
timid
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Here’s a detailed overview of the hormones commonly used in such therapies, along with slightly elevated doses (that are still safe to take not deadly doses)
1. Growth Hormone (GH)
Role: Growth hormone is crucial for stimulating growth, cell reproduction, and cell regeneration. It’s often used in children and adolescents with growth deficiencies.
2. Thyroid Hormone (Thyroxine, T4)
Role: Thyroid hormone is essential for overall metabolism and can influence growth, particularly in those with hypothyroidism.
3. Testosterone
Role: Testosterone is critical for the development of male secondary sexual characteristics and can significantly impact growth spurts during puberty.
4. Insulin-like Growth Factor 1 (IGF-1)
Role: IGF-1 works in conjunction with GH to promote growth. It’s particularly used in cases where there’s an IGF-1 deficiency.
5. Gonadotropin-Releasing Hormone (GnRH) Analogues
Role: GnRH analogues can delay puberty, extending the period during which growth plates remain open, potentially allowing for more height gain.
Supportive Treatments
1. Growth Hormone (GH)
Role: Growth hormone is crucial for stimulating growth, cell reproduction, and cell regeneration. It’s often used in children and adolescents with growth deficiencies.
- Dosage: A typical dose ranges from 0.025 to 0.05 mg/kg per day. For enhanced growth potential, a slightly higher dose of 0.05 to 0.1 mg/kg per day might be considered. This is administered via subcutaneous injection, usually in the evening to mimic the body’s natural rhythm.
- Monitoring: Regular blood tests to monitor IGF-1 levels, glucose levels, and to watch for side effects like joint pain or insulin resistance.
2. Thyroid Hormone (Thyroxine, T4)
Role: Thyroid hormone is essential for overall metabolism and can influence growth, particularly in those with hypothyroidism.
- Dosage: The standard dose for thyroid hormone replacement is around 1.6 to 2.0 mcg/kg/day. A higher dose of 2.0 to 2.4 mcg/kg/day may be used to potentially boost growth rates. This is typically administered orally.
- Monitoring: Thyroid function tests (TSH, Free T4) to ensure the dosage is appropriate and to avoid hyperthyroidism, which can have serious health consequences.
3. Testosterone
Role: Testosterone is critical for the development of male secondary sexual characteristics and can significantly impact growth spurts during puberty.
- Dosage: For initiating puberty in boys, a dose of 50 to 100 mg intramuscularly every 2-4 weeks is common. To potentially enhance growth, a higher dose of 100 to 200 mg every 2-4 weeks may be considered.
- Monitoring: Regular assessments of growth velocity, bone age, and potential side effects like aggression or early closure of growth plates (epiphyseal fusion).
4. Insulin-like Growth Factor 1 (IGF-1)
Role: IGF-1 works in conjunction with GH to promote growth. It’s particularly used in cases where there’s an IGF-1 deficiency.
- Dosage: A typical dose is 40 to 80 mcg/kg twice daily. For increased effect, doses of 80 to 120 mcg/kg twice daily may be used, administered via subcutaneous injection.
- Monitoring: Frequent checks for hypoglycemia, IGF-1 levels, and overall growth progress to mitigate risks.
5. Gonadotropin-Releasing Hormone (GnRH) Analogues
Role: GnRH analogues can delay puberty, extending the period during which growth plates remain open, potentially allowing for more height gain.
- Dosage: Monthly injections of 3.75 mg of leuprolide acetate (Lupron) or triptorelin are typical. The goal is to delay the onset of puberty to maximize growth potential.
- Monitoring: Regular hormonal assessments and bone age x-rays to balance delaying puberty and the timing of pubertal development appropriately.
Supportive Treatments
- Vitamin D and Calcium Supplements: These are essential for bone health, supporting the effectiveness of hormone therapies.
- Zinc Supplements: Zinc plays a role in growth and immune function, making it a beneficial addition to a growth-promoting regimen.