling, reducing PI3K and p-Akt activities"
"Berberine administration decreased protein synthesis and increased degradation in muscles of normal and db/db mice"
Brutal af, JFL at mk677 niggas paying for 2 things that essentially counteract eachother
Taking low dose insulin is unironically better way to lower blood sugar.
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