Boosting IGF-1 for recovery from iatrogenic botulism?

[Bewusst]

As many of you know, I suffer from iatrogenic botulism, a paralytic condition caused by botox injections. The IGF-1 signaling pathway plays a key role in the recovery of muscle function, presynaptic nerve sprouting and stabilization of neuromuscular junctions, which makes it an interesting treatment option imo.
https://onlinelibrary.wiley.com/doi/pdf/10.1002/jor.20131

I was wondering if CJC-1295 + a GHRP like ipamorelin would provide enough of a systemic IGF-1 boost to increase myogenin expression and accelerate my recovery. I‘ve never used peptides before (except from BPC-157) and the main thing I‘m worried about are the negative effects on insulin sensitivity since I know people who became type 2 diabetic from using growth hormone secretagogues for 12+ weeks.

Has anyone used these peptides before and experienced hyperglycemia/insulin resistance? What were your fasting blood glucose readings before, during and after your peptide cycle?

@Seth Walsh @Cope @Mayorga @Madness your input is needed
@turkproducer I recall you have experience with peptides

 

[Bewusst]

Again not listed in new posts, fix this already please

 

[Bewusst]

@Strike_Poseidon do you think CJC-1295 without DAC is safe? I recall you mentioned somewhere that cjc dac could permanently damage the pituitary gland

 

[thickdickdaddy27]

(PDF) Significant increase of plasma IGF-1, insulin and serum antioxidant enzyme by chromium supplementation

PDF | A study was conducted in 360 day old broiler chicks to study the effects of chromium (Cr) from inorganic (Cr chloride), organic (Chromium... | Find, read and cite all the research you need on ResearchGate

www.researchgate.net

 

[turkproducer]

hello, i don’t have extensive experience but from what i heard definitely hex/cjc was used for recovery of the body

i’m not well versed with these as much as you may think

 

[Bitch]

Bumping this thread. I want the OP to find out.

 

[Bewusst]

(PDF) Significant increase of plasma IGF-1, insulin and serum antioxidant enzyme by chromium supplementation

PDF | A study was conducted in 360 day old broiler chicks to study the effects of chromium (Cr) from inorganic (Cr chloride), organic (Chromium... | Find, read and cite all the research you need on ResearchGate

www.researchgate.net

Unfortunately, chromium(III) could be oxidized intracellularly to the highly carcinogenic chromium(V) and -(VI) compounds due to production of strong oxidants like hydrogen peroxide. I‘d rather not mess with it and risk DNA damage

 

[Bewusst]

hello, i don’t have extensive experience but from what i heard definitely hex/cjc was used for recovery of the body

i’m not well versed with these as much as you may think

Which peptides did you use and what side effects did you experience?

 

[ReverseNorwoodPill]

I know the answer but didn’t get tagged so 0

 

[Bewusst]

I know the answer but didn’t get tagged so 0

@ReverseNorwoodPill

 

[ReverseNorwoodPill]

@ReverseNorwoodPill

Was capping sorry bro no idea

 

[turkproducer]

Which peptides did you use and what side effects did you experience?

i didn’t experience much, just increased hunger and better sleep

hex/ghrp alternated, and cjc no dac, occasionally swapped for dac

 

[Bewusst]

i didn’t experience much, just increased hunger and better sleep

hex/ghrp alternated, and cjc no dac, occasionally swapped for dac

Any problems when you came off in terms of adjustment? Did you get bloodwork done?

 

[turkproducer]

Any problems when you came off in terms of adjustment? Did you get bloodwork done?

nope, but i took it easy because i’m prone to diabetes

and no i didn’t, sorry

 

[Bewusst]

Bump.

Come on, I know many of you have used peptides

 

[Bewusst]

@PubertyMaxxer didn‘t you use peptides? Any blood sugar issues?

 

[PubertyMaxxer]

@PubertyMaxxer didn‘t you use peptides? Any blood sugar issues?

I even used pharma HGH, no cm was grown

 

[Bewusst]

I even used pharma HGH, no cm was grown

I know but I asked you about your blood sugar and insulin sensitivity. I‘m not trying to grow taller

 

[Deleted member 17429]

ty since I know people who became type 2 diabetic from using growth hormone secretagogues for 12+ weeks.

Were they able to reverse their situation? This is scary info. I use MK677 for 10 weeks and 1 week off. I know this isn’t the point of the thread, but what did their diet look like?

 

[Deleted member 17429]

I even used pharma HGH, no cm was grown

How is this possible? Were your plates open?
@FreakkForLife

 

[FreakkForLife]

How is this possible? Were your plates open?
@FreakkForLife

He Barely blasted 4iu and that too for 4 months only.

I have read his case and seen all his posts regarding that,he believes that nobody can grow with HGH just because HE was a fool to waste his money(9000€) on Pharma genotropin, and barely 4iu for 4 months.

Some people take time to grow,that's why i recommend every1 to blast hgh for 1 year atleast Also, because growth with HGH is non linear-u can grow 0.1 inch in 8 -10 months and then suddenly grow 1-2 inches in the next 2-4 months.
This is non-linear growth.

But he didn't think of all this before and now is stuck as a 5'7 shortcel and now is going to get LL in turkey.

The children who grow with HGH the most(2.5-4 inches per year) in studies blast Above 0.32 mg/kg/week,and 0.4mg/kg/week is even better(it's mentioned week but actually the dose is calculated per 6 days not 7 days).
So,for a 70 kg guy,u need to blast 11-14iu pharma HgH and u would see gains of 2.5-4+ inches per year.
If u are blasting generic hgh,then u need to blast 15-17iu per day.
If u think 11-14 iu of pahrma hgh everyday is too much, then u can blast lesser amounts but don't go below 7iu per day
And increase the time period for which u will be blasting hgh,4 months is too less,do it at least 1 year to see atleast 2-4 inches,if u want more then blast for more time,like 1-2 years

 

[Deleted member 17429]

He Barely blasted 4iu and that too for 4 months only.

I have read his case and seen all his posts regarding that,he believes that nobody can grow with HGH just because HE was a fool to waste his money(9000€) on Pharma genotropin, and barely 4iu for 4 months.

Some people take time to grow,that's why i recommend every1 to blast hgh for 1 year atleast Also, because growth with HGH is non linear-u can grow 0.1 inch in 8 -10 months and then suddenly grow 1-2 inches in the next 2-4 months.
This is non-linear growth.

But he didn't think of all this before and now is stuck as a 5'7 shortcel and now is going to get LL in turkey.

The children who grow with HGH the most(2.5-4 inches per year) in studies blast Above 0.32 mg/kg/week,and 0.4mg/kg/week is even better(it's mentioned week but actually the dose is calculated per 6 days not 7 days).
So,for a 70 kg guy,u need to blast 11-14iu pharma HgH and u would see gains of 2.5-4+ inches per year.
If u are blasting generic hgh,then u need to blast 15-17iu per day.
If u think 11-14 iu of pahrma hgh everyday is too much, then u can blast lesser amounts but don't go below 7iu per day
And increase the time period for which u will be blasting hgh,4 months is too less,do it at least 1 year to see atleast 2-4 inches,if u want more then blast for more time,like 1-2 years

Is english your first language?
Also link to studies where people grew 2.5-4 inches PER YEAR, that’s ridiclous

 

[FreakkForLife]

Were they able to reverse their situation? This is scary info. I use MK677 for 10 weeks and 1 week off. I know this isn’t the point of the thread, but what did their diet look like?

I know but I asked you about your blood sugar and insulin sensitivity. I‘m not trying to grow taller

@Bewusst what do u think about using chromium picolinate and alpha lipolic acid for reducing blood sugar??
I read that 200-300 mcg of Chromium Piccinolate and 300 mg alpha lipolic acid can reduce blood sugar after hgh//Peptdies usage.

This is my alternative to berberine since berberine impairs muscle synthesis and causes other problems according to this study.
https://looksmax.org/threads/berberine-is-a-retarded-supplement-must-read-if-considering-it.517739/.
3)do u think taking glucophage/metformin will have the same side effects as berberine?


4)also what do u think about actos? Some guys there said 15 mg actos can be used for reducing blood sugar

 

[FreakkForLife]

Is english your first language?
Also link to studies where people grew 2.5-4 inches PER YEAR, that’s ridiclous

Just search Nelly maurus et al anastrozole and growth hormone study.
I think it was from 2014,2016 or 2018, but u will find it by searching the text i mentioned

And the second one is Juan sotos and Naomi tokar 2014 study growth hormone significantly increases height in idiopathic short children.


Is something wrong with my English??

 

[Deleted member 17429]

Just search Nelly maurus et al anastrozole and growth hormone study.

There's another study like that i don't remember.
But i will try to link it

Meanwhile other studies show that pharma grade GH won’t get you more then 3 inches by the end of it. Interesting stuff.

 

[Bewusst]

Were they able to reverse their situation? This is scary info. I use MK677 for 10 weeks and 1 week off. I know this isn’t the point of the thread, but what did their diet look like?

I honestly don't know since I'm not in touch with these people anymore. Some had been diagnosed and were put on metformin by their doctor. That was six years ago and I don't know how they're doing today

 

[FreakkForLife]

@Bewusst what do u think about using chromium picolinate and alpha lipolic acid for reducing blood sugar??
I read that 200-300 mcg of Chromium Piccinolate and 300 mg alpha lipolic acid can reduce blood sugar after hgh//Peptdies usage.

This is my alternative to berberine since berberine impairs muscle synthesis and causes other problems according to this study.
https://looksmax.org/threads/berberine-is-a-retarded-supplement-must-read-if-considering-it.517739/.
3)do u think taking glucophage/metformin will have the same side effects as berberine?


4)also what do u think about actos? Some guys there said 15 mg actos can be used for reducing blood sugar

@Bewusst what do u Think?

 

[FreakkForLife]

Meanwhile other studies show that pharma grade GH won’t get you more then 3 inches by the end of it. Interesting stuff.

If u read the Juan sotos 2014 study they mention all the reasons why it's that

Firsty, that's because they use less doses,mostly 0.23 mg/kg/week which is quite a low dose,doses below 0.3mg/kg/week yield low results, whereas doses above 0.3 mg/kg/week yield much better results.
0.4 mg/kg/week giving quite satisfactory results.

Secondly,they include familial Iss children which significantly brings down the average (Juan sotos study elaborates on this why-in short familial iss children have some growth problems due to which their body dosent respond to hgh that well,so thier height increase from hgh is lesser,often these chidlren are not diagnosied properly and aren't categorised separately,so they bring down the average height gain of the group)



Also ,they consider the averages,so i guess there are many guys who gain above 3 inches even in those old studies

 

[Bewusst]

@Bewusst what do u Think?

I think that I personally wouldn't bother with exogenous HGH or GH boosting drugs in the first place