Debloating guide – A deep dive into Epleronone and Furosemide - The truth about debloating

[str8xx]

song name?

nvm, found it -

she's my collar - gorillaz [slowed]​

 

[jxcob.79]

Good thread man, Ordered Eplerenone a couple of days ago for the first time to combat bloating from some of the stuff i’m taking. Hope it works and goes well

well how is it? why won't you take like 400mg to get a permanent debloat

 

[tokaeyyer]

View attachment 3709760
Debloating guide – A deep dive into Epleronone and Furosemide
The truth about debloating
Part 4



Introduction

Spoiler: Introduction

The prerequisite to this thread is being at a low bf%, optimally around around 8-12%. If you aren’t lean, what the fuck are you doing?

Be aware that during development cutting too hard will be contraproductive. Only proceed with this thread if you are aware of that.

Debloating is one of the best techniques to drastically improve your looks, you’ll look as lean as you really are.

This thread will cover real methods to stay chiseled.

Common misinformations about debloating

Spoiler: Common misinformations about debloating

There is a lot of BS out there when it comes to debloating, be it drinking more water to flush out the extra sodium.

Keep in mind debloating is temporary, partially. You should never drain your body of water and electrolytes for extended periods.

Prolonged dehydration is linked to health complications like chronic kidney disease.[1]

What causes bloating?

Spoiler: What causes bloating?

The mineralocorticoid receptor (MR) is the primary mediator of the fluid, electrolyte and hemodynamic homeostasis of the body. It is part of the RAAS.

View attachment 3709832

We can directly modify the body's fluid homeostasis by influencing the ligands of the MR.

The primary endogenous agonist of the MR is aldosterone. Progesterone and cortisol both bind to the MR with similar affinity, though they appear to have low agonistic activity. This could be because progesterone is converted into inactive compounds[2] and cortisol is deactivated by renal cells expressing 11β-HSD2, which converts it into cortisone.[3]

Steroid users experience bloating primarily because of increased renin and angiotensin II levels, both of which are part of the RAAS, leading to an increase in aldosterone. High E2 levels also cause bloating, as estradiol increases angiotensinogen.[4]

Insulin also causes bloating by activating the RAAS and reducing ANP.[5]

View attachment 3709855View attachment 3709856

There are plenty of other compounds that cause bloating including minoxidil. Fortunately, there is a solution to all of this.

How to permanently debloat

Spoiler: How to permanently debloat

The great thing about modifying the MR pathway directly is that it is the holy grail for negating bloating from most of the compounds you use in your Looksmaxxing journey.

There are several MR antagonists like Eplerenone, Spironolactone and Finerenone. They all vary in parameters like selectivity and effectiveness.

Spironolactone is one of the least selective MR antagonists, meaning it has a non-negligible binding affinity to other receptors like the AR, PR and ER, making it one of the worst options.[6]

In fact, Spironolactone could be compared to anti-androgen treatment with cyproterone acetate.[7]

Eplerenone on the other hand was structurally derived from Spironolactone. It has a slightly weaker binding affinity to the MR but is more selective with only minimal binding affinity to other receptors, making it the best choice.[8]

Other MR antagonists like Finerenone are worth considering, but the best option would be to just stick with Eplerenone.

Dosages for Epleronone

Spoiler: Dosages for Eplerone

Now for the fun part: Experiment with a dosage of 25-50mg first to check for drug tolerance. Increase that dose to a max. of 200-400mg depending on parameters like bloating and secondarily blood pressure.[8.5] You can take Eplerenone long-term without any significant side effects except for disregulated electrolytes. Seriously, keep them in check.

to permanently stay debloated take 100-400mg of Eplerenone depending on the severity of the water retention. Just be aware of potential electrolyte dysregulation and DYOR.

To debloat temporarily consider using a loop diuretic like furosemide. The ideal dose would be between 40-80mg taken a few hours before the desired time window. Don’t forget that abuse of this compound can lead to serious side effects such as ototoxicity.

The best time of the day to use Eplerenone is in the morning, when your aldosterone levels spike.[9]

View attachment 3709879

In fact, Eplerenone may even be a great addition to support your cardiovascular health, as it does the following:
- Reduces coronary vascular inflammation and oxidative stress
- Improves endothelial function, ventricular remodeling, norepinephrine uptake, and heart rate variability
- Attenuates platelet aggregation
[10]

How to temporarily debloat

Spoiler: How to temporarily debloat

A stronger and temporary alternative to MR antagonists are the so called loop diuretics. They work by inhibiting sodium and chloride reabsorption in the kidneys, thus promoting the excretion of water and electrolytes.

The most commonly used loop diuretic is furosemide. Keep in mind that dosages vary drastically between different diuretics. 40mg of furosemide is equivalent to 20mg of torsemide and 1mg of bumetanide.[11]

You should only use loop diuretics temporarily, as they may result in side effects like ototoxicity (loss of hearing)[12, 13]. Also check for possible drug interactions.

Dosages for furosemide

Spoiler: Dosages for furosemide

Typical dosages of furosemide in studies range from 20 to 120mg. I would strictly advise against dosages above 120mg.[14]

Take the furosemide a few hours before the time window in which you want to be debloated. Also try to reduce your water and electrolyte intake throughout the day.

Conclusion

Spoiler: Conclusion

to permanently stay debloated take 100-400mg of Eplerenone depending on the severity of the water retention. Just be aware of potential electrolyte dysregulation and DYOR.

To debloat temporarily consider using a loop diuretic like furosemide. The ideal dose would be between 40-80mg taken a few hours before the desired time window. Don’t forget that abuse of this compound can lead to side effects such as ototoxicity.

Spoiler: Tags

@chadisbeingmade @Magnum Opus @Orc @Clavicular @halloweed

​

Where do you source furomeside in Germany

 

[highteirnormie]

View attachment 3709760
Debloating guide – A deep dive into Epleronone and Furosemide
The truth about debloating
Part 4



Introduction

Spoiler: Introduction

The prerequisite to this thread is being at a low bf%, optimally around around 8-12%. If you aren’t lean, what the fuck are you doing?

Be aware that during development cutting too hard will be contraproductive. Only proceed with this thread if you are aware of that.

Debloating is one of the best techniques to drastically improve your looks, you’ll look as lean as you really are.

This thread will cover real methods to stay chiseled.

Common misinformations about debloating

Spoiler: Common misinformations about debloating

There is a lot of BS out there when it comes to debloating, be it drinking more water to flush out the extra sodium.

Keep in mind debloating is temporary, partially. You should never drain your body of water and electrolytes for extended periods.

Prolonged dehydration is linked to health complications like chronic kidney disease.[1]

What causes bloating?

Spoiler: What causes bloating?

The mineralocorticoid receptor (MR) is the primary mediator of the fluid, electrolyte and hemodynamic homeostasis of the body. It is part of the RAAS.

View attachment 3709832

We can directly modify the body's fluid homeostasis by influencing the ligands of the MR.

The primary endogenous agonist of the MR is aldosterone. Progesterone and cortisol both bind to the MR with similar affinity, though they appear to have low agonistic activity. This could be because progesterone is converted into inactive compounds[2] and cortisol is deactivated by renal cells expressing 11β-HSD2, which converts it into cortisone.[3]

Steroid users experience bloating primarily because of increased renin and angiotensin II levels, both of which are part of the RAAS, leading to an increase in aldosterone. High E2 levels also cause bloating, as estradiol increases angiotensinogen.[4]

Insulin also causes bloating by activating the RAAS and reducing ANP.[5]

View attachment 3709855View attachment 3709856

There are plenty of other compounds that cause bloating including minoxidil. Fortunately, there is a solution to all of this.

How to permanently debloat

Spoiler: How to permanently debloat

The great thing about modifying the MR pathway directly is that it is the holy grail for negating bloating from most of the compounds you use in your Looksmaxxing journey.

There are several MR antagonists like Eplerenone, Spironolactone and Finerenone. They all vary in parameters like selectivity and effectiveness.

Spironolactone is one of the least selective MR antagonists, meaning it has a non-negligible binding affinity to other receptors like the AR, PR and ER, making it one of the worst options.[6]

In fact, Spironolactone could be compared to anti-androgen treatment with cyproterone acetate.[7]

Eplerenone on the other hand was structurally derived from Spironolactone. It has a slightly weaker binding affinity to the MR but is more selective with only minimal binding affinity to other receptors, making it the best choice.[8]

Other MR antagonists like Finerenone are worth considering, but the best option would be to just stick with Eplerenone.

Dosages for Epleronone

Spoiler: Dosages for Eplerone

Now for the fun part: Experiment with a dosage of 25-50mg first to check for drug tolerance. Increase that dose to a max. of 200-400mg depending on parameters like bloating and secondarily blood pressure.[8.5] You can take Eplerenone long-term without any significant side effects except for disregulated electrolytes. Seriously, keep them in check.

to permanently stay debloated take 100-400mg of Eplerenone depending on the severity of the water retention. Just be aware of potential electrolyte dysregulation and DYOR.

To debloat temporarily consider using a loop diuretic like furosemide. The ideal dose would be between 40-80mg taken a few hours before the desired time window. Don’t forget that abuse of this compound can lead to serious side effects such as ototoxicity.

The best time of the day to use Eplerenone is in the morning, when your aldosterone levels spike.[9]

View attachment 3709879

In fact, Eplerenone may even be a great addition to support your cardiovascular health, as it does the following:
- Reduces coronary vascular inflammation and oxidative stress
- Improves endothelial function, ventricular remodeling, norepinephrine uptake, and heart rate variability
- Attenuates platelet aggregation
[10]

How to temporarily debloat

Spoiler: How to temporarily debloat

A stronger and temporary alternative to MR antagonists are the so called loop diuretics. They work by inhibiting sodium and chloride reabsorption in the kidneys, thus promoting the excretion of water and electrolytes.

The most commonly used loop diuretic is furosemide. Keep in mind that dosages vary drastically between different diuretics. 40mg of furosemide is equivalent to 20mg of torsemide and 1mg of bumetanide.[11]

You should only use loop diuretics temporarily, as they may result in side effects like ototoxicity (loss of hearing)[12, 13]. Also check for possible drug interactions.

Dosages for furosemide

Spoiler: Dosages for furosemide

Typical dosages of furosemide in studies range from 20 to 120mg. I would strictly advise against dosages above 120mg.[14]

Take the furosemide a few hours before the time window in which you want to be debloated. Also try to reduce your water and electrolyte intake throughout the day.

Conclusion

Spoiler: Conclusion

to permanently stay debloated take 100-400mg of Eplerenone depending on the severity of the water retention. Just be aware of potential electrolyte dysregulation and DYOR.

To debloat temporarily consider using a loop diuretic like furosemide. The ideal dose would be between 40-80mg taken a few hours before the desired time window. Don’t forget that abuse of this compound can lead to side effects such as ototoxicity.

Spoiler: Tags

@chadisbeingmade @Magnum Opus @Orc @Clavicular @halloweed

​

Bro I’m a kid how do I afford ahit like this

 

[mr G]

Thanks for this thread man i was planning to buy eplerenone, bookmarked

source?

 

[jxcob.79]

Ah that explains why sounds have seemed to got quieter
I’ve been spamming 80/120 mg furo a lot late

Ah that explains why sounds have seemed to got quieter
I’ve been spamming 80/120 mg furo a lot lately

you know any good places to get eplenerone without a prescription?

 

[jxcob.79]

View attachment 3709760
Debloating guide – A deep dive into Epleronone and Furosemide
The truth about debloating
Part 4



Introduction

Spoiler: Introduction

The prerequisite to this thread is being at a low bf%, optimally around around 8-12%. If you aren’t lean, what the fuck are you doing?

Be aware that during development cutting too hard will be contraproductive. Only proceed with this thread if you are aware of that.

Debloating is one of the best techniques to drastically improve your looks, you’ll look as lean as you really are.

This thread will cover real methods to stay chiseled.

Common misinformations about debloating

Spoiler: Common misinformations about debloating

There is a lot of BS out there when it comes to debloating, be it drinking more water to flush out the extra sodium.

Keep in mind debloating is temporary, partially. You should never drain your body of water and electrolytes for extended periods.

Prolonged dehydration is linked to health complications like chronic kidney disease.[1]

What causes bloating?

Spoiler: What causes bloating?

The mineralocorticoid receptor (MR) is the primary mediator of the fluid, electrolyte and hemodynamic homeostasis of the body. It is part of the RAAS.

View attachment 3709832

We can directly modify the body's fluid homeostasis by influencing the ligands of the MR.

The primary endogenous agonist of the MR is aldosterone. Progesterone and cortisol both bind to the MR with similar affinity, though they appear to have low agonistic activity. This could be because progesterone is converted into inactive compounds[2] and cortisol is deactivated by renal cells expressing 11β-HSD2, which converts it into cortisone.[3]

Steroid users experience bloating primarily because of increased renin and angiotensin II levels, both of which are part of the RAAS, leading to an increase in aldosterone. High E2 levels also cause bloating, as estradiol increases angiotensinogen.[4]

Insulin also causes bloating by activating the RAAS and reducing ANP.[5]

View attachment 3709855View attachment 3709856

There are plenty of other compounds that cause bloating including minoxidil. Fortunately, there is a solution to all of this.

How to permanently debloat

Spoiler: How to permanently debloat

The great thing about modifying the MR pathway directly is that it is the holy grail for negating bloating from most of the compounds you use in your Looksmaxxing journey.

There are several MR antagonists like Eplerenone, Spironolactone and Finerenone. They all vary in parameters like selectivity and effectiveness.

Spironolactone is one of the least selective MR antagonists, meaning it has a non-negligible binding affinity to other receptors like the AR, PR and ER, making it one of the worst options.[6]

In fact, Spironolactone could be compared to anti-androgen treatment with cyproterone acetate.[7]

Eplerenone on the other hand was structurally derived from Spironolactone. It has a slightly weaker binding affinity to the MR but is more selective with only minimal binding affinity to other receptors, making it the best choice.[8]

Other MR antagonists like Finerenone are worth considering, but the best option would be to just stick with Eplerenone.

Dosages for Epleronone

Spoiler: Dosages for Eplerone

Now for the fun part: Experiment with a dosage of 25-50mg first to check for drug tolerance. Increase that dose to a max. of 200-400mg depending on parameters like bloating and secondarily blood pressure.[8.5] You can take Eplerenone long-term without any significant side effects except for disregulated electrolytes. Seriously, keep them in check.

to permanently stay debloated take 100-400mg of Eplerenone depending on the severity of the water retention. Just be aware of potential electrolyte dysregulation and DYOR.

To debloat temporarily consider using a loop diuretic like furosemide. The ideal dose would be between 40-80mg taken a few hours before the desired time window. Don’t forget that abuse of this compound can lead to serious side effects such as ototoxicity.

The best time of the day to use Eplerenone is in the morning, when your aldosterone levels spike.[9]

View attachment 3709879

In fact, Eplerenone may even be a great addition to support your cardiovascular health, as it does the following:
- Reduces coronary vascular inflammation and oxidative stress
- Improves endothelial function, ventricular remodeling, norepinephrine uptake, and heart rate variability
- Attenuates platelet aggregation
[10]

How to temporarily debloat

Spoiler: How to temporarily debloat

A stronger and temporary alternative to MR antagonists are the so called loop diuretics. They work by inhibiting sodium and chloride reabsorption in the kidneys, thus promoting the excretion of water and electrolytes.

The most commonly used loop diuretic is furosemide. Keep in mind that dosages vary drastically between different diuretics. 40mg of furosemide is equivalent to 20mg of torsemide and 1mg of bumetanide.[11]

You should only use loop diuretics temporarily, as they may result in side effects like ototoxicity (loss of hearing)[12, 13]. Also check for possible drug interactions.

Dosages for furosemide

Spoiler: Dosages for furosemide

Typical dosages of furosemide in studies range from 20 to 120mg. I would strictly advise against dosages above 120mg.[14]

Take the furosemide a few hours before the time window in which you want to be debloated. Also try to reduce your water and electrolyte intake throughout the day.

Conclusion

Spoiler: Conclusion

to permanently stay debloated take 100-400mg of Eplerenone depending on the severity of the water retention. Just be aware of potential electrolyte dysregulation and DYOR.

To debloat temporarily consider using a loop diuretic like furosemide. The ideal dose would be between 40-80mg taken a few hours before the desired time window. Don’t forget that abuse of this compound can lead to side effects such as ototoxicity.

Spoiler: Tags

@chadisbeingmade @Magnum Opus @Orc @Clavicular @halloweed

​

So i should take let's say 2 eplenerone 25mgs in the morning for lets say 4 days, and that'll "permanently" debloat me? Ofcourse i know it's not permanent, it is if you look after yourself or watch what you eat drink water blah blah, but that's correct right? I'm pretty sure taking more then 100mg in one instance is overdosing And im pretty sure taking potassium stuff while on it is also risky, like electrolyte drinks or tablets with potassium snuck inside it.

I know it's right there but im just making sure, saw some guy on here who seriously bugged out after taking it and im just making sure i don't end up like him lmao. And also, could you tell me how fast the effect will come? Let's say i take 50mg in the morning, when will i "fully debloat"? 2 hours? And if i keep taking it it'll stay like that, correct?

 

[Azie555]

So i should take let's say 2 eplenerone 25mgs in the morning for lets say 4 days, and that'll "permanently" debloat me? Ofcourse i know it's not permanent, it is if you look after yourself or watch what you eat drink water blah blah, but that's correct right? I'm pretty sure taking more then 100mg in one instance is overdosing And im pretty sure taking potassium stuff while on it is also risky, like electrolyte drinks or tablets with potassium snuck inside it.

I know it's right there but im just making sure, saw some guy on here who seriously bugged out after taking it and im just making sure i don't end up like him lmao. And also, could you tell me how fast the effect will come? Let's say i take 50mg in the morning, when will i "fully debloat"? 2 hours? And if i keep taking it it'll stay like that, correct?

I also like to know this i just bought eplenerone

 

[underatedgreycel]

So i should take let's say 2 eplenerone 25mgs in the morning for lets say 4 days, and that'll "permanently" debloat me? Ofcourse i know it's not permanent, it is if you look after yourself or watch what you eat drink water blah blah, but that's correct right? I'm pretty sure taking more then 100mg in one instance is overdosing And im pretty sure taking potassium stuff while on it is also risky, like electrolyte drinks or tablets with potassium snuck inside it.

I know it's right there but im just making sure, saw some guy on here who seriously bugged out after taking it and im just making sure i don't end up like him lmao. And also, could you tell me how fast the effect will come? Let's say i take 50mg in the morning, when will i "fully debloat"? 2 hours? And if i keep taking it it'll stay like that, correct?

So i should take let's say 2 eplenerone 25mgs in the morning for lets say 4 days, and that'll "permanently" debloat me? Ofcourse i know it's not permanent, it is if you look after yourself or watch what you eat drink water blah blah, but that's correct right? I'm pretty sure taking more then 100mg in one instance is overdosing And im pretty sure taking potassium stuff while on it is also risky, like electrolyte drinks or tablets with potassium snuck inside it.

I know it's right there but im just making sure, saw some guy on here who seriously bugged out after taking it and im just making sure i don't end up like him lmao. And also, could you tell me how fast the effect will come? Let's say i take 50mg in the morning, when will i "fully debloat"? 2 hours? And if i keep taking it it'll stay like that, correct?

I don’t take eplerenone yet but based on my research it depletes mostly salt and magnesium and leaves an excess of potassium. Also the whole entire point of the supplement is that it decreases bloating minerals and water retention in the whole body which is why this occurs

 

[jxcob.79]

I don’t take eplerenone yet but based on my research it depletes mostly salt and magnesium and leaves an excess of potassium. Also the whole entire point of the supplement is that it decreases bloating minerals and water retention in the whole body which is why this occurs

Yeah im aware, that doesn't really answer my question but yeah your research is right, that's what it does.

What's the point you're trying to make?

 

[Azie555]

Yeah im aware, that doesn't really answer my question but yeah your research is right, that's what it does.

What's the point you're trying to make?

Thread 'Dont use Epleronone before reading this. [important]' https://looksmax.org/threads/dont-use-epleronone-before-reading-this-important.1488909/

 

[jxcob.79]

Thread 'Dont use Epleronone before reading this. [important]' https://looksmax.org/threads/dont-use-epleronone-before-reading-this-important.1488909/

Yeah, side effects. Hyperkalemia only happens if you take too much, just take 50mg bro. If you take 200 in a day then don't be surprised. Oh and also if you actually end up taking like 100+mg or a high dose and somehow survive just watch how much potassium you eat, the smallest amount can tip you off.

 

[Part-Time Chad]

The secret to having a good face isn't necessarily to "debloat", but to have enough glycogen in your facial muscles, which creates attractive curves and contours in your face.

 

[Jonasㅤㅤ]

based on my research it depletes mostly salt and magnesium

Mirin researching, not like I included all of that info in the thread.

The secret to having a good face isn't necessarily to "debloat", but to have enough glycogen in your facial muscles, which creates attractive curves and contours in your face.

What a smart individual, bloating is the key apparently. Should have made a thread on MCR agonists instead.

 

[Azie555]

Mirin researching, not like I included all of that info in the thread.

What a smart individual, bloating is the key apparently. Should have made a thread on MCR agonists instead.
View attachment 3843398

should i stop drinking water while on eplenerone

 

[jxcob.79]

The weird thing about this is, ibhave been chiselled without taking eplerenone,hctz or Furosemide,i would like to repeat the same mechanism to be lean without taking any of those suplements,obiously i don't know what made me chiselled those days

What's your current dosage of eple? I recommend sticking to a decent diet after you cykle off, if you want it to be "permanent" you have to make it permanent. Don't expect to eat a bunch of processed shit aswell as fuck yourself with sodium and expect to still be debloated.

It's like going on creative mode in minecraft, getting good look and switching the gamemode to survival. From then on you have to survive (in this case not get bloated)

 

[jxcob.79]

indian forgot my eplerenone he’s doing a reship rn

how's it been then? I think you have it now right

 

[CyberPsychodelic]

What's your current dosage of eple? I recommend sticking to a decent diet after you cykle off, if you want it to be "permanent" you have to make it permanent. Don't expect to eat a bunch of processed shit aswell as fuck yourself with sodium and expect to still be debloated.

It's like going on creative mode in minecraft, getting good look and switching the gamemode to survival. From then on you have to survive (in this case not get bloated)

Yes this is true, however, what i mean is, can we eat procesed foods while on eplerenone? Does Eplerenone removes water retentiom even eating pasta , chiken or burgers? Or do we have to eat like some white saint to be debloated?

 

[jxcob.79]

Yes this is true, however, what i mean is, can we eat procesed foods while on eplerenone? Does Eplerenone removes water retentiom even eating pasta , chiken or burgers? Or do we have to eat like some white saint to be debloated?

Well you can, but just be careful. By that i mean just drink water, still consume a good potassium-sodium ratio so you don't get any more bloat and if the processed foods cause bloating then you'll know, and you'll be able to go workout or go on a run and burn it off just don't go too overboard with it, with or without epe i only eat like 1 fatty fast food meal a week

 

[CyberPsychodelic]

Well you can, but just be careful. By that i mean just drink water, still consume a good potassium-sodium ratio so you don't get any more bloat and if the processed foods cause bloating then you'll know, and you'll be able to go workout or go on a run and burn it off just don't go too overboard with it, with or without epe i only eat like 1 fatty fast food meal a week

Excellent advice, thank you very much jxcob. 79!!!

 

[SanTheTrucel]

I will tell my kids about the Jonas 2025 run

 

[jxcob.79]

Excellent advice, thank you very much jxcob. 79!!!

Welcome!

 

[RQQ]

View attachment 3709760
Debloating guide – A deep dive into Epleronone and Furosemide
The truth about debloating
Part 4



Introduction

Spoiler: Introduction

The prerequisite to this thread is being at a low bf%, optimally around around 8-12%. If you aren’t lean, what the fuck are you doing?

Be aware that during development cutting too hard will be contraproductive. Only proceed with this thread if you are aware of that.

Debloating is one of the best techniques to drastically improve your looks, you’ll look as lean as you really are.

This thread will cover real methods to stay chiseled.

Common misinformations about debloating

Spoiler: Common misinformations about debloating

There is a lot of BS out there when it comes to debloating, be it drinking more water to flush out the extra sodium.

Keep in mind debloating is temporary, partially. You should never drain your body of water and electrolytes for extended periods.

Prolonged dehydration is linked to health complications like chronic kidney disease.[1]

What causes bloating?

Spoiler: What causes bloating?

The mineralocorticoid receptor (MR) is the primary mediator of the fluid, electrolyte and hemodynamic homeostasis of the body. It is part of the RAAS.

View attachment 3709832

We can directly modify the body's fluid homeostasis by influencing the ligands of the MR.

The primary endogenous agonist of the MR is aldosterone. Progesterone and cortisol both bind to the MR with similar affinity, though they appear to have low agonistic activity. This could be because progesterone is converted into inactive compounds[2] and cortisol is deactivated by renal cells expressing 11β-HSD2, which converts it into cortisone.[3]

Steroid users experience bloating primarily because of increased renin and angiotensin II levels, both of which are part of the RAAS, leading to an increase in aldosterone. High E2 levels also cause bloating, as estradiol increases angiotensinogen.[4]

Insulin also causes bloating by activating the RAAS and reducing ANP.[5]

View attachment 3709855View attachment 3709856

There are plenty of other compounds that cause bloating including minoxidil. Fortunately, there is a solution to all of this.

How to permanently debloat

Spoiler: How to permanently debloat

The great thing about modifying the MR pathway directly is that it is the holy grail for negating bloating from most of the compounds you use in your Looksmaxxing journey.

There are several MR antagonists like Eplerenone, Spironolactone and Finerenone. They all vary in parameters like selectivity and effectiveness.

Spironolactone is one of the least selective MR antagonists, meaning it has a non-negligible binding affinity to other receptors like the AR, PR and ER, making it one of the worst options.[6]

In fact, Spironolactone could be compared to anti-androgen treatment with cyproterone acetate.[7]

Eplerenone on the other hand was structurally derived from Spironolactone. It has a slightly weaker binding affinity to the MR but is more selective with only minimal binding affinity to other receptors, making it the best choice.[8]

Other MR antagonists like Finerenone are worth considering, but the best option would be to just stick with Eplerenone.

Dosages for Epleronone

Spoiler: Dosages for Eplerone

Now for the fun part: Experiment with a dosage of 25-50mg first to check for drug tolerance. Increase that dose to a max. of 200-400mg depending on parameters like bloating and secondarily blood pressure.[8.5] You can take Eplerenone long-term without any significant side effects except for disregulated electrolytes. Seriously, keep them in check.

to permanently stay debloated take 100-400mg of Eplerenone depending on the severity of the water retention. Just be aware of potential electrolyte dysregulation and DYOR.

To debloat temporarily consider using a loop diuretic like furosemide. The ideal dose would be between 40-80mg taken a few hours before the desired time window. Don’t forget that abuse of this compound can lead to serious side effects such as ototoxicity.

The best time of the day to use Eplerenone is in the morning, when your aldosterone levels spike.[9]

View attachment 3709879

In fact, Eplerenone may even be a great addition to support your cardiovascular health, as it does the following:
- Reduces coronary vascular inflammation and oxidative stress
- Improves endothelial function, ventricular remodeling, norepinephrine uptake, and heart rate variability
- Attenuates platelet aggregation
[10]

How to temporarily debloat

Spoiler: How to temporarily debloat

A stronger and temporary alternative to MR antagonists are the so called loop diuretics. They work by inhibiting sodium and chloride reabsorption in the kidneys, thus promoting the excretion of water and electrolytes.

The most commonly used loop diuretic is furosemide. Keep in mind that dosages vary drastically between different diuretics. 40mg of furosemide is equivalent to 20mg of torsemide and 1mg of bumetanide.[11]

You should only use loop diuretics temporarily, as they may result in side effects like ototoxicity (loss of hearing)[12, 13]. Also check for possible drug interactions.

Dosages for furosemide

Spoiler: Dosages for furosemide

Typical dosages of furosemide in studies range from 20 to 120mg. I would strictly advise against dosages above 120mg.[14]

Take the furosemide a few hours before the time window in which you want to be debloated. Also try to reduce your water and electrolyte intake throughout the day.

Conclusion

Spoiler: Conclusion

to permanently stay debloated take 100-400mg of Eplerenone depending on the severity of the water retention. Just be aware of potential electrolyte dysregulation and DYOR.

To debloat temporarily consider using a loop diuretic like furosemide. The ideal dose would be between 40-80mg taken a few hours before the desired time window. Don’t forget that abuse of this compound can lead to side effects such as ototoxicity.

Spoiler: Tags

@chadisbeingmade @Magnum Opus @Orc @Clavicular @halloweed

​

thank you this is very good info also where can I find these things

 

[efidescontinuado]

I wonder how many greycels have died of heart failure after reading this thread

 

[Inquisitor]

I recommend reading every single section of this reply.

Just rape your ears theory.

Combine diuretics with a good side effect profile that modulate different pathways of the fluid homeostasis.

It is literally the same with AAS, you shouldn't just hammer the AR pathway.

Combining both actually mogs. Topical 5ARIs have different metabolites, thus different MOA, meaning they will nuke DHT topically even further differently than oral 5ARIs.

An ideal combination would be oral dut with topical dut, if a good vehicle is used.

I mentioned to check for possible drug interactions already.

Natural literally just means using less potent/safe and unisolated compounds.

"Drugs" are simply the isolated active ingredients.

@chadbeingmade @imontheloose

mirin, high IQ post.

 

[markidukisub5]

View attachment 3709760
Debloating guide – A deep dive into Epleronone and Furosemide
The truth about debloating
Part 4



Introduction

Spoiler: Introduction

The prerequisite to this thread is being at a low bf%, optimally around around 8-12%. If you aren’t lean, what the fuck are you doing?

Be aware that during development cutting too hard will be contraproductive. Only proceed with this thread if you are aware of that.

Debloating is one of the best techniques to drastically improve your looks, you’ll look as lean as you really are.

This thread will cover real methods to stay chiseled.

Common misinformations about debloating

Spoiler: Common misinformations about debloating

There is a lot of BS out there when it comes to debloating, be it drinking more water to flush out the extra sodium.

Keep in mind debloating is temporary, partially. You should never drain your body of water and electrolytes for extended periods.

Prolonged dehydration is linked to health complications like chronic kidney disease.[1]

What causes bloating?

Spoiler: What causes bloating?

The mineralocorticoid receptor (MR) is the primary mediator of the fluid, electrolyte and hemodynamic homeostasis of the body. It is part of the RAAS.

View attachment 3709832

We can directly modify the body's fluid homeostasis by influencing the ligands of the MR.

The primary endogenous agonist of the MR is aldosterone. Progesterone and cortisol both bind to the MR with similar affinity, though they appear to have low agonistic activity. This could be because progesterone is converted into inactive compounds[2] and cortisol is deactivated by renal cells expressing 11β-HSD2, which converts it into cortisone.[3]

Steroid users experience bloating primarily because of increased renin and angiotensin II levels, both of which are part of the RAAS, leading to an increase in aldosterone. High E2 levels also cause bloating, as estradiol increases angiotensinogen.[4]

Insulin also causes bloating by activating the RAAS and reducing ANP.[5]

View attachment 3709855View attachment 3709856

There are plenty of other compounds that cause bloating including minoxidil. Fortunately, there is a solution to all of this.

How to permanently debloat

Spoiler: How to permanently debloat

The great thing about modifying the MR pathway directly is that it is the holy grail for negating bloating from most of the compounds you use in your Looksmaxxing journey.

There are several MR antagonists like Eplerenone, Spironolactone and Finerenone. They all vary in parameters like selectivity and effectiveness.

Spironolactone is one of the least selective MR antagonists, meaning it has a non-negligible binding affinity to other receptors like the AR, PR and ER, making it one of the worst options.[6]

In fact, Spironolactone could be compared to anti-androgen treatment with cyproterone acetate.[7]

Eplerenone on the other hand was structurally derived from Spironolactone. It has a slightly weaker binding affinity to the MR but is more selective with only minimal binding affinity to other receptors, making it the best choice.[8]

Other MR antagonists like Finerenone are worth considering, but the best option would be to just stick with Eplerenone.

Dosages for Epleronone

Spoiler: Dosages for Eplerone

Now for the fun part: Experiment with a dosage of 25-50mg first to check for drug tolerance. Increase that dose to a max. of 200-400mg depending on parameters like bloating and secondarily blood pressure.[8.5] You can take Eplerenone long-term without any significant side effects except for disregulated electrolytes. Seriously, keep them in check.

to permanently stay debloated take 100-400mg of Eplerenone depending on the severity of the water retention. Just be aware of potential electrolyte dysregulation and DYOR.

To debloat temporarily consider using a loop diuretic like furosemide. The ideal dose would be between 40-80mg taken a few hours before the desired time window. Don’t forget that abuse of this compound can lead to serious side effects such as ototoxicity.

The best time of the day to use Eplerenone is in the morning, when your aldosterone levels spike.[9]

View attachment 3709879

In fact, Eplerenone may even be a great addition to support your cardiovascular health, as it does the following:
- Reduces coronary vascular inflammation and oxidative stress
- Improves endothelial function, ventricular remodeling, norepinephrine uptake, and heart rate variability
- Attenuates platelet aggregation
[10]

How to temporarily debloat

Spoiler: How to temporarily debloat

A stronger and temporary alternative to MR antagonists are the so called loop diuretics. They work by inhibiting sodium and chloride reabsorption in the kidneys, thus promoting the excretion of water and electrolytes.

The most commonly used loop diuretic is furosemide. Keep in mind that dosages vary drastically between different diuretics. 40mg of furosemide is equivalent to 20mg of torsemide and 1mg of bumetanide.[11]

You should only use loop diuretics temporarily, as they may result in side effects like ototoxicity (loss of hearing)[12, 13]. Also check for possible drug interactions.

Dosages for furosemide

Spoiler: Dosages for furosemide

Typical dosages of furosemide in studies range from 20 to 120mg. I would strictly advise against dosages above 120mg.[14]

Take the furosemide a few hours before the time window in which you want to be debloated. Also try to reduce your water and electrolyte intake throughout the day.

Conclusion

Spoiler: Conclusion

to permanently stay debloated take 100-400mg of Eplerenone depending on the severity of the water retention. Just be aware of potential electrolyte dysregulation and DYOR.

To debloat temporarily consider using a loop diuretic like furosemide. The ideal dose would be between 40-80mg taken a few hours before the desired time window. Don’t forget that abuse of this compound can lead to side effects such as ototoxicity.

Spoiler: Tags

@chadisbeingmade @Magnum Opus @Orc @Clavicular @halloweed

​

Good thread, but 12% is the most optimal. Latest studies show foids are attracted to it the most. Also single digits may cause health implications

 

[chadbeingmade]

Good thread, but 12% is the most optimal. Latest studies show foids are attracted to it the most. Also single digits may cause health implications

Are you fucking retarded or some shit, grey?

You can’t generalise the optimal body fat for everyone to one singular number. Fat distribution is different for everyone, the places at which fat is lost first/last is dependant on genetics.

Health implications my ass.

Take your shit back to tiktok.

 

[slaters]

How much mg should i take a day 25mg right? And when should i stop using it? Also should I stop eating food in high potassium when using Ep like banana cuz because of high potassium hyperkalemia can happen

U shouldn’t use diuretics if your not on anything else tbh

 

[Azie555]

U shouldn’t use diuretics if your not on anything else tbh

why

 

[slaters]

why

Because your gonna fry your kidneys when in reality it was your body fat or peanut sized cheekbones

 

[Azie555]

Because your gonna fry your kidneys when in reality it was your body fat or peanut sized cheekbones

i have low bf im lean asf

 

[leseed_]

View attachment 3709760
Debloating guide – A deep dive into Epleronone and Furosemide
The truth about debloating
Part 4



Introduction

Spoiler: Introduction

The prerequisite to this thread is being at a low bf%, optimally around around 8-12%. If you aren’t lean, what the fuck are you doing?

Be aware that during development cutting too hard will be contraproductive. Only proceed with this thread if you are aware of that.

Debloating is one of the best techniques to drastically improve your looks, you’ll look as lean as you really are.

This thread will cover real methods to stay chiseled.

Common misinformations about debloating

Spoiler: Common misinformations about debloating

There is a lot of BS out there when it comes to debloating, be it drinking more water to flush out the extra sodium.

Keep in mind debloating is temporary, partially. You should never drain your body of water and electrolytes for extended periods.

Prolonged dehydration is linked to health complications like chronic kidney disease.[1]

What causes bloating?

Spoiler: What causes bloating?

The mineralocorticoid receptor (MR) is the primary mediator of the fluid, electrolyte and hemodynamic homeostasis of the body. It is part of the RAAS.

View attachment 3709832

We can directly modify the body's fluid homeostasis by influencing the ligands of the MR.

The primary endogenous agonist of the MR is aldosterone. Progesterone and cortisol both bind to the MR with similar affinity, though they appear to have low agonistic activity. This could be because progesterone is converted into inactive compounds[2] and cortisol is deactivated by renal cells expressing 11β-HSD2, which converts it into cortisone.[3]

Steroid users experience bloating primarily because of increased renin and angiotensin II levels, both of which are part of the RAAS, leading to an increase in aldosterone. High E2 levels also cause bloating, as estradiol increases angiotensinogen.[4]

Insulin also causes bloating by activating the RAAS and reducing ANP.[5]

View attachment 3709855View attachment 3709856

There are plenty of other compounds that cause bloating including minoxidil. Fortunately, there is a solution to all of this.

How to permanently debloat

Spoiler: How to permanently debloat

The great thing about modifying the MR pathway directly is that it is the holy grail for negating bloating from most of the compounds you use in your Looksmaxxing journey.

There are several MR antagonists like Eplerenone, Spironolactone and Finerenone. They all vary in parameters like selectivity and effectiveness.

Spironolactone is one of the least selective MR antagonists, meaning it has a non-negligible binding affinity to other receptors like the AR, PR and ER, making it one of the worst options.[6]

In fact, Spironolactone could be compared to anti-androgen treatment with cyproterone acetate.[7]

Eplerenone on the other hand was structurally derived from Spironolactone. It has a slightly weaker binding affinity to the MR but is more selective with only minimal binding affinity to other receptors, making it the best choice.[8]

Other MR antagonists like Finerenone are worth considering, but the best option would be to just stick with Eplerenone.

Dosages for Epleronone

Spoiler: Dosages for Eplerone

Now for the fun part: Experiment with a dosage of 25-50mg first to check for drug tolerance. Increase that dose to a max. of 200-400mg depending on parameters like bloating and secondarily blood pressure.[8.5] You can take Eplerenone long-term without any significant side effects except for disregulated electrolytes. Seriously, keep them in check.

to permanently stay debloated take 100-400mg of Eplerenone depending on the severity of the water retention. Just be aware of potential electrolyte dysregulation and DYOR.

To debloat temporarily consider using a loop diuretic like furosemide. The ideal dose would be between 40-80mg taken a few hours before the desired time window. Don’t forget that abuse of this compound can lead to serious side effects such as ototoxicity.

The best time of the day to use Eplerenone is in the morning, when your aldosterone levels spike.[9]

View attachment 3709879

In fact, Eplerenone may even be a great addition to support your cardiovascular health, as it does the following:
- Reduces coronary vascular inflammation and oxidative stress
- Improves endothelial function, ventricular remodeling, norepinephrine uptake, and heart rate variability
- Attenuates platelet aggregation
[10]

How to temporarily debloat

Spoiler: How to temporarily debloat

A stronger and temporary alternative to MR antagonists are the so called loop diuretics. They work by inhibiting sodium and chloride reabsorption in the kidneys, thus promoting the excretion of water and electrolytes.

The most commonly used loop diuretic is furosemide. Keep in mind that dosages vary drastically between different diuretics. 40mg of furosemide is equivalent to 20mg of torsemide and 1mg of bumetanide.[11]

You should only use loop diuretics temporarily, as they may result in side effects like ototoxicity (loss of hearing)[12, 13]. Also check for possible drug interactions.

Dosages for furosemide

Spoiler: Dosages for furosemide

Typical dosages of furosemide in studies range from 20 to 120mg. I would strictly advise against dosages above 120mg.[14]

Take the furosemide a few hours before the time window in which you want to be debloated. Also try to reduce your water and electrolyte intake throughout the day.

Conclusion

Spoiler: Conclusion

to permanently stay debloated take 100-400mg of Eplerenone depending on the severity of the water retention. Just be aware of potential electrolyte dysregulation and DYOR.

To debloat temporarily consider using a loop diuretic like furosemide. The ideal dose would be between 40-80mg taken a few hours before the desired time window. Don’t forget that abuse of this compound can lead to side effects such as ototoxicity.

Spoiler: Tags

@chadisbeingmade @Magnum Opus @Orc @Clavicular @halloweed

​

links to parts 1-3?

 

[markidukisub5]

Are you fucking retarded or some shit, grey?

You can’t generalise the optimal body fat for everyone to one singular number. Fat distribution is different for everyone, the places at which fat is lost first/last is dependant on genetics.

Health implications my ass.

Take your shit back to tiktok.

Syfm nigger, It is fucking avarage index for everyone, retard. Yes, fat distribution is different for everyone, I have never said that we have same genetics and shi. And health indicators directly influence your attractiveness. Fucking incel kid