nopill_
Iron
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I DO NOT CONDONE OR PROMOTE THE USE OF UNPRESCRIBED MEDICAL COMPOUNDS. INFORMATIVE AND EDUCATIONAL PURPOSE. THIS FUNCTIONS AS A WARNING FOR FUTURE REFERENCE, FOR THE SAKE OF HARM REDUCTION.
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Erdafitinib is a targeted anticancer medication that blocks proteins called fibroblast growth factor receptors (FGFRs). Some cancers develop changes (mutations or fusions) in the FGFR2 or FGFR3 genes, causing tumor cells to grow uncontrollably.
Keywords: AE (Adverse effects/events), Hyperphosphatemia, CSR, (Central Serous Retinopathy), Xerosis, Hand-Foot Syndrome, Paronychia, Onycholisis and Dysgeusia.
But, we all know that you, the one reading this in this putrid place, isn't informing themselves on erdafitinib for anti-cancer purposes.
So, I'm going to talk about what you must know before blasting a cancer treatment medication.
————————————————————
Erdafitinib causes adverse or side effects in approximately every patient on treatment, within the first, second or third month, sometimes, within the first week. With ≈99% of patients reporting at least one Adverse Effects.
This also varies with dosing, as higher the dose, higher the rate and amount of AE.
Within all of the adverse effects, the most common, with a dose of 2mg or higher (i repeat, the higher the dose, the higher the rate and severity of the symptons) are:
• Hypesphosphatemia is the elevated levels of phosphate levels in blood due to the FGFR1 and FGFR3 inhibition. Can cause renal calcification (kidney stones or crystal formation). However, this is rare ocurrence due to it being caused by the prolonged extension or constant maintenance of a high hyperphosphatemia, (be careful with it, don't be a retard) This condition doesn't have visible symptoms, can only be detected through bloodwork.
• Stomatitis is the inflammation of oral mucus, this can cause mouth injury, pain when talking or eating, burning sensation. This can be avoided through lowering the dose or stopping the complete ingestion of the medication.
• Diarrhea, this can be in many ways, bland pr liquid defecation, loss of electrolytes, dehydration. You already know this. This sympton will stop after you stop taking the medication.
• Dry mouth, less saliva, bad breath, can be difficult to eat. Also stops when you stop dosing.
• Fatigue, persistent tiredness. Also stops when you stop dosing
• Xerosis (Dry skin), important dryness of the skin. This can cause dead skin peeling or itching. Also stops after you stop dosing.
• Nail disorders, weak nails, bland nails, peeling of the nails, changes in thickness, abnormal growth, changes in color. Also stops after you stop dosing.
• Alopecia, significant or small hairloss, hair thinning, weaker lashes or brows, generally not severe. Effects reverted after you stop dosing.
• Hand-Foot syndrome, inflammation lf hands and feet, redness, swelling. In moderate cases, pain, skin peeling, dryness. In severe cases, blisters, ulcers, and difficulty walking.
• Constipation, difficulty shitting, bloating, abdominal pain, extreme sensation of shitting.
• Less/loss of apetite
• Dysgeusia, the alteration of taste, temporarily or during the duration of the medication.
• Nausea, especially after taking the medication for the first time or during the firsts hours, can cause vomiting.
• Anemia, less bloodcells and hemoglobin, can cause paleness, tiredness, dizziness, shortness of breath. Dissapears after stopping the medication.
• Dry eyes, itching, burning, can stop after stopping the dose.
• Blurred vision, can be caused by CSR or can appear alone.
• CSR (Central serous retinopathy), dot or lines can appear in your vision, blurry vision, accumulation of liquid below the retina. This condition can develop within the first to fourth month.
• Paronychia, the inflammation of the skin or flesh next to or under the nail. Dissapears after the medication.
• Onycholysis, the gradual separation of the nail and skin. Can become infected. Can also be reverted with the reduction or removal of medication.
• Scoliosis, bone deformation or other serious developmental issues, this cannot be fully confirmed nor declined, as which clinical trials on young patients has not been done for research purposes. FGFR1–FGFR3 signaling is essential for normal skeletal development, cartilage maturation, and growth plate function. Because of this, inhibition of FGFR during adolescence may theoretically interfere with normal bone growth while the skeleton is still developing.
Although scoliosis or skeletal deformities have not been established as adverse effects of erdafitinib in humans, pediatric and juvenile animal studies with FGFR inhibitors have raised concerns regarding:
The long-term consequences of off-label FGFR inhibition in healthy adolescents are unknown, as erdafitinib has not been studied for this purpose
DISCLAIMER: Death has been reported in patients with ongoing treatment, although these is more likely to be associated with the progression of the cancer disease rather than the Erdafitinib or conditions caused by Erdafitinib itself.
Although, the patients victim of death, is associated to be older than 65. As stated here. (But, I say again, it is important to be noted, no matter the age.)
Note:
Most adverse effects improve or resolve after dose reduction or discontinuation. However, some, particularly ocular toxicities such as central serous retinopathy, may persist or leave residual visual impairment in some cases of patients.
————————————————————
So, after knowing most of the AE, how can you avoid or cure some of them?
Hyperphosphatemia can be regulated taking sevelamar, which is a phosphate binder that binds to the phosphate absorbed through food or already existing in the blood. Although a bloodwork or renal hepatical revision every 2 or 3 weeks is advised.
CSR is a condition that cannot be prevented nor reduced (if it develops in the first place), but can be helped with artificial tears, this does not cure or improve the disease, it only deals with the dry eyes symptoms. Artifial tears can be obtained without prescription and applied daily for 2 - 3 times a day.
Hand-foot disorder can be reverted with the removal or reduction of the medication, but cannot be fully removed while dosing (if it develops).
Nail disorders work the same as the HFS (Hand-foot syndrome). So can disinfected or taken care of with usual precautions if developed. Also reverted when you stop taking Erdafitinib or dissapear with reduction of treatment.
————————————————————
Here's the hope or cope you can take:
Deaths reported in clinical trials occurred mainly in older patients with advanced cancer and were usually attributed to disease progression rather than erdafitinib itself. This does not mean the drug is safe in healthy or younger individuals.
So, in short Erdafitinib presents risks worth being seriously concious about.
————————————————————
My personal opinion:
I know a lot of you are planning on starting Erdafitinib, I recommend only taking ancillaries in case you do.
Ancillaries are compounds that prevent or mitigate or help with side effects, like sevelamar for hyperphosphatemia, artificial tesrs for dry eyes in case of CSR, etc.
However, erdafitinib symptons don't have a lot of usable or existing ancillaries other than the already mentioned, or simply removal of treatment or reduction of dose.
Combining other growth factors like HGH with Erdafitinib is uncertainly risky (as for Erdafitinib being already risky), since i didn't find any studies and don't know about drug-drug synergies or effects. Even if there are not any conflicting results from combining the drugs, HGH already poses It's own risks, which can upregulate the risk profile.
As for dosing, i strongly recommend to not surpass 9mg, (any dose is already toxic, but taking more 9mg poses way more risk) as in healthy teens, weight to dose ratio is very important. Exceeding the dose may result in severe side effects or toxicity.
Furthermore, seek medical attention immediately if you develop:
• Sudden vision loss.
• Severe eye pain.
• Chest pain or shortness of breath.
• Persistent vomiting preventing hydration.
• Severe dehydration.
• Confusion or neurological symptoms.
• Signs of infection around detached nails
My final thoughts: I strongly advise you to do your own research, search for people your age that are on Erda or had taken erda, look up the doses, get a good source, don't be a retard and follow the security protocols, as for it is not worth to just skip the side effects.
One thing is tanking them while reducing them and another thing is straight up ignoring them.
I myself haven't researched fully what Erdafitinib does, what can disrupt it's effects, what drugs not to take Erda with, precautions or ancillaries. So get informed before doing any shit, your spine and height are you responsability.
Get a scan, get sevelamar and tear drops before taking erda, check up on your symptoms everyday when taking it and be safe.
As for external experiences, you can look up for anecdotes on tiktok: @Thienblahblah, @ChangErda.
And some people that are or have taken Erda, have shared their experiences on this forum. Search it up for reference.
P.D: Sorry for bad english. Love you bhai
Sources: Source, source, source & source.
————————————————————
Erdafitinib is a targeted anticancer medication that blocks proteins called fibroblast growth factor receptors (FGFRs). Some cancers develop changes (mutations or fusions) in the FGFR2 or FGFR3 genes, causing tumor cells to grow uncontrollably.
Keywords: AE (Adverse effects/events), Hyperphosphatemia, CSR, (Central Serous Retinopathy), Xerosis, Hand-Foot Syndrome, Paronychia, Onycholisis and Dysgeusia.
But, we all know that you, the one reading this in this putrid place, isn't informing themselves on erdafitinib for anti-cancer purposes.
So, I'm going to talk about what you must know before blasting a cancer treatment medication.
————————————————————
Erdafitinib causes adverse or side effects in approximately every patient on treatment, within the first, second or third month, sometimes, within the first week. With ≈99% of patients reporting at least one Adverse Effects.
This also varies with dosing, as higher the dose, higher the rate and amount of AE.
Within all of the adverse effects, the most common, with a dose of 2mg or higher (i repeat, the higher the dose, the higher the rate and severity of the symptons) are:
| Hyperphosphatemia | ~70 - 80% |
| Stomatitis | ~45 - 60% |
| Diarrhea | ~40 - 50% |
| Dry mouth | ~35 - 45% |
| Fatigue | ~30 - 40% |
| Dry skin (Xerosis) | ~30 - 40% |
| Nail disorders | ~30 - 40% |
| Alopecia | ~25 - 35% |
| Palmar-plantar erythrodysesthesia syndrome (Hand-foot syndrome) | ~25 - 30% |
| Constipation | ~20 - 30% |
| Decreased appetite | ~20 - 30% |
| Dysgeusia | ~20 - 30% |
| Nausea | ~20 - 30% |
| Anemia | ~20 - 30% |
| Dry eye | ~20 - 30% |
| Blurred vision | ~15 - 25% |
| Central serous retinopathy (CSR) / Retinal pigment epithelial detachment (RPED) | ~15 - 25% |
| Paronychia | ~15 - 25% |
| Onycholysis | ~10 - 20% |
• Hypesphosphatemia is the elevated levels of phosphate levels in blood due to the FGFR1 and FGFR3 inhibition. Can cause renal calcification (kidney stones or crystal formation). However, this is rare ocurrence due to it being caused by the prolonged extension or constant maintenance of a high hyperphosphatemia, (be careful with it, don't be a retard) This condition doesn't have visible symptoms, can only be detected through bloodwork.
• Stomatitis is the inflammation of oral mucus, this can cause mouth injury, pain when talking or eating, burning sensation. This can be avoided through lowering the dose or stopping the complete ingestion of the medication.
• Diarrhea, this can be in many ways, bland pr liquid defecation, loss of electrolytes, dehydration. You already know this. This sympton will stop after you stop taking the medication.
• Dry mouth, less saliva, bad breath, can be difficult to eat. Also stops when you stop dosing.
• Fatigue, persistent tiredness. Also stops when you stop dosing
• Xerosis (Dry skin), important dryness of the skin. This can cause dead skin peeling or itching. Also stops after you stop dosing.
• Nail disorders, weak nails, bland nails, peeling of the nails, changes in thickness, abnormal growth, changes in color. Also stops after you stop dosing.
• Alopecia, significant or small hairloss, hair thinning, weaker lashes or brows, generally not severe. Effects reverted after you stop dosing.
• Hand-Foot syndrome, inflammation lf hands and feet, redness, swelling. In moderate cases, pain, skin peeling, dryness. In severe cases, blisters, ulcers, and difficulty walking.
• Constipation, difficulty shitting, bloating, abdominal pain, extreme sensation of shitting.
• Less/loss of apetite
• Dysgeusia, the alteration of taste, temporarily or during the duration of the medication.
• Nausea, especially after taking the medication for the first time or during the firsts hours, can cause vomiting.
• Anemia, less bloodcells and hemoglobin, can cause paleness, tiredness, dizziness, shortness of breath. Dissapears after stopping the medication.
• Dry eyes, itching, burning, can stop after stopping the dose.
• Blurred vision, can be caused by CSR or can appear alone.
• CSR (Central serous retinopathy), dot or lines can appear in your vision, blurry vision, accumulation of liquid below the retina. This condition can develop within the first to fourth month.
• Paronychia, the inflammation of the skin or flesh next to or under the nail. Dissapears after the medication.
• Onycholysis, the gradual separation of the nail and skin. Can become infected. Can also be reverted with the reduction or removal of medication.
• Scoliosis, bone deformation or other serious developmental issues, this cannot be fully confirmed nor declined, as which clinical trials on young patients has not been done for research purposes. FGFR1–FGFR3 signaling is essential for normal skeletal development, cartilage maturation, and growth plate function. Because of this, inhibition of FGFR during adolescence may theoretically interfere with normal bone growth while the skeleton is still developing.
Although scoliosis or skeletal deformities have not been established as adverse effects of erdafitinib in humans, pediatric and juvenile animal studies with FGFR inhibitors have raised concerns regarding:
- Growth plate abnormalities.
- Impaired longitudinal bone growth.
- Delayed or abnormal ossification.
- Potential effects on skeletal development.
The long-term consequences of off-label FGFR inhibition in healthy adolescents are unknown, as erdafitinib has not been studied for this purpose
DISCLAIMER: Death has been reported in patients with ongoing treatment, although these is more likely to be associated with the progression of the cancer disease rather than the Erdafitinib or conditions caused by Erdafitinib itself.
Although, the patients victim of death, is associated to be older than 65. As stated here. (But, I say again, it is important to be noted, no matter the age.)
Note:
Most adverse effects improve or resolve after dose reduction or discontinuation. However, some, particularly ocular toxicities such as central serous retinopathy, may persist or leave residual visual impairment in some cases of patients.
————————————————————
So, after knowing most of the AE, how can you avoid or cure some of them?
Hyperphosphatemia can be regulated taking sevelamar, which is a phosphate binder that binds to the phosphate absorbed through food or already existing in the blood. Although a bloodwork or renal hepatical revision every 2 or 3 weeks is advised.
CSR is a condition that cannot be prevented nor reduced (if it develops in the first place), but can be helped with artificial tears, this does not cure or improve the disease, it only deals with the dry eyes symptoms. Artifial tears can be obtained without prescription and applied daily for 2 - 3 times a day.
Hand-foot disorder can be reverted with the removal or reduction of the medication, but cannot be fully removed while dosing (if it develops).
Nail disorders work the same as the HFS (Hand-foot syndrome). So can disinfected or taken care of with usual precautions if developed. Also reverted when you stop taking Erdafitinib or dissapear with reduction of treatment.
————————————————————
Here's the hope or cope you can take:
Deaths reported in clinical trials occurred mainly in older patients with advanced cancer and were usually attributed to disease progression rather than erdafitinib itself. This does not mean the drug is safe in healthy or younger individuals.
So, in short Erdafitinib presents risks worth being seriously concious about.
————————————————————
My personal opinion:
I know a lot of you are planning on starting Erdafitinib, I recommend only taking ancillaries in case you do.
Ancillaries are compounds that prevent or mitigate or help with side effects, like sevelamar for hyperphosphatemia, artificial tesrs for dry eyes in case of CSR, etc.
However, erdafitinib symptons don't have a lot of usable or existing ancillaries other than the already mentioned, or simply removal of treatment or reduction of dose.
Combining other growth factors like HGH with Erdafitinib is uncertainly risky (as for Erdafitinib being already risky), since i didn't find any studies and don't know about drug-drug synergies or effects. Even if there are not any conflicting results from combining the drugs, HGH already poses It's own risks, which can upregulate the risk profile.
As for dosing, i strongly recommend to not surpass 9mg, (any dose is already toxic, but taking more 9mg poses way more risk) as in healthy teens, weight to dose ratio is very important. Exceeding the dose may result in severe side effects or toxicity.
Furthermore, seek medical attention immediately if you develop:
• Sudden vision loss.
• Severe eye pain.
• Chest pain or shortness of breath.
• Persistent vomiting preventing hydration.
• Severe dehydration.
• Confusion or neurological symptoms.
• Signs of infection around detached nails
My final thoughts: I strongly advise you to do your own research, search for people your age that are on Erda or had taken erda, look up the doses, get a good source, don't be a retard and follow the security protocols, as for it is not worth to just skip the side effects.
One thing is tanking them while reducing them and another thing is straight up ignoring them.
I myself haven't researched fully what Erdafitinib does, what can disrupt it's effects, what drugs not to take Erda with, precautions or ancillaries. So get informed before doing any shit, your spine and height are you responsability.
Get a scan, get sevelamar and tear drops before taking erda, check up on your symptoms everyday when taking it and be safe.
As for external experiences, you can look up for anecdotes on tiktok: @Thienblahblah, @ChangErda.
And some people that are or have taken Erda, have shared their experiences on this forum. Search it up for reference.
P.D: Sorry for bad english. Love you bhai
Sources: Source, source, source & source.
