Epigenetics: The Connection Between Beauty And Health

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𝕯𝖝𝕯 𝖈𝖗𝖊𝖜 𝕸𝖆𝖘𝖙𝖊𝖗
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How Modern Life Destroys Your Genes, Hormones, and Cellular Machinery (and How to Reclaim Your Looks)​

The answer isn’t “luck”—it’s a combination of fucked-up epigenetics, hormonal imbalances, inflammation, oxidative stress, and more. Here’s how your environment and lifestyle rewrite your biology and what you need to do to hack it back.

EPIGENETICS & GENE EXPRESSION

Your genes aren’t destiny—they’re constantly being rewritten by your lifestyle

DNA Methylation: Methyl groups stick to your DNA (CpG islands) and silence genes. Excess methylation—driven by high sugar, processed foods, and toxic exposures (BPA, microplastics)—shuts down genes for collagen production and antioxidant defenses. (Aging Cell, PMID: 24983061)

Histone Modifications: Chemical tags (acetyl, methyl groups) on histones control DNA packaging. A diet low in antioxidants and chronic stress push histones into a repressive state, silencing repair genes and ramping up inflammation. (Epigenetics, PMID: 25678660)

MicroRNAs: These tiny RNA pieces fine-tune gene expression. Toxin exposure and poor nutrition distort miRNA profiles, reducing collagen synthesis and accelerating aging. (Clinical Epigenetics, PMID: 28255644)

AGEs: Advanced glycation end-products from excess sugar bind to and damage proteins like collagen, locking in harmful epigenetic changes. (Diabetes, PMID: 15918433)

Ditch processed shit, eat antioxidant-rich whole foods, and minimize toxic exposures (BPA-free, reduce blue light)

Here Are Some Good Threads:

HORMONES : BUILD OR BREAK YOU

Your hormones are the masterminds behind your looks and performance

HGH & IGF-1: HGH from your pituitary tells your liver to produce IGF-1, which drives cell proliferation, bone growth, and muscle hypertrophy. Without proper HGH/IGF-1, your craniofacial structure and muscle mass suffer. Studies in GHD kids prove even low-dose HGH can normalize facial dimensions

Testosterone & DHT: Testosterone, synthesized from cholesterol, binds to androgen receptors to stimulate bone formation and muscle synthesis (via mTOR) and inhibit fat storage. DHT, a more potent derivative produced by 5-alpha reductase, sharpens your facial features and promotes proper beard growth. Low levels leave you soft and flabby. (Am J Hum Biol, PMID: 22068786)

Cortisol: Chronic stress spikes cortisol, which increases fat storage (via upregulating LPL), degrades collagen, and suppresses anabolic hormones. High cortisol means a bloated, aged appearance. (Psychosomatic Medicine, PMID: 24053391)

Additional Players: Melatonin acts as a DNA-protecting antioxidant, and DHEA, a precursor hormone, supports overall vitality. Androsterone, a DHT metabolite, influences metabolism and even acts as a neurosteroid.

Eat cholesterol-rich, nutrient-dense foods; lift heavy compound movements; get solid sunlight (or supplement with vitamin D3); and cut out endocrine disruptors like plastics and seed oils also use L-theanine for reduced cortisol

Here Are Some Good Threads:

CELLULAR ENERGY & MITOCHONDRIAL FUNCTION

Your mitochondria are your cellular powerhouses—they fuel everything with ATP

ATP Production: Through oxidative phosphorylation, mitochondria convert nutrients into ATP. Efficient ATP is essential for muscle contraction, cell repair, and fat oxidation

Impact: Inefficient mitochondria result in low energy, poor fat metabolism, and increased oxidative stress, leading to a tired, aged appearance. (Nature Communications, PMID: 25416742)

Fat Oxidation: Proper breakdown of triglycerides via beta-oxidation keeps your body lean and your features sharp. High triglycerides mean you're puffy and weak. (AJCN, PMID: 23060417)

Use cold exposure to boost mitochondrial biogenesis, red light therapy to stimulate cytochrome c oxidase, and adopt a ketogenic diet or intermittent fasting to force fat oxidation you can also supplement methylene blue for mitochondrial support

Here Are Some Good Threads:

INFLAMMATION, OXIDATIVE STRESS & CELLULAR SENESCENCE

It’s not just hormones and mitochondria—chronic inflammation and oxidative damage are silently aging you
Oxidative Stress: Reactive oxygen species (ROS) damage DNA, proteins, and lipids. Excess ROS triggers cellular senescence and epigenetic alterations that accelerate aging

Inflammation: Constant low-grade inflammation, fueled by poor diet and stress, not only damages tissues but also alters gene expression toward a catabolic state
Telomere Shortening: Chronic stress and oxidative stress shorten telomeres—the protective caps on your chromosomes—leading to premature cellular aging. (Circulation, PMID: 21807624)

Ramp up your intake of antioxidants (vitamin C, E, polyphenols), reduce inflammatory foods (processed sugars, seed oils), and incorporate anti-inflammatory supplements like omega-3s, resveratrol, and curcumin

Here Are Some Good Threads:

ADDITIONAL FACTORS: GUT MICROBIOME, CIRCADIAN RHYTHM, & SIRTUINS

Beyond the obvious, several high-level mechanisms play into your appearance

Gut Microbiome: Your gut health affects systemic inflammation and nutrient absorption, which in turn influences skin quality and hormone production. Dysbiosis leads to increased inflammatory cytokines that harm your epigenome. (Nature, PMID: 28218504)

Circadian Rhythm: Disrupted sleep patterns due to blue light exposure or erratic schedules throw off hormone production (like melatonin and HGH) and worsen your epigenetic markers

Sirtuins (SIRT1): These proteins regulate cellular aging and stress responses. Activating sirtuins (through caloric restriction, resveratrol, etc.) helps maintain youthful gene expression and cellular repair. (Cell Metabolism, PMID: 20580441)

Optimize your gut with fermented foods and probiotics; maintain a strict sleep schedule with proper dark periods; and consider sirtuin activators if you’re serious about longevity

Here Are Some Good Threads:


You weren’t born weak or ugly—the modern lifestyle has fucked up your genetic expression and hormone profiles.​

TL;DR – The Brutal Truth​

Your looks and energy are a raw, biochemical equation:
Epigenetics: Junk food, stress, and toxins hypermethylate your DNA, repress repair genes, and accelerate aging
Hormones: Low HGH/IGF-1, testosterone/DHT, and high cortisol make you look weak and aged
Mitochondria: Poor ATP production and fat oxidation leave you tired and bloated
Inflammation & Oxidative Stress: Constant low-grade inflammation and ROS damage accelerate cellular aging
Additional Factors: A fucked-up gut, disrupted circadian rhythm, and low sirtuin activity further screw your overall potential
Genetics: still play the main role but you weren't supposed to be ugly
TAGS: @fr0st @maarda @ER enjoyer @Zagro @REGULUS @Jonas2k7 @staton @HostSamurai @trench @superpsycho @Ashoimex @sover @h111 @halloweed @PsychoH

this took a long time damnn

@Numb The Pain @Alexanderr @NumbThePain @TechnoBoss BOTB worthy? :forcedsmile:
 
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How Modern Life Destroys Your Genes, Hormones, and Cellular Machinery (and How to Reclaim Your Looks)​

The answer isn’t “luck”—it’s a combination of fucked-up epigenetics, hormonal imbalances, inflammation, oxidative stress, and more. Here’s how your environment and lifestyle rewrite your biology and what you need to do to hack it back.

EPIGENETICS & GENE EXPRESSION

Your genes aren’t destiny—they’re constantly being rewritten by your lifestyle

DNA Methylation: Methyl groups stick to your DNA (CpG islands) and silence genes. Excess methylation—driven by high sugar, processed foods, and toxic exposures (BPA, microplastics)—shuts down genes for collagen production and antioxidant defenses. (Aging Cell, PMID: 24983061)

Histone Modifications: Chemical tags (acetyl, methyl groups) on histones control DNA packaging. A diet low in antioxidants and chronic stress push histones into a repressive state, silencing repair genes and ramping up inflammation. (Epigenetics, PMID: 25678660)

MicroRNAs: These tiny RNA pieces fine-tune gene expression. Toxin exposure and poor nutrition distort miRNA profiles, reducing collagen synthesis and accelerating aging. (Clinical Epigenetics, PMID: 28255644)

AGEs: Advanced glycation end-products from excess sugar bind to and damage proteins like collagen, locking in harmful epigenetic changes. (Diabetes, PMID: 15918433)

Ditch processed shit, eat antioxidant-rich whole foods, and minimize toxic exposures (BPA-free, reduce blue light)

Here Are Some Good Threads:

HORMONES : BUILD OR BREAK YOU

Your hormones are the masterminds behind your looks and performance

HGH & IGF-1: HGH from your pituitary tells your liver to produce IGF-1, which drives cell proliferation, bone growth, and muscle hypertrophy. Without proper HGH/IGF-1, your craniofacial structure and muscle mass suffer. Studies in GHD kids prove even low-dose HGH can normalize facial dimensions

Testosterone & DHT: Testosterone, synthesized from cholesterol, binds to androgen receptors to stimulate bone formation and muscle synthesis (via mTOR) and inhibit fat storage. DHT, a more potent derivative produced by 5-alpha reductase, sharpens your facial features and promotes proper beard growth. Low levels leave you soft and flabby. (Am J Hum Biol, PMID: 22068786)

Cortisol: Chronic stress spikes cortisol, which increases fat storage (via upregulating LPL), degrades collagen, and suppresses anabolic hormones. High cortisol means a bloated, aged appearance. (Psychosomatic Medicine, PMID: 24053391)

Additional Players: Melatonin acts as a DNA-protecting antioxidant, and DHEA, a precursor hormone, supports overall vitality. Androsterone, a DHT metabolite, influences metabolism and even acts as a neurosteroid.

Eat cholesterol-rich, nutrient-dense foods; lift heavy compound movements; get solid sunlight (or supplement with vitamin D3); and cut out endocrine disruptors like plastics and seed oils also use L-theanine for reduced cortisol

Here Are Some Good Threads:

CELLULAR ENERGY & MITOCHONDRIAL FUNCTION

Your mitochondria are your cellular powerhouses—they fuel everything with ATP

ATP Production: Through oxidative phosphorylation, mitochondria convert nutrients into ATP. Efficient ATP is essential for muscle contraction, cell repair, and fat oxidation

Impact: Inefficient mitochondria result in low energy, poor fat metabolism, and increased oxidative stress, leading to a tired, aged appearance. (Nature Communications, PMID: 25416742)

Fat Oxidation: Proper breakdown of triglycerides via beta-oxidation keeps your body lean and your features sharp. High triglycerides mean you're puffy and weak. (AJCN, PMID: 23060417)

Use cold exposure to boost mitochondrial biogenesis, red light therapy to stimulate cytochrome c oxidase, and adopt a ketogenic diet or intermittent fasting to force fat oxidation you can also supplement methylene blue for mitochondrial support

Here Are Some Good Threads:

INFLAMMATION, OXIDATIVE STRESS & CELLULAR SENESCENCE

It’s not just hormones and mitochondria—chronic inflammation and oxidative damage are silently aging you
Oxidative Stress: Reactive oxygen species (ROS) damage DNA, proteins, and lipids. Excess ROS triggers cellular senescence and epigenetic alterations that accelerate aging

Inflammation: Constant low-grade inflammation, fueled by poor diet and stress, not only damages tissues but also alters gene expression toward a catabolic state
Telomere Shortening: Chronic stress and oxidative stress shorten telomeres—the protective caps on your chromosomes—leading to premature cellular aging. (Circulation, PMID: 21807624)

Ramp up your intake of antioxidants (vitamin C, E, polyphenols), reduce inflammatory foods (processed sugars, seed oils), and incorporate anti-inflammatory supplements like omega-3s, resveratrol, and curcumin

Here Are Some Good Threads:

ADDITIONAL FACTORS: GUT MICROBIOME, CIRCADIAN RHYTHM, & SIRTUINS

Beyond the obvious, several high-level mechanisms play into your appearance

Gut Microbiome: Your gut health affects systemic inflammation and nutrient absorption, which in turn influences skin quality and hormone production. Dysbiosis leads to increased inflammatory cytokines that harm your epigenome. (Nature, PMID: 28218504)

Circadian Rhythm: Disrupted sleep patterns due to blue light exposure or erratic schedules throw off hormone production (like melatonin and HGH) and worsen your epigenetic markers

Sirtuins (SIRT1): These proteins regulate cellular aging and stress responses. Activating sirtuins (through caloric restriction, resveratrol, etc.) helps maintain youthful gene expression and cellular repair. (Cell Metabolism, PMID: 20580441)

Optimize your gut with fermented foods and probiotics; maintain a strict sleep schedule with proper dark periods; and consider sirtuin activators if you’re serious about longevity

Here Are Some Good Threads:


You weren’t born weak or ugly—the modern lifestyle has fucked up your genetic expression and hormone profiles.​

TL;DR – The Brutal Truth​

Your looks and energy are a raw, biochemical equation:
Epigenetics: Junk food, stress, and toxins hypermethylate your DNA, repress repair genes, and accelerate aging
Hormones: Low HGH/IGF-1, testosterone/DHT, and high cortisol make you look weak and aged
Mitochondria: Poor ATP production and fat oxidation leave you tired and bloated
Inflammation & Oxidative Stress: Constant low-grade inflammation and ROS damage accelerate cellular aging
Additional Factors: A fucked-up gut, disrupted circadian rhythm, and low sirtuin activity further screw your overall potential
Genetics: still play the main role but you weren't supposed to be ugly
TAGS: @fr0st @maarda @ER enjoyer @Zagro @REGULUS @Jonas2k7 @staton @HostSamurai @trench @superpsycho @Ashoimex @sover @h111 @halloweed @PsychoH

this took a long time damnn

@Numb The Pain @Alexanderr @NumbThePain @TechnoBoss BOTB worthy? :forcedsmile:
Very in depth thread bhai, should get more recognition from others :feelsokman:
 
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How Modern Life Destroys Your Genes, Hormones, and Cellular Machinery (and How to Reclaim Your Looks)​

The answer isn’t “luck”—it’s a combination of fucked-up epigenetics, hormonal imbalances, inflammation, oxidative stress, and more. Here’s how your environment and lifestyle rewrite your biology and what you need to do to hack it back.

EPIGENETICS & GENE EXPRESSION

Your genes aren’t destiny—they’re constantly being rewritten by your lifestyle

DNA Methylation: Methyl groups stick to your DNA (CpG islands) and silence genes. Excess methylation—driven by high sugar, processed foods, and toxic exposures (BPA, microplastics)—shuts down genes for collagen production and antioxidant defenses. (Aging Cell, PMID: 24983061)

Histone Modifications: Chemical tags (acetyl, methyl groups) on histones control DNA packaging. A diet low in antioxidants and chronic stress push histones into a repressive state, silencing repair genes and ramping up inflammation. (Epigenetics, PMID: 25678660)

MicroRNAs: These tiny RNA pieces fine-tune gene expression. Toxin exposure and poor nutrition distort miRNA profiles, reducing collagen synthesis and accelerating aging. (Clinical Epigenetics, PMID: 28255644)

AGEs: Advanced glycation end-products from excess sugar bind to and damage proteins like collagen, locking in harmful epigenetic changes. (Diabetes, PMID: 15918433)

Ditch processed shit, eat antioxidant-rich whole foods, and minimize toxic exposures (BPA-free, reduce blue light)

Here Are Some Good Threads:

HORMONES : BUILD OR BREAK YOU

Your hormones are the masterminds behind your looks and performance

HGH & IGF-1: HGH from your pituitary tells your liver to produce IGF-1, which drives cell proliferation, bone growth, and muscle hypertrophy. Without proper HGH/IGF-1, your craniofacial structure and muscle mass suffer. Studies in GHD kids prove even low-dose HGH can normalize facial dimensions

Testosterone & DHT: Testosterone, synthesized from cholesterol, binds to androgen receptors to stimulate bone formation and muscle synthesis (via mTOR) and inhibit fat storage. DHT, a more potent derivative produced by 5-alpha reductase, sharpens your facial features and promotes proper beard growth. Low levels leave you soft and flabby. (Am J Hum Biol, PMID: 22068786)

Cortisol: Chronic stress spikes cortisol, which increases fat storage (via upregulating LPL), degrades collagen, and suppresses anabolic hormones. High cortisol means a bloated, aged appearance. (Psychosomatic Medicine, PMID: 24053391)

Additional Players: Melatonin acts as a DNA-protecting antioxidant, and DHEA, a precursor hormone, supports overall vitality. Androsterone, a DHT metabolite, influences metabolism and even acts as a neurosteroid.

Eat cholesterol-rich, nutrient-dense foods; lift heavy compound movements; get solid sunlight (or supplement with vitamin D3); and cut out endocrine disruptors like plastics and seed oils also use L-theanine for reduced cortisol

Here Are Some Good Threads:

CELLULAR ENERGY & MITOCHONDRIAL FUNCTION

Your mitochondria are your cellular powerhouses—they fuel everything with ATP

ATP Production: Through oxidative phosphorylation, mitochondria convert nutrients into ATP. Efficient ATP is essential for muscle contraction, cell repair, and fat oxidation

Impact: Inefficient mitochondria result in low energy, poor fat metabolism, and increased oxidative stress, leading to a tired, aged appearance. (Nature Communications, PMID: 25416742)

Fat Oxidation: Proper breakdown of triglycerides via beta-oxidation keeps your body lean and your features sharp. High triglycerides mean you're puffy and weak. (AJCN, PMID: 23060417)

Use cold exposure to boost mitochondrial biogenesis, red light therapy to stimulate cytochrome c oxidase, and adopt a ketogenic diet or intermittent fasting to force fat oxidation you can also supplement methylene blue for mitochondrial support

Here Are Some Good Threads:

INFLAMMATION, OXIDATIVE STRESS & CELLULAR SENESCENCE

It’s not just hormones and mitochondria—chronic inflammation and oxidative damage are silently aging you
Oxidative Stress: Reactive oxygen species (ROS) damage DNA, proteins, and lipids. Excess ROS triggers cellular senescence and epigenetic alterations that accelerate aging

Inflammation: Constant low-grade inflammation, fueled by poor diet and stress, not only damages tissues but also alters gene expression toward a catabolic state
Telomere Shortening: Chronic stress and oxidative stress shorten telomeres—the protective caps on your chromosomes—leading to premature cellular aging. (Circulation, PMID: 21807624)

Ramp up your intake of antioxidants (vitamin C, E, polyphenols), reduce inflammatory foods (processed sugars, seed oils), and incorporate anti-inflammatory supplements like omega-3s, resveratrol, and curcumin

Here Are Some Good Threads:

ADDITIONAL FACTORS: GUT MICROBIOME, CIRCADIAN RHYTHM, & SIRTUINS

Beyond the obvious, several high-level mechanisms play into your appearance

Gut Microbiome: Your gut health affects systemic inflammation and nutrient absorption, which in turn influences skin quality and hormone production. Dysbiosis leads to increased inflammatory cytokines that harm your epigenome. (Nature, PMID: 28218504)

Circadian Rhythm: Disrupted sleep patterns due to blue light exposure or erratic schedules throw off hormone production (like melatonin and HGH) and worsen your epigenetic markers

Sirtuins (SIRT1): These proteins regulate cellular aging and stress responses. Activating sirtuins (through caloric restriction, resveratrol, etc.) helps maintain youthful gene expression and cellular repair. (Cell Metabolism, PMID: 20580441)

Optimize your gut with fermented foods and probiotics; maintain a strict sleep schedule with proper dark periods; and consider sirtuin activators if you’re serious about longevity

Here Are Some Good Threads:


You weren’t born weak or ugly—the modern lifestyle has fucked up your genetic expression and hormone profiles.​

TL;DR – The Brutal Truth​

Your looks and energy are a raw, biochemical equation:
Epigenetics: Junk food, stress, and toxins hypermethylate your DNA, repress repair genes, and accelerate aging
Hormones: Low HGH/IGF-1, testosterone/DHT, and high cortisol make you look weak and aged
Mitochondria: Poor ATP production and fat oxidation leave you tired and bloated
Inflammation & Oxidative Stress: Constant low-grade inflammation and ROS damage accelerate cellular aging
Additional Factors: A fucked-up gut, disrupted circadian rhythm, and low sirtuin activity further screw your overall potential
Genetics: still play the main role but you weren't supposed to be ugly
TAGS: @fr0st @maarda @ER enjoyer @Zagro @REGULUS @Jonas2k7 @staton @HostSamurai @trench @superpsycho @Ashoimex @sover @h111 @halloweed @PsychoH

this took a long time damnn

@Numb The Pain @Alexanderr @NumbThePain @TechnoBoss BOTB worthy? :forcedsmile:
botb indeed;

good formating, incel; keep rotting and making such guides and you maybe become one of the greats here
 
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botb indeed;

good formating, incel; keep rotting and making such guides and you maybe become one of the greats here
@Master you heard him boyo :Comfy:
 
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How Modern Life Destroys Your Genes, Hormones, and Cellular Machinery (and How to Reclaim Your Looks)​

The answer isn’t “luck”—it’s a combination of fucked-up epigenetics, hormonal imbalances, inflammation, oxidative stress, and more. Here’s how your environment and lifestyle rewrite your biology and what you need to do to hack it back.

EPIGENETICS & GENE EXPRESSION

Your genes aren’t destiny—they’re constantly being rewritten by your lifestyle

DNA Methylation: Methyl groups stick to your DNA (CpG islands) and silence genes. Excess methylation—driven by high sugar, processed foods, and toxic exposures (BPA, microplastics)—shuts down genes for collagen production and antioxidant defenses. (Aging Cell, PMID: 24983061)

Histone Modifications: Chemical tags (acetyl, methyl groups) on histones control DNA packaging. A diet low in antioxidants and chronic stress push histones into a repressive state, silencing repair genes and ramping up inflammation. (Epigenetics, PMID: 25678660)

MicroRNAs: These tiny RNA pieces fine-tune gene expression. Toxin exposure and poor nutrition distort miRNA profiles, reducing collagen synthesis and accelerating aging. (Clinical Epigenetics, PMID: 28255644)

AGEs: Advanced glycation end-products from excess sugar bind to and damage proteins like collagen, locking in harmful epigenetic changes. (Diabetes, PMID: 15918433)

Ditch processed shit, eat antioxidant-rich whole foods, and minimize toxic exposures (BPA-free, reduce blue light)

Here Are Some Good Threads:

HORMONES : BUILD OR BREAK YOU

Your hormones are the masterminds behind your looks and performance

HGH & IGF-1: HGH from your pituitary tells your liver to produce IGF-1, which drives cell proliferation, bone growth, and muscle hypertrophy. Without proper HGH/IGF-1, your craniofacial structure and muscle mass suffer. Studies in GHD kids prove even low-dose HGH can normalize facial dimensions

Testosterone & DHT: Testosterone, synthesized from cholesterol, binds to androgen receptors to stimulate bone formation and muscle synthesis (via mTOR) and inhibit fat storage. DHT, a more potent derivative produced by 5-alpha reductase, sharpens your facial features and promotes proper beard growth. Low levels leave you soft and flabby. (Am J Hum Biol, PMID: 22068786)

Cortisol: Chronic stress spikes cortisol, which increases fat storage (via upregulating LPL), degrades collagen, and suppresses anabolic hormones. High cortisol means a bloated, aged appearance. (Psychosomatic Medicine, PMID: 24053391)

Additional Players: Melatonin acts as a DNA-protecting antioxidant, and DHEA, a precursor hormone, supports overall vitality. Androsterone, a DHT metabolite, influences metabolism and even acts as a neurosteroid.

Eat cholesterol-rich, nutrient-dense foods; lift heavy compound movements; get solid sunlight (or supplement with vitamin D3); and cut out endocrine disruptors like plastics and seed oils also use L-theanine for reduced cortisol

Here Are Some Good Threads:

CELLULAR ENERGY & MITOCHONDRIAL FUNCTION

Your mitochondria are your cellular powerhouses—they fuel everything with ATP

ATP Production: Through oxidative phosphorylation, mitochondria convert nutrients into ATP. Efficient ATP is essential for muscle contraction, cell repair, and fat oxidation

Impact: Inefficient mitochondria result in low energy, poor fat metabolism, and increased oxidative stress, leading to a tired, aged appearance. (Nature Communications, PMID: 25416742)

Fat Oxidation: Proper breakdown of triglycerides via beta-oxidation keeps your body lean and your features sharp. High triglycerides mean you're puffy and weak. (AJCN, PMID: 23060417)

Use cold exposure to boost mitochondrial biogenesis, red light therapy to stimulate cytochrome c oxidase, and adopt a ketogenic diet or intermittent fasting to force fat oxidation you can also supplement methylene blue for mitochondrial support

Here Are Some Good Threads:

INFLAMMATION, OXIDATIVE STRESS & CELLULAR SENESCENCE

It’s not just hormones and mitochondria—chronic inflammation and oxidative damage are silently aging you
Oxidative Stress: Reactive oxygen species (ROS) damage DNA, proteins, and lipids. Excess ROS triggers cellular senescence and epigenetic alterations that accelerate aging

Inflammation: Constant low-grade inflammation, fueled by poor diet and stress, not only damages tissues but also alters gene expression toward a catabolic state
Telomere Shortening: Chronic stress and oxidative stress shorten telomeres—the protective caps on your chromosomes—leading to premature cellular aging. (Circulation, PMID: 21807624)

Ramp up your intake of antioxidants (vitamin C, E, polyphenols), reduce inflammatory foods (processed sugars, seed oils), and incorporate anti-inflammatory supplements like omega-3s, resveratrol, and curcumin

Here Are Some Good Threads:

ADDITIONAL FACTORS: GUT MICROBIOME, CIRCADIAN RHYTHM, & SIRTUINS

Beyond the obvious, several high-level mechanisms play into your appearance

Gut Microbiome: Your gut health affects systemic inflammation and nutrient absorption, which in turn influences skin quality and hormone production. Dysbiosis leads to increased inflammatory cytokines that harm your epigenome. (Nature, PMID: 28218504)

Circadian Rhythm: Disrupted sleep patterns due to blue light exposure or erratic schedules throw off hormone production (like melatonin and HGH) and worsen your epigenetic markers

Sirtuins (SIRT1): These proteins regulate cellular aging and stress responses. Activating sirtuins (through caloric restriction, resveratrol, etc.) helps maintain youthful gene expression and cellular repair. (Cell Metabolism, PMID: 20580441)

Optimize your gut with fermented foods and probiotics; maintain a strict sleep schedule with proper dark periods; and consider sirtuin activators if you’re serious about longevity

Here Are Some Good Threads:


You weren’t born weak or ugly—the modern lifestyle has fucked up your genetic expression and hormone profiles.​

TL;DR – The Brutal Truth​

Your looks and energy are a raw, biochemical equation:
Epigenetics: Junk food, stress, and toxins hypermethylate your DNA, repress repair genes, and accelerate aging
Hormones: Low HGH/IGF-1, testosterone/DHT, and high cortisol make you look weak and aged
Mitochondria: Poor ATP production and fat oxidation leave you tired and bloated
Inflammation & Oxidative Stress: Constant low-grade inflammation and ROS damage accelerate cellular aging
Additional Factors: A fucked-up gut, disrupted circadian rhythm, and low sirtuin activity further screw your overall potential
Genetics: still play the main role but you weren't supposed to be ugly
TAGS: @fr0st @maarda @ER enjoyer @Zagro @REGULUS @Jonas2k7 @staton @HostSamurai @trench @superpsycho @Ashoimex @sover @h111 @halloweed @PsychoH

this took a long time damnn

@Numb The Pain @Alexanderr @NumbThePain @TechnoBoss BOTB worthy? :forcedsmile:
Both worthy man just needs more recognition again:feelsokman:
 
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@Ur fav sub 5 @Zodiac @acertyxx_ @antipsychotics Can you rep this thread bhais
 
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good thread, its insane to me that sm people dont know the importance of gut health
 
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How Modern Life Destroys Your Genes, Hormones, and Cellular Machinery (and How to Reclaim Your Looks)​

The answer isn’t “luck”—it’s a combination of fucked-up epigenetics, hormonal imbalances, inflammation, oxidative stress, and more. Here’s how your environment and lifestyle rewrite your biology and what you need to do to hack it back.

EPIGENETICS & GENE EXPRESSION

Your genes aren’t destiny—they’re constantly being rewritten by your lifestyle

DNA Methylation: Methyl groups stick to your DNA (CpG islands) and silence genes. Excess methylation—driven by high sugar, processed foods, and toxic exposures (BPA, microplastics)—shuts down genes for collagen production and antioxidant defenses. (Aging Cell, PMID: 24983061)

Histone Modifications: Chemical tags (acetyl, methyl groups) on histones control DNA packaging. A diet low in antioxidants and chronic stress push histones into a repressive state, silencing repair genes and ramping up inflammation. (Epigenetics, PMID: 25678660)

MicroRNAs: These tiny RNA pieces fine-tune gene expression. Toxin exposure and poor nutrition distort miRNA profiles, reducing collagen synthesis and accelerating aging. (Clinical Epigenetics, PMID: 28255644)

AGEs: Advanced glycation end-products from excess sugar bind to and damage proteins like collagen, locking in harmful epigenetic changes. (Diabetes, PMID: 15918433)

Ditch processed shit, eat antioxidant-rich whole foods, and minimize toxic exposures (BPA-free, reduce blue light)

Here Are Some Good Threads:

HORMONES : BUILD OR BREAK YOU

Your hormones are the masterminds behind your looks and performance

HGH & IGF-1: HGH from your pituitary tells your liver to produce IGF-1, which drives cell proliferation, bone growth, and muscle hypertrophy. Without proper HGH/IGF-1, your craniofacial structure and muscle mass suffer. Studies in GHD kids prove even low-dose HGH can normalize facial dimensions

Testosterone & DHT: Testosterone, synthesized from cholesterol, binds to androgen receptors to stimulate bone formation and muscle synthesis (via mTOR) and inhibit fat storage. DHT, a more potent derivative produced by 5-alpha reductase, sharpens your facial features and promotes proper beard growth. Low levels leave you soft and flabby. (Am J Hum Biol, PMID: 22068786)

Cortisol: Chronic stress spikes cortisol, which increases fat storage (via upregulating LPL), degrades collagen, and suppresses anabolic hormones. High cortisol means a bloated, aged appearance. (Psychosomatic Medicine, PMID: 24053391)

Additional Players: Melatonin acts as a DNA-protecting antioxidant, and DHEA, a precursor hormone, supports overall vitality. Androsterone, a DHT metabolite, influences metabolism and even acts as a neurosteroid.

Eat cholesterol-rich, nutrient-dense foods; lift heavy compound movements; get solid sunlight (or supplement with vitamin D3); and cut out endocrine disruptors like plastics and seed oils also use L-theanine for reduced cortisol

Here Are Some Good Threads:

CELLULAR ENERGY & MITOCHONDRIAL FUNCTION

Your mitochondria are your cellular powerhouses—they fuel everything with ATP

ATP Production: Through oxidative phosphorylation, mitochondria convert nutrients into ATP. Efficient ATP is essential for muscle contraction, cell repair, and fat oxidation

Impact: Inefficient mitochondria result in low energy, poor fat metabolism, and increased oxidative stress, leading to a tired, aged appearance. (Nature Communications, PMID: 25416742)

Fat Oxidation: Proper breakdown of triglycerides via beta-oxidation keeps your body lean and your features sharp. High triglycerides mean you're puffy and weak. (AJCN, PMID: 23060417)

Use cold exposure to boost mitochondrial biogenesis, red light therapy to stimulate cytochrome c oxidase, and adopt a ketogenic diet or intermittent fasting to force fat oxidation you can also supplement methylene blue for mitochondrial support

Here Are Some Good Threads:

INFLAMMATION, OXIDATIVE STRESS & CELLULAR SENESCENCE

It’s not just hormones and mitochondria—chronic inflammation and oxidative damage are silently aging you
Oxidative Stress: Reactive oxygen species (ROS) damage DNA, proteins, and lipids. Excess ROS triggers cellular senescence and epigenetic alterations that accelerate aging

Inflammation: Constant low-grade inflammation, fueled by poor diet and stress, not only damages tissues but also alters gene expression toward a catabolic state
Telomere Shortening: Chronic stress and oxidative stress shorten telomeres—the protective caps on your chromosomes—leading to premature cellular aging. (Circulation, PMID: 21807624)

Ramp up your intake of antioxidants (vitamin C, E, polyphenols), reduce inflammatory foods (processed sugars, seed oils), and incorporate anti-inflammatory supplements like omega-3s, resveratrol, and curcumin

Here Are Some Good Threads:

ADDITIONAL FACTORS: GUT MICROBIOME, CIRCADIAN RHYTHM, & SIRTUINS

Beyond the obvious, several high-level mechanisms play into your appearance

Gut Microbiome: Your gut health affects systemic inflammation and nutrient absorption, which in turn influences skin quality and hormone production. Dysbiosis leads to increased inflammatory cytokines that harm your epigenome. (Nature, PMID: 28218504)

Circadian Rhythm: Disrupted sleep patterns due to blue light exposure or erratic schedules throw off hormone production (like melatonin and HGH) and worsen your epigenetic markers

Sirtuins (SIRT1): These proteins regulate cellular aging and stress responses. Activating sirtuins (through caloric restriction, resveratrol, etc.) helps maintain youthful gene expression and cellular repair. (Cell Metabolism, PMID: 20580441)

Optimize your gut with fermented foods and probiotics; maintain a strict sleep schedule with proper dark periods; and consider sirtuin activators if you’re serious about longevity

Here Are Some Good Threads:


You weren’t born weak or ugly—the modern lifestyle has fucked up your genetic expression and hormone profiles.​

TL;DR – The Brutal Truth​

Your looks and energy are a raw, biochemical equation:
Epigenetics: Junk food, stress, and toxins hypermethylate your DNA, repress repair genes, and accelerate aging
Hormones: Low HGH/IGF-1, testosterone/DHT, and high cortisol make you look weak and aged
Mitochondria: Poor ATP production and fat oxidation leave you tired and bloated
Inflammation & Oxidative Stress: Constant low-grade inflammation and ROS damage accelerate cellular aging
Additional Factors: A fucked-up gut, disrupted circadian rhythm, and low sirtuin activity further screw your overall potential
Genetics: still play the main role but you weren't supposed to be ugly
TAGS: @fr0st @maarda @ER enjoyer @Zagro @REGULUS @Jonas2k7 @staton @HostSamurai @trench @superpsycho @Ashoimex @sover @h111 @halloweed @PsychoH

this took a long time damnn

@Numb The Pain @Alexanderr @NumbThePain @TechnoBoss BOTB worthy? :forcedsmile:
Read every single molecule mirin high Iq thread :love:
 
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I read every molecule nigga
High effort thread should be added to botb
 
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Water thread
 
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if you have any questions feel free to pm me btw :Comfy:



also tagging some high iqcels that i hope that'll make some criticism and tell me if i made any mistakes @Orc @NZb6Air @Rigged @Seth Walsh @enchanted_elixir
@NorwoodAscender
 

How Modern Life Destroys Your Genes, Hormones, and Cellular Machinery (and How to Reclaim Your Looks)​

The answer isn’t “luck”—it’s a combination of fucked-up epigenetics, hormonal imbalances, inflammation, oxidative stress, and more. Here’s how your environment and lifestyle rewrite your biology and what you need to do to hack it back.

EPIGENETICS & GENE EXPRESSION

Your genes aren’t destiny—they’re constantly being rewritten by your lifestyle

DNA Methylation: Methyl groups stick to your DNA (CpG islands) and silence genes. Excess methylation—driven by high sugar, processed foods, and toxic exposures (BPA, microplastics)—shuts down genes for collagen production and antioxidant defenses. (Aging Cell, PMID: 24983061)

Histone Modifications: Chemical tags (acetyl, methyl groups) on histones control DNA packaging. A diet low in antioxidants and chronic stress push histones into a repressive state, silencing repair genes and ramping up inflammation. (Epigenetics, PMID: 25678660)

MicroRNAs: These tiny RNA pieces fine-tune gene expression. Toxin exposure and poor nutrition distort miRNA profiles, reducing collagen synthesis and accelerating aging. (Clinical Epigenetics, PMID: 28255644)

AGEs: Advanced glycation end-products from excess sugar bind to and damage proteins like collagen, locking in harmful epigenetic changes. (Diabetes, PMID: 15918433)

Ditch processed shit, eat antioxidant-rich whole foods, and minimize toxic exposures (BPA-free, reduce blue light)

Here Are Some Good Threads:

HORMONES : BUILD OR BREAK YOU

Your hormones are the masterminds behind your looks and performance

HGH & IGF-1: HGH from your pituitary tells your liver to produce IGF-1, which drives cell proliferation, bone growth, and muscle hypertrophy. Without proper HGH/IGF-1, your craniofacial structure and muscle mass suffer. Studies in GHD kids prove even low-dose HGH can normalize facial dimensions

Testosterone & DHT: Testosterone, synthesized from cholesterol, binds to androgen receptors to stimulate bone formation and muscle synthesis (via mTOR) and inhibit fat storage. DHT, a more potent derivative produced by 5-alpha reductase, sharpens your facial features and promotes proper beard growth. Low levels leave you soft and flabby. (Am J Hum Biol, PMID: 22068786)

Cortisol: Chronic stress spikes cortisol, which increases fat storage (via upregulating LPL), degrades collagen, and suppresses anabolic hormones. High cortisol means a bloated, aged appearance. (Psychosomatic Medicine, PMID: 24053391)

Additional Players: Melatonin acts as a DNA-protecting antioxidant, and DHEA, a precursor hormone, supports overall vitality. Androsterone, a DHT metabolite, influences metabolism and even acts as a neurosteroid.

Eat cholesterol-rich, nutrient-dense foods; lift heavy compound movements; get solid sunlight (or supplement with vitamin D3); and cut out endocrine disruptors like plastics and seed oils also use L-theanine for reduced cortisol

Here Are Some Good Threads:

CELLULAR ENERGY & MITOCHONDRIAL FUNCTION

Your mitochondria are your cellular powerhouses—they fuel everything with ATP

ATP Production: Through oxidative phosphorylation, mitochondria convert nutrients into ATP. Efficient ATP is essential for muscle contraction, cell repair, and fat oxidation

Impact: Inefficient mitochondria result in low energy, poor fat metabolism, and increased oxidative stress, leading to a tired, aged appearance. (Nature Communications, PMID: 25416742)

Fat Oxidation: Proper breakdown of triglycerides via beta-oxidation keeps your body lean and your features sharp. High triglycerides mean you're puffy and weak. (AJCN, PMID: 23060417)

Use cold exposure to boost mitochondrial biogenesis, red light therapy to stimulate cytochrome c oxidase, and adopt a ketogenic diet or intermittent fasting to force fat oxidation you can also supplement methylene blue for mitochondrial support

Here Are Some Good Threads:

INFLAMMATION, OXIDATIVE STRESS & CELLULAR SENESCENCE

It’s not just hormones and mitochondria—chronic inflammation and oxidative damage are silently aging you
Oxidative Stress: Reactive oxygen species (ROS) damage DNA, proteins, and lipids. Excess ROS triggers cellular senescence and epigenetic alterations that accelerate aging

Inflammation: Constant low-grade inflammation, fueled by poor diet and stress, not only damages tissues but also alters gene expression toward a catabolic state
Telomere Shortening: Chronic stress and oxidative stress shorten telomeres—the protective caps on your chromosomes—leading to premature cellular aging. (Circulation, PMID: 21807624)

Ramp up your intake of antioxidants (vitamin C, E, polyphenols), reduce inflammatory foods (processed sugars, seed oils), and incorporate anti-inflammatory supplements like omega-3s, resveratrol, and curcumin

Here Are Some Good Threads:

ADDITIONAL FACTORS: GUT MICROBIOME, CIRCADIAN RHYTHM, & SIRTUINS

Beyond the obvious, several high-level mechanisms play into your appearance

Gut Microbiome: Your gut health affects systemic inflammation and nutrient absorption, which in turn influences skin quality and hormone production. Dysbiosis leads to increased inflammatory cytokines that harm your epigenome. (Nature, PMID: 28218504)

Circadian Rhythm: Disrupted sleep patterns due to blue light exposure or erratic schedules throw off hormone production (like melatonin and HGH) and worsen your epigenetic markers

Sirtuins (SIRT1): These proteins regulate cellular aging and stress responses. Activating sirtuins (through caloric restriction, resveratrol, etc.) helps maintain youthful gene expression and cellular repair. (Cell Metabolism, PMID: 20580441)

Optimize your gut with fermented foods and probiotics; maintain a strict sleep schedule with proper dark periods; and consider sirtuin activators if you’re serious about longevity

Here Are Some Good Threads:


You weren’t born weak or ugly—the modern lifestyle has fucked up your genetic expression and hormone profiles.​

TL;DR – The Brutal Truth​

Your looks and energy are a raw, biochemical equation:
Epigenetics: Junk food, stress, and toxins hypermethylate your DNA, repress repair genes, and accelerate aging
Hormones: Low HGH/IGF-1, testosterone/DHT, and high cortisol make you look weak and aged
Mitochondria: Poor ATP production and fat oxidation leave you tired and bloated
Inflammation & Oxidative Stress: Constant low-grade inflammation and ROS damage accelerate cellular aging
Additional Factors: A fucked-up gut, disrupted circadian rhythm, and low sirtuin activity further screw your overall potential
Genetics: still play the main role but you weren't supposed to be ugly
TAGS: @fr0st @maarda @ER enjoyer @Zagro @REGULUS @Jonas2k7 @staton @HostSamurai @trench @superpsycho @Ashoimex @sover @h111 @halloweed @PsychoH

this took a long time damnn

@Numb The Pain @Alexanderr @NumbThePain @TechnoBoss BOTB worthy? :forcedsmile:
nice information
 
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How Modern Life Destroys Your Genes, Hormones, and Cellular Machinery (and How to Reclaim Your Looks)​

The answer isn’t “luck”—it’s a combination of fucked-up epigenetics, hormonal imbalances, inflammation, oxidative stress, and more. Here’s how your environment and lifestyle rewrite your biology and what you need to do to hack it back.

EPIGENETICS & GENE EXPRESSION

Your genes aren’t destiny—they’re constantly being rewritten by your lifestyle

DNA Methylation: Methyl groups stick to your DNA (CpG islands) and silence genes. Excess methylation—driven by high sugar, processed foods, and toxic exposures (BPA, microplastics)—shuts down genes for collagen production and antioxidant defenses. (Aging Cell, PMID: 24983061)

Histone Modifications: Chemical tags (acetyl, methyl groups) on histones control DNA packaging. A diet low in antioxidants and chronic stress push histones into a repressive state, silencing repair genes and ramping up inflammation. (Epigenetics, PMID: 25678660)

MicroRNAs: These tiny RNA pieces fine-tune gene expression. Toxin exposure and poor nutrition distort miRNA profiles, reducing collagen synthesis and accelerating aging. (Clinical Epigenetics, PMID: 28255644)

AGEs: Advanced glycation end-products from excess sugar bind to and damage proteins like collagen, locking in harmful epigenetic changes. (Diabetes, PMID: 15918433)

Ditch processed shit, eat antioxidant-rich whole foods, and minimize toxic exposures (BPA-free, reduce blue light)

Here Are Some Good Threads:

HORMONES : BUILD OR BREAK YOU

Your hormones are the masterminds behind your looks and performance

HGH & IGF-1: HGH from your pituitary tells your liver to produce IGF-1, which drives cell proliferation, bone growth, and muscle hypertrophy. Without proper HGH/IGF-1, your craniofacial structure and muscle mass suffer. Studies in GHD kids prove even low-dose HGH can normalize facial dimensions

Testosterone & DHT: Testosterone, synthesized from cholesterol, binds to androgen receptors to stimulate bone formation and muscle synthesis (via mTOR) and inhibit fat storage. DHT, a more potent derivative produced by 5-alpha reductase, sharpens your facial features and promotes proper beard growth. Low levels leave you soft and flabby. (Am J Hum Biol, PMID: 22068786)

Cortisol: Chronic stress spikes cortisol, which increases fat storage (via upregulating LPL), degrades collagen, and suppresses anabolic hormones. High cortisol means a bloated, aged appearance. (Psychosomatic Medicine, PMID: 24053391)

Additional Players: Melatonin acts as a DNA-protecting antioxidant, and DHEA, a precursor hormone, supports overall vitality. Androsterone, a DHT metabolite, influences metabolism and even acts as a neurosteroid.

Eat cholesterol-rich, nutrient-dense foods; lift heavy compound movements; get solid sunlight (or supplement with vitamin D3); and cut out endocrine disruptors like plastics and seed oils also use L-theanine for reduced cortisol

Here Are Some Good Threads:

CELLULAR ENERGY & MITOCHONDRIAL FUNCTION

Your mitochondria are your cellular powerhouses—they fuel everything with ATP

ATP Production: Through oxidative phosphorylation, mitochondria convert nutrients into ATP. Efficient ATP is essential for muscle contraction, cell repair, and fat oxidation

Impact: Inefficient mitochondria result in low energy, poor fat metabolism, and increased oxidative stress, leading to a tired, aged appearance. (Nature Communications, PMID: 25416742)

Fat Oxidation: Proper breakdown of triglycerides via beta-oxidation keeps your body lean and your features sharp. High triglycerides mean you're puffy and weak. (AJCN, PMID: 23060417)

Use cold exposure to boost mitochondrial biogenesis, red light therapy to stimulate cytochrome c oxidase, and adopt a ketogenic diet or intermittent fasting to force fat oxidation you can also supplement methylene blue for mitochondrial support

Here Are Some Good Threads:

INFLAMMATION, OXIDATIVE STRESS & CELLULAR SENESCENCE

It’s not just hormones and mitochondria—chronic inflammation and oxidative damage are silently aging you
Oxidative Stress: Reactive oxygen species (ROS) damage DNA, proteins, and lipids. Excess ROS triggers cellular senescence and epigenetic alterations that accelerate aging

Inflammation: Constant low-grade inflammation, fueled by poor diet and stress, not only damages tissues but also alters gene expression toward a catabolic state
Telomere Shortening: Chronic stress and oxidative stress shorten telomeres—the protective caps on your chromosomes—leading to premature cellular aging. (Circulation, PMID: 21807624)

Ramp up your intake of antioxidants (vitamin C, E, polyphenols), reduce inflammatory foods (processed sugars, seed oils), and incorporate anti-inflammatory supplements like omega-3s, resveratrol, and curcumin

Here Are Some Good Threads:

ADDITIONAL FACTORS: GUT MICROBIOME, CIRCADIAN RHYTHM, & SIRTUINS

Beyond the obvious, several high-level mechanisms play into your appearance

Gut Microbiome: Your gut health affects systemic inflammation and nutrient absorption, which in turn influences skin quality and hormone production. Dysbiosis leads to increased inflammatory cytokines that harm your epigenome. (Nature, PMID: 28218504)

Circadian Rhythm: Disrupted sleep patterns due to blue light exposure or erratic schedules throw off hormone production (like melatonin and HGH) and worsen your epigenetic markers

Sirtuins (SIRT1): These proteins regulate cellular aging and stress responses. Activating sirtuins (through caloric restriction, resveratrol, etc.) helps maintain youthful gene expression and cellular repair. (Cell Metabolism, PMID: 20580441)

Optimize your gut with fermented foods and probiotics; maintain a strict sleep schedule with proper dark periods; and consider sirtuin activators if you’re serious about longevity

Here Are Some Good Threads:


You weren’t born weak or ugly—the modern lifestyle has fucked up your genetic expression and hormone profiles.​

TL;DR – The Brutal Truth​

Your looks and energy are a raw, biochemical equation:
Epigenetics: Junk food, stress, and toxins hypermethylate your DNA, repress repair genes, and accelerate aging
Hormones: Low HGH/IGF-1, testosterone/DHT, and high cortisol make you look weak and aged
Mitochondria: Poor ATP production and fat oxidation leave you tired and bloated
Inflammation & Oxidative Stress: Constant low-grade inflammation and ROS damage accelerate cellular aging
Additional Factors: A fucked-up gut, disrupted circadian rhythm, and low sirtuin activity further screw your overall potential
Genetics: still play the main role but you weren't supposed to be ugly
TAGS: @fr0st @maarda @ER enjoyer @Zagro @REGULUS @Jonas2k7 @staton @HostSamurai @trench @superpsycho @Ashoimex @sover @h111 @halloweed @PsychoH

this took a long time damnn

@Numb The Pain @Alexanderr @NumbThePain @TechnoBoss BOTB worthy? :forcedsmile:
legit
 
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How Modern Life Destroys Your Genes, Hormones, and Cellular Machinery (and How to Reclaim Your Looks)​

The answer isn’t “luck”—it’s a combination of fucked-up epigenetics, hormonal imbalances, inflammation, oxidative stress, and more. Here’s how your environment and lifestyle rewrite your biology and what you need to do to hack it back.

EPIGENETICS & GENE EXPRESSION

Your genes aren’t destiny—they’re constantly being rewritten by your lifestyle

DNA Methylation: Methyl groups stick to your DNA (CpG islands) and silence genes. Excess methylation—driven by high sugar, processed foods, and toxic exposures (BPA, microplastics)—shuts down genes for collagen production and antioxidant defenses. (Aging Cell, PMID: 24983061)

Histone Modifications: Chemical tags (acetyl, methyl groups) on histones control DNA packaging. A diet low in antioxidants and chronic stress push histones into a repressive state, silencing repair genes and ramping up inflammation. (Epigenetics, PMID: 25678660)

MicroRNAs: These tiny RNA pieces fine-tune gene expression. Toxin exposure and poor nutrition distort miRNA profiles, reducing collagen synthesis and accelerating aging. (Clinical Epigenetics, PMID: 28255644)

AGEs: Advanced glycation end-products from excess sugar bind to and damage proteins like collagen, locking in harmful epigenetic changes. (Diabetes, PMID: 15918433)

Ditch processed shit, eat antioxidant-rich whole foods, and minimize toxic exposures (BPA-free, reduce blue light)

Here Are Some Good Threads:

HORMONES : BUILD OR BREAK YOU

Your hormones are the masterminds behind your looks and performance

HGH & IGF-1: HGH from your pituitary tells your liver to produce IGF-1, which drives cell proliferation, bone growth, and muscle hypertrophy. Without proper HGH/IGF-1, your craniofacial structure and muscle mass suffer. Studies in GHD kids prove even low-dose HGH can normalize facial dimensions

Testosterone & DHT: Testosterone, synthesized from cholesterol, binds to androgen receptors to stimulate bone formation and muscle synthesis (via mTOR) and inhibit fat storage. DHT, a more potent derivative produced by 5-alpha reductase, sharpens your facial features and promotes proper beard growth. Low levels leave you soft and flabby. (Am J Hum Biol, PMID: 22068786)

Cortisol: Chronic stress spikes cortisol, which increases fat storage (via upregulating LPL), degrades collagen, and suppresses anabolic hormones. High cortisol means a bloated, aged appearance. (Psychosomatic Medicine, PMID: 24053391)

Additional Players: Melatonin acts as a DNA-protecting antioxidant, and DHEA, a precursor hormone, supports overall vitality. Androsterone, a DHT metabolite, influences metabolism and even acts as a neurosteroid.

Eat cholesterol-rich, nutrient-dense foods; lift heavy compound movements; get solid sunlight (or supplement with vitamin D3); and cut out endocrine disruptors like plastics and seed oils also use L-theanine for reduced cortisol

Here Are Some Good Threads:

CELLULAR ENERGY & MITOCHONDRIAL FUNCTION

Your mitochondria are your cellular powerhouses—they fuel everything with ATP

ATP Production: Through oxidative phosphorylation, mitochondria convert nutrients into ATP. Efficient ATP is essential for muscle contraction, cell repair, and fat oxidation

Impact: Inefficient mitochondria result in low energy, poor fat metabolism, and increased oxidative stress, leading to a tired, aged appearance. (Nature Communications, PMID: 25416742)

Fat Oxidation: Proper breakdown of triglycerides via beta-oxidation keeps your body lean and your features sharp. High triglycerides mean you're puffy and weak. (AJCN, PMID: 23060417)

Use cold exposure to boost mitochondrial biogenesis, red light therapy to stimulate cytochrome c oxidase, and adopt a ketogenic diet or intermittent fasting to force fat oxidation you can also supplement methylene blue for mitochondrial support

Here Are Some Good Threads:

INFLAMMATION, OXIDATIVE STRESS & CELLULAR SENESCENCE

It’s not just hormones and mitochondria—chronic inflammation and oxidative damage are silently aging you
Oxidative Stress: Reactive oxygen species (ROS) damage DNA, proteins, and lipids. Excess ROS triggers cellular senescence and epigenetic alterations that accelerate aging

Inflammation: Constant low-grade inflammation, fueled by poor diet and stress, not only damages tissues but also alters gene expression toward a catabolic state
Telomere Shortening: Chronic stress and oxidative stress shorten telomeres—the protective caps on your chromosomes—leading to premature cellular aging. (Circulation, PMID: 21807624)

Ramp up your intake of antioxidants (vitamin C, E, polyphenols), reduce inflammatory foods (processed sugars, seed oils), and incorporate anti-inflammatory supplements like omega-3s, resveratrol, and curcumin

Here Are Some Good Threads:

ADDITIONAL FACTORS: GUT MICROBIOME, CIRCADIAN RHYTHM, & SIRTUINS

Beyond the obvious, several high-level mechanisms play into your appearance

Gut Microbiome: Your gut health affects systemic inflammation and nutrient absorption, which in turn influences skin quality and hormone production. Dysbiosis leads to increased inflammatory cytokines that harm your epigenome. (Nature, PMID: 28218504)

Circadian Rhythm: Disrupted sleep patterns due to blue light exposure or erratic schedules throw off hormone production (like melatonin and HGH) and worsen your epigenetic markers

Sirtuins (SIRT1): These proteins regulate cellular aging and stress responses. Activating sirtuins (through caloric restriction, resveratrol, etc.) helps maintain youthful gene expression and cellular repair. (Cell Metabolism, PMID: 20580441)

Optimize your gut with fermented foods and probiotics; maintain a strict sleep schedule with proper dark periods; and consider sirtuin activators if you’re serious about longevity

Here Are Some Good Threads:


You weren’t born weak or ugly—the modern lifestyle has fucked up your genetic expression and hormone profiles.​

TL;DR – The Brutal Truth​

Your looks and energy are a raw, biochemical equation:
Epigenetics: Junk food, stress, and toxins hypermethylate your DNA, repress repair genes, and accelerate aging
Hormones: Low HGH/IGF-1, testosterone/DHT, and high cortisol make you look weak and aged
Mitochondria: Poor ATP production and fat oxidation leave you tired and bloated
Inflammation & Oxidative Stress: Constant low-grade inflammation and ROS damage accelerate cellular aging
Additional Factors: A fucked-up gut, disrupted circadian rhythm, and low sirtuin activity further screw your overall potential
Genetics: still play the main role but you weren't supposed to be ugly
TAGS: @fr0st @maarda @ER enjoyer @Zagro @REGULUS @Jonas2k7 @staton @HostSamurai @trench @superpsycho @Ashoimex @sover @h111 @halloweed @PsychoH

this took a long time damnn

@Numb The Pain @Alexanderr @NumbThePain @TechnoBoss BOTB worthy? :forcedsmile:
idk if you have seen it but could i get an opinion since yall are active rn @Orc @TechnoBoss @NumbThePain @Numb The Pain :Comfy:




@Ron.Belgrade @0hMan
 
Last edited:
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idk if you have seen it but could i get an opinion since yall are active rn @Orc @TechnoBoss @NumbThePain @Numb The Pain :Comfy:




@Ron.Belgrade @0hMan
It looks high effort. Skimmed if briefly but I will read it to completion another time when I have the chance. Bookmarked for future reference.
 
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It looks high effort. Skimmed if briefly but I will read it to completion another time when I have the chance. Bookmarked for future reference.
ngl you are the only mod that atleast gives a reply to my questions love you bhai ❤️:love:
 
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How Modern Life Destroys Your Genes, Hormones, and Cellular Machinery (and How to Reclaim Your Looks)​

The answer isn’t “luck”—it’s a combination of fucked-up epigenetics, hormonal imbalances, inflammation, oxidative stress, and more. Here’s how your environment and lifestyle rewrite your biology and what you need to do to hack it back.

EPIGENETICS & GENE EXPRESSION

Your genes aren’t destiny—they’re constantly being rewritten by your lifestyle

DNA Methylation: Methyl groups stick to your DNA (CpG islands) and silence genes. Excess methylation—driven by high sugar, processed foods, and toxic exposures (BPA, microplastics)—shuts down genes for collagen production and antioxidant defenses. (Aging Cell, PMID: 24983061)

Histone Modifications: Chemical tags (acetyl, methyl groups) on histones control DNA packaging. A diet low in antioxidants and chronic stress push histones into a repressive state, silencing repair genes and ramping up inflammation. (Epigenetics, PMID: 25678660)

MicroRNAs: These tiny RNA pieces fine-tune gene expression. Toxin exposure and poor nutrition distort miRNA profiles, reducing collagen synthesis and accelerating aging. (Clinical Epigenetics, PMID: 28255644)

AGEs: Advanced glycation end-products from excess sugar bind to and damage proteins like collagen, locking in harmful epigenetic changes. (Diabetes, PMID: 15918433)

Ditch processed shit, eat antioxidant-rich whole foods, and minimize toxic exposures (BPA-free, reduce blue light)

Here Are Some Good Threads:

HORMONES : BUILD OR BREAK YOU

Your hormones are the masterminds behind your looks and performance

HGH & IGF-1: HGH from your pituitary tells your liver to produce IGF-1, which drives cell proliferation, bone growth, and muscle hypertrophy. Without proper HGH/IGF-1, your craniofacial structure and muscle mass suffer. Studies in GHD kids prove even low-dose HGH can normalize facial dimensions

Testosterone & DHT: Testosterone, synthesized from cholesterol, binds to androgen receptors to stimulate bone formation and muscle synthesis (via mTOR) and inhibit fat storage. DHT, a more potent derivative produced by 5-alpha reductase, sharpens your facial features and promotes proper beard growth. Low levels leave you soft and flabby. (Am J Hum Biol, PMID: 22068786)

Cortisol: Chronic stress spikes cortisol, which increases fat storage (via upregulating LPL), degrades collagen, and suppresses anabolic hormones. High cortisol means a bloated, aged appearance. (Psychosomatic Medicine, PMID: 24053391)

Additional Players: Melatonin acts as a DNA-protecting antioxidant, and DHEA, a precursor hormone, supports overall vitality. Androsterone, a DHT metabolite, influences metabolism and even acts as a neurosteroid.

Eat cholesterol-rich, nutrient-dense foods; lift heavy compound movements; get solid sunlight (or supplement with vitamin D3); and cut out endocrine disruptors like plastics and seed oils also use L-theanine for reduced cortisol

Here Are Some Good Threads:

CELLULAR ENERGY & MITOCHONDRIAL FUNCTION

Your mitochondria are your cellular powerhouses—they fuel everything with ATP

ATP Production: Through oxidative phosphorylation, mitochondria convert nutrients into ATP. Efficient ATP is essential for muscle contraction, cell repair, and fat oxidation

Impact: Inefficient mitochondria result in low energy, poor fat metabolism, and increased oxidative stress, leading to a tired, aged appearance. (Nature Communications, PMID: 25416742)

Fat Oxidation: Proper breakdown of triglycerides via beta-oxidation keeps your body lean and your features sharp. High triglycerides mean you're puffy and weak. (AJCN, PMID: 23060417)

Use cold exposure to boost mitochondrial biogenesis, red light therapy to stimulate cytochrome c oxidase, and adopt a ketogenic diet or intermittent fasting to force fat oxidation you can also supplement methylene blue for mitochondrial support

Here Are Some Good Threads:

INFLAMMATION, OXIDATIVE STRESS & CELLULAR SENESCENCE

It’s not just hormones and mitochondria—chronic inflammation and oxidative damage are silently aging you
Oxidative Stress: Reactive oxygen species (ROS) damage DNA, proteins, and lipids. Excess ROS triggers cellular senescence and epigenetic alterations that accelerate aging

Inflammation: Constant low-grade inflammation, fueled by poor diet and stress, not only damages tissues but also alters gene expression toward a catabolic state
Telomere Shortening: Chronic stress and oxidative stress shorten telomeres—the protective caps on your chromosomes—leading to premature cellular aging. (Circulation, PMID: 21807624)

Ramp up your intake of antioxidants (vitamin C, E, polyphenols), reduce inflammatory foods (processed sugars, seed oils), and incorporate anti-inflammatory supplements like omega-3s, resveratrol, and curcumin

Here Are Some Good Threads:

ADDITIONAL FACTORS: GUT MICROBIOME, CIRCADIAN RHYTHM, & SIRTUINS

Beyond the obvious, several high-level mechanisms play into your appearance

Gut Microbiome: Your gut health affects systemic inflammation and nutrient absorption, which in turn influences skin quality and hormone production. Dysbiosis leads to increased inflammatory cytokines that harm your epigenome. (Nature, PMID: 28218504)

Circadian Rhythm: Disrupted sleep patterns due to blue light exposure or erratic schedules throw off hormone production (like melatonin and HGH) and worsen your epigenetic markers

Sirtuins (SIRT1): These proteins regulate cellular aging and stress responses. Activating sirtuins (through caloric restriction, resveratrol, etc.) helps maintain youthful gene expression and cellular repair. (Cell Metabolism, PMID: 20580441)

Optimize your gut with fermented foods and probiotics; maintain a strict sleep schedule with proper dark periods; and consider sirtuin activators if you’re serious about longevity

Here Are Some Good Threads:


You weren’t born weak or ugly—the modern lifestyle has fucked up your genetic expression and hormone profiles.​

TL;DR – The Brutal Truth​

Your looks and energy are a raw, biochemical equation:
Epigenetics: Junk food, stress, and toxins hypermethylate your DNA, repress repair genes, and accelerate aging
Hormones: Low HGH/IGF-1, testosterone/DHT, and high cortisol make you look weak and aged
Mitochondria: Poor ATP production and fat oxidation leave you tired and bloated
Inflammation & Oxidative Stress: Constant low-grade inflammation and ROS damage accelerate cellular aging
Additional Factors: A fucked-up gut, disrupted circadian rhythm, and low sirtuin activity further screw your overall potential
Genetics: still play the main role but you weren't supposed to be ugly
TAGS: @fr0st @maarda @ER enjoyer @Zagro @REGULUS @Jonas2k7 @staton @HostSamurai @trench @superpsycho @Ashoimex @sover @h111 @halloweed @PsychoH

this took a long time damnn

@Numb The Pain @Alexanderr @NumbThePain @TechnoBoss BOTB worthy? :forcedsmile:
Hight Iq
 
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good thread, its insane to me that sm people dont know the importance of gut health
its wildy misunderstood, rogan and huberman convinced people that sugar, artificial sweeteners, fiber and vegetables were bad for gut health but rarely ever took a look at literally any athlete for their studies that ate insane amounts of sugar/carbs. Tried convincing teenagers that the only diet is raw meat raw milk and avocadoes

so there isn't super concrete evidence on what disrupts your gut microbiome because most studies have a study that will contradict it because no one is eating nothing but sucralose all day for 3 months straight its like r/tressless all over again

general consensus is just to eat probiotic foods almost nothing else matters after that
 
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bump
 
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dnr yet but bookmarked
 
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D-Limonene is great for getting gut health in order. Large amounts of that on an empty stomach will really knock the crap out of the bad stuff in the small intestine.
 
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nice thread man. are u that guy who joined in 2019? I think I saw ur heightmax thread before.
 
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How Modern Life Destroys Your Genes, Hormones, and Cellular Machinery (and How to Reclaim Your Looks)​

The answer isn’t “luck”—it’s a combination of fucked-up epigenetics, hormonal imbalances, inflammation, oxidative stress, and more. Here’s how your environment and lifestyle rewrite your biology and what you need to do to hack it back.

EPIGENETICS & GENE EXPRESSION

Your genes aren’t destiny—they’re constantly being rewritten by your lifestyle

DNA Methylation: Methyl groups stick to your DNA (CpG islands) and silence genes. Excess methylation—driven by high sugar, processed foods, and toxic exposures (BPA, microplastics)—shuts down genes for collagen production and antioxidant defenses. (Aging Cell, PMID: 24983061)

Histone Modifications: Chemical tags (acetyl, methyl groups) on histones control DNA packaging. A diet low in antioxidants and chronic stress push histones into a repressive state, silencing repair genes and ramping up inflammation. (Epigenetics, PMID: 25678660)

MicroRNAs: These tiny RNA pieces fine-tune gene expression. Toxin exposure and poor nutrition distort miRNA profiles, reducing collagen synthesis and accelerating aging. (Clinical Epigenetics, PMID: 28255644)

AGEs: Advanced glycation end-products from excess sugar bind to and damage proteins like collagen, locking in harmful epigenetic changes. (Diabetes, PMID: 15918433)

Ditch processed shit, eat antioxidant-rich whole foods, and minimize toxic exposures (BPA-free, reduce blue light)

Here Are Some Good Threads:

HORMONES : BUILD OR BREAK YOU

Your hormones are the masterminds behind your looks and performance

HGH & IGF-1: HGH from your pituitary tells your liver to produce IGF-1, which drives cell proliferation, bone growth, and muscle hypertrophy. Without proper HGH/IGF-1, your craniofacial structure and muscle mass suffer. Studies in GHD kids prove even low-dose HGH can normalize facial dimensions

Testosterone & DHT: Testosterone, synthesized from cholesterol, binds to androgen receptors to stimulate bone formation and muscle synthesis (via mTOR) and inhibit fat storage. DHT, a more potent derivative produced by 5-alpha reductase, sharpens your facial features and promotes proper beard growth. Low levels leave you soft and flabby. (Am J Hum Biol, PMID: 22068786)

Cortisol: Chronic stress spikes cortisol, which increases fat storage (via upregulating LPL), degrades collagen, and suppresses anabolic hormones. High cortisol means a bloated, aged appearance. (Psychosomatic Medicine, PMID: 24053391)

Additional Players: Melatonin acts as a DNA-protecting antioxidant, and DHEA, a precursor hormone, supports overall vitality. Androsterone, a DHT metabolite, influences metabolism and even acts as a neurosteroid.

Eat cholesterol-rich, nutrient-dense foods; lift heavy compound movements; get solid sunlight (or supplement with vitamin D3); and cut out endocrine disruptors like plastics and seed oils also use L-theanine for reduced cortisol

Here Are Some Good Threads:

CELLULAR ENERGY & MITOCHONDRIAL FUNCTION

Your mitochondria are your cellular powerhouses—they fuel everything with ATP

ATP Production: Through oxidative phosphorylation, mitochondria convert nutrients into ATP. Efficient ATP is essential for muscle contraction, cell repair, and fat oxidation

Impact: Inefficient mitochondria result in low energy, poor fat metabolism, and increased oxidative stress, leading to a tired, aged appearance. (Nature Communications, PMID: 25416742)

Fat Oxidation: Proper breakdown of triglycerides via beta-oxidation keeps your body lean and your features sharp. High triglycerides mean you're puffy and weak. (AJCN, PMID: 23060417)

Use cold exposure to boost mitochondrial biogenesis, red light therapy to stimulate cytochrome c oxidase, and adopt a ketogenic diet or intermittent fasting to force fat oxidation you can also supplement methylene blue for mitochondrial support

Here Are Some Good Threads:

INFLAMMATION, OXIDATIVE STRESS & CELLULAR SENESCENCE

It’s not just hormones and mitochondria—chronic inflammation and oxidative damage are silently aging you
Oxidative Stress: Reactive oxygen species (ROS) damage DNA, proteins, and lipids. Excess ROS triggers cellular senescence and epigenetic alterations that accelerate aging

Inflammation: Constant low-grade inflammation, fueled by poor diet and stress, not only damages tissues but also alters gene expression toward a catabolic state
Telomere Shortening: Chronic stress and oxidative stress shorten telomeres—the protective caps on your chromosomes—leading to premature cellular aging. (Circulation, PMID: 21807624)

Ramp up your intake of antioxidants (vitamin C, E, polyphenols), reduce inflammatory foods (processed sugars, seed oils), and incorporate anti-inflammatory supplements like omega-3s, resveratrol, and curcumin

Here Are Some Good Threads:

ADDITIONAL FACTORS: GUT MICROBIOME, CIRCADIAN RHYTHM, & SIRTUINS

Beyond the obvious, several high-level mechanisms play into your appearance

Gut Microbiome: Your gut health affects systemic inflammation and nutrient absorption, which in turn influences skin quality and hormone production. Dysbiosis leads to increased inflammatory cytokines that harm your epigenome. (Nature, PMID: 28218504)

Circadian Rhythm: Disrupted sleep patterns due to blue light exposure or erratic schedules throw off hormone production (like melatonin and HGH) and worsen your epigenetic markers

Sirtuins (SIRT1): These proteins regulate cellular aging and stress responses. Activating sirtuins (through caloric restriction, resveratrol, etc.) helps maintain youthful gene expression and cellular repair. (Cell Metabolism, PMID: 20580441)

Optimize your gut with fermented foods and probiotics; maintain a strict sleep schedule with proper dark periods; and consider sirtuin activators if you’re serious about longevity

Here Are Some Good Threads:


You weren’t born weak or ugly—the modern lifestyle has fucked up your genetic expression and hormone profiles.​

TL;DR – The Brutal Truth​

Your looks and energy are a raw, biochemical equation:
Epigenetics: Junk food, stress, and toxins hypermethylate your DNA, repress repair genes, and accelerate aging
Hormones: Low HGH/IGF-1, testosterone/DHT, and high cortisol make you look weak and aged
Mitochondria: Poor ATP production and fat oxidation leave you tired and bloated
Inflammation & Oxidative Stress: Constant low-grade inflammation and ROS damage accelerate cellular aging
Additional Factors: A fucked-up gut, disrupted circadian rhythm, and low sirtuin activity further screw your overall potential
Genetics: still play the main role but you weren't supposed to be ugly
TAGS: @fr0st @maarda @ER enjoyer @Zagro @REGULUS @Jonas2k7 @staton @HostSamurai @trench @superpsycho @Ashoimex @sover @h111 @halloweed @PsychoH

this took a long time damnn

@Numb The Pain @Alexanderr @NumbThePain @TechnoBoss BOTB worthy? :forcedsmile:
high iq thread mirin
 
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im eren yeager
 
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"[...] incorporate anti-inflammatory supplements like omega-3s"

:feelswhy: bruh
 
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Reactions: menas
wait i thought you may be into ray peat but then you recommend pufas, im confused
 
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Reactions: menas
wait i thought you may be into ray peat but then you recommend pufas, im confused
i just do my own research in general. Also it isn't that deep lmao but i heard they could help with inflammation and i kept the advice parts short since i added way more detailed threads under all of the parts


also tbh i never saw ray peats opinion on pufas before, thanks for letting me know.
 
Last edited:
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How Modern Life Destroys Your Genes, Hormones, and Cellular Machinery (and How to Reclaim Your Looks)​

The answer isn’t “luck”—it’s a combination of fucked-up epigenetics, hormonal imbalances, inflammation, oxidative stress, and more. Here’s how your environment and lifestyle rewrite your biology and what you need to do to hack it back.

EPIGENETICS & GENE EXPRESSION

Your genes aren’t destiny—they’re constantly being rewritten by your lifestyle

DNA Methylation: Methyl groups stick to your DNA (CpG islands) and silence genes. Excess methylation—driven by high sugar, processed foods, and toxic exposures (BPA, microplastics)—shuts down genes for collagen production and antioxidant defenses. (Aging Cell, PMID: 24983061)

Histone Modifications: Chemical tags (acetyl, methyl groups) on histones control DNA packaging. A diet low in antioxidants and chronic stress push histones into a repressive state, silencing repair genes and ramping up inflammation. (Epigenetics, PMID: 25678660)

MicroRNAs: These tiny RNA pieces fine-tune gene expression. Toxin exposure and poor nutrition distort miRNA profiles, reducing collagen synthesis and accelerating aging. (Clinical Epigenetics, PMID: 28255644)

AGEs: Advanced glycation end-products from excess sugar bind to and damage proteins like collagen, locking in harmful epigenetic changes. (Diabetes, PMID: 15918433)

Ditch processed shit, eat antioxidant-rich whole foods, and minimize toxic exposures (BPA-free, reduce blue light)

Here Are Some Good Threads:

HORMONES : BUILD OR BREAK YOU

Your hormones are the masterminds behind your looks and performance

HGH & IGF-1: HGH from your pituitary tells your liver to produce IGF-1, which drives cell proliferation, bone growth, and muscle hypertrophy. Without proper HGH/IGF-1, your craniofacial structure and muscle mass suffer. Studies in GHD kids prove even low-dose HGH can normalize facial dimensions

Testosterone & DHT: Testosterone, synthesized from cholesterol, binds to androgen receptors to stimulate bone formation and muscle synthesis (via mTOR) and inhibit fat storage. DHT, a more potent derivative produced by 5-alpha reductase, sharpens your facial features and promotes proper beard growth. Low levels leave you soft and flabby. (Am J Hum Biol, PMID: 22068786)

Cortisol: Chronic stress spikes cortisol, which increases fat storage (via upregulating LPL), degrades collagen, and suppresses anabolic hormones. High cortisol means a bloated, aged appearance. (Psychosomatic Medicine, PMID: 24053391)

Additional Players: Melatonin acts as a DNA-protecting antioxidant, and DHEA, a precursor hormone, supports overall vitality. Androsterone, a DHT metabolite, influences metabolism and even acts as a neurosteroid.

Eat cholesterol-rich, nutrient-dense foods; lift heavy compound movements; get solid sunlight (or supplement with vitamin D3); and cut out endocrine disruptors like plastics and seed oils also use L-theanine for reduced cortisol

Here Are Some Good Threads:

CELLULAR ENERGY & MITOCHONDRIAL FUNCTION

Your mitochondria are your cellular powerhouses—they fuel everything with ATP

ATP Production: Through oxidative phosphorylation, mitochondria convert nutrients into ATP. Efficient ATP is essential for muscle contraction, cell repair, and fat oxidation

Impact: Inefficient mitochondria result in low energy, poor fat metabolism, and increased oxidative stress, leading to a tired, aged appearance. (Nature Communications, PMID: 25416742)

Fat Oxidation: Proper breakdown of triglycerides via beta-oxidation keeps your body lean and your features sharp. High triglycerides mean you're puffy and weak. (AJCN, PMID: 23060417)

Use cold exposure to boost mitochondrial biogenesis, red light therapy to stimulate cytochrome c oxidase, and adopt a ketogenic diet or intermittent fasting to force fat oxidation you can also supplement methylene blue for mitochondrial support

Here Are Some Good Threads:

INFLAMMATION, OXIDATIVE STRESS & CELLULAR SENESCENCE

It’s not just hormones and mitochondria—chronic inflammation and oxidative damage are silently aging you
Oxidative Stress: Reactive oxygen species (ROS) damage DNA, proteins, and lipids. Excess ROS triggers cellular senescence and epigenetic alterations that accelerate aging

Inflammation: Constant low-grade inflammation, fueled by poor diet and stress, not only damages tissues but also alters gene expression toward a catabolic state
Telomere Shortening: Chronic stress and oxidative stress shorten telomeres—the protective caps on your chromosomes—leading to premature cellular aging. (Circulation, PMID: 21807624)

Ramp up your intake of antioxidants (vitamin C, E, polyphenols), reduce inflammatory foods (processed sugars, seed oils), and incorporate anti-inflammatory supplements like omega-3s, resveratrol, and curcumin

Here Are Some Good Threads:

ADDITIONAL FACTORS: GUT MICROBIOME, CIRCADIAN RHYTHM, & SIRTUINS

Beyond the obvious, several high-level mechanisms play into your appearance

Gut Microbiome: Your gut health affects systemic inflammation and nutrient absorption, which in turn influences skin quality and hormone production. Dysbiosis leads to increased inflammatory cytokines that harm your epigenome. (Nature, PMID: 28218504)

Circadian Rhythm: Disrupted sleep patterns due to blue light exposure or erratic schedules throw off hormone production (like melatonin and HGH) and worsen your epigenetic markers

Sirtuins (SIRT1): These proteins regulate cellular aging and stress responses. Activating sirtuins (through caloric restriction, resveratrol, etc.) helps maintain youthful gene expression and cellular repair. (Cell Metabolism, PMID: 20580441)

Optimize your gut with fermented foods and probiotics; maintain a strict sleep schedule with proper dark periods; and consider sirtuin activators if you’re serious about longevity

Here Are Some Good Threads:


You weren’t born weak or ugly—the modern lifestyle has fucked up your genetic expression and hormone profiles.​

TL;DR – The Brutal Truth​

Your looks and energy are a raw, biochemical equation:
Epigenetics: Junk food, stress, and toxins hypermethylate your DNA, repress repair genes, and accelerate aging
Hormones: Low HGH/IGF-1, testosterone/DHT, and high cortisol make you look weak and aged
Mitochondria: Poor ATP production and fat oxidation leave you tired and bloated
Inflammation & Oxidative Stress: Constant low-grade inflammation and ROS damage accelerate cellular aging
Additional Factors: A fucked-up gut, disrupted circadian rhythm, and low sirtuin activity further screw your overall potential
Genetics: still play the main role but you weren't supposed to be ugly
TAGS: @fr0st @maarda @ER enjoyer @Zagro @REGULUS @Jonas2k7 @staton @HostSamurai @trench @superpsycho @Ashoimex @sover @h111 @halloweed @PsychoH

this took a long time damnn

@Numb The Pain @Alexanderr @NumbThePain @TechnoBoss BOTB worthy? :forcedsmile:
When I read epigenetics I thoujght you where going to go into genes being turned on and off (or becoming dormant). Any idea though if we can test for epigenetic changes? With my identical twin bro never using aas and e blasting huge amounts of androgens from a young age id love to see if their was some sort of change on the genetic level induced.
 
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Reactions: menas
When I read epigenetics I thoujght you where going to go into genes being turned on and off (or becoming dormant). Any idea though if we can test for epigenetic changes? With my identical twin bro never using aas and e blasting huge amounts of androgens from a young age id love to see if their was some sort of change on the genetic level induced.
even if you manage to get tests i don't think it'll give 100% true results tbh since it is impossible that you are %100 identical
 
water wet straw yellow
 

How Modern Life Destroys Your Genes, Hormones, and Cellular Machinery (and How to Reclaim Your Looks)​

The answer isn’t “luck”—it’s a combination of fucked-up epigenetics, hormonal imbalances, inflammation, oxidative stress, and more. Here’s how your environment and lifestyle rewrite your biology and what you need to do to hack it back.

EPIGENETICS & GENE EXPRESSION

Your genes aren’t destiny—they’re constantly being rewritten by your lifestyle

DNA Methylation: Methyl groups stick to your DNA (CpG islands) and silence genes. Excess methylation—driven by high sugar, processed foods, and toxic exposures (BPA, microplastics)—shuts down genes for collagen production and antioxidant defenses. (Aging Cell, PMID: 24983061)

Histone Modifications: Chemical tags (acetyl, methyl groups) on histones control DNA packaging. A diet low in antioxidants and chronic stress push histones into a repressive state, silencing repair genes and ramping up inflammation. (Epigenetics, PMID: 25678660)

MicroRNAs: These tiny RNA pieces fine-tune gene expression. Toxin exposure and poor nutrition distort miRNA profiles, reducing collagen synthesis and accelerating aging. (Clinical Epigenetics, PMID: 28255644)

AGEs: Advanced glycation end-products from excess sugar bind to and damage proteins like collagen, locking in harmful epigenetic changes. (Diabetes, PMID: 15918433)

Ditch processed shit, eat antioxidant-rich whole foods, and minimize toxic exposures (BPA-free, reduce blue light)

Here Are Some Good Threads:

HORMONES : BUILD OR BREAK YOU

Your hormones are the masterminds behind your looks and performance

HGH & IGF-1: HGH from your pituitary tells your liver to produce IGF-1, which drives cell proliferation, bone growth, and muscle hypertrophy. Without proper HGH/IGF-1, your craniofacial structure and muscle mass suffer. Studies in GHD kids prove even low-dose HGH can normalize facial dimensions

Testosterone & DHT: Testosterone, synthesized from cholesterol, binds to androgen receptors to stimulate bone formation and muscle synthesis (via mTOR) and inhibit fat storage. DHT, a more potent derivative produced by 5-alpha reductase, sharpens your facial features and promotes proper beard growth. Low levels leave you soft and flabby. (Am J Hum Biol, PMID: 22068786)

Cortisol: Chronic stress spikes cortisol, which increases fat storage (via upregulating LPL), degrades collagen, and suppresses anabolic hormones. High cortisol means a bloated, aged appearance. (Psychosomatic Medicine, PMID: 24053391)

Additional Players: Melatonin acts as a DNA-protecting antioxidant, and DHEA, a precursor hormone, supports overall vitality. Androsterone, a DHT metabolite, influences metabolism and even acts as a neurosteroid.

Eat cholesterol-rich, nutrient-dense foods; lift heavy compound movements; get solid sunlight (or supplement with vitamin D3); and cut out endocrine disruptors like plastics and seed oils also use L-theanine for reduced cortisol

Here Are Some Good Threads:

CELLULAR ENERGY & MITOCHONDRIAL FUNCTION

Your mitochondria are your cellular powerhouses—they fuel everything with ATP

ATP Production: Through oxidative phosphorylation, mitochondria convert nutrients into ATP. Efficient ATP is essential for muscle contraction, cell repair, and fat oxidation

Impact: Inefficient mitochondria result in low energy, poor fat metabolism, and increased oxidative stress, leading to a tired, aged appearance. (Nature Communications, PMID: 25416742)

Fat Oxidation: Proper breakdown of triglycerides via beta-oxidation keeps your body lean and your features sharp. High triglycerides mean you're puffy and weak. (AJCN, PMID: 23060417)

Use cold exposure to boost mitochondrial biogenesis, red light therapy to stimulate cytochrome c oxidase, and adopt a ketogenic diet or intermittent fasting to force fat oxidation you can also supplement methylene blue for mitochondrial support

Here Are Some Good Threads:

INFLAMMATION, OXIDATIVE STRESS & CELLULAR SENESCENCE

It’s not just hormones and mitochondria—chronic inflammation and oxidative damage are silently aging you
Oxidative Stress: Reactive oxygen species (ROS) damage DNA, proteins, and lipids. Excess ROS triggers cellular senescence and epigenetic alterations that accelerate aging

Inflammation: Constant low-grade inflammation, fueled by poor diet and stress, not only damages tissues but also alters gene expression toward a catabolic state
Telomere Shortening: Chronic stress and oxidative stress shorten telomeres—the protective caps on your chromosomes—leading to premature cellular aging. (Circulation, PMID: 21807624)

Ramp up your intake of antioxidants (vitamin C, E, polyphenols), reduce inflammatory foods (processed sugars, seed oils), and incorporate anti-inflammatory supplements like omega-3s, resveratrol, and curcumin

Here Are Some Good Threads:

ADDITIONAL FACTORS: GUT MICROBIOME, CIRCADIAN RHYTHM, & SIRTUINS

Beyond the obvious, several high-level mechanisms play into your appearance

Gut Microbiome: Your gut health affects systemic inflammation and nutrient absorption, which in turn influences skin quality and hormone production. Dysbiosis leads to increased inflammatory cytokines that harm your epigenome. (Nature, PMID: 28218504)

Circadian Rhythm: Disrupted sleep patterns due to blue light exposure or erratic schedules throw off hormone production (like melatonin and HGH) and worsen your epigenetic markers

Sirtuins (SIRT1): These proteins regulate cellular aging and stress responses. Activating sirtuins (through caloric restriction, resveratrol, etc.) helps maintain youthful gene expression and cellular repair. (Cell Metabolism, PMID: 20580441)

Optimize your gut with fermented foods and probiotics; maintain a strict sleep schedule with proper dark periods; and consider sirtuin activators if you’re serious about longevity

Here Are Some Good Threads:


You weren’t born weak or ugly—the modern lifestyle has fucked up your genetic expression and hormone profiles.​

TL;DR – The Brutal Truth​

Your looks and energy are a raw, biochemical equation:
Epigenetics: Junk food, stress, and toxins hypermethylate your DNA, repress repair genes, and accelerate aging
Hormones: Low HGH/IGF-1, testosterone/DHT, and high cortisol make you look weak and aged
Mitochondria: Poor ATP production and fat oxidation leave you tired and bloated
Inflammation & Oxidative Stress: Constant low-grade inflammation and ROS damage accelerate cellular aging
Additional Factors: A fucked-up gut, disrupted circadian rhythm, and low sirtuin activity further screw your overall potential
Genetics: still play the main role but you weren't supposed to be ugly
TAGS: @fr0st @maarda @ER enjoyer @Zagro @REGULUS @Jonas2k7 @staton @HostSamurai @trench @superpsycho @Ashoimex @sover @h111 @halloweed @PsychoH

this took a long time damnn

@Numb The Pain @Alexanderr @NumbThePain @TechnoBoss BOTB worthy? :forcedsmile:
water, who doesnt know this........
 
  • JFL
Reactions: menas

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