FutureSlayer
Go back to sleep, Ellen
- Joined
- Oct 4, 2019
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The time has come to stop wandering aimlessly through nootropic fluff and build a proper BlackPill guideline (like those doctors use but in our optics lmao) for pharmacological use, both long-term and short-term
I’m calling in the three main voices in this field @Cope @Alexanderr @AscendingHero to finally synthesize a serious, layered approach. We need a framework that addresses:
-Chronic use substances that are sustainable and actually work
- Acute use compounds for specific high stakes situations (social dominance, verbal fluency, mental stillness, job interviews, exams, dates)
-Risk/reward mapping (long term health profile, hair, libido, cortisol, etc.)
CANDIDATES:
Long-Term Core Stack (Baseline Mental Edge):
Noradrenaline α2-agonist
-Clonidine 0.05–0.2 mg/day
MAO-A/B inhibitor
-Nardil (Phenelzine) 60 mg/day
Histone Deacetylase (HDAC) inhibitor
-Vorinostat 50 mg/day (PERMANENT changes after a while, crazy stuff)
Dopaminergic
-Bromantane 50–100 mg/day
Neurotrophic peptide mix
-Cerebrolysin 10 mg/week, cycles of 10–20 days
Anxiety sweating/primary hyperhidrosis/scialorrea
-Glycopirrolate 2mg/day
Short-Term Kill Mode for special events
(To add to the previous stack):
Dopamine/norepinephrine reuptake inhibitor
-Ritalin (Methylphenidate) 10–20 mg IR / 36–54 mg XR
α2δ-subunit modulator
-Lyrica (Pregabalin) 450 mg (or should have been put in the baseline stack paired with 10mg memantine to counteract tolerance? or maybe in a grey zone which we can cycle it on and off for a period like cerebrolysin?)
GABA-B receptor agonist
-Baclofen 50 mg
β-adrenergic blocker
-Propranolol 40 mg
Still researching this stack by @Cope and trying to figure out which of those would be beneficial in the guideline
Anti-Glutamatergic Stack -
What should we address further? Any pathway I am missing? I get at the day this is probably a trial-end-error approach as our physiologies are different and can not me synthetized in a simple guideline but it’s still worth a try at least to emphasize pros and cons, also does someone now of a way to safely target gaba A receptors? inb4 alcol lol
@Clavicular @thecel @Jason Voorhees @AlexBrown84 @CalulArgintiu59 @Clqs @Boyoshutup @Bitterschön
clone thread since nobody is bothering to reply to the one with a less catchy title
I’m calling in the three main voices in this field @Cope @Alexanderr @AscendingHero to finally synthesize a serious, layered approach. We need a framework that addresses:
-Chronic use substances that are sustainable and actually work
- Acute use compounds for specific high stakes situations (social dominance, verbal fluency, mental stillness, job interviews, exams, dates)
-Risk/reward mapping (long term health profile, hair, libido, cortisol, etc.)
CANDIDATES:
Long-Term Core Stack (Baseline Mental Edge):
Noradrenaline α2-agonist
-Clonidine 0.05–0.2 mg/day
MAO-A/B inhibitor
-Nardil (Phenelzine) 60 mg/day
Histone Deacetylase (HDAC) inhibitor
-Vorinostat 50 mg/day (PERMANENT changes after a while, crazy stuff)
Dopaminergic
-Bromantane 50–100 mg/day
Neurotrophic peptide mix
-Cerebrolysin 10 mg/week, cycles of 10–20 days
Anxiety sweating/primary hyperhidrosis/scialorrea
-Glycopirrolate 2mg/day
Short-Term Kill Mode for special events
(To add to the previous stack):
Dopamine/norepinephrine reuptake inhibitor
-Ritalin (Methylphenidate) 10–20 mg IR / 36–54 mg XR
α2δ-subunit modulator
-Lyrica (Pregabalin) 450 mg (or should have been put in the baseline stack paired with 10mg memantine to counteract tolerance? or maybe in a grey zone which we can cycle it on and off for a period like cerebrolysin?)
GABA-B receptor agonist
-Baclofen 50 mg
β-adrenergic blocker
-Propranolol 40 mg
Still researching this stack by @Cope and trying to figure out which of those would be beneficial in the guideline
Anti-Glutamatergic Stack -
- Riluzole: Inhibits glutamate release and enhances reuptake.
- Lamotrigine: Blocks sodium channels, reducing glutamate release.
- Oxcarbazepine: Stabilizes neuronal membranes and dampens excitatory firing.
- Pregabalin: Inhibits calcium influx to reduce neurotransmitter release.
- Baclofen (optional): Activates GABA-B
receptors to indirectly suppress glutamate.
What should we address further? Any pathway I am missing? I get at the day this is probably a trial-end-error approach as our physiologies are different and can not me synthetized in a simple guideline but it’s still worth a try at least to emphasize pros and cons, also does someone now of a way to safely target gaba A receptors? inb4 alcol lol
@Clavicular @thecel @Jason Voorhees @AlexBrown84 @CalulArgintiu59 @Clqs @Boyoshutup @Bitterschön
clone thread since nobody is bothering to reply to the one with a less catchy title
