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Iron
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There has been a lot of fear around crashing e2, its completely understandable,
but we have the technology to counteract all the sides as i will explain in this thread.
PS if you think crashing E2 is pointless for height then just gtfo iqlet
.
(also first post so formatting sucks)
What does all of the above even mean?, i will demonstrate a cycle to counteract all 3 topics,
including OTC options and UGL options since some of this stuff is impossible to source
Please bumb i made ts shit at 15 while getting ready for skool
but we have the technology to counteract all the sides as i will explain in this thread.
PS if you think crashing E2 is pointless for height then just gtfo iqlet
.(also first post so formatting sucks)
Disclaimer: This content is for strictly educational and theoretical purposes only. I do not condone, encourage, or facilitate the use of any chemical compounds, legal or illegal. Always consult a medical professional.
Category 1: The brain,
1. cofilin, killing your brain. When you deprive the brain of estrogens, tens of problems arise including cofilin.
arguably cofilin is the most damaging part of this whole process but i will discuss the other problems later down the road.
what is cofilin and why does it matter: in the brain there's a part called the hippocampus, the hippocampus is literally the storage of all your memories, the terrifying part is that it shrinks rapidly without estrogen, that's the feeling of brain fog. The way this works is by the Actin, simply put cofilin gets released since there's no estrogen holding it down and it attacks actin.
PMID: 20696146, PMID: 24611062
2. serotonin, the happy hormone. to cut things short the raphe nuclei goes numb once estrogen is nuked, its the manufacturer of the happy hormone. Estrogen receptor beta is literally the printing machine needed to create all the enzymes to make serotonin, we can easily replace this action because the enzymes are flex-able and do not need ERB to be produced there are other methods, under normal conditions a machine called TPH2 collects your L-tryptophan from food and converts it into 5-HTP (the main ingredient for serotonin) then a secondary machine called AAAD takes those 5-HTP and converts them into serotonin, we can completely bypass this process.
PMID: 24033289
3. Energy, without estrogen your brain LITERALLY starves, estrogen spoon feeds your brain energy (Glucose). but in a state where estrogen is nuked the whole glucose pathway is shut down meaning even if we simply find a way to get glucose into the brain it wont work because estrogen holds those pathways open, the brain has developed smart alternative ways that do not need glucose at all instead it also accepts other sorts of energy like Acetyl-L-Carnitine and Exogenous ketones, both are excellent fuel sources that your brain accepts perfectly but they work differently, one burns slowly replicating glucose exactly (acetyl-L-carnitine) and the other burns fast giving you a spike in energy (mct oil)
PMID: 23994581
1. cofilin, killing your brain. When you deprive the brain of estrogens, tens of problems arise including cofilin.
arguably cofilin is the most damaging part of this whole process but i will discuss the other problems later down the road.
what is cofilin and why does it matter: in the brain there's a part called the hippocampus, the hippocampus is literally the storage of all your memories, the terrifying part is that it shrinks rapidly without estrogen, that's the feeling of brain fog. The way this works is by the Actin, simply put cofilin gets released since there's no estrogen holding it down and it attacks actin.
PMID: 20696146, PMID: 24611062
2. serotonin, the happy hormone. to cut things short the raphe nuclei goes numb once estrogen is nuked, its the manufacturer of the happy hormone. Estrogen receptor beta is literally the printing machine needed to create all the enzymes to make serotonin, we can easily replace this action because the enzymes are flex-able and do not need ERB to be produced there are other methods, under normal conditions a machine called TPH2 collects your L-tryptophan from food and converts it into 5-HTP (the main ingredient for serotonin) then a secondary machine called AAAD takes those 5-HTP and converts them into serotonin, we can completely bypass this process.
PMID: 24033289
3. Energy, without estrogen your brain LITERALLY starves, estrogen spoon feeds your brain energy (Glucose). but in a state where estrogen is nuked the whole glucose pathway is shut down meaning even if we simply find a way to get glucose into the brain it wont work because estrogen holds those pathways open, the brain has developed smart alternative ways that do not need glucose at all instead it also accepts other sorts of energy like Acetyl-L-Carnitine and Exogenous ketones, both are excellent fuel sources that your brain accepts perfectly but they work differently, one burns slowly replicating glucose exactly (acetyl-L-carnitine) and the other burns fast giving you a spike in energy (mct oil)
PMID: 23994581
Category 2: Bones,
simply put, you cant save your bones, they will become brittle and hollow from the inside leading to you becoming more prone to injuries, however there are ways to mitigate this and even completely recover after your iqlet ass crashes e2 for years, here's the science behind it anyway.
1. Osteoclasts, the bone demolition. The molecules that go berserk destroying your bones and leaving them hollow without estrogen to hold them down. firstly in normal conditions estrogen releases decoys OPG (Osteoprotegerin) that sacrifice themselves to save your bones, the osteoclasts get confused and attack the decoys, secondly cytokines, your thyroid releases PTH (Parathyroid Hormone) which directly signals osteoclasts to start drilling your bones taking the calcium and dumping it into the bloodstream (likely why your bloodwork shows high calcium), thirdly osteoclasts literally forget how to die once their job is done, they will stay in the bone confused and continue chopping at your bones without estrogen to kill them
PMID: 18358
2. Osteoblasts, the bone rebuilding. osteoblasts suddenly die too early without finishing their jobs of rebuilding the bone, Your body creates new osteoblasts from a pool of blank slate cells in your bone marrow called Mesenchymal Stem Cells (MSCs), these cells actively recruit new osteoblasts, The Wnt Pathway also actively hires new osteoblasts through collagen type 1
PMID: 24340027
simply put, you cant save your bones, they will become brittle and hollow from the inside leading to you becoming more prone to injuries, however there are ways to mitigate this and even completely recover after your iqlet ass crashes e2 for years, here's the science behind it anyway.
1. Osteoclasts, the bone demolition. The molecules that go berserk destroying your bones and leaving them hollow without estrogen to hold them down. firstly in normal conditions estrogen releases decoys OPG (Osteoprotegerin) that sacrifice themselves to save your bones, the osteoclasts get confused and attack the decoys, secondly cytokines, your thyroid releases PTH (Parathyroid Hormone) which directly signals osteoclasts to start drilling your bones taking the calcium and dumping it into the bloodstream (likely why your bloodwork shows high calcium), thirdly osteoclasts literally forget how to die once their job is done, they will stay in the bone confused and continue chopping at your bones without estrogen to kill them
PMID: 18358
2. Osteoblasts, the bone rebuilding. osteoblasts suddenly die too early without finishing their jobs of rebuilding the bone, Your body creates new osteoblasts from a pool of blank slate cells in your bone marrow called Mesenchymal Stem Cells (MSCs), these cells actively recruit new osteoblasts, The Wnt Pathway also actively hires new osteoblasts through collagen type 1
PMID: 24340027
Category 3: libido,
for your sake i wont dive deep into this category because there's SO much to discuss
PMID:
24024838
26908066
24480244
10999781
for your sake i wont dive deep into this category because there's SO much to discuss
PMID:
24024838
26908066
24480244
10999781
What does all of the above even mean?
, i will demonstrate a cycle to counteract all 3 topics,including OTC options and UGL options since some of this stuff is impossible to source
For the brain the very very simple fix is getting estrogen into the brain exclusively
using DHED (10β,17β-Dihydroxyestra-1,4-dien-3-one) but gl sourcing that so here's the otc solution
Next the bones, there are 3 phases of osteoporosis (brittle bones), each compound has a different strength, phase 1 is for minor osteoporosis, phase 2 mild osteoporosis seen in pre-menopause women and phase 3 is extreme osteoporosis seen in elderly
CHOOSE ONLY ONE ACCORDING TO YOUR OSTEOPOROSIS STATE
next the libido,
using DHED (10β,17β-Dihydroxyestra-1,4-dien-3-one) but gl sourcing that so here's the otc solution
| Compound | Dose | Description |
| 5-HTP | 100mg – 200mg | Bypasses the frozen TPH2 assembly line entirely, delivering the direct mid-point material straight to the brain cells. |
| P5P | 20mg | Plugs directly into the AAAD enzyme like a battery, sparking the immediate conversion of 5-HTP into active Serotonin. |
| ECGC | 400mg | Temporarily shuts down AAAD enzymes in the gut and bloodstream, forcing the 5-HTP to travel safely to the brain instead of converting early and causing severe nausea. |
| Bacopa Monnieri (50% Bacosides) | 1,000mg | Triggers a BDNF/NGF signaling cascade that activates LIMK (an enzyme that plugs an off-switch onto Cofilin, stopping it from chopping your F-actin rebar). Simultaneously acts as a PAM to physically force your downregulated receptor antennas to become hyper-sensitive to serotonin again. |
| Lithium Orotate | 5mg | Inhibits HDAC, keeping the epigenetic gates inside your brain cells wide open so the blueprints for cellular repair, BDNF printing, and structural growth stay completely accessible. |
| ALCAR | 1000mg | fatty acids straight into the mitochondria by bypassing the locked glucose doors. |
| MCT oil | 20ML | high-octane racing fuel that enters the brain through a completely separate, unlocked pathway. |
Next the bones, there are 3 phases of osteoporosis (brittle bones), each compound has a different strength, phase 1 is for minor osteoporosis, phase 2 mild osteoporosis seen in pre-menopause women and phase 3 is extreme osteoporosis seen in elderly
CHOOSE ONLY ONE ACCORDING TO YOUR OSTEOPOROSIS STATE
| Compound | Dosage | Description |
| Romosozumab | 210 mg monthly (Subcutaneous) | Unlocks the master Wnt pathway by destroying Sclerostin. It forces massive new bone construction while simultaneously dampening destruction signals. |
| Alendronate | 70 mg once weekly (Oral) | Serves as the primary oral shield. It binds to the bone mineral surface and forces hyperactive osteoclasts into cellular suicide upon contact, locking in Phase 1 gains without requiring IV access. |
| Vitamin D3 | 5,000 IU daily (Oral) | Drives maximum intestinal calcium absorption. Keeps blood levels saturated so the parathyroid glands stay asleep, shutting down the systemic PTH destruction alarm. |
next the libido,
| Compound | Daily Target Dosage |
| trans-Resveratrol | 250mg - 500mg |
| Standardized Grape Seed Extract (GSE) | 100mg - 300mg |
| 5-MTHF (Active Folate) | 1mg - 5mg |
| Palmitoylethanolamide (PEA) | 400mg - 600mg |
| D-Mannose | 1500mg - 2000mg |
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