71 transgenic murine models that may have increased lifespan or healthspan

[Youㅤ]

AMP-activated protein kinase (AMPK) overexpression
Klotho overexpression
SIRT1 overexpression
IGF-1 receptor knockout
P53 knockout
P16 knockout
Telomerase overexpression
FOXO3 overexpression
Methionine restriction
Mitochondrial antioxidants (e.g., catalase or superoxide dismutase overexpression)
Growth hormone receptor knockout
mTOR pathway inhibition (e.g., TSC1 or TSC2 knockout)
Insulin receptor substrate knockout
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) overexpression
Adiponectin overexpression
Leptin receptor knockout
Heat shock protein overexpression (e.g., HSP70 or HSP90)
DNA repair enzyme overexpression (e.g., WRN or ERCC1)
Autophagy-related gene knockout (e.g., Atg5 or Atg7)
Antioxidant enzyme overexpression (e.g., glutathione peroxidase or thioredoxin)
SOD1 overexpression
SOD2 overexpression
Nrf2 overexpression
NF-κB pathway inhibition (e.g., IκB kinase knockout)
PPARα overexpression
PPARδ overexpression
PPARγ coactivator 1-alpha (PGC-1α) overexpression
Peroxisome proliferator-activated receptor gamma (PPARγ) overexpression
FGF21 overexpression
Ghrelin knockout
Ghrelin receptor knockout
FGF receptor knockout
Notch pathway inhibition (e.g., Notch1 or Notch2 knockout)
Sonic hedgehog pathway inhibition (e.g., Smoothened or Patched knockout)
Wnt pathway inhibition (e.g., β-catenin knockout)
Hippo pathway inhibition (e.g., MST1 or LATS2 knockout)
Jak/Stat pathway inhibition (e.g., STAT3 or STAT5 knockout)
TGF-β pathway inhibition (e.g., TGF-β receptor knockout)
Myostatin knockout
Growth differentiation factor 11 (GDF11) knockout
Insulin-like growth factor binding protein (IGFBP) overexpression
Follistatin overexpression
Apolipoprotein E (ApoE) knockout
Prolactin receptor knockout
Thyroid hormone receptor knockout
Peroxisome biogenesis factor (PEX) knockout
Ras pathway inhibition (e.g., Ras or Raf knockout)
Akt pathway inhibition (e.g., Akt1 or Akt2 knockout)
Rictor knockout
S6 kinase knockout
Sterol regulatory element-binding proteins (SREBPs) knockout
Liver X receptor (LXR) knockout
Androgen receptor knockout
Estrogen receptor knockout
Thyroid hormone receptor knockout
Retinoblastoma protein (Rb) knockout
Cyclin-dependent kinase (CDK) inhibitor overexpression
P21 knockout
P27 knockout
Retinoic acid receptor (RAR) knockout
Peroxisome proliferator-activated receptor gamma (PPARγ) knockout
Uncoupling protein (UCP) overexpression
NAD+-dependent protein deacetylase SIRT6 overexpression
c-Jun N-terminal kinase (JNK) knockout
Suppressor of cytokine signaling (SOCS) overexpression
Adenosine monophosphate-activated protein kinase (AMPK) knockout
HIF-1α knockout
Endothelial nitric oxide synthase (eNOS) knockout
Farnesoid X receptor (FXR) knockout
Fatty acid desaturase (FADS) knockout
Hepatic lipase knockout

 

[Youㅤ]

i wish @enchanted_elixir was still here , maybe he could make a thread on this im too lazy to research all these

 

[LVZZO]

Waste of time
What foods and habits translate in increased health and lifespan are way better
There are some dudes that have good protocols just copy things depending on your goals

https://www.youtube.com/@conqueragingordietrying1797/videos

 

[Youㅤ]

Waste of time
What foods and habits translate in increased health and lifespan are way better
There are some dudes that have good protocols just copy things depending on your goals

https://www.youtube.com/@conqueragingordietrying1797/videos

well if we know how these genes affect ageing then we can better speculate on how certain lifestyle factors influence ageing .

michael lustgarten is good

 

[Youㅤ]

Klotho overexpression

https://journals.physiology.org/doi/full/10.1152/ajprenal.00609.2020?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org

 

[LVZZO]

Do you know if resveratrol as any benefits at all or is harmful ?
This guy keeps throwing shade at it and says David Sinclair is full of shit

https://www.youtube.com/@DrBradStanfield/search?query=resveratrol

Apparently it doesn't activate SIRT1 like first claimed, but I think there are other benefits

 

[Youㅤ]

Do you know if resveratrol as any benefits at all or is harmful ?
This guy keeps throwing shade at it and says David Sinclair is full of shot

https://www.youtube.com/@DrBradStanfield/search?query=resveratrol

Apparently it doesn't activate SIRT1 like first claimed, but I think there are other benefits

resveratrol doesnt have great evidence from what i can tell . i dont want to criticize it tho , its potentially overrhyped may have some mild benefits and side effects .