LegitUser
Gluttonmaxxed gypsy from the council estate
- Joined
- Apr 30, 2024
- Posts
- 938
- Reputation
- 1,090
I saw a tweet the other day that hypothesised the spike protein has the ability to turn multiple proteins into prions.
He then posted this follow up tweet last night, and honestly, dude might be right. This hypothesis explains the sudden deaths, cardiac issues, and a host of other health issues that we have been seeing of late.
'll try and put this info in the best order I can to make my point. I'll include links so that you can read more if you so fancy.
First of all...
Types of prion diseases include:
www.hopkinsmedicine.org
Now, what does this have to do with Covid? Keep reading...
Prions are considered a subclass of amyloids in which protein aggregation becomes self-perpetuating and infectious.
Protein aggregation is a process by which modified, oxidized, misfolded or damaged proteins bind together and coalesce into a larger mass which no longer possesses the original function(s) of its component parts.
www.ncbi.nlm.nih.gov
https://www.sciencedirect.com/topic... is a process,of Ageing and Development, 2019
Primary or light chain (AL) amyloidosis is the most common type of systemic amyloidosis. It is a protein misfolding and metabolism disorder in which insoluble fibrils are deposited in various tissues, causing organ dysfunction and eventually death; therefore, early detection is crucial.
www.ncbi.nlm.nih.gov
In AL amyloidosis, biomarkers such as FLCs (free light chains), natriuretic peptides and troponins are the most extensively studied and validated.
www.ncbi.nlm.nih.gov
What are Free Light Chains?
1. Light chains make up part of the structure of immunoglobulins.
2. Immunoglobulins are made by white blood cells called plasma cells (they help protect you against infection and illness).
3. The light chains attach themselves to the heavy chains and are then called bound light chains. When you have more light chains than heavy chains, those extra light chains are called "free" because they don't bind to the heavy chains. They are released in the blood instead. The more free light chains in your blood, the more plasma cells you have. This may mean there is a problem with the plasma cells.
www.urmc.rochester.edu
Cardiac amyloidosis (CA) is due to extracellular myocardial deposition of misfolded proteins resulting in severe cardiac dysfunction and death. The precursors of amyloid fibrils, able of determining a relevant cardiac infiltration, are immunoglobulin-free light chains (AL amyloidosis) and transthyretin (TTR) (both wild and mutated types).
pubmed.ncbi.nlm.nih.gov
www.news-medical.net
I didn't know whether I should include this or not, but I will anyway. It definitely explains these random sudden deaths we've been seeing.
What is troponin?
Troponin is a protein found in your muscles, including your heart. When your heart is injured or damaged, troponin is released into your blood.
www.bhf.org.uk
"In this analysis of individuals with confirmed SARS-CoV-2 infection, hs troponin I levels of men aged 54 or older significantly increased after infection. They remained elevated for at least 14 months after diagnosis. This suggests the possibility of an ongoing, long-term, low-grade myocardial injury."
www.ncbi.nlm.nih.gov
"mice that had not been administered FLCs (free light chains) had no detectable prion titers in spleens."
https://www.researchgate.net/public...cytes_is_not_required_for_prion_neuroinvasion
He then posted this follow up tweet last night, and honestly, dude might be right. This hypothesis explains the sudden deaths, cardiac issues, and a host of other health issues that we have been seeing of late.
'll try and put this info in the best order I can to make my point. I'll include links so that you can read more if you so fancy.
First of all...
What are prion diseases?
Prion diseases comprise several conditions. A prion is a type of protein that can trigger normal proteins in the brain to fold abnormally. Prion diseases can affect both humans and animals. They are sometimes spread to humans by infected meat products. In many cases, the source of the abnormal protein is unknown. The most common form of prion disease that affects humans is Creutzfeldt-Jakob disease (CJD).Types of prion diseases include:
- CJD
- Variant CJD
- Variably protease-sensitive prionopathy (VPSPr)
- Gerstmann-Sträussler-Scheinker disease (GSS)
What causes prion disease?
Normal prion protein is found on the surface of many cells. Prion diseases occur when this protein becomes abnormal and clumps in the brain. It then causes brain damage. This abnormal buildup of protein in the brain can lead to memory problems, personality changes, and trouble with movement. Experts still don't know a lot about prion diseases. But unfortunately, these disorders are often fatal.
Prion Diseases
Prion diseases comprise several conditions. A prion is a type of protein that can trigger normal proteins in the brain to fold abnormally. Prion diseases can affect both humans and animals and are sometimes transmitted to humans by infected meat products. The most common form of prion disease...www.hopkinsmedicine.org
Now, what does this have to do with Covid? Keep reading...
Prions are considered a subclass of amyloids in which protein aggregation becomes self-perpetuating and infectious.
Protein aggregation is a process by which modified, oxidized, misfolded or damaged proteins bind together and coalesce into a larger mass which no longer possesses the original function(s) of its component parts.
Amyloids or prions? That is the question
Despite major efforts devoted to understanding the phenomenon of prion transmissibility, it is still poorly understood how this property is encoded in the amino acid sequence. In recent years, experimental data on yeast prion domains allow to start at ...
https://www.sciencedirect.com/topic... is a process,of Ageing and Development, 2019
Primary or light chain (AL) amyloidosis is the most common type of systemic amyloidosis. It is a protein misfolding and metabolism disorder in which insoluble fibrils are deposited in various tissues, causing organ dysfunction and eventually death; therefore, early detection is crucial.
Light Chain Amyloidosis: Epidemiology, Staging, and Prognostication
Amyloidosis is a disorder of protein misfolding and metabolism in which insoluble fibrils are deposited in various tissues, causing organ dysfunction and eventually death. Out of the 60-plus heterogeneous amyloidogenic proteins that have been identified, ...
In AL amyloidosis, biomarkers such as FLCs (free light chains), natriuretic peptides and troponins are the most extensively studied and validated.
Circulating biomarkers in diagnosis and management of cardiac amyloidosis: a review for internist
Cardiac amyloidosis (CA) is due to extracellular myocardial deposition of misfolded proteins resulting in severe cardiac dysfunction and death. The precursors of amyloid fibrils, able of determining a relevant cardiac infiltration, are immunoglobulin-free ...
What are Free Light Chains?
1. Light chains make up part of the structure of immunoglobulins.
2. Immunoglobulins are made by white blood cells called plasma cells (they help protect you against infection and illness).
3. The light chains attach themselves to the heavy chains and are then called bound light chains. When you have more light chains than heavy chains, those extra light chains are called "free" because they don't bind to the heavy chains. They are released in the blood instead. The more free light chains in your blood, the more plasma cells you have. This may mean there is a problem with the plasma cells.
Free Light Chains (Blood) - Health Encyclopedia - University of Rochester Medical Center
www.urmc.rochester.edu
Cardiac amyloidosis (CA) is due to extracellular myocardial deposition of misfolded proteins resulting in severe cardiac dysfunction and death. The precursors of amyloid fibrils, able of determining a relevant cardiac infiltration, are immunoglobulin-free light chains (AL amyloidosis) and transthyretin (TTR) (both wild and mutated types).
Circulating biomarkers in diagnosis and management of cardiac amyloidosis: a review for internist - PubMed
Cardiac amyloidosis (CA) is due to extracellular myocardial deposition of misfolded proteins resulting in severe cardiac dysfunction and death. The precursors of amyloid fibrils, able of determining a relevant cardiac infiltration, are immunoglobulin-free light chains (AL amyloidosis) and...
Researchers discover possible connection between harmful amyloid production and COVID-19 symptoms
In patients with serious and long-term COVID-19, disturbed blood coagulation has often been observed. Now, researchers at Linköping University, Sweden, have discovered that the body's immune system can affect the spike protein on the surface of the SARS-CoV-2 virus, leading to the production of...www.news-medical.net
I didn't know whether I should include this or not, but I will anyway. It definitely explains these random sudden deaths we've been seeing.
What is troponin?
Troponin is a protein found in your muscles, including your heart. When your heart is injured or damaged, troponin is released into your blood.
What is troponin?
Troponin is a protein that's released into the bloodstream during a heart attack. A troponin blood test can help doctors diagnose a heart attack .www.bhf.org.uk
"In this analysis of individuals with confirmed SARS-CoV-2 infection, hs troponin I levels of men aged 54 or older significantly increased after infection. They remained elevated for at least 14 months after diagnosis. This suggests the possibility of an ongoing, long-term, low-grade myocardial injury."
Mild COVID-19 induces early, quantifiable, persistent troponin I elevations in elder men
Elderly patients, especially men, are at risk of increased morbidity from coronavirus disease 2019 (COVID-19). Long-term data on troponin I levels in longitudinal observational studies of outpatients with mild to moderate COVID-19 are scarce.This controlled ...
"mice that had not been administered FLCs (free light chains) had no detectable prion titers in spleens."
PrP expression in B lymphocytes is not required for prion neuroinvasion (1999 study).
https://www.researchgate.net/public...cytes_is_not_required_for_prion_neuroinvasion
