Deleted member 1973
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“limb length correlates with temperature and latitude”
“limb length can be modified within a single generation by rearing young littermate animals at warm and cold temperatures during the postnatal growth period”
“Growth plate morphology was unexpectedly similar at cold and warm temperatures. There were no major appreciable differences in overall size, shape, or organization of the cartilage.”
“variation in adult long bone length between inbred mouse strains was primarily generated by growth rate differences that occurred during a phase of rapid bone elongation between 3 and 5 weeks ago.”
lack of enough temperature is a limiting factor on height growth
” at high temperature extremes outside of a tolerable physiological range, heat does negatively impact body growth.”
Take cold showers for potential height growth,
“Without countercurrent heat exchangers in a cold environment, blood will rapidly lose temperature as it flows to the distal-most parts of the appendages.
Core temperature would consequently drop as cool venous blood returns to the body core. One mechanism to combat a whole-body cooling effect is to reduce the total outflow of blood flow to the appendages by regulating vasomotor tone”
The study mentions that heat can induce bone marrow expansion. Equilibrium temperature can increase calcium uptake. Cold temperature induces endoplasmic reticulum stress. HSP70 expression is affected by temperature. Hydrostatic Pressure also increases HSP70. HMGB1 is negatively correlated with temperature. HMGB1 seems to encourage the early stages of chondrogenesis. This would be a good thing in the formation of the growth but could be a bad thing in the later stages as it may affect the degree of endochondral ossification of the growth plate reducing longitudinal bone growth. But mice that lack HMGB1 have shorter bones. Heat also can include TRPV4 activation. TRPV4 may modulate bone elongation by affecting cell volume in chondrocytes. However, continuously active TRPV4 mutants have abnormal endochondral ossification and reduced longitudinal bone growth.
” warm temperature could facilitate bone elongation by increasing the number of cells that could become bone forming osteoblasts at the chondro-osseous junction. There is also evidence that cold could limit bone elongation by directly inhibiting osteoclast activity.”
Which this would mean that heat wouldn’t play a role in neo-growth plate formation.
“disrupted blood flow markedly impairs limb growth”
So blood flow seems to be the most promising way to increase longitudinal bone growth (Assuming growth plates are open)
“limb length can be modified within a single generation by rearing young littermate animals at warm and cold temperatures during the postnatal growth period”
“Growth plate morphology was unexpectedly similar at cold and warm temperatures. There were no major appreciable differences in overall size, shape, or organization of the cartilage.”
“variation in adult long bone length between inbred mouse strains was primarily generated by growth rate differences that occurred during a phase of rapid bone elongation between 3 and 5 weeks ago.”
lack of enough temperature is a limiting factor on height growth
” at high temperature extremes outside of a tolerable physiological range, heat does negatively impact body growth.”
Take cold showers for potential height growth,
“Without countercurrent heat exchangers in a cold environment, blood will rapidly lose temperature as it flows to the distal-most parts of the appendages.
Core temperature would consequently drop as cool venous blood returns to the body core. One mechanism to combat a whole-body cooling effect is to reduce the total outflow of blood flow to the appendages by regulating vasomotor tone”
The study mentions that heat can induce bone marrow expansion. Equilibrium temperature can increase calcium uptake. Cold temperature induces endoplasmic reticulum stress. HSP70 expression is affected by temperature. Hydrostatic Pressure also increases HSP70. HMGB1 is negatively correlated with temperature. HMGB1 seems to encourage the early stages of chondrogenesis. This would be a good thing in the formation of the growth but could be a bad thing in the later stages as it may affect the degree of endochondral ossification of the growth plate reducing longitudinal bone growth. But mice that lack HMGB1 have shorter bones. Heat also can include TRPV4 activation. TRPV4 may modulate bone elongation by affecting cell volume in chondrocytes. However, continuously active TRPV4 mutants have abnormal endochondral ossification and reduced longitudinal bone growth.
” warm temperature could facilitate bone elongation by increasing the number of cells that could become bone forming osteoblasts at the chondro-osseous junction. There is also evidence that cold could limit bone elongation by directly inhibiting osteoclast activity.”
Which this would mean that heat wouldn’t play a role in neo-growth plate formation.
“disrupted blood flow markedly impairs limb growth”
So blood flow seems to be the most promising way to increase longitudinal bone growth (Assuming growth plates are open)
