Blasting 15ui HGH a day | 2 weeks since my first thread UPDATE

[sub5fatie]

FOR CONTEXT :

Hi, I made a thread 2 weeks ago saying I was starting to blast hgh, and now we are 2 weeks after that thread, I started first week at 10 ui a day, and now I am at 15 ui a day, separated of 2 takes, one morning, one before sleeping, as well as 30mg mk667 before sleeping.


What do I feel :

I sleep like a complete baby, my sleep have never been this reposing, I wake up each day with shit ton of energy like I slept for a year

I am FUCKING hungry EVERY SINGLE SECOND OF THE DAY, the hungerness is absolutely gigantic, I feel like a complete ogre, and it's hard not to fall of for carbs, so I bought a shit ton of chicken, pre-cook them, and each time I am hungry, I take the chicken, with milk, and vitamins.

Just before sleeping when I feel tired it's like my toes and hands have ants on them, I feel them in a weird way, but each time I do not mind it and get to sleep very easily.

I didn't measure my height yet and I am only gonna do it in 2 weeks, after a whole month of blasting hgh.

I lost 4kg of pure fat


SIDE EFFECTS

It actually helped my acnea what the fuck? I didn't know it helped acnea in any way, but now I have extremely less acnee.

The first week I was bloated as fuck, like my body was full of water retention, no potassium could help it in any way, but it drained itself after the 7 first days.

 

[hax]

acromegaly?

 

[thereallegend]

Any changes in bone mass?

 

[asdvek]

Start working out and doing high intensity high rep lateral raises you'll build shoulders extremely fast

 

[copercel123]

FOR CONTEXT :

Hi, I made a thread 2 weeks ago saying I was starting to blast hgh, and now we are 2 weeks after that thread, I started first week at 10 ui a day, and now I am at 15 ui a day, separated of 2 takes, one morning, one before sleeping, as well as 30mg mk667 before sleeping.


What do I feel :

I sleep like a complete baby, my sleep have never been this reposing, I wake up each day with shit ton of energy like I slept for a year

I am FUCKING hungry EVERY SINGLE SECOND OF THE DAY, the hungerness is absolutely gigantic, I feel like a complete ogre, and it's hard not to fall of for carbs, so I bought a shit ton of chicken, pre-cook them, and each time I am hungry, I take the chicken, with milk, and vitamins.

Just before sleeping when I feel tired it's like my toes and hands have ants on them, I feel them in a weird way, but each time I do not mind it and get to sleep very easily.

I didn't measure my height yet and I am only gonna do it in 2 weeks, after a whole month of blasting hgh.

I lost 4kg of pure fat


SIDE EFFECTS

It actually helped my acnea what the fuck? I didn't know it helped acnea in any way, but now I have extremely less acnee.

The first week I was bloated as fuck, like my body was full of water retention, no potassium could help it in any way, but it drained itself after the 7 first days.

 

[Ray0n]

FOR CONTEXT :

Hi, I made a thread 2 weeks ago saying I was starting to blast hgh, and now we are 2 weeks after that thread, I started first week at 10 ui a day, and now I am at 15 ui a day, separated of 2 takes, one morning, one before sleeping, as well as 30mg mk667 before sleeping.


What do I feel :

I sleep like a complete baby, my sleep have never been this reposing, I wake up each day with shit ton of energy like I slept for a year

I am FUCKING hungry EVERY SINGLE SECOND OF THE DAY, the hungerness is absolutely gigantic, I feel like a complete ogre, and it's hard not to fall of for carbs, so I bought a shit ton of chicken, pre-cook them, and each time I am hungry, I take the chicken, with milk, and vitamins.

Just before sleeping when I feel tired it's like my toes and hands have ants on them, I feel them in a weird way, but each time I do not mind it and get to sleep very easily.

I didn't measure my height yet and I am only gonna do it in 2 weeks, after a whole month of blasting hgh.

I lost 4kg of pure fat


SIDE EFFECTS

It actually helped my acnea what the fuck? I didn't know it helped acnea in any way, but now I have extremely less acnee.

The first week I was bloated as fuck, like my body was full of water retention, no potassium could help it in any way, but it drained itself after the 7 first days.

mirin keep going

 

[Mushroom]

FOR CONTEXT :

Hi, I made a thread 2 weeks ago saying I was starting to blast hgh, and now we are 2 weeks after that thread, I started first week at 10 ui a day, and now I am at 15 ui a day, separated of 2 takes, one morning, one before sleeping, as well as 30mg mk667 before sleeping.


What do I feel :

I sleep like a complete baby, my sleep have never been this reposing, I wake up each day with shit ton of energy like I slept for a year

I am FUCKING hungry EVERY SINGLE SECOND OF THE DAY, the hungerness is absolutely gigantic, I feel like a complete ogre, and it's hard not to fall of for carbs, so I bought a shit ton of chicken, pre-cook them, and each time I am hungry, I take the chicken, with milk, and vitamins.

Just before sleeping when I feel tired it's like my toes and hands have ants on them, I feel them in a weird way, but each time I do not mind it and get to sleep very easily.

I didn't measure my height yet and I am only gonna do it in 2 weeks, after a whole month of blasting hgh.

I lost 4kg of pure fat


SIDE EFFECTS

It actually helped my acnea what the fuck? I didn't know it helped acnea in any way, but now I have extremely less acnee.

The first week I was bloated as fuck, like my body was full of water retention, no potassium could help it in any way, but it drained itself after the 7 first days.

acneeeee

 

[childishkillah]

Start working out and doing high intensity high rep lateral raises you'll build shoulders extremely fast

Why high rep?

 

[VrillFatNoob24]

FOR CONTEXT :

Hi, I made a thread 2 weeks ago saying I was starting to blast hgh, and now we are 2 weeks after that thread, I started first week at 10 ui a day, and now I am at 15 ui a day, separated of 2 takes, one morning, one before sleeping, as well as 30mg mk667 before sleeping.


What do I feel :

I sleep like a complete baby, my sleep have never been this reposing, I wake up each day with shit ton of energy like I slept for a year

I am FUCKING hungry EVERY SINGLE SECOND OF THE DAY, the hungerness is absolutely gigantic, I feel like a complete ogre, and it's hard not to fall of for carbs, so I bought a shit ton of chicken, pre-cook them, and each time I am hungry, I take the chicken, with milk, and vitamins.

Just before sleeping when I feel tired it's like my toes and hands have ants on them, I feel them in a weird way, but each time I do not mind it and get to sleep very easily.

I didn't measure my height yet and I am only gonna do it in 2 weeks, after a whole month of blasting hgh.

I lost 4kg of pure fat


SIDE EFFECTS

It actually helped my acnea what the fuck? I didn't know it helped acnea in any way, but now I have extremely less acnee.

The first week I was bloated as fuck, like my body was full of water retention, no potassium could help it in any way, but it drained itself after the 7 first days.

mirin

 

[FunkyFlamingo]

FOR CONTEXT :

Hi, I made a thread 2 weeks ago saying I was starting to blast hgh, and now we are 2 weeks after that thread, I started first week at 10 ui a day, and now I am at 15 ui a day, separated of 2 takes, one morning, one before sleeping, as well as 30mg mk667 before sleeping.


What do I feel :

I sleep like a complete baby, my sleep have never been this reposing, I wake up each day with shit ton of energy like I slept for a year

I am FUCKING hungry EVERY SINGLE SECOND OF THE DAY, the hungerness is absolutely gigantic, I feel like a complete ogre, and it's hard not to fall of for carbs, so I bought a shit ton of chicken, pre-cook them, and each time I am hungry, I take the chicken, with milk, and vitamins.

Just before sleeping when I feel tired it's like my toes and hands have ants on them, I feel them in a weird way, but each time I do not mind it and get to sleep very easily.

I didn't measure my height yet and I am only gonna do it in 2 weeks, after a whole month of blasting hgh.

I lost 4kg of pure fat


SIDE EFFECTS

It actually helped my acnea what the fuck? I didn't know it helped acnea in any way, but now I have extremely less acnee.

The first week I was bloated as fuck, like my body was full of water retention, no potassium could help it in any way, but it drained itself after the 7 first days.

before and after pics?

 

[FunkyFlamingo]

Start working out and doing high intensity high rep lateral raises you'll build shoulders extremely fast

trash ass advice, never do above 14 reps for an exercise especially shoulders, a high androgen receptor area

 

[HandsomeHustler]

What a waste without thyroid support and ai

 

[jflkiefmaxxing]

FOR CONTEXT :

Hi, I made a thread 2 weeks ago saying I was starting to blast hgh, and now we are 2 weeks after that thread, I started first week at 10 ui a day, and now I am at 15 ui a day, separated of 2 takes, one morning, one before sleeping, as well as 30mg mk667 before sleeping.


What do I feel :

I sleep like a complete baby, my sleep have never been this reposing, I wake up each day with shit ton of energy like I slept for a year

I am FUCKING hungry EVERY SINGLE SECOND OF THE DAY, the hungerness is absolutely gigantic, I feel like a complete ogre, and it's hard not to fall of for carbs, so I bought a shit ton of chicken, pre-cook them, and each time I am hungry, I take the chicken, with milk, and vitamins.

Just before sleeping when I feel tired it's like my toes and hands have ants on them, I feel them in a weird way, but each time I do not mind it and get to sleep very easily.

I didn't measure my height yet and I am only gonna do it in 2 weeks, after a whole month of blasting hgh.

I lost 4kg of pure fat


SIDE EFFECTS

It actually helped my acnea what the fuck? I didn't know it helped acnea in any way, but now I have extremely less acnee.

The first week I was bloated as fuck, like my body was full of water retention, no potassium could help it in any way, but it drained itself after the 7 first days.

15 fucking ui 15 bombaclart eggs!

 

[jflkiefmaxxing]

FOR CONTEXT :

Hi, I made a thread 2 weeks ago saying I was starting to blast hgh, and now we are 2 weeks after that thread, I started first week at 10 ui a day, and now I am at 15 ui a day, separated of 2 takes, one morning, one before sleeping, as well as 30mg mk667 before sleeping.


What do I feel :

I sleep like a complete baby, my sleep have never been this reposing, I wake up each day with shit ton of energy like I slept for a year

I am FUCKING hungry EVERY SINGLE SECOND OF THE DAY, the hungerness is absolutely gigantic, I feel like a complete ogre, and it's hard not to fall of for carbs, so I bought a shit ton of chicken, pre-cook them, and each time I am hungry, I take the chicken, with milk, and vitamins.

Just before sleeping when I feel tired it's like my toes and hands have ants on them, I feel them in a weird way, but each time I do not mind it and get to sleep very easily.

I didn't measure my height yet and I am only gonna do it in 2 weeks, after a whole month of blasting hgh.

I lost 4kg of pure fat


SIDE EFFECTS

It actually helped my acnea what the fuck? I didn't know it helped acnea in any way, but now I have extremely less acnee.

The first week I was bloated as fuck, like my body was full of water retention, no potassium could help it in any way, but it drained itself after the 7 first days.

Larp

 

[asdvek]

Why high rep?

androgen receptors

 

[asdvek]

trash ass advice, never do above 14 reps for an exercise especially shoulders, a high androgen receptor area

you should be doing high-rep workouts to grow your shoulders, buddy, stay in your lane or I shut your fucking mouth you little slut

 

[FunkyFlamingo]

you should be doing high-rep workouts to grow your shoulders, buddy, stay in your lane or I shut your fucking mouth you little slut

show physique retard wtf is wrong with you with that dumbass advice

 

[asdvek]

show physique retard wtf is wrong with you with that dumbass advice

little slut, time to shut the fuck up

 

[Mainlander]

What a waste without thyroid support and ai

What counts as thyroid support

Like Support Support?

Or taking thyroid hormones

 

[FunkyFlamingo]

little slut, time to shut the fuck up

intern in the champion league final while you milan cucks are watching them

 

[asdvek]

intern in the champion league final while you milan cucks are watching them

i don't even support milan buddy

 

[HandsomeHustler]

What counts as thyroid support

Like Support Support?

Or taking thyroid hormones

Hormones, like T4 its the best while on hgh

 

[Mainlander]

Hormones, like T4 its the best while on hgh

Im on 5 IU ed do I Need it?

 

[Claymoreboy0118]

trash ass advice, never do above 14 reps for an exercise especially shoulders, a high androgen receptor area

holy cardio

 

[FunkyFlamingo]

holy cardio

yea lol I started with14 and now around 8

 

[sub5fatie]

acromegaly?

No, acromegaly won't build in such a short period of time, I'll see afterwards, but no signs of it yet, my hands feel completely normal, and I am debloated rn, no bloats anywhere

 

[sub5fatie]

Any changes in bone mass?

My ramus SLIGHTLY developped, like 1mm when calculated with my radio, the doctor said my ramus developped and my palate expanded

 

[sub5fatie]

What a waste without thyroid support and ai

Thyroid if not taken care of it is gonna burn muscles

AI ? What for ? I am still young, if I start blasting AI now it is gonna make my growth palate close earlier instead of delay it, you should only take AI if your bone age is 17 -17,5, after my radio, my bone age is measured at 16, my doctor recommended me to start taking AI after 6 month of conitnue HGH usage.

 

[sub5fatie]

Start working out and doing high intensity high rep lateral raises you'll build shoulders extremely fast

I decided that while on my HGH cycle, I won't do any workout, after discussing it with my doctor, hurting muscle tissue is gonna make the HGH focus on muscle reconstruction and reduce the efficacity of it's bone reconstruction. so for my whole HGH cycle, I won't do any workout, except walking obviously. Also, I built muscle extremely fast without doing anything, my body is recomposing and is actually building muscle without me doing anything, like I was on steroid, but I am not

 

[Mainlander]

Are you not scared of diabetis

 

[ASCENSCI0N]

how much is this costing you?

 

[HandsomeHustler]

Im on 5 IU ed do I Need it?

Only if you get symptoms of being hypothyroid for me it was the appetite and metabolic changes

 

[HandsomeHustler]

Thyroid if not taken care of it is gonna burn muscles

AI ? What for ? I am still young, if I start blasting AI now it is gonna make my growth palate close earlier instead of delay it, you should only take AI if your bone age is 17 -17,5, after my radio, my bone age is measured at 16, my doctor recommended me to start taking HGH after 6 month of conitnue HGH usage.

AI is beneficial much earlier for the slowing down of you BA and less estrogen through AI wont close your plates any earlier. I wouldnt trust my doc for shit if he fucked my mom and prescribed me 15 iu of HGH ed and 30mg of mk in combination.

 

[Mainlander]

AI is beneficial much earlier for the slowing down of you BA and less estrogen through AI wont close your plates any earlier. I wouldnt trust my doc for shit if he fucked my mom and prescribed me 15 iu of HGH ed and 30mg of mk in combination.

How the hell did your doc give you that much HGH

Do you have a sickness?

 

[niggacum492139]

Where are you getting the moeny for this nigga

 

[sub5fatie]

Are you not scared of diabetis

no

 

[sub5fatie]

AI is beneficial much earlier for the slowing down of you BA and less estrogen through AI wont close your plates any earlier. I wouldnt trust my doc for shit if he fucked my mom and prescribed me 15 iu of HGH ed and 30mg of mk in combination.

No it isn’t, actually isn’t at all, please inform yourseld, but blocking your estrogen too early will just cause your growth palate.

 

[lukePILL]

you should be doing high-rep workouts to grow your shoulders, buddy, stay in your lane or I shut your fucking mouth you little slut

nigger shut the fuck up you dont know shit

 

[Frogooboi]

Why high rep?

He not gymceled enough know optimal motor recruitment methods

 

[Mainlander]

no

How dude thats Literally diabetis speedrun

 

[Inquisitor]

FOR CONTEXT :

Hi, I made a thread 2 weeks ago saying I was starting to blast hgh, and now we are 2 weeks after that thread, I started first week at 10 ui a day, and now I am at 15 ui a day, separated of 2 takes, one morning, one before sleeping, as well as 30mg mk667 before sleeping.


What do I feel :

I sleep like a complete baby, my sleep have never been this reposing, I wake up each day with shit ton of energy like I slept for a year

I am FUCKING hungry EVERY SINGLE SECOND OF THE DAY, the hungerness is absolutely gigantic, I feel like a complete ogre, and it's hard not to fall of for carbs, so I bought a shit ton of chicken, pre-cook them, and each time I am hungry, I take the chicken, with milk, and vitamins.

Just before sleeping when I feel tired it's like my toes and hands have ants on them, I feel them in a weird way, but each time I do not mind it and get to sleep very easily.

I didn't measure my height yet and I am only gonna do it in 2 weeks, after a whole month of blasting hgh.

I lost 4kg of pure fat


SIDE EFFECTS

It actually helped my acnea what the fuck? I didn't know it helped acnea in any way, but now I have extremely less acnee.

The first week I was bloated as fuck, like my body was full of water retention, no potassium could help it in any way, but it drained itself after the 7 first days.

pls tell me you're training and taking advantage of that close to bodybuilding HGH dosages plssss

 

[latent]

HGH is only somewhat good when used for bodybuilding

 

[Donkeyballs]

mean final height in 22 children with ISS (age, 12.5±1.6 years) treated at a dose of 0.22 mg/kg per week (divided in three injections per week) for 4.4±1.6 years was 0.5 SDS (3.7cm) greater than the control group.

So basically, non GH deficient children with an age of 12.5±1.6, were treated with hgh for 4.4±1.6 years and only increased their adult height by a mean of 3.7cm (0.5sds) compared to a control group.

Realistically hgh will do jack shit unless you are young enough and/or have low percentile (not necessarily deficient) subhuman hormones for which then someone may 'incentivize' the body to grow to a certain extent, this is why bloodwork is important and at least taking an AI

 

[sub5fatie]

So basically, non GH deficient children with an age of 12.5±1.6, were treated with hgh for 4.4±1.6 years and only increased their adult height by a mean of 3.7cm (0.5sds) compared to a control group.

Realistically hgh will do jack shit unless you are young enough and/or have low percentile (not necessarily deficient) subhuman hormones for which then someone may 'incentivize' the body to grow to a certain extent, this is why bloodwork is important and at least taking an AI

Your source is talking about 3 doses a week, of 0.22mg per kg which is a small dose, I am at 2 dose a day, at 15ui, it does increase by a few the final height.

 

[Donkeyballs]

Your source is talking about 3 doses a week, of 0.22mg per kg which is a small dose, I am at 2 dose a day, at 15ui, it does increase by a few the final height.

for children its not so much of a small dose, but lets ignore your age, and other parameters and lets see if you take if for around 4 years with no AI, good luck!

 

[mandiblade]

So basically, non GH deficient children with an age of 12.5±1.6, were treated with hgh for 4.4±1.6 years and only increased their adult height by a mean of 3.7cm (0.5sds) compared to a control group.

Realistically hgh will do jack shit unless you are young enough and/or have low percentile (not necessarily deficient) subhuman hormones for which then someone may 'incentivize' the body to grow to a certain extent, this is why bloodwork is important and at least taking an AI

This doesn't really make sense. By what mechanism can the body "sense" its total height and cease longitudinal bone growth in the presence of elevated IGF-1?

@chadisbeingmade @imontheloose
To my knowledge, I have not seen you address this elsewhere
Thanks in advance

 

[Donkeyballs]

This doesn't really make sense. By what mechanism can the body "sense" its total height and cease longitudinal bone growth in the presence of elevated IGF-1?

@chadisbeingmade @imontheloose
To my knowledge, I have not seen you address this elsewhere
Thanks in advance

Longitudinal bone growth primarily stops because of sufficient growth, which is what accomplishes skeletal maturity.
Long bones stop growing in length due to the ossification of growth plates/growth plate senescence which is common knowledge.

Igf1 is not the only factor in longitudinal bone growth and its efficiency is greatly diminished. We do not stop growing solely because of decreasing gh/igf1, that's just a factor, a consequence of our body reaching skeletal maturity.
Gh/Igf1 accelerate skeletal maturity and puberty in general, hgh treatment alone on non deficient children for years increase adult height by some cms and rapidly reach skeletal maturation that's why AIs are used.
Only when the growth plate is active and open (aka only when you are growing) will hgh/igf1 have a notable effect.

Spoiler: More in depth explanation and examples

Direct gh function in longitudinal bone growth is by stimulating resting chondrocytes in the growth plate meanwhile igf1 focuses primarily on the proliferation of chondrocytes and osteoblasts through differentiation of the respective progenitor cells.
Which are mainly MSCs and the resting chondrocytes. As we reach skeletal maturity and age the pool lineage of these chondroblast/osteoblast progenitors deplete,ezh2 a histone methyltransferase for example in normal function maintains the stemness of these cells and prevents them from differentiating into chondroblasts and osteoblasts, both directly and mainly from increased h3k27me3 markers which inhibit tgfb and downstream differentiation genes such as sox4 which is vital for EMT and hence the MSC pool, and sox9 vital for chondrogenesis, it also inhibits various osteogentic master genes such as bmps, wnt/b and hence runx2, osterix, dlx5, etc.
Other factors such as fgfr3 which supress chodrogenesis differentiation and proliferation, basically it limits the rate of bone growth.
FGF21 increases fgfr3 and antagonizes the stimulatory effects of growth hormone on chondrocytes.

no amount of HGH/IGF1 can reactivate chondrogenesis in the metaphysis.

 

[KeepCopingLads]

update of height growth?

 

[mandiblade]

Longitudinal bone growth primarily stops because of sufficient growth, which is what accomplishes skeletal maturity.
Long bones stop growing in length due to the ossification of growth plates/growth plate senescence which is common knowledge.

Epiphyseal growth place ossification is mediated by your height?

Igf1 is not the only factor in longitudinal bone growth and its efficiency is greatly diminished

Diminished in what circumstances? Near the end of growth plate fusion? I'm not talking about that.

We do not stop growing solely because of decreasing gh/igf1, that's just a factor, a consequence of our body reaching skeletal maturity

Decreases in hormones are mediated by skeletal maturity?

Gh/Igf1 accelerate skeletal maturity and puberty in general, hgh treatment alone on non deficient children for years increase adult height by some cms and rapidly reach skeletal maturation that's why AIs are used.

This is my question. In children, why on the planet wouldn't hgh treatment increase adult height by half a foot? I know it doesn't happen, by why not?

Only when the growth plate is active and open (aka only when you are growing) will hgh/igf1 have a notable effect.

Yes, but this is the condition of those children. Why don't they grow half a foot?

Direct gh function in longitudinal bone growth is by stimulating resting chondrocytes in the growth plate meanwhile igf1 focuses primarily on the proliferation of chondrocytes and osteoblasts through differentiation of the respective progenitor cells.
Which are mainly MSCs and the resting chondrocytes. As we reach skeletal maturity and age the pool lineage of these chondroblast/osteoblast progenitors deplete,ezh2 a histone methyltransferase for example in normal function maintains the stemness of these cells and prevents them from differentiating into chondroblasts and osteoblasts, both directly and mainly from increased h3k27me3 markers which inhibit tgfb and downstream differentiation genes such as sox4 which is vital for EMT and hence the MSC pool, and sox9 vital for chondrogenesis, it also inhibits various osteogentic master genes such as bmps, wnt/b and hence runx2, osterix, dlx5, etc.
Other factors such as fgfr3 which supress chodrogenesis differentiation and proliferation, basically it limits the rate of bone growth.
FGF21 increases fgfr3 and antagonizes the stimulatory effects of growth hormone on chondrocytes.

Highiq. Time for a lot of googling and pubmed rotting.
Anyhow, this all seems to simply happen with age. In children, if you interfere with growth by pinning them with hgh, why wouldn't they grow half a foot?

In addition, how on earth do growth spurts work then? Naturally producing 30ius of hgh for a month?

 

[Donkeyballs]

Yes, but this is the condition of those children. Why don't they grow half a foot?
In children, if you interfere with growth by pinning them with hgh, why wouldn't they grow half a foot? This is my question. In children, why on the planet wouldn't hgh treatment increase adult height by half a foot? I know it doesn't happen, by why not?

Because the children already have normal percentiles of these hormones, so bringing them up to a higher percentile will
have not very significant effects in most cases since other factors are more important.
However im not saying gh/igf1 is pretty much useless. Alone? Mostly, but combined with other compounds,
such as an AI which is very vital can produce greater results as shown in various studies compared
to just hgh treatment. Estrogen induces terminal differentiation of chondrocytes and eventual growth plate closure, this makes GH/IGF-1 ineffective. Estrogens also reduce IGF-1R signaling efficiency via the estrogen receptor pathways.

I think OPs stack is missing an AI, thats why I responsed with a study done on non gh deficient children with only hgh.

Epiphyseal growth place ossification is mediated by your height?

-Mediated by the bone growth, whether it can contribute to your height depending on the long bone is another thing. Time itself does not directly ossify our growth plates.

Spoiler: Study statements

The fact that growth plate senescence occurs with increasing age suggests the possibility that
senescence is driven by a timing mechanism within the growth plate, such as a biological clock;
however several studies indicate that this is not the case. Conditions that slow growth in the
growth plate also slow the entire development program of growth plate senescence, suggesting that
the process of growth, rather than age per se, is the underlying driver of senescence.
https://pmc.ncbi.nlm.nih.gov/articl...t=with increasing age.-,The,-fact that growth

Although linear growth is highly regulated by endocrine factors, this decline in growth rate does not appear to be caused by a change in hormone levels. Indeed, there is no known growth-regulating hormone whose concentration changes in a pattern that would explain the slowing of linear growth. For example, circulating insulin-like growth factor-I concentrations rise during early childhood as growth is slowing [1]


when growth plates are transplanted between rabbits of different ages, the growth rate of the transplanted growth plates depends on the age of the donor animal rather than the recipient [2], indicating that the decline in growth rate is primarily due to a mechanism intrinsic to the growth plates themselves. (Maybe we should growth plate transplant max? jfl)

Diminished in what circumstances? Near the end of growth plate fusion? I'm not talking about that.

By efficiency diminished I mean its effects exerted on the growth plate itself,
igf1 cant execute its function properly in this context if there is no significant
cell progenitor pool in the growth plate to proliferate chondroblasts and osteoblasts.
Also studies claim: IGF1R expression is highest in the germinal zone of the growth plate and decreases in hypertrophic chondrocytes. (Rat study)
A study claims: In senescent and dedifferentiated chondrocytes, it was found that TGF-β, BMP-2, SOX9, and IGF-1 are downregulated.
Late in adolescence, there is often a rise in IGFBPs and the igf1/IGFBP ratio increases, various IGFBPs function is to sequester igf1 with high affinity away from their receptors
through it. big part of this diminished efficienty is through characteristics igf1's targets, chondroblasts and osteoblasts express fewer igf-1 receptors as they differentiate or age, this is because with increased bone maturation, osteoblasts shift towards a quiescient state or osteocyte conversion, and their igf-1 responsiveness is reduced.

Decreases in hormones are mediated by skeletal maturity?

What I'm trying to say is that decreases in these hormones correlate with the processes that occur when reaching skeletal maturity.
So it plays a role of reaching skeletal maturity although it is not mediated by skeletal maturity directly.
The decrease of these hormones is through various mechanisms. Ghrh (growth hormone realising hormone)
and the GnRH in general decrease through negative feedbacks as our sexual hormones keep increasing.
For example through the estrogen receptors alpha in kisspeptin (which stimulates gnRH) and the gnRH
neurones themselves.

Spoiler: epigenetic role

Also genetics/epigenetics have a big role. DNA methylation (which suppreses gene transcription)
occurs at the Gnrh1 promoter through increases H3k27me3 marks which I have talked about.
Also H3K4me3 marks are lowered and etc there are dozens of transcription factors, neuronal imputs and
etc that drives this. Some have considered anti-caner tazemetostat medication which inhibits ezh2 and
hence inhibits the adding of methyl groups to h3k27, this could reactivate silenced osteogenic and chondrogenic genes.
Also all these h3k27me3, h3K4me3 stuff are histones modifications. In h3k27me3 h3 means histone 3, k27
means lysine 27 and me3 means trimethylation (3 methyl groups). Methylation is an epigentic regulator.
histone methylation can either silence genes through chromatin condensation or the opposite.
This can be determined by the lysine methylated in this case.
Meanwhile DNA methylation represses gene transcrtipio usually, especially at CpG islands.

In addition, how on earth do growth spurts work then? Naturally producing 30ius of hgh for a month?

The main growth spurt occurs after the onset of puberty, the GnRH pulsatility increases, which
increases sex steroids and gh/igf1. This rapidly increases growth and matures the bone. After the main
growth spurt your body follows a more linear growth pattern.
This is the main growth spurt everyone has, smaller growth spurts may occur during childhood but are rarer during adolescence and can be even be catch up growth/delayed growth plate senescence which is the
mechanisms of 'late bloomers.'
Something to be understood is that the gnRH dosent operate by an off and on switch, the pulses are non linear and pulsatile, meaning it is released in short bursts followed by periods of inactivity.
That could explain the growth spurts although most follow linear growth after the main growth spurt,
thats why that chart with height growth and percentiles are used by doctors, even if there are
exceptions.