Exemestane is NOT a SHIT Inhibitor - GTFIH (36% sup is a myth)

[Paul.jnxy]

The term Aromasin only supresses 36% of serum e2 in healthy male homosapiens is heavily misused or not understood in the community by the likes of, well, me.

"Pharmacokinetics and dose finding of a potent aromatase inhibitor, aromasin (exemestane), in young males."
Link
Its a short fucking read so if you can't read through it you are a fucking Attentionspancel.

"Exemestane suppressed plasma estradiol comparably with either dose [25 mg, 38% (P ≤ 0.002); 50 mg, 32% (P ≤ 0.008)], with a reciprocal increase in testosterone concentrations (60% and 56%; P ≤ 0.003 for both)."

This is the exact quote straight from the paper.

Here is the FUCKING FLAW: They only ran 25 mg in healthy men FOR 10 FUCKING DAYS. That's it.

50 mg only suppressed 32% while 25 mg suppressed 38%. This shows the study was too fucking short to reach a steady effect.

Now you may ask if we actually know aromasins suppression.
The Answer is actually YES we might from a couple sources even.

Official Prescribing Information (FDA / Pfizer Label)
Exact quote:
"Plasma estrogen (estradiol, estrone, and estrone sulfate) suppression was seen starting at a 5 mg daily dose of exemestane, with a maximum suppression of at least 85% to 95% achieved at a 25-mg dose. Exemestane 25 mg daily reduced whole body aromatization (as measured by injecting radiolabeled androstenedione) by 98% in postmenopausal women with breast cancer."

Does this apply to you? Not really. Yet men and women aromatese the same fucking way so the dif is unprobable to be huge.

Couple more studies showing exemestane might be decent:
-https://jamanetwork.com/journals/jamaoncology/fullarticle/2802824#:~:text=Serrano%20D%2C%20Gandini%20S%2C%20Thomas%20P%2C%20et%20al.,Oncol.%202023%3B9%20%285%29%3A664%E2%80%93672.%20doi%3A10.1001%2Fjamaoncol.2023.0089%20Supplement%201.%20eTable%201.
-

In vivo inhibition of aromatization by exemestane, a novel irreversible aromatase inhibitor, in postmenopausal breast cancer patients - PubMed

The effect of exemestane (6-methylenandrosta-1,4-diene-3,17-dione) 25 mg p.o. once daily on in vivo aromatization was studied in 10 postmenopausal women with advanced breast cancer. Aromatization was determined before treatment and after 6-8 weeks on therapy by administering a bolus injection of...

pubmed.ncbi.nlm.nih.gov

No spellcheck or anything as I am on my bike cycling back home from the gym.

Tagging random nighas: @Niebvll @zennn @anondude @alexbrown8384 @strongmtn @ICL @stacyslayer.12569 idk forgot some ppl probably.

Wish me luck on my math finals tmrw morning

 

[anondude]

So it was just one shit study that made no one use it?

 

[Paul.jnxy]

@lmnopq @AtrophicPyra @exyonf @slendermanmax

 

[Paul.jnxy]

So it was just one shit study that made no one use it?

Yuh. People can't read. (including me looks like it) For height tho letro is still superior to all inhibs. Combinationtherapy is always the best.

 

[sziabattya]

@ICL 6th tag

 

[Paul.jnxy]

Bump my low effort thread.

 

[Paul.jnxy]

Bump

 

[Paul.jnxy]

Bump

 

[Niebvll]

nice
had an argument about this on another forum some time ago
good to know I was right

 

[Paul.jnxy]

nice
had an argument about this on another forum some time ago
good to know I was right

Yeah bbg

 

[lmnopq]

Everyone’s knows it’s good, and true heightmaxxers know it’s the best as it’s the best to combine with tamoxifen becuase it’s steroidal

 

[strongmtn]

The term Aromasin only supresses 36% of serum e2 in healthy male homosapiens is heavily misused or not understood in the community by the likes of, well, me.

"Pharmacokinetics and dose finding of a potent aromatase inhibitor, aromasin (exemestane), in young males."
Link
Its a short fucking read so if you can't read through it you are a fucking Attentionspancel.

"Exemestane suppressed plasma estradiol comparably with either dose [25 mg, 38% (P ≤ 0.002); 50 mg, 32% (P ≤ 0.008)], with a reciprocal increase in testosterone concentrations (60% and 56%; P ≤ 0.003 for both)."

This is the exact quote straight from the paper.

Here is the FUCKING FLAW: They only ran 25 mg in healthy men FOR 10 FUCKING DAYS. That's it.

50 mg only suppressed 32% while 25 mg suppressed 38%. This shows the study was too fucking short to reach a steady effect.

Now you may ask if we actually know aromasins suppression.
The Answer is actually YES we might from a couple sources even.

Official Prescribing Information (FDA / Pfizer Label)
Exact quote:
"Plasma estrogen (estradiol, estrone, and estrone sulfate) suppression was seen starting at a 5 mg daily dose of exemestane, with a maximum suppression of at least 85% to 95% achieved at a 25-mg dose. Exemestane 25 mg daily reduced whole body aromatization (as measured by injecting radiolabeled androstenedione) by 98% in postmenopausal women with breast cancer."

Does this apply to you? Not really. Yet men and women aromatese the same fucking way so the dif is unprobable to be huge.

Couple more studies showing exemestane might be decent:
-https://jamanetwork.com/journals/jamaoncology/fullarticle/2802824#:~:text=Serrano%20D%2C%20Gandini%20S%2C%20Thomas%20P%2C%20et%20al.,Oncol.%202023%3B9%20%285%29%3A664%E2%80%93672.%20doi%3A10.1001%2Fjamaoncol.2023.0089%20Supplement%201.%20eTable%201.
-

In vivo inhibition of aromatization by exemestane, a novel irreversible aromatase inhibitor, in postmenopausal breast cancer patients - PubMed

The effect of exemestane (6-methylenandrosta-1,4-diene-3,17-dione) 25 mg p.o. once daily on in vivo aromatization was studied in 10 postmenopausal women with advanced breast cancer. Aromatization was determined before treatment and after 6-8 weeks on therapy by administering a bolus injection of...

pubmed.ncbi.nlm.nih.gov

No spellcheck or anything as I am on my bike cycling back home from the gym.

Tagging random nighas: @Niebvll @zennn @anondude @alexbrown8384 @strongmtn @ICL @stacyslayer.12569 idk forgot some ppl probably.

Wish me luck on my math finals tmrw morning

thank you, good luck on your maths tmrw

 

[alexbrown8384]

Cool

 

[Paul.jnxy]

thank you, good luck on your maths tmrw

Thanks brah

 

[incellife]

mirin the effort good debunk

 

[Paul.jnxy]

mirin the effort good debunk

Thanks. Took me 10 minutes.

 

[exyonf]

The term Aromasin only supresses 36% of serum e2 in healthy male homosapiens is heavily misused or not understood in the community by the likes of, well, me.

"Pharmacokinetics and dose finding of a potent aromatase inhibitor, aromasin (exemestane), in young males."
Link
Its a short fucking read so if you can't read through it you are a fucking Attentionspancel.

"Exemestane suppressed plasma estradiol comparably with either dose [25 mg, 38% (P ≤ 0.002); 50 mg, 32% (P ≤ 0.008)], with a reciprocal increase in testosterone concentrations (60% and 56%; P ≤ 0.003 for both)."

This is the exact quote straight from the paper.

Here is the FUCKING FLAW: They only ran 25 mg in healthy men FOR 10 FUCKING DAYS. That's it.

50 mg only suppressed 32% while 25 mg suppressed 38%. This shows the study was too fucking short to reach a steady effect.

Now you may ask if we actually know aromasins suppression.
The Answer is actually YES we might from a couple sources even.

Official Prescribing Information (FDA / Pfizer Label)
Exact quote:
"Plasma estrogen (estradiol, estrone, and estrone sulfate) suppression was seen starting at a 5 mg daily dose of exemestane, with a maximum suppression of at least 85% to 95% achieved at a 25-mg dose. Exemestane 25 mg daily reduced whole body aromatization (as measured by injecting radiolabeled androstenedione) by 98% in postmenopausal women with breast cancer."

Does this apply to you? Not really. Yet men and women aromatese the same fucking way so the dif is unprobable to be huge.

Couple more studies showing exemestane might be decent:
-https://jamanetwork.com/journals/jamaoncology/fullarticle/2802824#:~:text=Serrano%20D%2C%20Gandini%20S%2C%20Thomas%20P%2C%20et%20al.,Oncol.%202023%3B9%20%285%29%3A664%E2%80%93672.%20doi%3A10.1001%2Fjamaoncol.2023.0089%20Supplement%201.%20eTable%201.
-

In vivo inhibition of aromatization by exemestane, a novel irreversible aromatase inhibitor, in postmenopausal breast cancer patients - PubMed

The effect of exemestane (6-methylenandrosta-1,4-diene-3,17-dione) 25 mg p.o. once daily on in vivo aromatization was studied in 10 postmenopausal women with advanced breast cancer. Aromatization was determined before treatment and after 6-8 weeks on therapy by administering a bolus injection of...

pubmed.ncbi.nlm.nih.gov

No spellcheck or anything as I am on my bike cycling back home from the gym.

Tagging random nighas: @Niebvll @zennn @anondude @alexbrown8384 @strongmtn @ICL @stacyslayer.12569 idk forgot some ppl probably.

Wish me luck on my math finals tmrw morning

@lmnopq @AtrophicPyra @exyonf @slendermanmax

I agree with the thread, but aromasin is shit either way. If your goal is height Aromasin is the worst option here because of how shitty it penetrates the GP and how low it suppresses the estradiol. Aromasin is also hated just because it reduces the half life of androgens via. pissing jfl.
It's good to pair with NAAAS, but honestly I would just stick to Letrozole or Arimidex.
Good luck on your exam!

 

[Paul.jnxy]

I agree with the thread, but aromasin is shit either way. If your goal is height Aromasin is the worst option here because of how shitty it penetrates the GP and how low it suppresses the estradiol. Aromasin is also hated just because it reduces the half life of androgens via. pissing jfl.
It's good to pair with NAAAS, but honestly I would just stick to Letrozole or Arimidex.
Good luck on your exam!

Yes agreed. There is not a molecule of evidence for increasing FAH in humans or delaying BA in general. It’s good to use in combo therapy to minimise rebound from stystemic e2 suppression. Letro for the local suppression once systemic is basically eradicated by aromasin. I mean if you are on androgens it’s not the best for optimality but better safe then sorry. Trust me you do not want to deal with a e2 rebound.

I probably barely passed my exam maybe even failed. It is what it is.

 

[AtrophicPyra]

I agree with the thread, but aromasin is shit either way. If your goal is height Aromasin is the worst option here because of how shitty it penetrates the GP and how low it suppresses the estradiol. Aromasin is also hated just because it reduces the half life of androgens via. pissing jfl.
It's good to pair with NAAAS, but honestly I would just stick to Letrozole or Arimidex.
Good luck on your exam!

Aromasin penetrates all tissues equally just like any other ai, it’s smarter to use it as a background ai to prevent a huge rebound if u miss an anastrazole or letrzole dose and just chronically use 12.5mg ed

Also androgens half life don’t get reduced via pissing and even if it did, all ais make u piss more bec of lower water retention due to lower e2

 

[Paul.jnxy]

Aromasin penetrates all tissues equally just like any other ai, it’s smarter to use it as a background ai to prevent a huge rebound if u miss an anastrazole or letrzole dose and just chronically use 12.5mg ed

Also androgens half life don’t get reduced via pissing and even if it did, all ais make u piss more bec of lower water retention due to lower e2

No. It actually does shorten your androgens half life due to it inducing UGT2B17 expression. This is documented. Il link a source if you like. I use letro and Exemestane for maximal suppression and rebound min . 25 my ed for a few weeks to lower systemic e2 permanently so letro can do its job better at the growth plate. Then alternate between letro 1.25 mg eod and exemestane 12.5 eod for maintenance

 

[AtrophicPyra]

Yes agreed. There is not a molecule of evidence for increasing FAH in humans or delaying BA in general. It’s good to use in combo therapy to minimise rebound from stystemic e2 suppression. Letro for the local suppression once systemic is basically eradicated by aromasin. I mean if you are on androgens it’s not the best for optimality but better safe then sorry. Trust me you do not want to deal with a e2 rebound.

I probably barely passed my exam maybe even failed. It is what it is.

No. It actually does shorten your androgens half life due to it inducing UGT2B17 expression. This is documented. Il link a source if you like. I use letro and Exemestane for maximal suppression and rebound min . 25 my ed for a few weeks to lower systemic e2 permanently so letro can do its job better at the growth plate. Then alternate between letro 1.25 mg eod and exemestane 12.5 eod for maintenance

Oh shit I didn’t know that wtf

Buying anastrazole tmrw bec it showed better final predicted height,

But all ais target all tissues equally not sure why u think letro targets growth plates more than aromasin or smth

 

[AtrophicPyra]

No. It actually does shorten your androgens half life due to it inducing UGT2B17 expression. This is documented. Il link a source if you like. I use letro and Exemestane for maximal suppression and rebound min . 25 my ed for a few weeks to lower systemic e2 permanently so letro can do its job better at the growth plate. Then alternate between letro 1.25 mg eod and exemestane 12.5 eod for maintenance

No. It actually does shorten your androgens half life due to it inducing UGT2B17 expression. This is documented. Il link a source if you like. I use letro and Exemestane for maximal suppression and rebound min . 25 my ed for a few weeks to lower systemic e2 permanently so letro can do its job better at the growth plate. Then alternate between letro 1.25 mg eod and exemestane 12.5 eod for maintenance

Oh my goodness nigga it’s over I was using aromasin by itself thinking it was all unicorns and rainbows and shit

No wonder my lifts went down upon using it

 

[Paul.jnxy]

Oh shit I didn’t know that wtf

Buying anastrazole tmrw bec it showed better final predicted height,

But all ais target all tissues equally not sure why u think letro targets growth plates more than aromasin or smth

Letro mogs. Suppression solely it was undectable in serum blood levels. The reason the PAG is the same with anastrazole is becouse letro increases test by stimulating LSH and FSH and that test converts into e2 locally. So if your suppress your HPTA axis with 20 MGs test per week your LSH and FSH won’t be able to respond accordingly to the low e2. (Bro science and my theory not real evidence). I will try this and document it.

 

[Paul.jnxy]

Oh my goodness nigga it’s over I was using aromasin by itself thinking it was all unicorns and rainbows and shit

No wonder my lifts went down upon using it

It’s not over. Who gives a fuck about lifts anyway. All you want is too mog.