psychotic444
i did some punk rock
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Important Disclaimer:
* This is purely theoretical/experimental discussion based on in-vitro and animal studies.
* Long-term human safety data regarding high-dose FGFR3 inhibition via Meclizine is virtually non-existent.
* Meclizine has anticholinergic properties (drowsiness, cognitive fog, dry mouth), so long-term daily use comes with clear health risks.
* Do not take this as medical advice or a recommendation.
Hey guys
I was researching theoretical FGFR3 inhibitors that could potentially be used for heightmaxxing / longitudinal bone growth before plates fully fuse.
While drugs like Erdafitinib are extremely expensive and hard to source, there is scientific evidence suggesting that Meclizine (a common OTC antihistamine/anti-vertigo medication) acts as an FGFR3 signaling inhibitor.
Study: https://www.nature.com/articles/s41598-017-07044-8 Meclizine promotes longitudinal bone growth - Nature (2017)
According to the paper, Meclizine downregulates the FGFR3 signaling pathway, which normally suppresses chondrocyte proliferation in growth plates.
* AGAIN Do not take this as medical advice or a recommendation.
Has anyone looked into the pharmacokinetics, dosage translation from mouse models, or potential stacks with CNP agonists?
* This is purely theoretical/experimental discussion based on in-vitro and animal studies.
* Long-term human safety data regarding high-dose FGFR3 inhibition via Meclizine is virtually non-existent.
* Meclizine has anticholinergic properties (drowsiness, cognitive fog, dry mouth), so long-term daily use comes with clear health risks.
* Do not take this as medical advice or a recommendation.
Hey guys
I was researching
theoretical FGFR3 inhibitors that could potentially be used for heightmaxxing / longitudinal bone growth before plates fully fuse.While drugs like Erdafitinib are extremely expensive and hard to source, there is scientific evidence suggesting that Meclizine (a common OTC antihistamine/anti-vertigo medication) acts as an FGFR3 signaling inhibitor.
Study: https://www.nature.com/articles/s41598-017-07044-8 Meclizine promotes longitudinal bone growth - Nature (2017)
According to the paper, Meclizine downregulates the FGFR3 signaling pathway, which normally suppresses chondrocyte proliferation in growth plates.
* AGAIN Do not take this as medical advice or a recommendation.
Has anyone looked into the pharmacokinetics, dosage translation from mouse models, or potential stacks with CNP agonists?
