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It's a hormetic stressor. Cold exposure releases cold shock proteins and activates BAT fat (Brown adipose tissue), which is mostly located on your upper back/shoulder area. BAT is a good type of fat which improves glucose homeostasis, insulin sensitivity; plays and important role in maintaining bone health and bone density, increases adiponectin levels by 70%. Centenarians (people who live past 100), and their offspring have been found to have higher adiponectin levels than those who aren't Centenarians.
Cold exposure increases circulating irisin. Irisin improves insulin sensitivity, increases bone quality and quantity, is involved in the building of lean muscle mass, and helps reduce obesity by converting white fat to brown fat, providing many of the same benefits of exercise.
Fibroblast Growth Factor 21 Production (FGF-21) has been documented as a pathway to longevity. BAT activation through cold exposure up-regulates circulating fibroblast growth factor 21 (FGF21) in humans by 37%. FGF21 improves insulin sensitivity and glucose metabolism which may partially explain its longevity promoting benefits.
Under basal environmental temperatures, HDAC3 primes expression of UCP1 and the brown fat thermogenic program to ensure acute cold survival through the deacetylation and activation of PGC-1alpha. (PGC1alpha pathway is responsible for mitogenesis and neurogenesis; the growth of new mitochondria in cells and the growth of new brain cells.)
Cold exposure increases SIRT1 phosphorylation/activity in both skeletal muscle and BAT, increasing thermogenesis and insulin sensitivity through deacetylation of PGC-1alpha and other protein targets. Elevated SIRT1 levels in people are associated with increased human longevity. SIRT1 (and the other sirtuins) have many metabolic effects, but an important one for improving health and longevity is the fact that SIRT1 increases insulin sensitivity and glucose control in skeletal muscles, triggers the browning of white fat and increases BAT activity.
It's a hormetic stressor. Cold exposure releases cold shock proteins and activates BAT fat (Brown adipose tissue), which is mostly located on your upper back/shoulder area. BAT is a good type of fat which improves glucose homeostasis, insulin sensitivity; plays and important role in maintaining bone health and bone density, increases adiponectin levels by 70%. Centenarians (people who live past 100), and their offspring have been found to have higher adiponectin levels than those who aren't Centenarians.
Cold exposure increases circulating irisin. Irisin improves insulin sensitivity, increases bone quality and quantity, is involved in the building of lean muscle mass, and helps reduce obesity by converting white fat to brown fat, providing many of the same benefits of exercise.
Fibroblast Growth Factor 21 Production (FGF-21) has been documented as a pathway to longevity. BAT activation through cold exposure up-regulates circulating fibroblast growth factor 21 (FGF21) in humans by 37%. FGF21 improves insulin sensitivity and glucose metabolism which may partially explain its longevity promoting benefits.
Under basal environmental temperatures, HDAC3 primes expression of UCP1 and the brown fat thermogenic program to ensure acute cold survival through the deacetylation and activation of PGC-1alpha. (PGC1alpha pathway is responsible for mitogenesis and neurogenesis; the growth of new mitochondria in cells and the growth of new brain cells.)
Cold exposure increases SIRT1 phosphorylation/activity in both skeletal muscle and BAT, increasing thermogenesis and insulin sensitivity through deacetylation of PGC-1alpha and other protein targets. Elevated SIRT1 levels in people are associated with increased human longevity. SIRT1 (and the other sirtuins) have many metabolic effects, but an important one for improving health and longevity is the fact that SIRT1 increases insulin sensitivity and glucose control in skeletal muscles, triggers the browning of white fat and increases BAT activity.
