Dutasteride, considered to be the last line of hairloss drugs is still pretty shit when you think about it

[Rabbi]

The toughest pill to swallow is that dutasteride (and finasteride) while being the most effective drugs we currently have are still pretty shit at what they do.

People often point out that dutasteride nukes 90-95% of DHT but that’s a mistake. That’s serum DHT, if you are looking for anti balding effects what you’re really concerned about is scalp DHT, thinning of hair occurs locally at the scalp so systemic levels are secondary to local levels.

So how much does it reduce scalp DHT by?
Well it’s quite underwhelming.

The efficacy and safety of dutasteride compared with finasteride in treating men with androgenetic alopecia: a systematic review and meta-analysis - PMC

We performed a meta-analysis to evaluate the efficacy and safety of dutasteride and finasteride in treating men with androgenetic alopecia (AGA) during a 24-week treatment cycle. Randomized controlled trials of dutasteride and finasteride for ...

pmc.ncbi.nlm.nih.gov

A related clinical study stated that 0.5 mg/day of dutasteride could lower scalp DHT levels by more than 51%, and 5 mg/day of finasteride could lower scalp DHT levels by ~41%

Barely 1/2 of scalp DHT at the cost of 90% of serum DHT is a pretty trash price if you ask me and I say this as someone who has been on Dut for a long time.

This goes to show why a topical anti-androgen that does not go systemic will mog AR inhibitor to Gandy heaven. Currently RU may do that but its long term safety profile is unknown due to never completing phase 3 trials. Pyrilutamide is the next major runner up but the previous study did not look so good hopefully the current trials running it at a higher dose yield something.

 

[Vincent Freeman]

 

[Evgeniy291]

The toughest pill to swallow is that dutasteride (and finasteride) while being the most effective drugs we currently have are still pretty shit at what they do.

People often point out that dutasteride nukes 90-95% of DHT but that’s a mistake. That’s serum DHT, if you are looking for anti balding effects what you’re really concerned about is scalp DHT, thinning of hair occurs locally at the scalp so systemic levels are secondary to local levels.

So how much does it reduce scalp DHT by?
Well it’s quite underwhelming.

The efficacy and safety of dutasteride compared with finasteride in treating men with androgenetic alopecia: a systematic review and meta-analysis - PMC

We performed a meta-analysis to evaluate the efficacy and safety of dutasteride and finasteride in treating men with androgenetic alopecia (AGA) during a 24-week treatment cycle. Randomized controlled trials of dutasteride and finasteride for ...

pmc.ncbi.nlm.nih.gov

Barely 1/2 of scalp DHT at the cost of 90% of serum DHT is a pretty trash price if you ask me and I say this as someone who has been on Dut for a long time.

This goes to show why a topical anti-androgen that does not go systemic will mog AR inhibitor to Gandy heaven. Currently RU may do that but its long term safety profile is unknown due to never completing phase 3 trials. Pyrilutamide is the next major runner up but the previous study did not look so good hopefully the current trials running it at a higher dose yield something.

fin blocks 70% of scalp dht iirc.
And you shouldn't even need more than that, you will already bald 3 times slower.
And if ur cycling just use RU while on it, potentially duta if you want to be extra safe

Also fyi 2.5mg duta blocks 95% of scalp dht

 

[Deleted member 131140]

AI will bring a cure for male pattern baldness

But by the time that happens, you and me will be out of a livelihood.

 

[Rabbi]

fin blocks 70% of scalp dht iirc.
And you shouldn't even need more than that, you will already bald 3 times slower.
And if ur cycling just use RU while on it, potentially duta if you want to be extra safe

Also fyi 2.5mg duta blocks 95% of scalp dht

Re-read the study
You’re thinking serum

 

[Rabbi]

AI will bring a cure for male pattern baldness

But by the time that happens, you and me will be out of a livelihood.

I cannot deny that

 

[Deleted member 131140]

I cannot deny that

Join the Indian Army, that is the only solution. Either you get to oversee a cool drone in 2039 or you get shot in the head by Pakistani terrorists

 

[Rabbi]

@Clavicular I saw your vid on dutasteride you should probably have a read.

Also there is no such thing as type 1 and 2 DHT just fyi

 

[Richard Cheese]

Topicals don't appeal to me personally. Too much work and potential to harm people around you. There's a reason everyone switched to oral min. I know it'd be a hassle but they should make 2.5mg of dut an actual pill it still wouldn't be RU tier but it would halt everything for most people.

 

[BoredPrince]

Topicals don't appeal to me personally. Too much work and potential to harm people around you. There's a reason everyone switched to oral min. I know it'd be a hassle but they should make 2.5mg of dut an actual pill it still wouldn't be RU tier but it would halt everything for most people.

Yeah I'm with you there, putting a solution every day on your hair is much more hassle than just taking a pill

I'm on fin rn but I'll have to switch to dut

 

[Rabbi]

Topicals don't appeal to me personally. Too much work and potential to harm people around you. There's a reason everyone switched to oral min. I know it'd be a hassle but they should make 2.5mg of dut an actual pill it still wouldn't be RU tier but it would halt everything for most people.

0.5mg dut and 5mg oral min is the easiest combo for stopping the reaper and regaining ground should suffice for 80%+

However I don’t see a way around topical use if you’re an aggressive norwooder unless you are a hyper responder

 

[Rabbi]

Topicals don't appeal to me personally. Too much work and potential to harm people around you. There's a reason everyone switched to oral min. I know it'd be a hassle but they should make 2.5mg of dut an actual pill it still wouldn't be RU tier but it would halt everything for most people.

Also I have to say minox foam Mogs the fuck out of minox solution

 

[Deleted member 138051]

The toughest pill to swallow is that dutasteride (and finasteride) while being the most effective drugs we currently have are still pretty shit at what they do.

People often point out that dutasteride nukes 90-95% of DHT but that’s a mistake. That’s serum DHT, if you are looking for anti balding effects what you’re really concerned about is scalp DHT, thinning of hair occurs locally at the scalp so systemic levels are secondary to local levels.

So how much does it reduce scalp DHT by?
Well it’s quite underwhelming.

The efficacy and safety of dutasteride compared with finasteride in treating men with androgenetic alopecia: a systematic review and meta-analysis - PMC

We performed a meta-analysis to evaluate the efficacy and safety of dutasteride and finasteride in treating men with androgenetic alopecia (AGA) during a 24-week treatment cycle. Randomized controlled trials of dutasteride and finasteride for ...

pmc.ncbi.nlm.nih.gov

Barely 1/2 of scalp DHT at the cost of 90% of serum DHT is a pretty trash price if you ask me and I say this as someone who has been on Dut for a long time.

This goes to show why a topical anti-androgen that does not go systemic will mog AR inhibitor to Gandy heaven. Currently RU may do that but its long term safety profile is unknown due to never completing phase 3 trials. Pyrilutamide is the next major runner up but the previous study did not look so good hopefully the current trials running it at a higher dose yield something.

@copercel123 @chadisbeingmade @Jonasㅤㅤ⠀ thoughts?
@kazama

 

[Chad]

@copercel123 @chadisbeingmade @Jonasㅤㅤ⠀ thoughts?
@kazama

RU combined with dutasteride is the only way.

2.5mg Dut reduces scalp DHT by 80%. IDK why anyone takes 0.5mg. 5x the dosage =/= 5x side effects.

The fact 0.5mg blocks 50% is irrelevant to me. Just use 2.5mg.

I can’t understand keeping such a worthless hormone in your body that doesn’t have a single function. All it will do is destroy your skin and hair. I literally feel the exact same with 0 sides on 2.5mg Dut ED. I use RU in DMSO also.

 

[Rabbi]

RU combined with dutasteride is the only way.

2.5mg Dut reduces scalp DHT by 80%. IDK why anyone takes 0.5mg. 5x the dosage =/= 5x side effects. In my case it’s 5x0 because I don’t have any sides.

The fact 0.5mg blocks 50% is irrelevant to me. Just use 2.5mg.

I can’t understand keeping such a worthless hormone in your body that doesn’t have a single function. All it will do is destroy your skin and hair. I literally feel the exact same with 0 sides on 2.5mg Dut ED. I use RU in DMSO also.

Interesting I’ve only ever been given 0.5 mg by my derm I’ll ask about 2.5mg next time. My order of RU should come in a few weeks we will see how it goes

 

[SoNotFunny]

Interesting I’ve only ever been given 0.5 mg by my derm I’ll ask about 2.5mg next time. My order of RU should come in a few weeks we will see how it goes

started RU two weeks ago, so far no sides. i see little fuzz on my temples, not sure if that's from ru or min before i quit

 

[Rabbi]

started RU two weeks ago, so far no sides. i see little fuzz on my temples, not sure if that's from ru or min before i quit

Where’d you source your RU from? I ordered from anageninc

 

[Rabbi]

Mirin. Ideally try why some raw RU powder to store in the freezer. Will be cheaper and RU isn’t the most stable so making frequent solutions is ideal.

2.5mg defo mogs to oblivion.
View attachment 3789318

Mirin the full dose, I’ve ordered just the RU by itself for now to trial and test. If it works out next time around I’ll be buying their RU powder and PG + Eth to compound the doses.

 

[CEO]

I can’t understand keeping such a worthless hormone in your body that doesn’t have a single function. All it will do is destroy your skin and hair.

Hey bro, can you elaborate a bit more to this greycel about how DHT could potentially harm skin? That's a first

 

[SoNotFunny]

Where’d you source your RU from? I ordered from anageninc

Yeah, that's where I got it from

 

[Chad]

Mirin the full dose, I’ve ordered just the RU by itself for now to trial and test. If it works out next time around I’ll be buying their RU powder and PG + Eth to compound the doses.

Mirin.

Hey bro, can you elaborate a bit more to this greycel about how DHT could potentially harm skin? That's a first

DHT, type 1 specifically, is going to cause up regulation of sebaceous gland. That means they are going to produce more oil and sebum. More oil and sebum = more acne. It also detriments your elastin. Prevent it from doing so because once it gets nuked you can’t do shit about it.

It’s probably one of the best anti aging drugs.

When this nigga stoped Dut to conceive, if you see pics he looked to have aged 10 years in 1.

 

[CEO]

Mirin.


DHT, type 1 specifically, is going to cause up regulation of sebaceous gland. That means they are going to produce more oil and sebum. More oil and sebum = more acne. It also detriments your elastin. Prevent it from doing so because once it gets nuked you can’t do shit about it.

It’s probably one of the best anti aging drugs.

When this nigga stoped Dut to conceive, if you see pics he looked to have aged 10 years in 1.

Wow okay, thanks a lot for sharing as usual brother. Yup, Ashton Kutcher is an amazing poster-boy example lol. I appreciate it.

 

[Rabbi]

Mirin.


DHT, type 1 specifically, is going to cause up regulation of sebaceous gland. That means they are going to produce more oil and sebum. More oil and sebum = more acne. It also detriments your elastin. Prevent it from doing so because once it gets nuked you can’t do shit about it.

It’s probably one of the best anti aging drugs.

When this nigga stoped Dut to conceive, if you see pics he looked to have aged 10 years in 1.

When you say DHT type 1 you mean the 5 ar type right? I don’t think DHT has types

 

[lurker999]

When this nigga stoped Dut to conceive, if you see pics he looked to have aged 10 years in 1.

he also had a disease tho

 

[CEO]

When you say DHT type 1 you mean the 5 ar type right? I don’t think DHT has types

Rabbi Bibi, I believe there are two types.

ChadGPT response:

Type 1 5-alpha reductase: Mostly found in the skin (including the scalp), sebaceous glands, and some other tissues. It contributes to DHT production but plays a smaller role in hair follicle miniaturization.

Type 2 5-alpha reductase: Found mainly in hair follicles (scalp and beard), prostate, and genital tissue. This is the main culprit for producing DHT that causes hair follicle shrinkage and hair loss.

 

[Chad]

When you say DHT type 1 you mean the 5 ar type right? I don’t think DHT has types

There are 2 types of 5α-Reductase. Type 1 and Type 2. Fin blocks only type 2. Dut blocks both type 1 and type 2

 

[Rabbi]

Rabbi Bibi, I believe there are two types.

ChadGPT response:

Type 1 5-alpha reductase: Mostly found in the skin (including the scalp), sebaceous glands, and some other tissues. It contributes to DHT production but plays a smaller role in hair follicle miniaturization.

Type 2 5-alpha reductase: Found mainly in hair follicles (scalp and beard), prostate, and genital tissue. This is the main culprit for producing DHT that causes hair follicle shrinkage and hair loss.

Yes those are types of 5 alpha reductase (enzyme that makes DHT) not different types of DHT

 

[Soter]

The toughest pill to swallow is that dutasteride (and finasteride) while being the most effective drugs we currently have are still pretty shit at what they do.

People often point out that dutasteride nukes 90-95% of DHT but that’s a mistake. That’s serum DHT, if you are looking for anti balding effects what you’re really concerned about is scalp DHT, thinning of hair occurs locally at the scalp so systemic levels are secondary to local levels.

So how much does it reduce scalp DHT by?
Well it’s quite underwhelming.

The efficacy and safety of dutasteride compared with finasteride in treating men with androgenetic alopecia: a systematic review and meta-analysis - PMC

We performed a meta-analysis to evaluate the efficacy and safety of dutasteride and finasteride in treating men with androgenetic alopecia (AGA) during a 24-week treatment cycle. Randomized controlled trials of dutasteride and finasteride for ...

pmc.ncbi.nlm.nih.gov

Barely 1/2 of scalp DHT at the cost of 90% of serum DHT is a pretty trash price if you ask me and I say this as someone who has been on Dut for a long time.

This goes to show why a topical anti-androgen that does not go systemic will mog AR inhibitor to Gandy heaven. Currently RU may do that but its long term safety profile is unknown due to never completing phase 3 trials. Pyrilutamide is the next major runner up but the previous study did not look so good hopefully the current trials running it at a higher dose yield something.

topicals and especially RU is cope. You have to apply them every day and with a lot of topicals, your hairstyle will be fucked and you'll have to wash your hair before you go out, they often make your scalp itchy as well.
And then there's the fact that it's difficult to apply topicals evenly with consistent, effective doses across the entire balding area, especially if hair gets in the way.

dut is the best, just pop the pill and forget it, there is no need for a complicated bullshit "hair loss" routine, you can just chill + you get skin benefits too

 

[Deleted member 101350]

Mirin.


DHT, type 1 specifically, is going to cause up regulation of sebaceous gland. That means they are going to produce more oil and sebum. More oil and sebum = more acne. It also detriments your elastin. Prevent it from doing so because once it gets nuked you can’t do shit about it.

It’s probably one of the best anti aging drugs.

When this nigga stoped Dut to conceive, if you see pics he looked to have aged 10 years in 1.

But getting 2.5 is impossible, i keep trying to get it of indiamart but keep getting scammed…

 

[LefortCandidate]

you don't need that much scalp dht reduction for hairloss to stop and dht serum supression isn't a bad thing at all if you can tolerate it

 

[Foreverbrad]

Topicals don't appeal to me personally. Too much work and potential to harm people around you. There's a reason everyone switched to oral min. I know it'd be a hassle but they should make 2.5mg of dut an actual pill it still wouldn't be RU tier but it would halt everything for most people.

Accidentally chemically castrating other men around me sounds like a good idea actually. Time to start wearing topical dut for handshakes.