Can you locally inhibit estrogen in your growth plates while leaving it intact in the rest of your body?

[Ashikai]

Any non-steroidal i.e., anastrazole or letrozole.

Any reason over why you prefer them over steroidal ai?

 

[Spieldren]

Any reason over why you prefer them over steroidal ai?

There is almost always contradicting literature. You need to identify the nuance in each study to determine why the results were so different.
But the fact that the literature for Tamoxifen is so contradictory is what pushes me away.
You can safely use non-steroidal AI to push E2 to lower within RR and not affect cognitive development whatsoever (as indicated in the literature). As long as you dose responsibly and get frequent bloodwork, you will be ok.
Plus, non-steroidal AI is not progressive in its aromatase inhibition, compared to Aromasin that will be much harder to have an exact dosing for (as too little, too little, too much, and it's harder to reverse unless you dose bioidentical E2 until you have new aromatase enzymes made available as the existing ones were permanently shut down with a covalent bond).

Steroidal AI exhibits androgenic activity which can contribute to closure + is progressive so harder to dose safely.

 

[7evenvox22]

Okay pipe your ass down I quoted where aids said that androgenic activity contributes to closure and since tren is extremely androgenic compound I asked what's up with that.

Faggot coming at me like I said trenbolone closes growth plates

sorry bro, didn’t mean to offend you.
i just got heated cause i respect @Zagro and felt like i had to back him up.
wasn’t trying to come off rude or start anything, my bad genuinely.

 

[Ashikai]

Saw this on bioscience's tiktok, it sounds incredible on paper, though getting endoxifen is probably a pipe dream for me and most of us, so better put it at the back of my head

 

[aids]

This implies that androgen usage is bad for height increase but @Zagro pinned tren when actively trying to increase height?

17-hydroexemestane is a metabolite of Aromasin that accelerates closure.
Any androgenic compound will accelerate closure though to a relatively lesser extent to that of E2.
Tren is not excluded from this.

 

[coolman985]

@7evenvox22

17-hydroexemestane is a metabolite of Aromasin that accelerates closure.
Any androgenic compound will accelerate closure though to a relatively lesser extent to that of E2.
Tren is not excluded from this.

Wouldn’t this mean you shouldn’t pin any androgens when plates are open?

 

[7evenvox22]

@7evenvox22

Wouldn’t this mean you shouldn’t pin any androgens when plates are open?

17-hydroexemestane is a metabolite of Aromasin that accelerates closure.
Any androgenic compound will accelerate closure though to a relatively lesser extent to that of E2.
Tren is not excluded from this.

as i said before, the main thing behind plate closure is estrogen acting through the epiphyseal plate.
androgens might play a small indirect role, but without e2 signaling, plates usually stay open.

 

[coolman985]

So

as i said before, the main thing behind plate closure is estrogen acting through the epiphyseal plate.
androgens might play a small indirect role, but without e2 signaling, plates usually stay open.

then the androgenic properties of aromasin are not detrimental to plates?

 

[Hunter]

So

then the androgenic properties of aromasin are not detrimental to plates?

Read what everyone has been saying and you will see that this statement is correct

 

[7evenvox22]

So

then the androgenic properties of aromasin are not detrimental to plates?

yeah exactly, the androgenic part of aromasin isn’t really what causes closure.
aromasin’s mild androgenic activity doesn’t do much there if anything, it’s negligible compared to what e2 does at the plate level.
jfl at all the retards trying to act high iq and overcomplicate a fucking aromatase inhibitor.
at the end of the day, it lowers estrogen, and that's what fucking matters.
muhh muhh but according to this study stfu kys faggot nigger.
btw @coolman985 none of this is aimed at you I love u.

 

[coolman985]

yeah exactly, the androgenic part of aromasin isn’t really what causes closure.
aromasin’s mild androgenic activity doesn’t do much there if anything, it’s negligible compared to what e2 does at the plate level.

So why are other ais better then aromasin according to you?

 

[7evenvox22]

So why are other ais better then aromasin according to you?

mainly cause non-steroidal ai’s are easier to control and don’t have any androgenic or progestogenic side effects at all.
aromasin’s fine, but it’s stronger and harder to dose precisely since it’s irreversible.
with non-steroidals like letro or anastrozole, you can fine-tune suppression more consistently without any extra receptor activity.

 

[Zagro]

I agree about progressive part but how does the androgenic activity promote closure @Zagro

It doesn't ossify epiphyseal plates itself, it ages bones via the local AR signalling basically chondrocytes go from the proliferative state to the hypertrophic state quicker meaning instead of more bone growth you would get via the proliferation you mature the chondrocytes quicker and they just wait for a surge in estrogen to go in apoptosis, this is why estrogen is the main driver of epiphyseal plate ossification as it does the final strike to fully kill the chondrocytes meaning the possible bone growth, AR signalling just pushes it closer to closure but never actually closes the plates. Take a non-steroidal aromatase inhibitor if you want to minimise the androgenic load but aromasin's androgenic activity seems mild and gets rid of the risk of any estrogen-rebounds which could actually close your plates if occurred, wont happen as long as you aren't a retard with the dosages+are consistent but still.

This implies that androgen usage is bad for height increase but @Zagro pinned tren when actively trying to increase height?

Its only partly for height mainly for facial aesthetics and secondary sexual characteristics and it is good for height but I agree tren is excessive thus the reason I may remove it for now and use after my epiphyseal plates ossify cause its really good and has unique effects, although I'm not sure as it is addicting imo and doesn't really close the plates in theory.

@7evenvox22 I appreciate it man and this endoxifen shit seems really tempting might get some soon

@coolman985 androgens are pretty beneficial for height growth purposes they aren't detrimental in any other way than local AR signalling.

 

[androgenoverload]

mainly cause non-steroidal ai’s are easier to control and don’t have any androgenic or progestogenic side effects at all.
aromasin’s fine, but it’s stronger and harder to dose precisely since it’s irreversible.
with non-steroidals like letro or anastrozole, you can fine-tune suppression more consistently without any extra receptor activity.

Do you have a source for endoxifen?