Bioavaibility capsule vs liquid

[shuka]

This is more of a curious biology question i have rather than looksmaxx. I saw some sarms, mk677 or peptides and obviously vitamin supplements being sold at liquid format and capsule. And i remmber that time ago i saw thread here talking about how taking sublingual vitamin d3 k2 in liquid form has even better absorption cause that zone has a lot of peripheral veins and gets in to blood faster compared to capsule format. Wouldnt this same rule apply to almost all and sublingual be always better at absorption? Maybe it only work with water soluble compounds? But vitamin d is liposoluble idk .

 

[shuka]

Bump

 

[imontheloose]

Sir, what are you talking about? Sublingual is only better when it can a) be dissolved in saliva, b) cross the thin mouth lining very quickly, c) be potent at small doses of a couple mg, and d) gets wrecked by first-pass if swallowed. If any of those fail, most of the dose just gets swallowed anyway.

Sublingual for SARMs/MK is just marketing hype. They already have good bioavailability orally, not that you should be consuming them anyway, but it isn’t the pharmacokinetic upgrade that you think it is.

Nitroglycerin, nicotine, and fentanyl (@wishIwasSalludon’s favourite molecule), are great fits sublingually because they’re potent at small doses, decent solubility in saliva, very permeable, and high first-pass so sublingual shines. Most peptides are just too large, enzymatic, and have weak permeability. Very select few break this rule.

D3 works because it’s taken with oil and absorbed in the gut via micelles, not because it sat under a tongue. Formulation and PK is what matters.

Liquid = higher BA is not a rule.

 

[wishIwasSalludon]

fentanyl (@

@wishIwasSalludon’s favourite molecule)

I prefer weed bro

 

[imontheloose]

I prefer weed bro

White brah tying his shoe laces.