Could inhibition of fgfr3 lead to appositional growth within facial bones?

[Trerot]

Ive been researching and the science is confusing.
On paper, you would think that because fgfr3 is turned off, the bones could grow (appositional) due to this. However, the literature argues that the survival and longevity of the chrondocyte (in the mandible for example) follow fgfr2-3 expression
lmk your thoughts

 

[Trerot]

BUMPPPP

 

[true__moid]

bump

 

[topology]

I can assure you anyone who is going to respond does not know what they're talking about. Everyone here uses ChatGPT and likely is too broke to even use the paid models. You are going to get responses from over confident morons.

 

[AtrophicPyra]

I can assure you anyone who is going to respond does not know what they're talking about. Everyone here uses ChatGPT and likely is too broke to even use the paid models. You are going to get responses from over confident morons.

bababaBINGOOO

 

[Trerot]

I can assure you anyone who is going to respond does not know what they're talking about. Everyone here uses ChatGPT and likely is too broke to even use the paid models. You are going to get responses from over confident morons.

Your unfortunately correct

 

[AtrophicPyra]

Your unfortunately correct

im pretty sure i read a study where it lists the children who took erdafitinib had unwanted bone growth aswell

u gotta look for it though i lost that study ages ago

 

[Trerot]

im pretty sure i read a study where it lists the children who took erdafitinib had unwanted bone growth aswell

u gotta look for it though i lost that study ages ago

Fuhhh alr
If i find it it would be the equivalent of striking gold

 

[Shirobon]

Ive been researching and the science is confusing.
On paper, you would think that because fgfr3 is turned off, the bones could grow (appositional) due to this. However, the literature argues that the survival and longevity of the chrondocyte (in the mandible for example) follow fgfr2-3 expression
lmk your thoughts

no

 

[Trerot]

no

dude js said no

 

[Shirobon]

dude js said no

nvm thought u were saying erda


so tired of the erda threads im gunna die

fgfr3 is pretty important to periosteum building

and in general bone growth

dk its association tho

but ye do some research brah

 

[Shirobon]

nvm thought u were saying erda


so tired of the erda threads im gunna die

fgfr3 is pretty important to periosteum building

and in general bone growth

dk its association tho

but ye do some research brah

@AtrophicPyra smart boi give me ur opinion

 

[Trerot]

nvm thought u were saying erda


so tired of the erda threads im gunna die

fgfr3 is pretty important to periosteum building

and in general bone growth

dk its association tho

but ye do some research brah

Well erda would do the trick but there are so many fucking better fgfr3 inhibs irs so annoying

 

[Trerot]

@AtrophicPyra smart boi give me ur opinion

agreed

 

[Shirobon]

Well erda would do the trick but there are so many fucking better fgfr3 inhibs irs so annoying

eh cant comment
i dont like saying shi without knowing for certain

but if ur looking for stuff related to bone growth

maybe look into parathyroid hormone related pharmaceuticals

 

[Trerot]

eh cant comment
i dont like saying shi without knowing for certain

but if ur looking for stuff related to bone growth

maybe look into parathyroid hormone related pharmaceuticals

Yeah like abalo
Im probably gonna get erda anyways
dnr sides

 

[Shirobon]

Yeah like abalo
Im probably gonna get erda anyways

abalo ya but that likely wont be enough reasonably change anytghing
&
seems like ur getting erda for height
height stacks and yk dont rlly work well toogether

could be wrong doe, already 6,4 naturally so not very knowledgeable

dnr sides

nonononoonon

 

[Trerot]

abalo ya but that likely wont be enough reasonably change anytghing
&
seems like ur getting erda for height
height stacks and yk dont rlly work well toogether

could be wrong doe, already 6,4 naturally so not very knowledgeable

nonononoonon

Yeah definitely getting erda for height im a manlet
Only side im worried abt is blindess jfl

 

[Shirobon]

Yeah definitely getting erda for height im a manlet
Only side im worried abt is blindess jfl

sevelamer i think helps with that

prolly should look into it tho

https://www.drugs.com/cons/erdafitinib.html

https://www.drugs.com/monograph/erdafitinib.html

and den use like google scholar to look for things to help with sides

 

[Trerot]

sevelamer i think helps with that

prolly should look into it tho

https://www.drugs.com/cons/erdafitinib.html

https://www.drugs.com/monograph/erdafitinib.html

and den use like google scholar to look for things to help with sides

tf is google scholar lmao

 

[Shirobon]

tf is google scholar lmao

tool for searching exclusively studies

very useful for research

i use doximity which is limited to actual Practitioners in the medical field lul

 

[Trerot]

tool for searching exclusively studies

very useful for research

i use doximity which is limited to actual Practitioners in the medical field lul

wowww damn
u put me on

 

[Shirobon]

wowww damn
u put me on

there are others too

but ye it rlly helps when lookin into stuff

they have an ai feature which is ok

kinda buggy but ye helps when u don't know technical terms of things

 

[AtrophicPyra]

@AtrophicPyra smart boi give me ur opinion

im pretty sure i read a study where it lists the children who took erdafitinib had unwanted bone growth aswell

u gotta look for it though i lost that study ages ago