breaking news DNA double strand breaks

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https://www.researchgate.net/publication/385277778_Endogenous_neuronal_DNA_double-strand_breaks_are_not_sufficient_to_drive_brain_aging_and_neurodegeneration

"Strikingly, however, DSB accumulation caused by loss of C-NHEJ induces only minor epigenetic alterations and does not significantly affect gene expression, 3-D genome organization, or mutational outcomes at neuronal DSBs. Despite extensive aging-associated accumulation of neuronal DSBs, mice with neuronal Xrcc4 inactivation do not show neurodegeneration, neuroinflammation, reduced lifespan, or impaired memory and learning behavior."

 

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