Debloating guide – A deep dive into Epleronone and Furosemide - The truth about debloating

[SlayerJonas]

@Jonasㅤㅤ⠀

Between HGH/roids and oral minoxidil what do you think causes more bloat?

Depends on the dosages for both. I can just say for certain oral Minoxidil bloats you as fuck. High dose roids too without MCR antagonism or any alternatives.

 

[Androx]

another 200 IQ thread sir Jonas

 

[NotSo]

Take Eplerenone, Finerenone like my boy @Neucher or nothing.

Also Spironolactone isn't only an anti-androgen, it's also a partial agonist of the progesterone and estrogen receptor.

There is a reason why I strongly advise against it.

Enjoy feeling shit.

View attachment 3734719

It's literally a compound used in a clinical setting for multiple months on end at much higher dosages, but you rather believe a user called chickencurry.

It gets rid of water retention in your body, that's what it does.

Yes saar, direct causality of diuretics debloating surely means there aren't other factors influencing water retention!

retards.org

@Orc

It balances out your electrolytes obviously. Eplerenone is once again potassium-sparing.

Why would you drink a litre of coconut water a day when you could just take a small pill with no downsides for a cheaper price lol.

If new hair follicles come out, then obviously yes.

Looksmin transplant literally.

Any reason why Finerenone wasn't mentioned in this thread? It seems to be superior to Eplerenone much lower IC50 values than Eplerenone to MCR 17.8 vs 990 nM equal tissue distribution between heart and kidney at least in rodents, no CNS penetration and less effects on BP, only issue I see is shorter half life (half Eplerenone's or so)

 

[Dot1]

Bro I swear, literally need prescription for all of those things what the fuck im supposed to do

the hospitals gatekeeping

 

[iblamegenetics-]

thanks alot for this thread it has helped me so much

 

[SlayerJonas]

Bro I swear, literally need prescription for all of those things what the fuck im supposed to do

You can stick to volufiline and potassium choleride normie.

Any reason why Finerenone wasn't mentioned in this thread? It seems to be superior to Eplerenone much lower IC50 values than Eplerenone to MCR 17.8 vs 990 nM equal tissue distribution between heart and kidney at least in rodents, no CNS penetration and less effects on BP, only issue I see is shorter half life (half Eplerenone's or so)

It was mentioned. Why would you want to use a compound with a shorter half life for our purpose? Also Epl is a lot more available in the first place.

@imontheloose

 

[¿Nero]

Depends on the dosages for both. I can just say for certain oral Minoxidil bloats you as fuck. High dose roids too without MCR antagonism or any alternatives.

Amazing work Jonas

 

[imontheloose]

Bro I swear, literally need prescription for all of those things what the fuck im supposed to do

I'll sell you anything you want. No prescription needed. @chadisbeingmade recently bought GH off me for £7/IU. OP can also vouch. He got my £10/mL test cyp.

It was mentioned. Why would you want to use a compound with a shorter half life for our purpose? Also Epl is a lot more available in the first place.

@imontheloose

Can always add nebivolol (beta blocker, specifically 1 and 3) or modafinil (a sympathomimetic) for an extra push on vascularity if needed I guess. Seems totally fine. If you hate MRAs, you can always use amiloride for a purely ENaC-based diuretic. It depends on what the cause is at the end of the day.

 

[fkf3655]

water

 

[SlayerJonas]

I'll sell you anything you want. No prescription needed. @chadisbeingmade recently bought GH off me for £7/IU. OP can also vouch. He got my £10/mL test cyp.

I can vouch. Top quality test cyp you got there. Mirin the esterification skills.

Can always add nebivolol (beta blocker, specifically 1 and 3) or modafinil (a sympathomimetic) for an extra push on vascularity if needed I guess. Seems totally fine. If you hate MRAs, you can always use amiloride for a purely ENaC-based diuretic. It depends on what the cause is at the end of the day.

A beta blocker is essential for every roider even for just basic cardiovascular health. It mitigates most of the heart-related side effects.

water

Mind explaining how this thread is water, son?

Your underdeveloped brain wasn't able to go past the first two sentences.

 

[fkf3655]

I can vouch. Top quality test cyp you got there. Mirin the esterification skills.

A beta blocker is essential for every roider even for just basic cardiovascular health. It mitigates most of the heart-related side effects.

Mind explaining how this thread is water, son?

Your underdeveloped brain wasn't able to go past the first two sentences.

everyone knows this shit

 

[Inquisitor]

The ideal dose would be between 40-80mg taken a few hours before the desired time window. Don’t forget that abuse of this compound can lead to side effects such as ototoxicity

real, I took 120mg cuz 40mg and 80mg was doing shit, and started peeing like crazy and started hearing less, + began to suddenly lose balance

 

[Bergo]

isnt 400 mg daily too much

 

[oscar0819]

How often to take eplerenone?

 

[¿Nero]

@profmade

 

[CyberPsychodelic]

How often to take eplerenone?

Everyday 25 mgs

 

[elarwa]

View attachment 3709760
Debloating guide – A deep dive into Epleronone and Furosemide
The truth about debloating
Part 4



Introduction

Spoiler: Introduction

The prerequisite to this thread is being at a low bf%, optimally around around 8-12%. If you aren’t lean, what the fuck are you doing?

Be aware that during development cutting too hard will be contraproductive. Only proceed with this thread if you are aware of that.

Debloating is one of the best techniques to drastically improve your looks, you’ll look as lean as you really are.

This thread will cover real methods to stay chiseled.

Common misinformations about debloating

Spoiler: Common misinformations about debloating

There is a lot of BS out there when it comes to debloating, be it drinking more water to flush out the extra sodium.

Keep in mind debloating is temporary, partially. You should never drain your body of water and electrolytes for extended periods.

Prolonged dehydration is linked to health complications like chronic kidney disease.[1]

What causes bloating?

Spoiler: What causes bloating?

The mineralocorticoid receptor (MR) is the primary mediator of the fluid, electrolyte and hemodynamic homeostasis of the body. It is part of the RAAS.

View attachment 3709832

We can directly modify the body's fluid homeostasis by influencing the ligands of the MR.

The primary endogenous agonist of the MR is aldosterone. Progesterone and cortisol both bind to the MR with similar affinity, though they appear to have low agonistic activity. This could be because progesterone is converted into inactive compounds[2] and cortisol is deactivated by renal cells expressing 11β-HSD2, which converts it into cortisone.[3]

Steroid users experience bloating primarily because of increased renin and angiotensin II levels, both of which are part of the RAAS, leading to an increase in aldosterone. High E2 levels also cause bloating, as estradiol increases angiotensinogen.[4]

Insulin also causes bloating by activating the RAAS and reducing ANP.[5]

View attachment 3709855View attachment 3709856

There are plenty of other compounds that cause bloating including minoxidil. Fortunately, there is a solution to all of this.

How to permanently debloat

Spoiler: How to permanently debloat

The great thing about modifying the MR pathway directly is that it is the holy grail for negating bloating from most of the compounds you use in your Looksmaxxing journey.

There are several MR antagonists like Eplerenone, Spironolactone and Finerenone. They all vary in parameters like selectivity and effectiveness.

Spironolactone is one of the least selective MR antagonists, meaning it has a non-negligible binding affinity to other receptors like the AR, PR and ER, making it one of the worst options.[6]

In fact, Spironolactone could be compared to anti-androgen treatment with cyproterone acetate.[7]

Eplerenone on the other hand was structurally derived from Spironolactone. It has a slightly weaker binding affinity to the MR but is more selective with only minimal binding affinity to other receptors, making it the best choice.[8]

Other MR antagonists like Finerenone are worth considering, but the best option would be to just stick with Eplerenone.

Dosages for Epleronone

Spoiler: Dosages for Eplerone

Now for the fun part: Experiment with a dosage of 25-50mg first to check for drug tolerance. Increase that dose to a max. of 200-400mg depending on parameters like bloating and secondarily blood pressure.[8.5] You can take Eplerenone long-term without any significant side effects except for disregulated electrolytes. Seriously, keep them in check.

to permanently stay debloated take 100-400mg of Eplerenone depending on the severity of the water retention. Just be aware of potential electrolyte dysregulation and DYOR.

To debloat temporarily consider using a loop diuretic like furosemide. The ideal dose would be between 40-80mg taken a few hours before the desired time window. Don’t forget that abuse of this compound can lead to serious side effects such as ototoxicity.

The best time of the day to use Eplerenone is in the morning, when your aldosterone levels spike.[9]

View attachment 3709879

In fact, Eplerenone may even be a great addition to support your cardiovascular health, as it does the following:
- Reduces coronary vascular inflammation and oxidative stress
- Improves endothelial function, ventricular remodeling, norepinephrine uptake, and heart rate variability
- Attenuates platelet aggregation
[10]

How to temporarily debloat

Spoiler: How to temporarily debloat

A stronger and temporary alternative to MR antagonists are the so called loop diuretics. They work by inhibiting sodium and chloride reabsorption in the kidneys, thus promoting the excretion of water and electrolytes.

The most commonly used loop diuretic is furosemide. Keep in mind that dosages vary drastically between different diuretics. 40mg of furosemide is equivalent to 20mg of torsemide and 1mg of bumetanide.[11]

You should only use loop diuretics temporarily, as they may result in side effects like ototoxicity (loss of hearing)[12, 13]. Also check for possible drug interactions.

Dosages for furosemide

Spoiler: Dosages for furosemide

Typical dosages of furosemide in studies range from 20 to 120mg. I would strictly advise against dosages above 120mg.[14]

Take the furosemide a few hours before the time window in which you want to be debloated. Also try to reduce your water and electrolyte intake throughout the day.

Conclusion

Spoiler: Conclusion

to permanently stay debloated take 100-400mg of Eplerenone depending on the severity of the water retention. Just be aware of potential electrolyte dysregulation and DYOR.

To debloat temporarily consider using a loop diuretic like furosemide. The ideal dose would be between 40-80mg taken a few hours before the desired time window. Don’t forget that abuse of this compound can lead to side effects such as ototoxicity.

Spoiler: Tags

@chadisbeingmade @Magnum Opus @Orc @Clavicular @halloweed

​

Do something better with your time

 

[halyk]

For me, i notice a difference 100%

Pros: look lean asf, makes it look like i’ve got super good bone mass.

Cons: eye area gets nuked, (i get upper eye exposure even when i don’t usually have that much) and also feel very tired when i use it, (manageable tho)

what if ur coping and its just bad supraorbitals? ill buy furo and test myself

 

[garoutheincelReturn]

yeah just as an older guy obsessed with keeping my hair and youthfull skin i'm more and more interested in the effect of E and if there was no risk of getting gyno i would hop on E and bica or cypro while trying to maintain a decent physique just for the skin aging reversal gains.

you seem extremelly knowledgable do you know of some legit skin aging reversal procedure / injectable that doesn't involve inducing a damage to the skin to trigger new collagen?

Couldn't you just remove the gyno glands then blast some estrogen (not enough to shut you down but enough for collagen + hair) im planning on getting on dutasteride permanently after leaning down since DHT lowers Elastin

 

[Boyoshutup]

shortness of breath is a side effect I notice from epelerone usage does anybody know why?

 

[CopeTilliRope]

Couldn't you just remove the gyno glands then blast some estrogen (not enough to shut you down but enough for collagen + hair) im planning on getting on dutasteride permanently after leaning down since DHT lowers Elastin

interesting i never thought about it but you have to know gyno surgery kinda look bad most of the time and will give you " carved nipples " and the only thing i got for me is a perfect body with zyzzlike aesthetic that i would feel sad ruining and apparently there is a risk of regrowth as most retarded surgeon don't remove the entire gland but maybe rhis could work.

the other downsides of E that are refrainig me from trying it on top of assured gyno there are 3 major major negatives sides from guys that just want hair and better skin without the full body feminization

- you will loose penis size assurely ( even if i don't rly care )

- you will get wider hips for sure and a more feminized body fat redistribution and get a more " female " looking body which fucking sucks a a guy


- and the fucking worst one you will loose height due to spinal curves changes ( i talk to dr will powers and it happens to all his patient so no way to avoid that ) some even loose 2 fucking inches and i would km if i loose height


so to sum up E would keep you young in the face for life with perfect hair but you have to trade your body / dick and loose height it's kind of a hard choice to make tbh

 

[garoutheincelReturn]

interesting i never thought about it but you have to know gyno surgery kinda look bad most of the time and will give you " carved nipples " and the only thing i got for me is a perfect body with zyzzlike aesthetic that i would feel sad ruining and apparently there is a risk of regrowth as most retarded surgeon don't remove the entire gland but maybe rhis could work.

the other downsides of E that are refrainig me from trying it on top of assured gyno there are 3 major major negatives sides from guys that just want hair and better skin without the full body feminization

- you will loose penis size assurely ( even if i don't rly care )

- you will get wider hips for sure and a more feminized body fat redistribution and get a more " female " looking body which fucking sucks a a guy


- and the fucking worst one you will loose height due to spinal curves changes ( i talk to dr will powers and it happens to all his patient so no way to avoid that ) some even loose 2 fucking inches and i would km if i loose height


so to sum up E would keep you young in the face for life with perfect hair but you have to trade your body / dick and loose height it's kind of a hard choice to make tbh

NVM lol what about local estrogen creams or just NUKING dht since it's not really needed past puberty more testosterone and more estrogen can be beneficial for youthmaxing

 

[balta0]

View attachment 3709760
Debloating guide – A deep dive into Epleronone and Furosemide
The truth about debloating
Part 4



Introduction

Spoiler: Introduction

The prerequisite to this thread is being at a low bf%, optimally around around 8-12%. If you aren’t lean, what the fuck are you doing?

Be aware that during development cutting too hard will be contraproductive. Only proceed with this thread if you are aware of that.

Debloating is one of the best techniques to drastically improve your looks, you’ll look as lean as you really are.

This thread will cover real methods to stay chiseled.

Common misinformations about debloating

Spoiler: Common misinformations about debloating

There is a lot of BS out there when it comes to debloating, be it drinking more water to flush out the extra sodium.

Keep in mind debloating is temporary, partially. You should never drain your body of water and electrolytes for extended periods.

Prolonged dehydration is linked to health complications like chronic kidney disease.[1]

What causes bloating?

Spoiler: What causes bloating?

The mineralocorticoid receptor (MR) is the primary mediator of the fluid, electrolyte and hemodynamic homeostasis of the body. It is part of the RAAS.

View attachment 3709832

We can directly modify the body's fluid homeostasis by influencing the ligands of the MR.

The primary endogenous agonist of the MR is aldosterone. Progesterone and cortisol both bind to the MR with similar affinity, though they appear to have low agonistic activity. This could be because progesterone is converted into inactive compounds[2] and cortisol is deactivated by renal cells expressing 11β-HSD2, which converts it into cortisone.[3]

Steroid users experience bloating primarily because of increased renin and angiotensin II levels, both of which are part of the RAAS, leading to an increase in aldosterone. High E2 levels also cause bloating, as estradiol increases angiotensinogen.[4]

Insulin also causes bloating by activating the RAAS and reducing ANP.[5]

View attachment 3709855View attachment 3709856

There are plenty of other compounds that cause bloating including minoxidil. Fortunately, there is a solution to all of this.

How to permanently debloat

Spoiler: How to permanently debloat

The great thing about modifying the MR pathway directly is that it is the holy grail for negating bloating from most of the compounds you use in your Looksmaxxing journey.

There are several MR antagonists like Eplerenone, Spironolactone and Finerenone. They all vary in parameters like selectivity and effectiveness.

Spironolactone is one of the least selective MR antagonists, meaning it has a non-negligible binding affinity to other receptors like the AR, PR and ER, making it one of the worst options.[6]

In fact, Spironolactone could be compared to anti-androgen treatment with cyproterone acetate.[7]

Eplerenone on the other hand was structurally derived from Spironolactone. It has a slightly weaker binding affinity to the MR but is more selective with only minimal binding affinity to other receptors, making it the best choice.[8]

Other MR antagonists like Finerenone are worth considering, but the best option would be to just stick with Eplerenone.

Dosages for Epleronone

Spoiler: Dosages for Eplerone

Now for the fun part: Experiment with a dosage of 25-50mg first to check for drug tolerance. Increase that dose to a max. of 200-400mg depending on parameters like bloating and secondarily blood pressure.[8.5] You can take Eplerenone long-term without any significant side effects except for disregulated electrolytes. Seriously, keep them in check.

to permanently stay debloated take 100-400mg of Eplerenone depending on the severity of the water retention. Just be aware of potential electrolyte dysregulation and DYOR.

To debloat temporarily consider using a loop diuretic like furosemide. The ideal dose would be between 40-80mg taken a few hours before the desired time window. Don’t forget that abuse of this compound can lead to serious side effects such as ototoxicity.

The best time of the day to use Eplerenone is in the morning, when your aldosterone levels spike.[9]

View attachment 3709879

In fact, Eplerenone may even be a great addition to support your cardiovascular health, as it does the following:
- Reduces coronary vascular inflammation and oxidative stress
- Improves endothelial function, ventricular remodeling, norepinephrine uptake, and heart rate variability
- Attenuates platelet aggregation
[10]

How to temporarily debloat

Spoiler: How to temporarily debloat

A stronger and temporary alternative to MR antagonists are the so called loop diuretics. They work by inhibiting sodium and chloride reabsorption in the kidneys, thus promoting the excretion of water and electrolytes.

The most commonly used loop diuretic is furosemide. Keep in mind that dosages vary drastically between different diuretics. 40mg of furosemide is equivalent to 20mg of torsemide and 1mg of bumetanide.[11]

You should only use loop diuretics temporarily, as they may result in side effects like ototoxicity (loss of hearing)[12, 13]. Also check for possible drug interactions.

Dosages for furosemide

Spoiler: Dosages for furosemide

Typical dosages of furosemide in studies range from 20 to 120mg. I would strictly advise against dosages above 120mg.[14]

Take the furosemide a few hours before the time window in which you want to be debloated. Also try to reduce your water and electrolyte intake throughout the day.

Conclusion

Spoiler: Conclusion

to permanently stay debloated take 100-400mg of Eplerenone depending on the severity of the water retention. Just be aware of potential electrolyte dysregulation and DYOR.

To debloat temporarily consider using a loop diuretic like furosemide. The ideal dose would be between 40-80mg taken a few hours before the desired time window. Don’t forget that abuse of this compound can lead to side effects such as ototoxicity.

Spoiler: Tags

@chadisbeingmade @Magnum Opus @Orc @Clavicular @halloweed

​

So taking a drug prescribed for hypertension and cardio insufficiency will make you lean because of the minimal binding in MR? U crazy

 

[MolnOner]

I know this question has been asked several times but where can i get Furosemide or Epleronone if i live in Europe, specifically Sweden. I would use India mart but the customs here love to search sketchy packages outside of Europe sooo where can i get them?

 

[CopeTilliRope]

NVM lol what about local estrogen creams or just NUKING dht since it's not really needed past puberty more testosterone and more estrogen can be beneficial for youthmaxing

i don't thin topical e can replicate even 1/10 of the power of systemic hrt just like topical fin sucks compared to oral for hair. and yeah you can nuke dht safely with dut i do that without sides but the increase is e is non efficient to reverse or preserve youth you need wayyy more e

 

[Pilinko]

What have the results been like? Im interested in using myself

Good thread man, Ordered Eplerenone a couple of days ago for the first time to combat bloating from some of the stuff i’m taking. Hope it works and goes well

 

[bruhtoobrutal]

What have the results been like? Im interested in using myself

indian forgot my eplerenone he’s doing a reship rn

 

[Pilinko]

indian forgot my eplerenone he’s doing a reship rn

Damn thats gotta be annoying. Would love to know your experience once you start using it.

Ive never bought from indiamart tbh does that happen often? Im considering getting some mk from there but dont wanna get fucked on shipping.

 

[bruhtoobrutal]

Damn thats gotta be annoying. Would love to know your experience once you start using it.

Ive never bought from indiamart tbh does that happen often? Im considering getting some mk from there but dont wanna get fucked on shipping.

Naw he got everything right just accidentally mixed up it up. Hes giving it to me for free now. Also dont buy MK

 

[Pilinko]

Why do you say that? One of my friends uses it so he could hook me up locally but I just want to go online for convienience and I also dont feel like explaining the blackpill and why im taking MK without going to the gym.


Also thanks for the insight on indiamart, sounds like good service.

 

[Deleted member 114837]

TOOK it so far saw no results.
Unlike with furosemide.
It's been a week.

You shouldn't take any dose higher than 50 mg for eplerenone.

And op should have mentionned that if you take any medication containing baclofene - muscle relaxant -, gabapentin, or a lot of other medication that lot of people use normally, you can make the side effects regarding your heart even bigger. It's extremely risky.

I would only advice to take it for a short period of time to see how you react to it AND IF IT REALLY debloats you/makes you more defined. If yes you can take it from time to time. If no just stop. I will up the dose to 75mg i had sides from it, for one more week, just to see if there is ANY result. If no i will throw it in the bin, and just continue leanmaxxing and taking occasionnally furosemide at 40 or 80mg max before a big event.
That's what everyone should do too.

 

[Boyoshutup]

TOOK it so far saw no results.
Unlike with furosemide.
It's been a week.

You shouldn't take any dose higher than 50 mg for eplerenone.

And op should have mentionned that if you take any medication containing baclofene - muscle relaxant -, gabapentin, or a lot of other medication that lot of people use normally, you can make the side effects regarding your heart even bigger. It's extremely risky.

I would only advice to take it for a short period of time to see how you react to it AND IF IT REALLY debloats you/makes you more defined. If yes you can take it from time to time. If no just stop. I will up the dose to 75mg i had sides from it, for one more week, just to see if there is ANY result. If no i will throw it in the bin, and just continue leanmaxxing and taking occasionnally furosemide at 40 or 80mg max before a big event.
That's what everyone should do too.

Hctz better tbh 3 days gap 25 mg keeps me debloated 24/7

 

[iblamebonesandxy]

We need natural ways for de bloating bro

 

[elnasca]

Hctz better tbh 3 days gap 25 mg keeps me debloated 24/7

I ordered 200 tablets of HCTZ yesterday from Indiamart, what's ur dosage and is the debloating deep?

 

[Evgeniy291]

Hctz better tbh 3 days gap 25 mg keeps me debloated 24/7

gatekeep

 

[Evgeniy291]

I ordered 200 tablets of HCTZ yesterday from Indiamart, what's ur dosage and is the debloating deep?

Read my guide

 

[elnasca]

Read my guide

Done. High effort &iq but I still have some questions. I’m thinking about doing mk677+hctz+eplerenone to minimize the bloat caused by mk (I never worked out before so I guess even if it’s a really soft ‘drug’ it’s gonna make it easier to build muscle + newbie gains), do you think it’s a good idea or should I just stick to hctz for debloating?

 

[Evgeniy291]

Done. High effort &iq but I still have some questions. I’m thinking about doing mk677+hctz+eplerenone to minimize the bloat caused by mk (I never worked out before so I guess even if it’s a really soft ‘drug’ it’s gonna make it easier to build muscle + newbie gains), do you think it’s a good idea or should I just stick to hctz for debloating?

I dont know I haven't used mk677, I did use eplerenone and it does help a bit I guess, since im on roids. But never really got anything special out of it

 

[Boyoshutup]

I ordered 200 tablets of HCTZ yesterday from Indiamart, what's ur dosage and is the debloating deep?

Definitely better then epelerone

 

[elnasca]

Definitely better then epelerone

Really? Online I can only find sources that says the opposite lol

 

[Boyoshutup]

Really? Online I can only find sources that says the opposite lol

Epelerone is much safer as it spares pottasium but its not as effective.

 

[elnasca]

Epelerone is much safer as it spares pottasium but its not as effective.

Have you ordered hctz from Indiamart?

 

[Askeladd93270]

I just want to have the lines the 1st guy has on his cheeks

 

[Mushroom]

View attachment 3709760
Debloating guide – A deep dive into Epleronone and Furosemide
The truth about debloating
Part 4



Introduction

Spoiler: Introduction

The prerequisite to this thread is being at a low bf%, optimally around around 8-12%. If you aren’t lean, what the fuck are you doing?

Be aware that during development cutting too hard will be contraproductive. Only proceed with this thread if you are aware of that.

Debloating is one of the best techniques to drastically improve your looks, you’ll look as lean as you really are.

This thread will cover real methods to stay chiseled.

Common misinformations about debloating

Spoiler: Common misinformations about debloating

There is a lot of BS out there when it comes to debloating, be it drinking more water to flush out the extra sodium.

Keep in mind debloating is temporary, partially. You should never drain your body of water and electrolytes for extended periods.

Prolonged dehydration is linked to health complications like chronic kidney disease.[1]

What causes bloating?

Spoiler: What causes bloating?

The mineralocorticoid receptor (MR) is the primary mediator of the fluid, electrolyte and hemodynamic homeostasis of the body. It is part of the RAAS.

View attachment 3709832

We can directly modify the body's fluid homeostasis by influencing the ligands of the MR.

The primary endogenous agonist of the MR is aldosterone. Progesterone and cortisol both bind to the MR with similar affinity, though they appear to have low agonistic activity. This could be because progesterone is converted into inactive compounds[2] and cortisol is deactivated by renal cells expressing 11β-HSD2, which converts it into cortisone.[3]

Steroid users experience bloating primarily because of increased renin and angiotensin II levels, both of which are part of the RAAS, leading to an increase in aldosterone. High E2 levels also cause bloating, as estradiol increases angiotensinogen.[4]

Insulin also causes bloating by activating the RAAS and reducing ANP.[5]

View attachment 3709855View attachment 3709856

There are plenty of other compounds that cause bloating including minoxidil. Fortunately, there is a solution to all of this.

How to permanently debloat

Spoiler: How to permanently debloat

The great thing about modifying the MR pathway directly is that it is the holy grail for negating bloating from most of the compounds you use in your Looksmaxxing journey.

There are several MR antagonists like Eplerenone, Spironolactone and Finerenone. They all vary in parameters like selectivity and effectiveness.

Spironolactone is one of the least selective MR antagonists, meaning it has a non-negligible binding affinity to other receptors like the AR, PR and ER, making it one of the worst options.[6]

In fact, Spironolactone could be compared to anti-androgen treatment with cyproterone acetate.[7]

Eplerenone on the other hand was structurally derived from Spironolactone. It has a slightly weaker binding affinity to the MR but is more selective with only minimal binding affinity to other receptors, making it the best choice.[8]

Other MR antagonists like Finerenone are worth considering, but the best option would be to just stick with Eplerenone.

Dosages for Epleronone

Spoiler: Dosages for Eplerone

Now for the fun part: Experiment with a dosage of 25-50mg first to check for drug tolerance. Increase that dose to a max. of 200-400mg depending on parameters like bloating and secondarily blood pressure.[8.5] You can take Eplerenone long-term without any significant side effects except for disregulated electrolytes. Seriously, keep them in check.

to permanently stay debloated take 100-400mg of Eplerenone depending on the severity of the water retention. Just be aware of potential electrolyte dysregulation and DYOR.

To debloat temporarily consider using a loop diuretic like furosemide. The ideal dose would be between 40-80mg taken a few hours before the desired time window. Don’t forget that abuse of this compound can lead to serious side effects such as ototoxicity.

The best time of the day to use Eplerenone is in the morning, when your aldosterone levels spike.[9]

View attachment 3709879

In fact, Eplerenone may even be a great addition to support your cardiovascular health, as it does the following:
- Reduces coronary vascular inflammation and oxidative stress
- Improves endothelial function, ventricular remodeling, norepinephrine uptake, and heart rate variability
- Attenuates platelet aggregation
[10]

How to temporarily debloat

Spoiler: How to temporarily debloat

A stronger and temporary alternative to MR antagonists are the so called loop diuretics. They work by inhibiting sodium and chloride reabsorption in the kidneys, thus promoting the excretion of water and electrolytes.

The most commonly used loop diuretic is furosemide. Keep in mind that dosages vary drastically between different diuretics. 40mg of furosemide is equivalent to 20mg of torsemide and 1mg of bumetanide.[11]

You should only use loop diuretics temporarily, as they may result in side effects like ototoxicity (loss of hearing)[12, 13]. Also check for possible drug interactions.

Dosages for furosemide

Spoiler: Dosages for furosemide

Typical dosages of furosemide in studies range from 20 to 120mg. I would strictly advise against dosages above 120mg.[14]

Take the furosemide a few hours before the time window in which you want to be debloated. Also try to reduce your water and electrolyte intake throughout the day.

Conclusion

Spoiler: Conclusion

to permanently stay debloated take 100-400mg of Eplerenone depending on the severity of the water retention. Just be aware of potential electrolyte dysregulation and DYOR.

To debloat temporarily consider using a loop diuretic like furosemide. The ideal dose would be between 40-80mg taken a few hours before the desired time window. Don’t forget that abuse of this compound can lead to side effects such as ototoxicity.

Spoiler: Tags

@chadisbeingmade @Magnum Opus @Orc @Clavicular @halloweed

​

what do you think about Hydrochlorothiazide ?

 

[Boyoshutup]

Have you ordered hctz from Indiamart?

Local pharma

 

[neko]

if i take eplerenone how much pottasium and sodium should i be getting per day

 

[SlayerJonas]

I recommend reading every single section of this reply.

real, I took 120mg cuz 40mg and 80mg was doing shit, and started peeing like crazy and started hearing less, + began to suddenly lose balance

Just rape your ears theory.

Combine diuretics with a good side effect profile that modulate different pathways of the fluid homeostasis.

It is literally the same with AAS, you shouldn't just hammer the AR pathway.

just like topical fin sucks compared to oral for hair

Combining both actually mogs. Topical 5ARIs have different metabolites, thus different MOA, meaning they will nuke DHT topically even further differently than oral 5ARIs.

An ideal combination would be oral dut with topical dut, if a good vehicle is used.

And op should have mentionned that if you take any medication containing baclofene - muscle relaxant -, gabapentin, or a lot of other medication that lot of people use normally

I mentioned to check for possible drug interactions already.

We need natural ways for de bloating

Natural literally just means using less potent/safe and unisolated compounds.

"Drugs" are simply the isolated active ingredients.

@chadbeingmade @imontheloose

 

[CopeTilliRope]

I recommend reading every single section of this reply.

Just rape your ears theory.

Combine diuretics with a good side effect profile that modulate different pathways of the fluid homeostasis.

It is literally the same with AAS, you shouldn't just hammer the AR pathway.

Combining both actually mogs. Topical 5ARIs have different metabolites, thus different MOA, meaning they will nuke DHT topically even further differently than oral 5ARIs.

An ideal combination would be oral dut with topical dut, if a good vehicle is used.

I mentioned to check for possible drug interactions already.

Natural literally just means using less potent/safe and unisolated compounds.

"Drugs" are simply the isolated active ingredients.

@chadbeingmade @imontheloose

true but if fucking hate using topicals. unfortunnately for people whose oral dut isnt enough it seems we will be stuck with using topicals forever i hope pp and gt will be enough to stop further loss in the future

 

[Azie555]

View attachment 3709760
Debloating guide – A deep dive into Epleronone and Furosemide
The truth about debloating
Part 4



Introduction

Spoiler: Introduction

The prerequisite to this thread is being at a low bf%, optimally around around 8-12%. If you aren’t lean, what the fuck are you doing?

Be aware that during development cutting too hard will be contraproductive. Only proceed with this thread if you are aware of that.

Debloating is one of the best techniques to drastically improve your looks, you’ll look as lean as you really are.

This thread will cover real methods to stay chiseled.

Common misinformations about debloating

Spoiler: Common misinformations about debloating

There is a lot of BS out there when it comes to debloating, be it drinking more water to flush out the extra sodium.

Keep in mind debloating is temporary, partially. You should never drain your body of water and electrolytes for extended periods.

Prolonged dehydration is linked to health complications like chronic kidney disease.[1]

What causes bloating?

Spoiler: What causes bloating?

The mineralocorticoid receptor (MR) is the primary mediator of the fluid, electrolyte and hemodynamic homeostasis of the body. It is part of the RAAS.

View attachment 3709832

We can directly modify the body's fluid homeostasis by influencing the ligands of the MR.

The primary endogenous agonist of the MR is aldosterone. Progesterone and cortisol both bind to the MR with similar affinity, though they appear to have low agonistic activity. This could be because progesterone is converted into inactive compounds[2] and cortisol is deactivated by renal cells expressing 11β-HSD2, which converts it into cortisone.[3]

Steroid users experience bloating primarily because of increased renin and angiotensin II levels, both of which are part of the RAAS, leading to an increase in aldosterone. High E2 levels also cause bloating, as estradiol increases angiotensinogen.[4]

Insulin also causes bloating by activating the RAAS and reducing ANP.[5]

View attachment 3709855View attachment 3709856

There are plenty of other compounds that cause bloating including minoxidil. Fortunately, there is a solution to all of this.

How to permanently debloat

Spoiler: How to permanently debloat

The great thing about modifying the MR pathway directly is that it is the holy grail for negating bloating from most of the compounds you use in your Looksmaxxing journey.

There are several MR antagonists like Eplerenone, Spironolactone and Finerenone. They all vary in parameters like selectivity and effectiveness.

Spironolactone is one of the least selective MR antagonists, meaning it has a non-negligible binding affinity to other receptors like the AR, PR and ER, making it one of the worst options.[6]

In fact, Spironolactone could be compared to anti-androgen treatment with cyproterone acetate.[7]

Eplerenone on the other hand was structurally derived from Spironolactone. It has a slightly weaker binding affinity to the MR but is more selective with only minimal binding affinity to other receptors, making it the best choice.[8]

Other MR antagonists like Finerenone are worth considering, but the best option would be to just stick with Eplerenone.

Dosages for Epleronone

Spoiler: Dosages for Eplerone

Now for the fun part: Experiment with a dosage of 25-50mg first to check for drug tolerance. Increase that dose to a max. of 200-400mg depending on parameters like bloating and secondarily blood pressure.[8.5] You can take Eplerenone long-term without any significant side effects except for disregulated electrolytes. Seriously, keep them in check.

to permanently stay debloated take 100-400mg of Eplerenone depending on the severity of the water retention. Just be aware of potential electrolyte dysregulation and DYOR.

To debloat temporarily consider using a loop diuretic like furosemide. The ideal dose would be between 40-80mg taken a few hours before the desired time window. Don’t forget that abuse of this compound can lead to serious side effects such as ototoxicity.

The best time of the day to use Eplerenone is in the morning, when your aldosterone levels spike.[9]

View attachment 3709879

In fact, Eplerenone may even be a great addition to support your cardiovascular health, as it does the following:
- Reduces coronary vascular inflammation and oxidative stress
- Improves endothelial function, ventricular remodeling, norepinephrine uptake, and heart rate variability
- Attenuates platelet aggregation
[10]

How to temporarily debloat

Spoiler: How to temporarily debloat

A stronger and temporary alternative to MR antagonists are the so called loop diuretics. They work by inhibiting sodium and chloride reabsorption in the kidneys, thus promoting the excretion of water and electrolytes.

The most commonly used loop diuretic is furosemide. Keep in mind that dosages vary drastically between different diuretics. 40mg of furosemide is equivalent to 20mg of torsemide and 1mg of bumetanide.[11]

You should only use loop diuretics temporarily, as they may result in side effects like ototoxicity (loss of hearing)[12, 13]. Also check for possible drug interactions.

Dosages for furosemide

Spoiler: Dosages for furosemide

Typical dosages of furosemide in studies range from 20 to 120mg. I would strictly advise against dosages above 120mg.[14]

Take the furosemide a few hours before the time window in which you want to be debloated. Also try to reduce your water and electrolyte intake throughout the day.

Conclusion

Spoiler: Conclusion

to permanently stay debloated take 100-400mg of Eplerenone depending on the severity of the water retention. Just be aware of potential electrolyte dysregulation and DYOR.

To debloat temporarily consider using a loop diuretic like furosemide. The ideal dose would be between 40-80mg taken a few hours before the desired time window. Don’t forget that abuse of this compound can lead to side effects such as ototoxicity.

Spoiler: Tags

@chadisbeingmade @Magnum Opus @Orc @Clavicular @halloweed

​

How much mg should i take a day 25mg right? And when should i stop using it? Also should I stop eating food in high potassium when using Ep like banana cuz because of high potassium hyperkalemia can happen

 

[str8xx]

no debloat for your 25% body fat face

View attachment 3710106

song name?