apn8197
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I recently made a guide ( debloat )
I went deeper into my research and found a way to limit the side effects of HCTZ even further.
Knowing that taking it alone rarely causes side effects
——
To limit any side effects
There is a name for this in medicine
And it is called: Co-amilozide:
It is a combination of amiloride + hydrochlorothiazide
——
This has been commercialized and is called co-amilozide
( As I mentioned, it contains either 5 mg of AMI and 50 mg of HCTZ or 2.5 mg of AMI and 25 mg of HCTZ )
-------
There are numerous studies that have specifically looked at the combination of amiloride - HCTZ.
Here are the main ones:
Andersson et al. 1984 (Clinical Pharmacology & Therapeutics)
Title: “Potassium sparing by amiloride during thiazide therapy in hypertension”
- Double-blind study in hypertensive patients.
- They specifically tested whether 2.5 mg of amiloride was sufficient to protect potassium when 25 mg of HCTZ was given (knowing that 5 mg of amiloride provides good protection against 50 mg of HCTZ).
- Result: yes the 2.5/25 combo did have a potassium-sparing effect compared with HCTZ 25 mg alone.
This is the study that most clearly justifies the low-dose 2.5/25 co-amilozide.
Another important study (slightly higher dose but same principle)
Larochelle & Logan, 1985 (Canadian Medical Association Journal)
- Comparison of HCTZ + amiloride (Moduret, therefore 5/50) vs HCTZ alone in 266 patients.
- Same effectiveness on blood pressure, but much less hypokalemia with the combo (14% vs 29%).
More recent and higher-quality study (PATHWAY-3, 2015-2016)
- This is the most modern and most widely cited study today:
- Comparison of HCTZ alone, amiloride alone, and a half-dose combination (starting at 5 mg amiloride + 12.5 mg HCTZ, then doubling).
- The half dose combination lowered blood pressure better and better protected metabolism (glucose) than HCTZ alone, while maintaining stable potassium.
In short
• The Andersson 1984 study is the one that directly validated that 2.5 mg of amiloride + 25 mg of HCTZ has a potassium-protective effect.
• The larger studies (including PATHWAY-3) confirm that combining amiloride + HCTZ is generally preferable to HCTZ alone for limiting side effects (especially hypokalemia and the impact on blood sugar).
For combination doses
Co-amilozide 2.5 mg / 25 mg → amiloride 2.5 mg + HCTZ 25 mg
• Co-amilozide 5 mg / 50 mg → amiloride 5 mg + HCTZ 50 mg
androgenic had already mentioned this method
And had even made a TikTok about it that had accumulated 2 million views and 188k likes:soja::soja::soja::soja:
note that this will not correct your blood pressure so do not overuse
---------------
Regarding the sources – finding 2.5 mg amiloride is impossible, so take co-amilozide directly. And for the 5/50 combination, you can either combine them or take co-amilozide
I went deeper into my research and found a way to limit the side effects of HCTZ even further.
Knowing that taking it alone rarely causes side effects
——
To limit any side effects
There is a name for this in medicine
And it is called: Co-amilozide:
It is a combination of amiloride + hydrochlorothiazide
——
This has been commercialized and is called co-amilozide
( As I mentioned, it contains either 5 mg of AMI and 50 mg of HCTZ or 2.5 mg of AMI and 25 mg of HCTZ )
-------
There are numerous studies that have specifically looked at the combination of amiloride - HCTZ.
Here are the main ones:
Andersson et al. 1984 (Clinical Pharmacology & Therapeutics)
Title: “Potassium sparing by amiloride during thiazide therapy in hypertension”
- Double-blind study in hypertensive patients.
- They specifically tested whether 2.5 mg of amiloride was sufficient to protect potassium when 25 mg of HCTZ was given (knowing that 5 mg of amiloride provides good protection against 50 mg of HCTZ).
- Result: yes the 2.5/25 combo did have a potassium-sparing effect compared with HCTZ 25 mg alone.
This is the study that most clearly justifies the low-dose 2.5/25 co-amilozide.
Another important study (slightly higher dose but same principle)
Larochelle & Logan, 1985 (Canadian Medical Association Journal)
- Comparison of HCTZ + amiloride (Moduret, therefore 5/50) vs HCTZ alone in 266 patients.
- Same effectiveness on blood pressure, but much less hypokalemia with the combo (14% vs 29%).
More recent and higher-quality study (PATHWAY-3, 2015-2016)
- This is the most modern and most widely cited study today:
- Comparison of HCTZ alone, amiloride alone, and a half-dose combination (starting at 5 mg amiloride + 12.5 mg HCTZ, then doubling).
- The half dose combination lowered blood pressure better and better protected metabolism (glucose) than HCTZ alone, while maintaining stable potassium.
In short
• The Andersson 1984 study is the one that directly validated that 2.5 mg of amiloride + 25 mg of HCTZ has a potassium-protective effect.
• The larger studies (including PATHWAY-3) confirm that combining amiloride + HCTZ is generally preferable to HCTZ alone for limiting side effects (especially hypokalemia and the impact on blood sugar).
For combination doses
Co-amilozide 2.5 mg / 25 mg → amiloride 2.5 mg + HCTZ 25 mg
• Co-amilozide 5 mg / 50 mg → amiloride 5 mg + HCTZ 50 mg
androgenic had already mentioned this method
And had even made a TikTok about it that had accumulated 2 million views and 188k likes:soja::soja::soja::soja:
note that this will not correct your blood pressure so do not overuse
---------------
Regarding the sources – finding 2.5 mg amiloride is impossible, so take co-amilozide directly. And for the 5/50 combination, you can either combine them or take co-amilozide
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