Careful if you're using Accutane and bulking up because you can develop stretchmarks or develop lose skin if you're cutting.

[TheImmortalBeauty]

Why Accutane can make you develop stretchmarks​

Accutane works by dramatically shrinking your sebaceous (oil) glands, cutting off oil production, and increasing cell turnover to prevent clogged pores. However, stretch marks are not a pore or oil issue they are a structural issue.

A stretch mark is essentially an internal scar. When the body expands too rapidly (due to growth spurts, bodybuilding, or pregnancy), the collagen and elastin fibers in the middle layer of the skin (the dermis) rupture.

Because Accutane severely dries out your skin and makes it fragile, your skin's elasticity and ability to heal are compromised while on the medication. Accutane can interfere with collagenase, an enzyme crucial for normal skin remodeling. If your body is actively expanding (for example, if you are bulking up at the gym) while you are taking Accutane, your skin cannot stretch to accommodate the new mass as easily, making you much more likely to develop new stretch marks.

Here is a closer look at the structural damage that occurs beneath the surface when a stretch mark forms

Why Accutane causes lose skin if you're on a cut​

For skin to tighten after weight loss, it relies entirely on its elasticity specifically the proteins collagen and elastin, which act like microscopic rubber bands in the deeper layers of your skin. Accutane disrupts this system in three major ways:

• Extreme Dehydration: Accutane drastically cuts off oil production, leading to systemic skin dryness. Well-hydrated, moisturized skin is elastic and supple; dry, lipid-depleted skin is brittle and rigid. When skin lacks moisture, its ability to recoil is severely compromised.
• Halted Tissue Remodeling: To shrink, your skin has to actively break down old tissue and rebuild new collagen to fit your new, smaller shape. Accutane alters the behavior of enzymes (like matrix metalloproteinases) that control this remodeling. The medication effectively puts your skin's natural repair-and-reshape cycle on "pause" until the treatment is over.
• Skin Thinning: While on the medication, your skin becomes notably thinner and more fragile. It loses some of the dense structural integrity required to firmly hold itself taut.

People have lost only 25 pounds when taking Accutane and resulted in moderate lose skin due to this.​