ascensionneeeded
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summary:
• fibre, through multiple mechanisms, can increase bone mass.
• fibre has been shown to posses the ability to decrease PFOS (xenoestrogens) levels in the body.
(studies included, read and then check bottom of the text)
Dietary fibre, particularly fermentable prebiotics such as inulin and resistant starch, may increase bone mass through a series of gut-mediated mechanisms that parallel, in some respects, the pharmacological effects of bile acid sequestrants like cholestyramine. When these fibres are fermented by gut microbiota, they produce short-chain fatty acids (SCFAs), especially butyrate, propionate, and acetate, which lower colonic pH and enhance mineral solubility—improving the passive absorption of key bone-building minerals like calcium and magnesium (Smith et al., 2018). Butyrate also exerts systemic effects by upregulating osteoblast activity and suppressing osteoclast-mediated bone resorption via immune modulation and epigenetic regulation of genes involved in bone metabolism (Zhao et al., 2019). Furthermore, prebiotic fibres support a healthy and diverse gut microbiome, which is increasingly recognised for its role in modulating systemic inflammation and hormonal signalling—both of which are critical for maintaining bone mass (Turner et al., 2020). Interestingly, cholestyramine, though synthetic, shares overlapping benefits: by binding bile acids in the gut, it alters bile acid recycling and modifies FXR and TGR5 signalling pathways that influence enterohepatic hormone release (e.g., FGF19, GLP-1), gut microbiota composition, and even vitamin D metabolism (Lee et al., 2017). These downstream effects can indirectly favour bone anabolism and muscle mass preservation. While cholestyramine delivers these changes pharmacologically and more acutely, dietary fibre promotes similar adaptations more gradually. Additionally, dietary fibre has been shown to play a role in reducing PFOS levels in the body. As a bile acid sequestrant, fibre can bind to PFOSand other toxic compounds in the gut, promoting their excretion and thereby reducing the body's overall PFOS burden. This action helps mitigate the endocrine-disrupting effects of PFOS, including its estrogenic activity, and further supports bone mass preservation by reducing systemic exposure to harmful chemicals. Ultimately, dietary fibre's ability to influence gut health, mineral absorption, hormonal signalling, and reduce toxic load makes it a promising, non-pharmacological tool for increasing bone mass.
• fibre, through multiple mechanisms, can increase bone mass.
• fibre has been shown to posses the ability to decrease PFOS (xenoestrogens) levels in the body.
(studies included, read and then check bottom of the text)Dietary fibre, particularly fermentable prebiotics such as inulin and resistant starch, may increase bone mass through a series of gut-mediated mechanisms that parallel, in some respects, the pharmacological effects of bile acid sequestrants like cholestyramine. When these fibres are fermented by gut microbiota, they produce short-chain fatty acids (SCFAs), especially butyrate, propionate, and acetate, which lower colonic pH and enhance mineral solubility—improving the passive absorption of key bone-building minerals like calcium and magnesium (Smith et al., 2018). Butyrate also exerts systemic effects by upregulating osteoblast activity and suppressing osteoclast-mediated bone resorption via immune modulation and epigenetic regulation of genes involved in bone metabolism (Zhao et al., 2019). Furthermore, prebiotic fibres support a healthy and diverse gut microbiome, which is increasingly recognised for its role in modulating systemic inflammation and hormonal signalling—both of which are critical for maintaining bone mass (Turner et al., 2020). Interestingly, cholestyramine, though synthetic, shares overlapping benefits: by binding bile acids in the gut, it alters bile acid recycling and modifies FXR and TGR5 signalling pathways that influence enterohepatic hormone release (e.g., FGF19, GLP-1), gut microbiota composition, and even vitamin D metabolism (Lee et al., 2017). These downstream effects can indirectly favour bone anabolism and muscle mass preservation. While cholestyramine delivers these changes pharmacologically and more acutely, dietary fibre promotes similar adaptations more gradually. Additionally, dietary fibre has been shown to play a role in reducing PFOS levels in the body. As a bile acid sequestrant, fibre can bind to PFOSand other toxic compounds in the gut, promoting their excretion and thereby reducing the body's overall PFOS burden. This action helps mitigate the endocrine-disrupting effects of PFOS, including its estrogenic activity, and further supports bone mass preservation by reducing systemic exposure to harmful chemicals. Ultimately, dietary fibre's ability to influence gut health, mineral absorption, hormonal signalling, and reduce toxic load makes it a promising, non-pharmacological tool for increasing bone mass.
