DEFYING NORWOOD - Uncovering One Of The Last Pillars Of Hair Regrowth

[Deleted member 110192]

Lemme condense this thread 4 y'all:

Nothing significant fore mentioning beez noted of that thread. We'se absorbed none enlightenment thereof.

Diddb zlznxbw?

 

[Сигма Бой]

Rofl. This is all years-old recycled info and near-broscience, not to mention with zero empirical evidence.

I see it's too late for everyone to not trip over themselves and glaze the OP, but before anyone actually tries this nonsense, go DYOR.
SwissTemples tried topical VPA quite publicly like a decade ago with all the same theorycrafting.
He eventually quietly conceded it doesn't do anything.

Also note that a common side of oral VPA, commonly taken as Depakote for seizures / manic depression, is hair loss.

As for the rest, RU is a toxic meme and KY is a Korean pipe dream.

Do more than just asking ChatGPT to regurgitate Reddit.

That's what's up!
Jonas2k7 turned angry after comparing myselves cnp thread against hisself.

Table

A table is a piece of furniture with a raised flat top and is supported most commonly by 1 to 4 legs (although some can have more). It is used as a surface for working at, eating from or on which to place things.[1][2] Some common types of tables are the dining room tables, which are used for...

looksmax.org

Anybody wielding AI isser NPC & must never teach.

 

[Сигма Бой]

Diddb zlznxbw?

Boujopp nikklorrryttf

 

[Сигма Бой]

Turbo high iq thread . Could replace turkeymaxxing with vpamaxxing

Muh table thread compares gooder against this AI core thread.

Table

A table is a piece of furniture with a raised flat top and is supported most commonly by 1 to 4 legs (although some can have more). It is used as a surface for working at, eating from or on which to place things.[1][2] Some common types of tables are the dining room tables, which are used for...

looksmax.org

 

[Deleted member 110192]

Muh table thread compares gooder against this AI core thread.

Table

A table is a piece of furniture with a raised flat top and is supported most commonly by 1 to 4 legs (although some can have more). It is used as a surface for working at, eating from or on which to place things.[1][2] Some common types of tables are the dining room tables, which are used for...

looksmax.org

Could you do a chair one next time please?

 

[Сигма Бой]

Could you do a chair one next time please?

4 sho, one moment.

 

[Сигма Бой]

Could you do a chair one next time please?

Chair 🪑

A chair is a type of seat, typically designed for one person and consisting of one or more legs, a flat or slightly angled seat and a back-rest. It may be made of wood, metal, or synthetic materials, and may be padded or upholstered in various colors and fabrics. Chairs vary in design. An...

looksmax.org

 

[DR. NICKGA]

Vpa and for sure pp405 don”t work

Both of those things don”t work, pure garbage

 

[DR. NICKGA]

Rofl. This is all years-old recycled info and near-broscience, not to mention with zero empirical evidence.

I see it's too late for everyone to not trip over themselves and glaze the OP, but before anyone actually tries this nonsense, go DYOR.
SwissTemples tried topical VPA quite publicly like a decade ago with all the same theorycrafting.
He eventually quietly conceded it doesn't do anything.

Also note that a common side of oral VPA, commonly taken as Depakote for seizures / manic depression, is hair loss.

As for the rest, RU is a toxic meme and KY is a Korean pipe dream.

Do more than just asking ChatGPT to regurgitate Reddit.

Exactly what i said

Vpa and for sure pp405 don”t work

Both of those things don”t work, pure garbage

 

[DR. NICKGA]

Rofl. This is all years-old recycled info and near-broscience, not to mention with zero empirical evidence.

I see it's too late for everyone to not trip over themselves and glaze the OP, but before anyone actually tries this nonsense, go DYOR.
SwissTemples tried topical VPA quite publicly like a decade ago with all the same theorycrafting.
He eventually quietly conceded it doesn't do anything.

Also note that a common side of oral VPA, commonly taken as Depakote for seizures / manic depression, is hair loss.

As for the rest, RU is a toxic meme and KY is a Korean pipe dream.

Do more than just asking ChatGPT to regurgitate Reddit.

But let them waste their time

 

[Sonder53]

View attachment 3861690
DEFYING NORWOOD:
UNCOVERING ONE OF THE LAST PILLARS OF HAIR REGROWTH
By Sadist

Spoiler: DISCLAIMER

DISCLAIMER: This thread may singlehandedly crash Turkey’s economy; @menas, sorry for your inevitable poverty in advance bud.

Spoiler: REAL DISCLAIMER

REAL DISCLAIMER: By no means is this medical advice. Even though the risks are low, everyone is different and some people may respond to this differently to others. Consult a medical professional before taking any of the following steps.

​

Sick of the dreaded Norwood Reaper, which has done seemingly irreversible damage to your precious hairline? Tried everything to get your luscious hair back, but still saw minimal hair regrowth? Well worry not - for daddy Sadist has you covered on this topic.

Before we start - this thread assumes that if you’re interested in yielding regrowth benefits from the info provided due to experiencing hair loss - you have a brain and are already taking optimal preventative measures to stop further hair loss.

Spoiler: THREAD SONG

---

Chapter I: Introduction​

Many different pathways are responsible for hair growth, or alternatively - its stagnation. Obviously, disrupting the right OR assisting the wrong pathways will jeopardize the entire hair growth process, and start the balding process. This is exactly what happens during androgenetic alopecia.

As we all know, Testosterone is converted into Dihydrotestosterone through 5alpha-reductase. DHT then binds to hair follicles, disrupting said essential hair growth pathways & causing said hair loss. 5AR inhibitors, such as Finasteride or Dutasteride stop this process by blocking 5AR activity, which therefore prevents Testosterone converting into DHT.

Whilst this stops further hair loss, old hairs usually never come back, especially at further stages of Norwood. Some people try to compensate by using products like Minoxidil, but it only does so much at hairline regrowth - so most give up, and end up getting a hair transplant.

---

Chapter II: One of the Most Important Hair Growth Pathways​

A very important hair growth pathway, which is almost completely inhibited during Norwood is the Wnt/β-catenin signaling pathway. It is responsible for transforming the hair follicle cycle from the telogen (resting) phase into anagen (growth) phase, which is absolutely crucial for proper hair development, as it promotes hair stem cell activation.

Whilst Minoxidil promotes hair regrowth in the alopecia-affected areas through stimulation of microcirculation around hair follicles, causing arteriolar vasodilation, it usually creates relatively mild improvements. This is entirely due to the fact that it does not target any hair growth pathways DIRECTLY, unlike…

---

Chapter III, Pt. 1: An Introduction to Valproic Acid​

Valproic Acid (which I will be referring to as VPA from now on) is an anticonvulsant, used to treat epilepsy, manic phases of bipolar disorder & other similar conditions. If ingested orally, it has NEGATIVE effects on hair regrowth.
So how does a seemingly random epilepsy medicine, which CONTRIBUTES to hair loss, come anywhere near being one of the best hair loss treatments?
Well, see - although it bares negative effects in its oral form - if converted into a topical solution, it becomes absolutely great for hair regrowth.

Topical VPA application inhibits the GSK3β protein, thereby allowing the aforementioned Wnt/β-catenin signaling to take place (as GSK3β inhibits Wnt/β-catenin). This, obviously, allows hair follicles to enter the previously-discussed anagen phase. Additionally, it activates Erk & Akt pathways, which also contribute to hair growth.

And since it is applied topically, its systemic effects are negligible compared to its oral form, which, as discussed earlier, can actually induce alopecia itself by depleting your body of trace minerals & biotin, overshadowing its positive effects on hair regrowth.

And just to put its strength into perspective - one study showed, that after a 24-week cycle, VPA significantly regrew hair in areas affected by Norwood III & even Norwood IV. In another study (this one done on foids but fuck it) it was shown, that after 6 months, hair count doubled (from about 49/cm^2 to about 99/cm^2). There’s more studies on it that show great results, but I would rather let you lot see just how well it works for yourself:

View attachment 3860799
Fig. 1:
a, b, c, d - 3 months VPA; e, f, g, h - 3 months Placebo
(bottom pictures showing extreme close-ups).


View attachment 3860807
Fig. 2:
Results that @Mr_wax talked about in his thread (even though he was struggling to make a 100% effective topical VPA due to incomplete solution, he still did manage to apply it, and this is the effect that he got).​

---

Chapter III, Pt. 2: Preparation of Topical VPA​

VPA is mainly only sold in oral forms. I have seen very few topical hair regrowth versions, and they are almost always criminally underdosed. A lot of sources sell oral VPA (in Minecraft), and since most of you lot already have your hands on such sources - I see absolutely no issue in acquiring said oral VPA (in Minecraft) & preparing your own topical solution.

When discussed earlier by some users on the forum (primarily on the aforementioned thread, as VPA has been generally slept on within the context of hair regrowth), most of them came across the same issue - its solubility. They were unable to dissolve the tablets properly, with the aim of leaving only VPA in the mix.

I’m going to teach you how to prepare exactly 100ml of the solution, as it is easy to calculate ingredient volumes for & because it’s way easier to prepare.

Yes, they do sell some VPA compounds in liquid form, but that doesn’t mean that they’re already good to go for topical application, as they’re meant to be injected. In this prep guide, I have added every essential ingredient and weighed the most optimal amounts to both ensure it has a long enough shelf life, AND optimal pharmacokinetics, so as little solution goes to waste, as possible. I’m going to keep the preparation process very concise & simple to make it more accessible to the average user. So here we go:

Ingredients (total needed for 100ml of our potion):​

8.5g Non-Prolonged Release Convulex (or any other non-prolonged valproic acid tablets; Whatever you use, make sure the amount of raw VPA you’re extracting ends up at 8.3-8.5g or just slightly above, as the optimal VPA concentration was found to be around 8.3%, and we do not want to underdose. Always double-check the purity of your VPA product of choice. If you have a source for pure VPA with no binders - definitely get that, as things like said Convulex would still have excipients left after dissolving, and although they don’t matter too much - it would still be nice to have purity as high as it can be, of course);

Around 100ml PBS (I recommend just buying 300-500ml tbh. I know PBS is kinda hard to source, but I managed to successfully order it within like 5min, so you probably can too) - this will be our solvent;

0.75ml Preservative Eco (you can use other preservatives, but this is just the easiest to source/use) - this will adjust the solution’s shelf life from UNDER 24h to OVER 30 days.

Equipment:
​

- 0.45um Filter paper;

- 100ml Spray bottle OR Dropper bottle;

- 1cc Syringe;

- Funnel;

- Two 100ml+ Beakers (optional, but handy for measuring volume).

Preparation:​

1.) Thoroughly crush up (or extract from capsules) 8.5g worth of Convulex;

2.) Add it to our first beaker containing 70ml of PBS;

3.) Stir well for 15-30min (yes this takes ages, but we NEED it to dissolve properly. Just browse Offtopic while doing that or some shit);

4.) Fold the filter paper as shown on the diagram:

View attachment 3861415

& fit it into the funnel, then insert this filter contraption you just made into the other, clean beaker;

5.) Pour the solution you made through the filter (do it gradually, so that it doesn’t overfill/splash) until all of it has passed through said filter & into the beaker. Then remove the filter;

6.) Draw & add 0.75ml of Preservative Eco using the syringe;

7.) Add more PBS until the total solution volume reaches 100ml;

8.) Stir for a few minutes to ensure everything is mixed;

9.) Carefully transfer what you just made into the dropper/spray bottle.

Storage & Usage Protocol:​

Store refrigerated at around 4ºC.

Apply all over alopecia-affected areas twice daily. For optimal results, consistently use for no less than 24 months.

Side effects profile:​

Irritation/Redness - <5% incidence;

Itching/dryness - very rare;

Allergic Dermatitis - <1% incidence;

(Recommended to) discontinue/reduce usage if any of these occur.

No tolerance/relapse upon discontinuation observed in any study.

---

Chapter IV: Our good old friend, GHK-Cu ​

Being the absolute beast of a compound that GHK-Cu is, not only does it provide a MASSIVE range of other various benefits, which you can read about in this great thread, but it also activates the Wnt/β-catenin pathway, as well as boosting collagen IV & elastin synthesis in the perifollicular extracellular matrix, which further strengthens the hair & improves its anchorage.

Other good news: since you stocked up on the PBS to craft the topical VPA - you now have a solution, which is superior to BAC water at reconstitution of GHK-Cu.

Optimal GHK-Cu protocols are usually 2-5mg/day. I personally use 2mg, as that is more than enough to reap all of its benefits, whilst saving you a lot of the compound.

All of the above is also explained in the aforementioned thread.

---

Chapter V: Other Similar Compounds​

There are a few other compounds similar to VPA that I have looked into for quite a bit, and was going to figure out & add their topical preparation methods to this thread - however, they are mostly unattainable in the right quantities/forms as of now. Things like PTD-DMB, a synthetic peptide that inhibits the CXXC5 protein, which is another known Wnt/β-catenin inhibitor; or Methyl Vanillate, which upregulates WNT10B expression in the scalp, thereby further upregulating Wnt/β-catenin activity - are only a few of these compounds. They have even been mixed & matched in clinical trials before, obviously showing synergistic effects, but unfortunately, as mentioned above, are currently not viable to DIY due to different limitations. Then, there’s PP405, but I won’t even start about that, as you cannot get your hands on it in ANY quantity as of now. If there were any other effective Wnt/β-catenin activators, I would have definitely added them to the cocktail.

There are some obscure topical products on the market claiming to have, for example PTD-DMB, but I simply do not trust them. If you want to, you can try mixing one of those with the VPA solution, but do so at your own & your money’s risk.

---

Chapter VI: “Ancillaries”​

I would greatly recommend combining the GHK-Cu/Topical VPA treatment with the following for the best synergistic effects:

- Good old topical minoxidil, applied twice daily (or alternatively, an optimal oral protocol). Benefits mentioned further up in the thread. Side effects include heart palpitations risk (uncommon) & tolerance buildup;

- Tretinoin on the affected areas (assuming you aren’t on it already - start with 0.025% EON & taper up after a few months of use) upregulates sulfotransferase enzyme & promotes follicular proliferation and differention (mainly due to it also promoting collagen & elastin syntehsis). Side effects include burning/itching/redness/chapping/slight hyperpigmentation of the skin, but they only usually persist at the beginning whilst the skin cell turnover is taking place;

- Microneedling the area twice weekly to improve absorption & further stimulate bloodflow and collagen synthesis - more info on microneedling here;

- Nightly application of RU58841 - does not only enforce hair loss prevention through AR binding, but also stimulates a lot of follicles into reentering the anagen phase - more info on RU58841 here.

---

Chapter VII: Prevention is Infinitely Better than Treatment


“You are as old as your hairline & collagen” ​

I have seen a lot of people constantly frantically search for effective & sustainable hair regrowth methods - but to no avail, ending up on a trip to Turkey. This guide is an effort to aid these people at, once again, returning their youthfulness with an effective technique. Sadly, basically nothing in this world, including this method, has a 100% success rate, even if something, again including this method, works really well.

My point is: Please do not let the Norwood Reaper get to you in the first place - and take proper precautions. There are plenty of guides on said percautions & how to take them properly.

Hope this helps bhais <3

Spoiler: Tagging Cuties

@menas (again jfl) @Zagro @chadbeingmade @Jonasㅤㅤ @AverageTevvezFan @curryascenderr @coispet @loyolaxavvierretard @truthhurts @BonesmashFinalBoss @AverageCurryEnjoyer

Where do you get your VPA from can’t find a source.

 

[Sadist]

Where do you get your VPA from can’t find a source.

what region are u in?

 

[Sadist]

Vpa and for sure pp405 don”t work

Both of those things don”t work, pure garbage

because?..

 

[Akatlyn]

What about topicals retinoids?

 

[Сигма Бой]

Exactly what i said

Ass sed tha self thang, read up!

 

[DR. NICKGA]

because?..

Try it out, and you will see for yourself

 

[thejcpenny]

hairloss is caused by ejaculation

 

[Sadist]

What about topicals retinoids?

i mentioned

 

[Deleted member 110192]

i mentioned

Niggas just be saying shi instead of reading the thread JFL.

 

[Sadist]

Lemme condense this thread 4 y'all:

Nothing significant fore mentioning beez noted of that thread. We'se absorbed none enlightenment thereof.

what even is going on atp

 

[Akatlyn]

i mentioned

Sorry I didn't see it

 

[thejcpenny]

prolactin is root cause:

The true and final cause for hairloss

The truth about hair loss (its not genetic) The more you ejaculate throughout your life that more your hair will fall because it is simply a biological indication of fertility for men (our mane). In our current generation with porn being so prevalent and masturbation being normalized, hair loss...

looksmax.org

you have to be alchemist to regrow that shit

 

[LTNUser]

What language do you speak brother?

Boujopp nikklorrryttf

 

[Сигма Бой]

What language do you speak brother?

God knows.

 

[Сигма Бой]

what even is going on atp

 

[aids]

Yes
you can’t even use 5ar blockers with a lot of steroids because it’ll either just simply not work or cause even more hairloss

Larp.
Can't use it with DHT derivatives because inhibiting 5AR doesn't do shit for that, i.e., you can use them but it won't help to mitigate hair loss as a result of the use of DHT derivatives.
Fin/Dut will never cause "more hairloss". It will at the very least prevent the conversion of exogenous testosterone to bioidentical DHT.

 

[slaters]

Larp.
Can't use it with DHT derivatives because inhibiting 5AR doesn't do shit for that, i.e., you can use them but it won't help to mitigate hair loss as a result of the use of DHT derivatives.
Fin/Dut will never cause "more hairloss". It will at the very least prevent the conversion of exogenous testosterone to bioidentical DHT.

I should’ve said it just doesn’t do shit your right
But 5ar in conjunction with nandrolones stop their conversion to dhn which will rape your hair more than with no 5ar

 

[aids]

I should’ve said it just doesn’t do shit your right

Don't worry, I get the point. The effect will vary obviously dependent on what you're using but for simple cycles, it will still help.

But 5ar in conjunction with nandrolones stop their conversion to dhn which will rape your hair more than with no 5ar

Not sure about this. So I'll take your word at face value.

 

[slaters]

Don't worry, I get the point. The effect will vary obviously dependent on what you're using but for simple cycles, it will still help.


Not sure about this. So I'll take your word at face value.

DHN is the less potent form of dht which is why people say stuff like deca are generally more hair safe but stopping that conversion to dhn means more blood circulation of nandrolone which bind more to your hair than dhn

 

[aids]

DHN is the less potent form of dht which is why people say stuff like deca are generally more hair safe but stopping that conversion to dhn means more blood circulation of nandrolone which bind more to your hair than dhn

Fair play, I've never considered taking a 19-nors so thankfully not something I need to worry about.
Good explanation though.

 

[slaters]

Fair play, I've never considered taking a 19-nors so thankfully not something I need to worry about.
Good explanation though.

Kiss me

 

[Sonder53]

what region are u in?

EU

 

[Akatlyn]

prolactin is root cause:

The true and final cause for hairloss

The truth about hair loss (its not genetic) The more you ejaculate throughout your life that more your hair will fall because it is simply a biological indication of fertility for men (our mane). In our current generation with porn being so prevalent and masturbation being normalized, hair loss...

looksmax.org

you have to be alchemist to regrow that shit

No this is just not true

 

[Deleted member 142979]

mirin effort

 

[swerveordie997]

No the topical I was gonna buy from originally might be bunk but I’m getting a source for VPA with no binders soon hopefully

Where u getting ur VPA from bro?

 

[wishIwasSalludon]

Very good thread and bookmarked

Nice job OP

 

[Sadist]

Where u getting ur VPA from bro?

quite a known source around here sells it (if youre from the EU)
i also recently realized indiamart sells 95%+ purity vpa powder so that mogs as well

 

[zaideas]

so dut and minoxidil won't save my hairline alone

 

[Sadist]

so dut and minoxidil won't save my hairline alone

they will; this is a topical (localized) preventative OR regrowth measure

 

[zaideas]

they will; this is a topical (localized) preventative OR regrowth measure

im at Norwood 2 but my sides are dense hair not empty with crown balding and I just started dut a month ago, do you thing I would eventually result to doing this

 

[Sadist]

im at Norwood 2 but my sides are dense hair not empty with crown balding and I just started dut a month ago, do you thing I would eventually result to doing this

idk man
ty the basics; if they dont work - be my guest

 

[Deleted member 138051]

View attachment 3861690
DEFYING NORWOOD:
UNCOVERING ONE OF THE LAST PILLARS OF HAIR REGROWTH
By Sadist

Spoiler: DISCLAIMER

DISCLAIMER: This thread may singlehandedly crash Turkey’s economy; @menas, sorry for your inevitable poverty in advance bud.

Spoiler: REAL DISCLAIMER

REAL DISCLAIMER: By no means is this medical advice. Even though the risks are low, everyone is different and some people may respond to this differently to others. Consult a medical professional before taking any of the following steps.

​

Sick of the dreaded Norwood Reaper, which has done seemingly irreversible damage to your precious hairline? Tried everything to get your luscious hair back, but still saw minimal hair regrowth? Well worry not - for daddy Sadist has you covered on this topic.

Before we start - this thread assumes that if you’re interested in yielding regrowth benefits from the info provided due to experiencing hair loss - you have a brain and are already taking optimal preventative measures to stop further hair loss.

Spoiler: THREAD SONG

---

Chapter I: Introduction​

Many different pathways are responsible for hair growth, or alternatively - its stagnation. Obviously, disrupting the right OR assisting the wrong pathways will jeopardize the entire hair growth process, and start the balding process. This is exactly what happens during androgenetic alopecia.

As we all know, Testosterone is converted into Dihydrotestosterone through 5alpha-reductase. DHT then binds to hair follicles, disrupting said essential hair growth pathways & causing said hair loss. 5AR inhibitors, such as Finasteride or Dutasteride stop this process by blocking 5AR activity, which therefore prevents Testosterone converting into DHT.

Whilst this stops further hair loss, old hairs usually never come back, especially at further stages of Norwood. Some people try to compensate by using products like Minoxidil, but it only does so much at hairline regrowth - so most give up, and end up getting a hair transplant.

---

Chapter II: One of the Most Important Hair Growth Pathways​

A very important hair growth pathway, which is almost completely inhibited during Norwood is the Wnt/β-catenin signaling pathway. It is responsible for transforming the hair follicle cycle from the telogen (resting) phase into anagen (growth) phase, which is absolutely crucial for proper hair development, as it promotes hair stem cell activation.

Whilst Minoxidil promotes hair regrowth in the alopecia-affected areas through stimulation of microcirculation around hair follicles, causing arteriolar vasodilation, it usually creates relatively mild improvements. This is entirely due to the fact that it does not target any hair growth pathways DIRECTLY, unlike…

---

Chapter III, Pt. 1: An Introduction to Valproic Acid​

Valproic Acid (which I will be referring to as VPA from now on) is an anticonvulsant, used to treat epilepsy, manic phases of bipolar disorder & other similar conditions. If ingested orally, it has NEGATIVE effects on hair regrowth.
So how does a seemingly random epilepsy medicine, which CONTRIBUTES to hair loss, come anywhere near being one of the best hair loss treatments?
Well, see - although it bares negative effects in its oral form - if converted into a topical solution, it becomes absolutely great for hair regrowth.

Topical VPA application inhibits the GSK3β protein, thereby allowing the aforementioned Wnt/β-catenin signaling to take place (as GSK3β inhibits Wnt/β-catenin). This, obviously, allows hair follicles to enter the previously-discussed anagen phase. Additionally, it activates Erk & Akt pathways, which also contribute to hair growth.

And since it is applied topically, its systemic effects are negligible compared to its oral form, which, as discussed earlier, can actually induce alopecia itself by depleting your body of trace minerals & biotin, overshadowing its positive effects on hair regrowth.

And just to put its strength into perspective - one study showed, that after a 24-week cycle, VPA significantly regrew hair in areas affected by Norwood III & even Norwood IV. In another study (this one done on foids but fuck it) it was shown, that after 6 months, hair count doubled (from about 49/cm^2 to about 99/cm^2). There’s more studies on it that show great results, but I would rather let you lot see just how well it works for yourself:

View attachment 3860799
Fig. 1:
a, b, c, d - 3 months VPA; e, f, g, h - 3 months Placebo
(bottom pictures showing extreme close-ups).


View attachment 3860807
Fig. 2:
Results that @Mr_wax talked about in his thread (even though he was struggling to make a 100% effective topical VPA due to incomplete solution, he still did manage to apply it, and this is the effect that he got).​

---

Chapter III, Pt. 2: Preparation of Topical VPA​

VPA is mainly only sold in oral forms. I have seen very few topical hair regrowth versions, and they are almost always criminally underdosed. A lot of sources sell oral VPA (in Minecraft), and since most of you lot already have your hands on such sources - I see absolutely no issue in acquiring said oral VPA (in Minecraft) & preparing your own topical solution.

When discussed earlier by some users on the forum (primarily on the aforementioned thread, as VPA has been generally slept on within the context of hair regrowth), most of them came across the same issue - its solubility. They were unable to dissolve the tablets properly, with the aim of leaving only VPA in the mix.

I’m going to teach you how to prepare exactly 100ml of the solution, as it is easy to calculate ingredient volumes for & because it’s way easier to prepare.

Yes, they do sell some VPA compounds in liquid form, but that doesn’t mean that they’re already good to go for topical application, as they’re meant to be injected. In this prep guide, I have added every essential ingredient and weighed the most optimal amounts to both ensure it has a long enough shelf life, AND optimal pharmacokinetics, so as little solution goes to waste, as possible. I’m going to keep the preparation process very concise & simple to make it more accessible to the average user. So here we go:

Ingredients (total needed for 100ml of our potion):​

8.5g Non-Prolonged Release Convulex (or any other non-prolonged valproic acid tablets; Whatever you use, make sure the amount of raw VPA you’re extracting ends up at 8.3-8.5g or just slightly above, as the optimal VPA concentration was found to be around 8.3%, and we do not want to underdose. Always double-check the purity of your VPA product of choice. If you have a source for pure VPA with no binders - definitely get that, as things like said Convulex would still have excipients left after dissolving, and although they don’t matter too much - it would still be nice to have purity as high as it can be, of course);

Around 100ml PBS (I recommend just buying 300-500ml tbh. I know PBS is kinda hard to source, but I managed to successfully order it within like 5min, so you probably can too) - this will be our solvent;

0.75ml Preservative Eco (you can use other preservatives, but this is just the easiest to source/use) - this will adjust the solution’s shelf life from UNDER 24h to OVER 30 days.

Equipment:
​

- 0.45um Filter paper;

- 100ml Spray bottle OR Dropper bottle;

- 1cc Syringe;

- Funnel;

- Two 100ml+ Beakers (optional, but handy for measuring volume).

Preparation:​

1.) Thoroughly crush up (or extract from capsules) 8.5g worth of Convulex;

2.) Add it to our first beaker containing 70ml of PBS;

3.) Stir well for 15-30min (yes this takes ages, but we NEED it to dissolve properly. Just browse Offtopic while doing that or some shit);

4.) Fold the filter paper as shown on the diagram:

View attachment 3861415

& fit it into the funnel, then insert this filter contraption you just made into the other, clean beaker;

5.) Pour the solution you made through the filter (do it gradually, so that it doesn’t overfill/splash) until all of it has passed through said filter & into the beaker. Then remove the filter;

6.) Draw & add 0.75ml of Preservative Eco using the syringe;

7.) Add more PBS until the total solution volume reaches 100ml;

8.) Stir for a few minutes to ensure everything is mixed;

9.) Carefully transfer what you just made into the dropper/spray bottle.

Storage & Usage Protocol:​

Store refrigerated at around 4ºC.

Apply all over alopecia-affected areas twice daily. For optimal results, consistently use for no less than 24 months.

Side effects profile:​

Irritation/Redness - <5% incidence;

Itching/dryness - very rare;

Allergic Dermatitis - <1% incidence;

(Recommended to) discontinue/reduce usage if any of these occur.

No tolerance/relapse upon discontinuation observed in any study.

---

Chapter IV: Our good old friend, GHK-Cu ​

Being the absolute beast of a compound that GHK-Cu is, not only does it provide a MASSIVE range of other various benefits, which you can read about in this great thread, but it also activates the Wnt/β-catenin pathway, as well as boosting collagen IV & elastin synthesis in the perifollicular extracellular matrix, which further strengthens the hair & improves its anchorage.

Other good news: since you stocked up on the PBS to craft the topical VPA - you now have a solution, which is superior to BAC water at reconstitution of GHK-Cu.

Optimal GHK-Cu protocols are usually 2-5mg/day. I personally use 2mg, as that is more than enough to reap all of its benefits, whilst saving you a lot of the compound.

All of the above is also explained in the aforementioned thread.

---

Chapter V: Other Similar Compounds​

There are a few other compounds similar to VPA that I have looked into for quite a bit, and was going to figure out & add their topical preparation methods to this thread - however, they are mostly unattainable in the right quantities/forms as of now. Things like PTD-DMB, a synthetic peptide that inhibits the CXXC5 protein, which is another known Wnt/β-catenin inhibitor; or Methyl Vanillate, which upregulates WNT10B expression in the scalp, thereby further upregulating Wnt/β-catenin activity - are only a few of these compounds. They have even been mixed & matched in clinical trials before, obviously showing synergistic effects, but unfortunately, as mentioned above, are currently not viable to DIY due to different limitations. Then, there’s PP405, but I won’t even start about that, as you cannot get your hands on it in ANY quantity as of now. If there were any other effective Wnt/β-catenin activators, I would have definitely added them to the cocktail.

There are some obscure topical products on the market claiming to have, for example PTD-DMB, but I simply do not trust them. If you want to, you can try mixing one of those with the VPA solution, but do so at your own & your money’s risk.

---

Chapter VI: “Ancillaries”​

I would greatly recommend combining the GHK-Cu/Topical VPA treatment with the following for the best synergistic effects:

- Good old topical minoxidil, applied twice daily (or alternatively, an optimal oral protocol). Benefits mentioned further up in the thread. Side effects include heart palpitations risk (uncommon) & tolerance buildup;

- Tretinoin on the affected areas (assuming you aren’t on it already - start with 0.025% EON & taper up after a few months of use) upregulates sulfotransferase enzyme & promotes follicular proliferation and differention (mainly due to it also promoting collagen & elastin syntehsis). Side effects include burning/itching/redness/chapping/slight hyperpigmentation of the skin, but they only usually persist at the beginning whilst the skin cell turnover is taking place;

- Microneedling the area twice weekly to improve absorption & further stimulate bloodflow and collagen synthesis - more info on microneedling here;

- Nightly application of RU58841 - does not only enforce hair loss prevention through AR binding, but also stimulates a lot of follicles into reentering the anagen phase - more info on RU58841 here.

---

Chapter VII: Prevention is Infinitely Better than Treatment


“You are as old as your hairline & collagen” ​

I have seen a lot of people constantly frantically search for effective & sustainable hair regrowth methods - but to no avail, ending up on a trip to Turkey. This guide is an effort to aid these people at, once again, returning their youthfulness with an effective technique. Sadly, basically nothing in this world, including this method, has a 100% success rate, even if something, again including this method, works really well.

My point is: Please do not let the Norwood Reaper get to you in the first place - and take proper precautions. There are plenty of guides on said percautions & how to take them properly.

Hope this helps bhais <3

Spoiler: Tagging Cuties

@menas (again jfl) @Zagro @chadbeingmade @Jonasㅤㅤ @AverageTevvezFan @curryascenderr @coispet @loyolaxavvierretard @truthhurts @BonesmashFinalBoss @AverageCurryEnjoyer

Good thread but kinda pointless.
Assuming you’re already at NW 2-4 it’s better to just take dut, RU and topical minoxidil with micro needling.

 

[Sadist]

Good thread but kinda pointless.
Assuming you’re already at NW 2-4 it’s better to just take dut, RU and topical minoxidil with micro needling.

brah
i said it in the thread brah
this is an amazing addition to the things listed
and far from pointless

 

[Kirby7000]

REP ME!!

reported. yw

 

[truexeno]

N

View attachment 3861690
DEFYING NORWOOD:
UNCOVERING ONE OF THE LAST PILLARS OF HAIR REGROWTH
By Sadist

Spoiler: DISCLAIMER

DISCLAIMER: This thread may singlehandedly crash Turkey’s economy; @menas, sorry for your inevitable poverty in advance bud.

Spoiler: REAL DISCLAIMER

REAL DISCLAIMER: By no means is this medical advice. Even though the risks are low, everyone is different and some people may respond to this differently to others. Consult a medical professional before taking any of the following steps.

​

Sick of the dreaded Norwood Reaper, which has done seemingly irreversible damage to your precious hairline? Tried everything to get your luscious hair back, but still saw minimal hair regrowth? Well worry not - for daddy Sadist has you covered on this topic.

Before we start - this thread assumes that if you’re interested in yielding regrowth benefits from the info provided due to experiencing hair loss - you have a brain and are already taking optimal preventative measures to stop further hair loss.

Spoiler: THREAD SONG

---

Chapter I: Introduction​

Many different pathways are responsible for hair growth, or alternatively - its stagnation. Obviously, disrupting the right OR assisting the wrong pathways will jeopardize the entire hair growth process, and start the balding process. This is exactly what happens during androgenetic alopecia.

As we all know, Testosterone is converted into Dihydrotestosterone through 5alpha-reductase. DHT then binds to hair follicles, disrupting said essential hair growth pathways & causing said hair loss. 5AR inhibitors, such as Finasteride or Dutasteride stop this process by blocking 5AR activity, which therefore prevents Testosterone converting into DHT.

Whilst this stops further hair loss, old hairs usually never come back, especially at further stages of Norwood. Some people try to compensate by using products like Minoxidil, but it only does so much at hairline regrowth - so most give up, and end up getting a hair transplant.

---

Chapter II: One of the Most Important Hair Growth Pathways​

A very important hair growth pathway, which is almost completely inhibited during Norwood is the Wnt/β-catenin signaling pathway. It is responsible for transforming the hair follicle cycle from the telogen (resting) phase into anagen (growth) phase, which is absolutely crucial for proper hair development, as it promotes hair stem cell activation.

Whilst Minoxidil promotes hair regrowth in the alopecia-affected areas through stimulation of microcirculation around hair follicles, causing arteriolar vasodilation, it usually creates relatively mild improvements. This is entirely due to the fact that it does not target any hair growth pathways DIRECTLY, unlike…

---

Chapter III, Pt. 1: An Introduction to Valproic Acid​

Valproic Acid (which I will be referring to as VPA from now on) is an anticonvulsant, used to treat epilepsy, manic phases of bipolar disorder & other similar conditions. If ingested orally, it has NEGATIVE effects on hair regrowth.
So how does a seemingly random epilepsy medicine, which CONTRIBUTES to hair loss, come anywhere near being one of the best hair loss treatments?
Well, see - although it bares negative effects in its oral form - if converted into a topical solution, it becomes absolutely great for hair regrowth.

Topical VPA application inhibits the GSK3β protein, thereby allowing the aforementioned Wnt/β-catenin signaling to take place (as GSK3β inhibits Wnt/β-catenin). This, obviously, allows hair follicles to enter the previously-discussed anagen phase. Additionally, it activates Erk & Akt pathways, which also contribute to hair growth.

And since it is applied topically, its systemic effects are negligible compared to its oral form, which, as discussed earlier, can actually induce alopecia itself by depleting your body of trace minerals & biotin, overshadowing its positive effects on hair regrowth.

And just to put its strength into perspective - one study showed, that after a 24-week cycle, VPA significantly regrew hair in areas affected by Norwood III & even Norwood IV. In another study (this one done on foids but fuck it) it was shown, that after 6 months, hair count doubled (from about 49/cm^2 to about 99/cm^2). There’s more studies on it that show great results, but I would rather let you lot see just how well it works for yourself:

View attachment 3860799
Fig. 1:
a, b, c, d - 3 months VPA; e, f, g, h - 3 months Placebo
(bottom pictures showing extreme close-ups).


View attachment 3860807
Fig. 2:
Results that @Mr_wax talked about in his thread (even though he was struggling to make a 100% effective topical VPA due to incomplete solution, he still did manage to apply it, and this is the effect that he got).​

---

Chapter III, Pt. 2: Preparation of Topical VPA​

VPA is mainly only sold in oral forms. I have seen very few topical hair regrowth versions, and they are almost always criminally underdosed. A lot of sources sell oral VPA (in Minecraft), and since most of you lot already have your hands on such sources - I see absolutely no issue in acquiring said oral VPA (in Minecraft) & preparing your own topical solution.

When discussed earlier by some users on the forum (primarily on the aforementioned thread, as VPA has been generally slept on within the context of hair regrowth), most of them came across the same issue - its solubility. They were unable to dissolve the tablets properly, with the aim of leaving only VPA in the mix.

I’m going to teach you how to prepare exactly 100ml of the solution, as it is easy to calculate ingredient volumes for & because it’s way easier to prepare.

Yes, they do sell some VPA compounds in liquid form, but that doesn’t mean that they’re already good to go for topical application, as they’re meant to be injected. In this prep guide, I have added every essential ingredient and weighed the most optimal amounts to both ensure it has a long enough shelf life, AND optimal pharmacokinetics, so as little solution goes to waste, as possible. I’m going to keep the preparation process very concise & simple to make it more accessible to the average user. So here we go:

Ingredients (total needed for 100ml of our potion):​

8.5g Non-Prolonged Release Convulex (or any other non-prolonged valproic acid tablets; Whatever you use, make sure the amount of raw VPA you’re extracting ends up at 8.3-8.5g or just slightly above, as the optimal VPA concentration was found to be around 8.3%, and we do not want to underdose. Always double-check the purity of your VPA product of choice. If you have a source for pure VPA with no binders - definitely get that, as things like said Convulex would still have excipients left after dissolving, and although they don’t matter too much - it would still be nice to have purity as high as it can be, of course);

Around 100ml PBS (I recommend just buying 300-500ml tbh. I know PBS is kinda hard to source, but I managed to successfully order it within like 5min, so you probably can too) - this will be our solvent;

0.75ml Preservative Eco (you can use other preservatives, but this is just the easiest to source/use) - this will adjust the solution’s shelf life from UNDER 24h to OVER 30 days.

Equipment:
​

- 0.45um Filter paper;

- 100ml Spray bottle OR Dropper bottle;

- 1cc Syringe;

- Funnel;

- Two 100ml+ Beakers (optional, but handy for measuring volume).

Preparation:​

1.) Thoroughly crush up (or extract from capsules) 8.5g worth of Convulex;

2.) Add it to our first beaker containing 70ml of PBS;

3.) Stir well for 15-30min (yes this takes ages, but we NEED it to dissolve properly. Just browse Offtopic while doing that or some shit);

4.) Fold the filter paper as shown on the diagram:

View attachment 3861415

& fit it into the funnel, then insert this filter contraption you just made into the other, clean beaker;

5.) Pour the solution you made through the filter (do it gradually, so that it doesn’t overfill/splash) until all of it has passed through said filter & into the beaker. Then remove the filter;

6.) Draw & add 0.75ml of Preservative Eco using the syringe;

7.) Add more PBS until the total solution volume reaches 100ml;

8.) Stir for a few minutes to ensure everything is mixed;

9.) Carefully transfer what you just made into the dropper/spray bottle.

Storage & Usage Protocol:​

Store refrigerated at around 4ºC.

Apply all over alopecia-affected areas twice daily. For optimal results, consistently use for no less than 24 months.

Side effects profile:​

Irritation/Redness - <5% incidence;

Itching/dryness - very rare;

Allergic Dermatitis - <1% incidence;

(Recommended to) discontinue/reduce usage if any of these occur.

No tolerance/relapse upon discontinuation observed in any study.

---

Chapter IV: Our good old friend, GHK-Cu ​

Being the absolute beast of a compound that GHK-Cu is, not only does it provide a MASSIVE range of other various benefits, which you can read about in this great thread, but it also activates the Wnt/β-catenin pathway, as well as boosting collagen IV & elastin synthesis in the perifollicular extracellular matrix, which further strengthens the hair & improves its anchorage.

Other good news: since you stocked up on the PBS to craft the topical VPA - you now have a solution, which is superior to BAC water at reconstitution of GHK-Cu.

Optimal GHK-Cu protocols are usually 2-5mg/day. I personally use 2mg, as that is more than enough to reap all of its benefits, whilst saving you a lot of the compound.

All of the above is also explained in the aforementioned thread.

---

Chapter V: Other Similar Compounds​

There are a few other compounds similar to VPA that I have looked into for quite a bit, and was going to figure out & add their topical preparation methods to this thread - however, they are mostly unattainable in the right quantities/forms as of now. Things like PTD-DMB, a synthetic peptide that inhibits the CXXC5 protein, which is another known Wnt/β-catenin inhibitor; or Methyl Vanillate, which upregulates WNT10B expression in the scalp, thereby further upregulating Wnt/β-catenin activity - are only a few of these compounds. They have even been mixed & matched in clinical trials before, obviously showing synergistic effects, but unfortunately, as mentioned above, are currently not viable to DIY due to different limitations. Then, there’s PP405, but I won’t even start about that, as you cannot get your hands on it in ANY quantity as of now. If there were any other effective Wnt/β-catenin activators, I would have definitely added them to the cocktail.

There are some obscure topical products on the market claiming to have, for example PTD-DMB, but I simply do not trust them. If you want to, you can try mixing one of those with the VPA solution, but do so at your own & your money’s risk.

---

Chapter VI: “Ancillaries”​

I would greatly recommend combining the GHK-Cu/Topical VPA treatment with the following for the best synergistic effects:

- Good old topical minoxidil, applied twice daily (or alternatively, an optimal oral protocol). Benefits mentioned further up in the thread. Side effects include heart palpitations risk (uncommon) & tolerance buildup;

- Tretinoin on the affected areas (assuming you aren’t on it already - start with 0.025% EON & taper up after a few months of use) upregulates sulfotransferase enzyme & promotes follicular proliferation and differention (mainly due to it also promoting collagen & elastin syntehsis). Side effects include burning/itching/redness/chapping/slight hyperpigmentation of the skin, but they only usually persist at the beginning whilst the skin cell turnover is taking place;

- Microneedling the area twice weekly to improve absorption & further stimulate bloodflow and collagen synthesis - more info on microneedling here;

- Nightly application of RU58841 - does not only enforce hair loss prevention through AR binding, but also stimulates a lot of follicles into reentering the anagen phase - more info on RU58841 here.

---

Chapter VII: Prevention is Infinitely Better than Treatment


“You are as old as your hairline & collagen” ​

I have seen a lot of people constantly frantically search for effective & sustainable hair regrowth methods - but to no avail, ending up on a trip to Turkey. This guide is an effort to aid these people at, once again, returning their youthfulness with an effective technique. Sadly, basically nothing in this world, including this method, has a 100% success rate, even if something, again including this method, works really well.

My point is: Please do not let the Norwood Reaper get to you in the first place - and take proper precautions. There are plenty of guides on said percautions & how to take them properly.

Hope this helps bhais <3

Spoiler: Tagging Cuties

@menas (again jfl) @Zagro @chadbeingmade @Jonasㅤㅤ @AverageTevvezFan @curryascenderr @coispet @loyolaxavvierretard @truthhurts @BonesmashFinalBoss @AverageCurryEnjoyer

Nice thread will read

 

[jeantheboneless]

Never heard of VPA before, studies are promosing tho, I will give it a try!

God tier thread btw

 

[iblamemygenes]

Ah nice shit I recently just ordered a big haul as well

drop the haul my nigga

 

[NerverBegan]

i'm on fin with a slight norwood atm,should i drop it and start this complex guide ? The only + would be that this anti-norwood algorithm won't give you heavy side effects like fin could grant

 

[Sadist]

i'm on fin with a slight norwood atm,should i drop it and start this complex guide ? The only + would be that this anti-norwood algorithm won't give you heavy side effects like fin could grant

keep fin but do start this. i have come to realize that this is a great prevention measure too. sides are minimal cos
topical.

all depends on ur 5ar activity and nw level; fin may be enough to prevent, but theres a good chance vpa will recover ur alr existing nw.

 

[vevcred]

Doesn’t Lithium Carbonate work similarly to this? Also reading the rest rn

Hey bro what are your thoughts on inhibiting GSK3B systematically as opposed to locally. Would you still get good results with something like Lithium that works similarly?

Bump

@Sadist what do you think about this?