❖EYE AREA
⬥ ━━━━━━━━━━━━━━━━━━━━ ⬥
SONG IG
used ai in here for some part and to make the thread good cause why not niggas and tables were made by ai too
i did not revised this thread this is a edited form my old thread and i could not explain other shi in depth due to file problems sorry
⬥ ━━━━━━━━━━━━━━━━━━━━ ⬥
SONG IG
used ai in here for some part and to make the thread good cause why not niggas and tables were made by ai too
i did not revised this thread this is a edited form my old thread and i could not explain other shi in depth due to file problems sorry
KEY TERMS AND COMPUNDS USED HERE (WATERS + NON WATER )
❖MINOXIDIL ( WATER + NON )
❖BIMATOPROST ( WATER )
❖HYDROQUINONE ( WATER +NON )
❖BRIMONIDINE ( WATER )
❖TRETINOIN ( WATER )
❖TAZAROTENE ( WATER )
❖GHK-CU ( WATER )
❖MATRIXYL 3000 ( WATER )
❖BOTOX ( WATER )
❖ VOLUFILINE ( WATER )
❖ VOLUPLUS( WATER )
❖ ARGIRELINE( WATER )
❖ RED LIGHT THERAPY( WATER )
❖ CHEMICAL PEELS ( COVERING ALL AT ONCE ) USED FOR UNDER EYE MOSTLY
❖ FRACTIONAL CO2 LASER FOR WRINKLES
❖ERBIUM YAG LASER WRINKLES
SINCE MOST OF TREATMENT AND COMPOUND ARE ALREADY EXPLAINED STUFF LIKE KOJIC ACID AZELAIC ACID WILL BE EXPLAINED IN SPECIFIC PART THAT SHIT AINT HARD AND THIS PART WILL BE TOO LONG THATS WHY AND WE WILL USE THIS FIX ANY SPECIFIC ISSUES
AND APPLICTION WILL ALSO BE TOLD BELOW
◈ CANTHAL TILT
Angle formation between lateral and medial canthus
❖PCT( POSITIVE CANTHAL TILT ): FORMS WHEN MEDIAL CANTHUS IS BELOW LATERAL CANTHUS 2 DEGREE PLUS ANGLE FORMATION
❖NCT( NEGATIVE CANTHAL TILT ): WHEN MEDIAL CANTHUS IS ABOVE LATERAL CANTHUS -1 DEGREE PLUS ANGLE FORMATION
❖NCT( NEUTRAL CANTHAL TILT ): WHEN MEDIAL CANTHUS IS AT SAME POSITION AS LATERAL CANTHUS SO 0 TO 1 DEGREE ANGLE FORMATION
IDEAL RANGE : 3 DEGREE TO 6.5 OR 7 DEGREE
❖ NCT DISADVANTAGES
Sad or Fatigued Appearance
It is perceived as prey eyes
This type of eye look more aged as you age more
Give bad face aesthetics
MORE TYPES OF CANTHAL TILT
❖ MASCULINE PCT
When a neutral lateral canthus is combined swung medial canthus ( downturned medial canthus ) this will give PCT and create a angular looking eye area and it will look masculine it looks straight and appears sharp .Also men are closer to neutral tilt due to higher nasal bridges.
❖ FEMININE PCT
PCT caused by swung up lateral canthus. lower eye on women is curved and roundish. rounder lower eyes are feminine and it is not for men even though PCT it self is ideal and women also tends to have sharp infra orbital rims
CANTHAL TILT SPECIFIC SURGERIES
❖ CANTHOPLASTY
A surgeon cuts the lateral canthus .detaches the tendon holding it in place then reattaches it higher up on the orbital bone. This physically raises the outer corner to create a positive tilt. It's a real surgical procedure done under local or general anesthesia with actual incisions sutures and has a recovery of several weeks Results will be permanent. A drug commonly used for to increase hair follicle at a given area or any area it comes in two way oral and topical
GO BELOW THE ORAL AND TOPICAL COMPARISON FOR NON WATER
It is a pro drug its needs conversion to work which mainly converted by SULT1A1( sulfotransferase enzyme) this enzyme exists in hair follicle
1. Prolongs Anagen phase (growth phase)
2. Shortens Telogen phase (shedding phase)
3.Follicle Cell proliferation (growth of cell at hair follicle)
4. Upregulates VEGF ( Vascular Endothelial Growth Factor) formation of new blood vessel
5. Active nutrients transportation
6.Blood vessel widens more blood flow
guess every one knows this lets get to the real deal
Minoxidil is inactive it self and is a neutral molecule when we apply or use minoxidil. SULT1A1 in hair follicle binds with minoxidil to form MINOXIDIL SULFATE ( ACTIVE FORM ) in this process SO3- binds with minoxidil via SULT1A1 enzyme and in simple terms the MINOXIDIL SULFATE opens ATP channel K+ ions rush out of cell this make cell more negative (hyper polarization ) hyperpolarized cell = relaxed cell which means blood vessel relaxes and widens blood flow
High SULT1A1 in follicles = converts lots of minoxidil = great response
Low SULT1A1 = barely any conversion = poor response
This is genetically determined but can be altered to some point
Some people genuinely cannot respond well to topical minoxidil no matter the dose
This is also why oral minoxidil mogs for some non-responders cause oral has much more SULT1A1 activity than topical in liver
Oral minoxidil is rapidly absorbed from the gastrointestinal tract, with about 90–95% of the drug entering the bloodstream while topical being 75% for scalp . It bypasses the scalp barrier and is transported to the hair follicles through systemic circulation, being converted into its active hair-growth form primarily by the liver. liver has highest SULT1A1 enzyme
it acts systemically by widening blood vessels and prolonging the hair growth (anagen) phase thats why it lowers blood pressure and fluctuate heart beat
APPLICATION AMOUNT WILL BE TOLD BELOW
NEW FINDING
MSM is a sulfur compound found in primitive plants ,animal and humans it also can be chemically made but the quantity is low in plants and animal and other foods
PHYSICAL PROPERTIES
Colorless, Odorless and white crystalline solid
MAIN USE
Commonly used for joint health supplement and is a anti inflammatory drug
SIDE EFFECTS
Mild gastrointestinal pain, headaches, insomnia, or skin rashes. not extreme tho
HOW THIS WORK FOR HAIR ?
1.SULFUR DONATION
MSM is a bioavailable sulfur it can provide bioavailable sulfur for SULT1A1 enzyme activity
2. ENHANCED PENETRATION
MSM increases cell membrane permeability when used with minoxidil it will penetrate deeper into skin works via ion and membrane modulation
Take this drug more than 3g a day to work but not fix for working with minoxidil due to
Low research for human hair but we have mechanism
FDA approved drug
pmc.ncbi.nlm.nih.gov
WATER . TYPE OF TOPICAL MINOXIDIL (USED AI )
Liquid Formulation
Uses propylene glycol and alcohol as a solvent base to help the minoxidil penetrate the skin barrier.
Pros: It comes with a precision dropper. This makes it incredibly easy to part long or thick hair and apply the fluid directly to the scalp
without wasting product on the hair shafts. It is also the most budget-friendly option.
Cons: Propylene glycol is a known allergen that frequently causes itching, redness, dryness, and dandruff-like flaking (contact dermatitis). It takes a long time to dry and can leave hair looking greasy or weighed down.
Foam Formulation
A propylene glycol-free formula that uses a mixture of propellants to turn the solution into an airy mousse that melts upon contact with body temperature.
Pros: It is highly recommended by dermatologists because it rarely irritates the scalp. It evaporates off the skin in roughly 30 seconds, leaves no greasy residue, and functions almost like a styling mousse to add volume.
Cons: It can be difficult to guide through long or dense hair, meaning a lot of product accidentally gets absorbed by the hair strands instead of the scalp. It is also generally more expensive than liquid.
Gel Formulation
A thickened, viscous base that holds the medication in place without dripping. Gels are rarely sold over-the-counter and are typically manufactured by specialized compounding pharmacies.
Pros: Excellent for localized hair loss, such as a receding hairline or thinning temples. Because it has a thick consistency, it stays exactly where you apply it, greatly reducing the risk of the product dripping down your face and causing unwanted facial hair growth. They are often compounded with secondary hair loss medications like finasteride or tretinoin.
Cons: Hardest to spread across large areas of the scalp (like the entire crown). It can clump the hair together as it dries, which may temporarily make thinning areas look more noticeable until it is completely dry
TLDR : FOAM > GEL > LIQUID
GO BELOW THE ORAL AND TOPICAL COMPARISON FOR NON WATER
It is a pro drug its needs conversion to work which mainly converted by SULT1A1( sulfotransferase enzyme) this enzyme exists in hair follicle
1. Prolongs Anagen phase (growth phase)
2. Shortens Telogen phase (shedding phase)
3.Follicle Cell proliferation (growth of cell at hair follicle)
4. Upregulates VEGF ( Vascular Endothelial Growth Factor) formation of new blood vessel
5. Active nutrients transportation
6.Blood vessel widens more blood flow
guess every one knows this lets get to the real deal
Minoxidil is inactive it self and is a neutral molecule when we apply or use minoxidil. SULT1A1 in hair follicle binds with minoxidil to form MINOXIDIL SULFATE ( ACTIVE FORM ) in this process SO3- binds with minoxidil via SULT1A1 enzyme and in simple terms the MINOXIDIL SULFATE opens ATP channel K+ ions rush out of cell this make cell more negative (hyper polarization ) hyperpolarized cell = relaxed cell which means blood vessel relaxes and widens blood flow
High SULT1A1 in follicles = converts lots of minoxidil = great response
Low SULT1A1 = barely any conversion = poor response
This is genetically determined but can be altered to some point
Some people genuinely cannot respond well to topical minoxidil no matter the dose
This is also why oral minoxidil mogs for some non-responders cause oral has much more SULT1A1 activity than topical in liver
Oral minoxidil is rapidly absorbed from the gastrointestinal tract, with about 90–95% of the drug entering the bloodstream while topical being 75% for scalp . It bypasses the scalp barrier and is transported to the hair follicles through systemic circulation, being converted into its active hair-growth form primarily by the liver. liver has highest SULT1A1 enzyme
it acts systemically by widening blood vessels and prolonging the hair growth (anagen) phase thats why it lowers blood pressure and fluctuate heart beat
APPLICATION AMOUNT WILL BE TOLD BELOW
NEW FINDING
MSM is a sulfur compound found in primitive plants ,animal and humans it also can be chemically made but the quantity is low in plants and animal and other foods
PHYSICAL PROPERTIES
Colorless, Odorless and white crystalline solid
MAIN USE
Commonly used for joint health supplement and is a anti inflammatory drug
SIDE EFFECTS
Mild gastrointestinal pain, headaches, insomnia, or skin rashes. not extreme tho
HOW THIS WORK FOR HAIR ?
1.SULFUR DONATION
MSM is a bioavailable sulfur it can provide bioavailable sulfur for SULT1A1 enzyme activity
2. ENHANCED PENETRATION
MSM increases cell membrane permeability when used with minoxidil it will penetrate deeper into skin works via ion and membrane modulation
Take this drug more than 3g a day to work but not fix for working with minoxidil due to
Low research for human hair but we have mechanism
FDA approved drug
Dietary Supplementation with Methylsulfonylmethane and Myo-Inosito Supports Hair Quality and Fecal Microbiome in Poodles - PMC
Methylsulfonylmethane (MSM) has been used as a supplement for skin nourishment, hair growth promotion, and hair quality improvement. Myo-inositol (MI) plays a role in various physiological processes in animals. The aim of this study is to assess the ...
pmc.ncbi.nlm.nih.gov
WATER . TYPE OF TOPICAL MINOXIDIL (USED AI )
Liquid Formulation
Uses propylene glycol and alcohol as a solvent base to help the minoxidil penetrate the skin barrier.
Pros: It comes with a precision dropper. This makes it incredibly easy to part long or thick hair and apply the fluid directly to the scalp
without wasting product on the hair shafts. It is also the most budget-friendly option.
Cons: Propylene glycol is a known allergen that frequently causes itching, redness, dryness, and dandruff-like flaking (contact dermatitis). It takes a long time to dry and can leave hair looking greasy or weighed down.
Foam Formulation
A propylene glycol-free formula that uses a mixture of propellants to turn the solution into an airy mousse that melts upon contact with body temperature.
Pros: It is highly recommended by dermatologists because it rarely irritates the scalp. It evaporates off the skin in roughly 30 seconds, leaves no greasy residue, and functions almost like a styling mousse to add volume.
Cons: It can be difficult to guide through long or dense hair, meaning a lot of product accidentally gets absorbed by the hair strands instead of the scalp. It is also generally more expensive than liquid.
Gel Formulation
A thickened, viscous base that holds the medication in place without dripping. Gels are rarely sold over-the-counter and are typically manufactured by specialized compounding pharmacies.
Pros: Excellent for localized hair loss, such as a receding hairline or thinning temples. Because it has a thick consistency, it stays exactly where you apply it, greatly reducing the risk of the product dripping down your face and causing unwanted facial hair growth. They are often compounded with secondary hair loss medications like finasteride or tretinoin.
Cons: Hardest to spread across large areas of the scalp (like the entire crown). It can clump the hair together as it dries, which may temporarily make thinning areas look more noticeable until it is completely dry
TLDR : FOAM > GEL > LIQUID
❖BIMATOPROST ( WATER )
Bimatoprost is a prostaglandin analogue originally a glaucoma drug (Lumigan eye drops) that dermatologists repurposed for cosmetic use after patients kept reporting unexpected hair and lash growth as a side effect.
It binds prostaglandin FP receptors on hair follicle cells, extending the anagen (active growth) phase of the hair cycle while simultaneously increasing the number of hairs in anagen at any given time. It also increases melanin in the hair shaft, making existing hairs appear darker and thicker. The FDA approved it as LATISSE specifically for eyelash hypotrichosis.(inadequate or sparse eyelashes) it is sold as LATISSE in a conc like 0.03% over the counter
SIDE EFFECTS
Periorbital fat atrophy the most important one. Long-term prostaglandin use around the eye can cause a subtle hollowing or deepening of the orbital area due to localized fat loss. This is reversible on discontinuation but takes months. Minimize by applying only to the lash line skin, not spreading around the orbital
i will give you tips to counter it
It binds prostaglandin FP receptors on hair follicle cells, extending the anagen (active growth) phase of the hair cycle while simultaneously increasing the number of hairs in anagen at any given time. It also increases melanin in the hair shaft, making existing hairs appear darker and thicker. The FDA approved it as LATISSE specifically for eyelash hypotrichosis.(inadequate or sparse eyelashes) it is sold as LATISSE in a conc like 0.03% over the counter
SIDE EFFECTS
Periorbital fat atrophy the most important one. Long-term prostaglandin use around the eye can cause a subtle hollowing or deepening of the orbital area due to localized fat loss. This is reversible on discontinuation but takes months. Minimize by applying only to the lash line skin, not spreading around the orbital
i will give you tips to counter it
❖HYDROQUINONE ( WATER +NON )
GO BEOW SIDE EFFECTS FOR NON WATER
HYDROQUINONE treats dark spots on the skin caused by hormones, aging, or sun exposure. It works by decreasing the amount of melanin, a pigment your body makes that gives your skin color. This reduces the appearance of dark spots. Sun prevention measures, including sunscreen, are often combined with this medication. It belongs to a group of medications called skin-lightening agents.
It's a phenolic compound that inhibits tyrosinase the rate-limiting enzyme in melanin synthesis but unlike other tyrosinase inhibitors it does this via multiple simultaneous mechanisms. It directly inhibits tyrosinase enzyme activity, suppresses tyrosinase gene transcription, degrades existing melanosomes, and is selectively cytotoxic to melanocytes at higher concentrations. It also inhibits DNA and RNA synthesis in melanocytes, slowing their proliferative activity. Nothing OTC comes close to this multi-point attack on the melanin pathway.
SIDE EFFECT
skin irritation redness, dryness, burning, itching, contact dermatitis, and rare, severe skin darkening (exogenous ochronosis).
Ochronosis : a rare condition where the skin develops a bluish-black or slate-gray discoloration due to the buildup of pigment in the tissues
NEW FINDING LOWERING CONC OF HYDROQUINONE IF YOU DONT HAVE LOWER CONC OF IT
HYDROQUINONE treats dark spots on the skin caused by hormones, aging, or sun exposure. It works by decreasing the amount of melanin, a pigment your body makes that gives your skin color. This reduces the appearance of dark spots. Sun prevention measures, including sunscreen, are often combined with this medication. It belongs to a group of medications called skin-lightening agents.
It's a phenolic compound that inhibits tyrosinase the rate-limiting enzyme in melanin synthesis but unlike other tyrosinase inhibitors it does this via multiple simultaneous mechanisms. It directly inhibits tyrosinase enzyme activity, suppresses tyrosinase gene transcription, degrades existing melanosomes, and is selectively cytotoxic to melanocytes at higher concentrations. It also inhibits DNA and RNA synthesis in melanocytes, slowing their proliferative activity. Nothing OTC comes close to this multi-point attack on the melanin pathway.
SIDE EFFECT
skin irritation redness, dryness, burning, itching, contact dermatitis, and rare, severe skin darkening (exogenous ochronosis).
Ochronosis : a rare condition where the skin develops a bluish-black or slate-gray discoloration due to the buildup of pigment in the tissues
NEW FINDING LOWERING CONC OF HYDROQUINONE IF YOU DONT HAVE LOWER CONC OF IT
❖BRIMONIDINE ( WATER )
Brimonidine relieves eye redness by acting as an alpha-2 adrenergic agonist. When applied as a low-dose eye drop (e.g., 0.025% found in over-the-counter options like LUMIFY), it directly binds to receptors on the tiny blood vessels in the whites of your eyes, causing them to narrow (constrict). this has the most lowest rebound effect ever compared to other eye redness drug . it is sold with 0.025%strength which is sold as LUMIFY over the counter and 0.1% to 0.2% which needs prescription is sold as ALPHAGAN p
SIDE EFFECT
Mostly minimal and rare and wont have too much side effect with 0.025% but there were mild difficulty with users in trial like Mild Irritation .Feeling something stuck in your eyes thats all
SIDE EFFECT
Mostly minimal and rare and wont have too much side effect with 0.025% but there were mild difficulty with users in trial like Mild Irritation .Feeling something stuck in your eyes thats all
❖TRETINOIN ( WATER )
I prefer this over other retinoids
RAR / RXR nuclear receptor activation
Tretinoin penetrates the stratum corneum(outermost layer of epidermis) and binds to Retinoic Acid Receptors (RARα, RARβ, RARγ) and Retinoid X Receptors (RXR) inside the nucleus. These are transcription factor proteins when tret binds them, the entire receptor complex physically attaches to DNA at specific sequences called Retinoic Acid Response Elements (RAREs). This is the master switch that triggers everything below.
RARγ is the dominant receptor in skin. This is why skin-specific retinoids (like tazarotene) are designed to preferentially bind RARγ, reducing systemic effects
Accelerated epidermal cell cycle via AP-1 suppression
Tret downregulates AP-1 transcription factor activity (specifically c-fos and c-jun proteins). AP-1 normally slows keratinocyte differentiation. By suppressing it, tret dramatically accelerates the skin cell lifecycle from 28 days to 14 days. Cells are made faster, travel to the surface faster, and shed faster. This is what clears acne (comedones are ejected), improves texture, and causes the purge (all latent comedones get pushed out at once).
This pathway is also why tret thins the stratum corneum short-term (increasing UV sensitivity and transepidermal water loss) before it thickens long-term.
Collagen I/III upregulation + MMP inhibition
Via RAR activation, tret directly upregulates gene expression of procollagen type I and type III in fibroblasts the structural proteins of the dermis. Simultaneously, it inhibits Matrix Metalloproteinases (MMP-1, MMP-3, MMP-9) the enzymes that break down existing collagen. The result: you are both building more collagen and destroying less of it. This is the mechanism behind long-term skin thickening, wrinkle reduction, and improved firmness.
This effect is cumulative and takes months. At 6–12 months, dermal collagen density measurably increases on biopsy. At 18 months, the dermis is meaningfully
thicker.
TGF-β pathway stimulation
Tret stimulates Transforming Growth Factor Beta (TGF-β) signalling, which activates fibroblasts to produce more extracellular matrix components including collagen, elastin, and fibronectin. This is a secondary collagen pathway that runs parallel to the direct RAR-mediated procollagen gene activation above.
Melanin redistribution + tyrosinase downregulation
Tret acts on melanocytes (pigment-producing cells) by reducing tyrosinase expression the rate limiting enzyme in melanin synthesis. It also accelerates keratinocyte turnover so melanin-loaded cells are shed faster, breaking up the clustered melanin deposits that cause hyperpigmentation. This is the dual mechanism behind post-inflammatory hyperpigmentation (PIH) clearance: less production AND faster shedding.
This is why tret evens skin tone
Comedolytic action + sebocyte differentiation regulation
Tret normalises follicular keratinisation the process where dead keratinocytes inside the pore clump together and form a plug (comedone). By accelerating turnover, those cells don't get a chance to clump. It also modulates sebocyte (sebum-producing cell) differentiation via RARγ, reducing sebum output over time. This is why tret is the most effective comedolytic agent and why acne doesn't return during active use.
VEGF modulation + new capillary formation
Long-term tret use stimulates formation of new, organized dermal capillaries via VEGF (Vascular Endothelial Growth Factor) modulation. This is why chronic tret users develop that "lit from within" glow improved vascularisation means better nutrient delivery and oxygen to skin cells, improving skin colour and radiance at a structural level
This takes 12+ months. It's also why tret causes visible redness early on temporary vasodilation before vascular remodeling occurs.
conc depends where to apply and where are you are starting form
same side effect as tazarotene but minimal
RAR / RXR nuclear receptor activation
Tretinoin penetrates the stratum corneum(outermost layer of epidermis) and binds to Retinoic Acid Receptors (RARα, RARβ, RARγ) and Retinoid X Receptors (RXR) inside the nucleus. These are transcription factor proteins when tret binds them, the entire receptor complex physically attaches to DNA at specific sequences called Retinoic Acid Response Elements (RAREs). This is the master switch that triggers everything below.
RARγ is the dominant receptor in skin. This is why skin-specific retinoids (like tazarotene) are designed to preferentially bind RARγ, reducing systemic effects
Accelerated epidermal cell cycle via AP-1 suppression
Tret downregulates AP-1 transcription factor activity (specifically c-fos and c-jun proteins). AP-1 normally slows keratinocyte differentiation. By suppressing it, tret dramatically accelerates the skin cell lifecycle from 28 days to 14 days. Cells are made faster, travel to the surface faster, and shed faster. This is what clears acne (comedones are ejected), improves texture, and causes the purge (all latent comedones get pushed out at once).
This pathway is also why tret thins the stratum corneum short-term (increasing UV sensitivity and transepidermal water loss) before it thickens long-term.
Collagen I/III upregulation + MMP inhibition
Via RAR activation, tret directly upregulates gene expression of procollagen type I and type III in fibroblasts the structural proteins of the dermis. Simultaneously, it inhibits Matrix Metalloproteinases (MMP-1, MMP-3, MMP-9) the enzymes that break down existing collagen. The result: you are both building more collagen and destroying less of it. This is the mechanism behind long-term skin thickening, wrinkle reduction, and improved firmness.
This effect is cumulative and takes months. At 6–12 months, dermal collagen density measurably increases on biopsy. At 18 months, the dermis is meaningfully
thicker.
TGF-β pathway stimulation
Tret stimulates Transforming Growth Factor Beta (TGF-β) signalling, which activates fibroblasts to produce more extracellular matrix components including collagen, elastin, and fibronectin. This is a secondary collagen pathway that runs parallel to the direct RAR-mediated procollagen gene activation above.
Melanin redistribution + tyrosinase downregulation
Tret acts on melanocytes (pigment-producing cells) by reducing tyrosinase expression the rate limiting enzyme in melanin synthesis. It also accelerates keratinocyte turnover so melanin-loaded cells are shed faster, breaking up the clustered melanin deposits that cause hyperpigmentation. This is the dual mechanism behind post-inflammatory hyperpigmentation (PIH) clearance: less production AND faster shedding.
This is why tret evens skin tone
Comedolytic action + sebocyte differentiation regulation
Tret normalises follicular keratinisation the process where dead keratinocytes inside the pore clump together and form a plug (comedone). By accelerating turnover, those cells don't get a chance to clump. It also modulates sebocyte (sebum-producing cell) differentiation via RARγ, reducing sebum output over time. This is why tret is the most effective comedolytic agent and why acne doesn't return during active use.
VEGF modulation + new capillary formation
Long-term tret use stimulates formation of new, organized dermal capillaries via VEGF (Vascular Endothelial Growth Factor) modulation. This is why chronic tret users develop that "lit from within" glow improved vascularisation means better nutrient delivery and oxygen to skin cells, improving skin colour and radiance at a structural level
This takes 12+ months. It's also why tret causes visible redness early on temporary vasodilation before vascular remodeling occurs.
conc depends where to apply and where are you are starting form
same side effect as tazarotene but minimal
❖TAZAROTENE ( WATER )
Its primary mechanism of action involves the selective activation of retinoic acid receptors (RAR-β and RAR-γ), which play important roles in regulating cell growth, differentiation, and apoptosis. By activating these receptors, tazarotene influences the expression of several downstream inducible genes, such as tazarotene-induced gene-1 (TIG1), TIG2, and TIG3. These genes play crucial roles in regulating melanoma cell proliferation, invasiveness, and immune responses in the tumor microenvironment.
Tazarotene’s mechanism of action. After entering the cell, tazarotene is converted into tazarotenic acid. It then enters the cell nucleus and binds to retinoic acid receptor (RAR), acting as an antagonist of AP1(c-jun/c-fos) and inhibiting the transcription of related genes. Alternatively, it binds to the retinoic acid response elements region of DNA and participates in the transcription of target genes, such as TIG1, TIG2, and TIG3. TIG—tazarotene-induced gene
TIG1 acts as an anti-proliferative agent. In conditions like acne and psoriasis, skin cells multiply way too fast, bunching up into rough patches, clogged pores, or scaly lesions.
TIG2 is primarily responsible for modulating the skin's immune response and calming the local inflammatory environment.
TIG3 is a major driver of terminal keratinocyte differentiation. It interacts with an enzyme called type I transglutaminase, which instructs newborn skin cells to mature properly as they move to the surface.
SIDE EFFECT
Skin peeling, dryness occurs to due to skin adaptation .itching or burning sensations extreme cases are skin pain swelling blistering or oozing skin .Sun Sensitivity
pmc.ncbi.nlm.nih.gov
Tazarotene’s mechanism of action. After entering the cell, tazarotene is converted into tazarotenic acid. It then enters the cell nucleus and binds to retinoic acid receptor (RAR), acting as an antagonist of AP1(c-jun/c-fos) and inhibiting the transcription of related genes. Alternatively, it binds to the retinoic acid response elements region of DNA and participates in the transcription of target genes, such as TIG1, TIG2, and TIG3. TIG—tazarotene-induced gene
TIG1 acts as an anti-proliferative agent. In conditions like acne and psoriasis, skin cells multiply way too fast, bunching up into rough patches, clogged pores, or scaly lesions.
TIG2 is primarily responsible for modulating the skin's immune response and calming the local inflammatory environment.
TIG3 is a major driver of terminal keratinocyte differentiation. It interacts with an enzyme called type I transglutaminase, which instructs newborn skin cells to mature properly as they move to the surface.
SIDE EFFECT
Skin peeling, dryness occurs to due to skin adaptation .itching or burning sensations extreme cases are skin pain swelling blistering or oozing skin .Sun Sensitivity
Exploring Potential Therapeutic Applications of Tazarotene: Gene Regulation Mechanisms and Effects on Melanoma Cell Growth - PMC
Tazarotene, a retinoid derivative, is widely used in treating skin conditions such as psoriasis and acne. Recent studies have demonstrated its potential as a promising therapeutic agent for treating melanoma in situ. Its primary mechanism of action ...
pmc.ncbi.nlm.nih.gov
❖GHK-CU ( WATER )
GHK-Cu stands for Glycyl-L-Histidyl-L-Lysine bound to a copper ion (Cu²⁺). It's a naturally occurring peptide found in human blood plasma, saliva, and urine. Your body produces it abundantly when you're young
Collagen & Elastin Production :Activates fibroblasts to produce more collagen types I, III, and elastin
Skin Remodeling :Breaks down old, damaged collagen (via MMP enzymes) and replaces it with fresh collagen.
Antioxidant Defense : The copper ion neutralizes free radicals and activates superoxide dismutase (SOD) one of the body's most powerful natural antioxidants.
Wound Healing & Repair : Accelerates healing of damaged tissue, reduces scarring, and restores the skin barrier. Originally researched for wound care before skincare.
Anti-Inflammatory : Suppresses inflammatory signals (TNF-α, IL-6) that cause chronic skin damage and accelerate aging.
This is also good for hair cause
Enlarges Hair Follicles GHK-Cu directly stimulates follicle size. Studies show it can enlarge miniaturized follicles back toward their original diameter — meaning thinner, weaker hairs get thicker and stronger.
Extends the Growth Phase (Anagen)Hair grows in cycles. GHK-Cu prolongs the anagen (active growth) phase
Boosts Blood Supply to the Scalp It promotes angiogenesis — the formation of new blood vessels. More blood flow to follicles means more oxygen and nutrients delivered directly to hair roots.
Blocks DHT Damage GHK-Cu has shown ability to reduce follicle sensitivity to DHT, slowing the miniaturization process.
GHK-Cu suppresses the inflammatory signals (same mechanism as on skin) that cause follicle damage.
INJECTION IS BETTER THAN TOPICAL BECAUSE IT IS MORE BIOAVIALABLE AND WORKS DIRECTLY
SIDE EFFECT
Not much except bruising at injection area and slight itchiness etc thats not too much if you apply well
Collagen & Elastin Production :Activates fibroblasts to produce more collagen types I, III, and elastin
Skin Remodeling :Breaks down old, damaged collagen (via MMP enzymes) and replaces it with fresh collagen.
Antioxidant Defense : The copper ion neutralizes free radicals and activates superoxide dismutase (SOD) one of the body's most powerful natural antioxidants.
Wound Healing & Repair : Accelerates healing of damaged tissue, reduces scarring, and restores the skin barrier. Originally researched for wound care before skincare.
Anti-Inflammatory : Suppresses inflammatory signals (TNF-α, IL-6) that cause chronic skin damage and accelerate aging.
This is also good for hair cause
Enlarges Hair Follicles GHK-Cu directly stimulates follicle size. Studies show it can enlarge miniaturized follicles back toward their original diameter — meaning thinner, weaker hairs get thicker and stronger.
Extends the Growth Phase (Anagen)Hair grows in cycles. GHK-Cu prolongs the anagen (active growth) phase
Boosts Blood Supply to the Scalp It promotes angiogenesis — the formation of new blood vessels. More blood flow to follicles means more oxygen and nutrients delivered directly to hair roots.
Blocks DHT Damage GHK-Cu has shown ability to reduce follicle sensitivity to DHT, slowing the miniaturization process.
GHK-Cu suppresses the inflammatory signals (same mechanism as on skin) that cause follicle damage.
INJECTION IS BETTER THAN TOPICAL BECAUSE IT IS MORE BIOAVIALABLE AND WORKS DIRECTLY
SIDE EFFECT
Not much except bruising at injection area and slight itchiness etc thats not too much if you apply well
❖MATRIXYL 3000 ( WATER )
Matrixyl 3000 is purely a ingredient. It comes in serums, creams, and moisturizers applied directly to skin. Unlike GHK-Cu which has injectable forms
Your skin is constantly breaking down old collagen and building new collagen. When collagen fibres break down, they release tiny fragments called matrikines. These fragments travel to nearby fibroblast cells and act as alarm signals
What Matrixyl 3000 does: It is a synthetic matrikine mimic. It sends the exact same emergency repair signal to fibroblasts but artificially, continuously, and without needing actual collagen damage to trigger it. Your skin stays in a constant state of active collagen synthesis whether damaged or not
This drug also aims to remove lines and wrinkles and gives a plump at that area not as botox but aims to remove bit by time
SIDE EFFECT
I cant recall any
Your skin is constantly breaking down old collagen and building new collagen. When collagen fibres break down, they release tiny fragments called matrikines. These fragments travel to nearby fibroblast cells and act as alarm signals
What Matrixyl 3000 does: It is a synthetic matrikine mimic. It sends the exact same emergency repair signal to fibroblasts but artificially, continuously, and without needing actual collagen damage to trigger it. Your skin stays in a constant state of active collagen synthesis whether damaged or not
This drug also aims to remove lines and wrinkles and gives a plump at that area not as botox but aims to remove bit by time
SIDE EFFECT
I cant recall any
❖BOTOX ( WATER )
Botulinum toxin is produced by a specific type of bacteria. In higher amounts, it can be poisonous. However, only small, weaker doses of botulinum toxin are used to reduce facial wrinkles
Botulinum toxin causes temporary muscle paralysis and reduced gland activity by blocking the release of acetylcholine (a chemical messenger) at nerve endings. This stops nerve signals from reaching muscles and glands, resulting in localized relaxation.
Botulinum Toxin acts by blocking neural transmission at four different sites in the body - the neuromuscular junction, autonomic ganglia, postganglionic parasympathetic nerve endings and postganglionic sympathetic nerve endings, all of which release the neurotransmitter Acetylcholine. It irreversibly blocks the release of acetylcholine, the principal neurotransmitter at the neuromuscular junction, without causing degeneration of the nerve terminals.
Hyperactive muscle contraction is caused by excessive release of Acetylcholine at the neuromuscular junction in certain disorders. Exaggerated muscle spasms are relieved by botulinum toxin providing reliable relief of symptoms. Botulinum toxin does not however provide a cure for the underlying disease process.
The botulinum-induced irreversible paralytic effect starts in 24 to 72 hours and is complete in four to seven days after injection. There is recovery of muscle function only with the formation of new nerve terminals and new synaptic contacts which takes about two to three months.
SIDE EFFECT
Flu-like symptoms Fatigue, mild fever, or body aches . Headaches or neck pain . Dry mouth or mild nausea . Eye-related issues: Dry eyes, watery eyes, or slight irritation
minor side effects which happens after application
Botulinum toxin causes temporary muscle paralysis and reduced gland activity by blocking the release of acetylcholine (a chemical messenger) at nerve endings. This stops nerve signals from reaching muscles and glands, resulting in localized relaxation.
Botulinum Toxin acts by blocking neural transmission at four different sites in the body - the neuromuscular junction, autonomic ganglia, postganglionic parasympathetic nerve endings and postganglionic sympathetic nerve endings, all of which release the neurotransmitter Acetylcholine. It irreversibly blocks the release of acetylcholine, the principal neurotransmitter at the neuromuscular junction, without causing degeneration of the nerve terminals.
Hyperactive muscle contraction is caused by excessive release of Acetylcholine at the neuromuscular junction in certain disorders. Exaggerated muscle spasms are relieved by botulinum toxin providing reliable relief of symptoms. Botulinum toxin does not however provide a cure for the underlying disease process.
The botulinum-induced irreversible paralytic effect starts in 24 to 72 hours and is complete in four to seven days after injection. There is recovery of muscle function only with the formation of new nerve terminals and new synaptic contacts which takes about two to three months.
SIDE EFFECT
Flu-like symptoms Fatigue, mild fever, or body aches . Headaches or neck pain . Dry mouth or mild nausea . Eye-related issues: Dry eyes, watery eyes, or slight irritation
minor side effects which happens after application
❖ VOLUFILINE ( WATER )
Volufiline is a viral drug it is a plant extract which will promote the fat cells to hold lipids in hypodermis deepest part of skin ofc its good for gentle change b this has actually improved breast area on women by 8.4 % so its the women were of age like 18 to 32 told them to use this for 56 days and the results were 8.4% tissue development this is a good result tbh it was a small scale study
www.leadingedgehealth.com
Volufiline combines a synthetic carrier with sarsasapogenin, a steroidal compound extracted from the roots of the Asian botanical Anemarrhena asphodeloides. Its proposed mechanism includes
Adipocyte Differentiation: It promotes the maturation and proliferation of pre-adipocytes (precursor fat cells) into mature, fully functioning fat cells.
Lipid Storage: It activates cell pathways involved in lipid regulation, instructing the existing and newly formed fat cells to accumulate and store more fat lipids in the hypodermis
Volumizing Effect: By boosting fat density in localized areas, it aims to create a plumper, firmer, and more filled-in appearance
well it cant replace filler, fat grafting or any surgical interventions but it gives a stubble result at application area
SIDE EFFECT
Not much expect flakiness clogged pore and causing acne since it is a oil based compound and a bit of skin irritation
Total Curve
Total Curve® restores lift to breasts. It gives you beautiful breasts without the pain, risks, and expense of breast augmentation surgery.
www.leadingedgehealth.com
Adipocyte Differentiation: It promotes the maturation and proliferation of pre-adipocytes (precursor fat cells) into mature, fully functioning fat cells.
Lipid Storage: It activates cell pathways involved in lipid regulation, instructing the existing and newly formed fat cells to accumulate and store more fat lipids in the hypodermis
Volumizing Effect: By boosting fat density in localized areas, it aims to create a plumper, firmer, and more filled-in appearance
well it cant replace filler, fat grafting or any surgical interventions but it gives a stubble result at application area
SIDE EFFECT
Not much expect flakiness clogged pore and causing acne since it is a oil based compound and a bit of skin irritation
❖ VOLUPLUS( WATER )
Voluplus is another patented active ingredient, generally utilized to enhance fullness, primarily formulated for bust and body contouring Same as Volufinile but works a bit different
It incorporates Macelignan (a natural compound derived from nutmeg) combined with a fatty acid carrier.
Similar to Volufiline, it targets fat tissue (adipose cells). It is designed to promote lipid storage and assist in the maturation of fat cells, helping to fill out the skin naturally in the areas where it is applied.
SIDE EFFECT
Same as Volufinile
It incorporates Macelignan (a natural compound derived from nutmeg) combined with a fatty acid carrier.
Similar to Volufiline, it targets fat tissue (adipose cells). It is designed to promote lipid storage and assist in the maturation of fat cells, helping to fill out the skin naturally in the areas where it is applied.
SIDE EFFECT
Same as Volufinile
❖ ARGIRELINE( WATER )
Argireline (Acetyl Hexapeptide-8) is a synthetic anti-aging peptide used in topical skincare to target expression wrinkles this is also called botox in a bottle but is not as potent as botox
Neurotransmitter release—which tells your muscles to contract . depends on a group of proteins called the SNARE complex (specifically the SNAP-25 protein)
Argireline is modeled after the N-terminal end of SNAP-25. Because of its similar molecular structure, it competes with SNAP-25 to attach to the SNARE complex.
By interfering with the formation and stability of this complex, Argireline prevents the release of acetylcholine (a neurotransmitter). Without these chemical signals, facial muscles contract less forcefully, preventing and softening expression lines.
Just know this can remove the depth of wrinkles by 30 % when applying this for a month
THIS DOESNT WORKS AS BOTOX DISSCUSSED IN THIS STUDY
https://pmc.ncbi.nlm.nih.gov/articles/PMC10665711/
SIDE EFFECT
Simple effect like temporary skin irritation, redness, tingling, or dryness etc not much
Neurotransmitter release—which tells your muscles to contract . depends on a group of proteins called the SNARE complex (specifically the SNAP-25 protein)
Argireline is modeled after the N-terminal end of SNAP-25. Because of its similar molecular structure, it competes with SNAP-25 to attach to the SNARE complex.
By interfering with the formation and stability of this complex, Argireline prevents the release of acetylcholine (a neurotransmitter). Without these chemical signals, facial muscles contract less forcefully, preventing and softening expression lines.
Just know this can remove the depth of wrinkles by 30 % when applying this for a month
THIS DOESNT WORKS AS BOTOX DISSCUSSED IN THIS STUDY
https://pmc.ncbi.nlm.nih.gov/articles/PMC10665711/
SIDE EFFECT
Simple effect like temporary skin irritation, redness, tingling, or dryness etc not much
❖ RED LIGHT THERAPY( WATER )
Red light therapy (RLT) is a non-invasive, low-level light treatment that uses specific red or near-infrared wavelengths ((630-850 nm) to stimulate cellular mitochondria, increasing adenosine triphosphate (ATP) production. It is primarily used for skin rejuvenation, reducing inflammation, accelerating wound healing, and treating pain
USED AI FOR CORRECTION
First, the cell absorbs red light (RL) photons.
These photons target an enzyme called cytochrome c oxidase (CCO).
In stressed or aging cells, CCO is bound by nitric oxide (NO). This clogs the electron transport chain and stops the cell from making energy effectively.
Photons in the 600 to 900nm range come in clutch. They hit the CCO enzyme, causing it to vibrate and release the trapped NO.
With the blockage cleared, the cell can now use oxygen to properly produce ATP (cellular energy).
The released NO exits the mitochondria and moves into the surrounding tissue, where it acts as a vasodilator to widen blood vessels and improve circulation.
RLT causes a tiny, helpful burst of reactive oxygen species (ROS). This triggers transcription factors and turns on genes responsible for antioxidant production and tissue remodeling.
The process stimulates fibroblasts, which directly helps to produce more collagen in the skin.
It modulates NF-κB pathways, effectively reducing pro-inflammatory markers.
It has also been shown to promote the differentiation of stem cells, helping the body heal and repair itself.
pmc.ncbi.nlm.nih.gov
USED AI FOR CORRECTION
First, the cell absorbs red light (RL) photons.
These photons target an enzyme called cytochrome c oxidase (CCO).
In stressed or aging cells, CCO is bound by nitric oxide (NO). This clogs the electron transport chain and stops the cell from making energy effectively.
Photons in the 600 to 900nm range come in clutch. They hit the CCO enzyme, causing it to vibrate and release the trapped NO.
With the blockage cleared, the cell can now use oxygen to properly produce ATP (cellular energy).
The released NO exits the mitochondria and moves into the surrounding tissue, where it acts as a vasodilator to widen blood vessels and improve circulation.
RLT causes a tiny, helpful burst of reactive oxygen species (ROS). This triggers transcription factors and turns on genes responsible for antioxidant production and tissue remodeling.
The process stimulates fibroblasts, which directly helps to produce more collagen in the skin.
It modulates NF-κB pathways, effectively reducing pro-inflammatory markers.
It has also been shown to promote the differentiation of stem cells, helping the body heal and repair itself.
Unlocking the Power of Light on the Skin: A Comprehensive Review on Photobiomodulation - PMC
Photobiomodulation (PBM) is a procedure that uses light to modulate cellular functions and biological processes. Over the past decades, PBM has gained considerable attention for its potential in various medical applications due to its non-invasive ...
pmc.ncbi.nlm.nih.gov
❖ CHEMICAL PEELS ( COVERING ALL AT ONCE ) USED FOR UNDER EYE MOSTLY
A chemical peel applies an acid solution to the skin that:
Breaks down the bonds between dead skin cells
Controlled damage triggers the skin's wound-healing response
The body produces new collagen and elastin
Old, damaged skin sheds and is replaced by new skin
Result: smoother texture, more even tone, reduced fine lines
The deeper the peel, the more the results but also the higher the risk, especially near the eyes.
used ai for this im lazy rn so
Lactic Acid The gold standard for this area. It's a mild AHA that hydrates while gently exfoliating, brightens dark circles, and is unlikely to cause irritation. (20% – 30%) A gentle, large-molecule alpha-hydroxy acid (AHA). It draws moisture into the skin while exfoliating, making it the premier choice for dry or sensitive skin. Clinical studies show 30% lactic acid often outperforms other AHAs for periorbital hyperpigmentation.
Mandelic Acid Another gentle AHA with a larger molecular size, meaning it penetrates slowly and is less irritating. Great for sensitive skin and targeting fine lines and pigmentation under the eyes. This makes it the safest acid choice for individuals with deeper skin tones, as it minimizes the risk of triggering rebound pigmentation.
Glycolic Acid (low concentration only)Effective for fine lines and dullness, but only at very low percentages (5% or less) near the eye area. Higher concentrations are too harsh here .A small-molecule AHA that penetrates deep and fast. While effective at boosting collagen and fading stubborn spots, its concentration must be strictly monitored to prevent irritation.
TCA (trichloroacetic acid)Used by dermatologists for deeper concerns like creepy skin or persistent dark circles. never DIY around the eyes.
Breaks down the bonds between dead skin cells
Controlled damage triggers the skin's wound-healing response
The body produces new collagen and elastin
Old, damaged skin sheds and is replaced by new skin
Result: smoother texture, more even tone, reduced fine lines
The deeper the peel, the more the results but also the higher the risk, especially near the eyes.
used ai for this im lazy rn so
Lactic Acid The gold standard for this area. It's a mild AHA that hydrates while gently exfoliating, brightens dark circles, and is unlikely to cause irritation. (20% – 30%) A gentle, large-molecule alpha-hydroxy acid (AHA). It draws moisture into the skin while exfoliating, making it the premier choice for dry or sensitive skin. Clinical studies show 30% lactic acid often outperforms other AHAs for periorbital hyperpigmentation.
Mandelic Acid Another gentle AHA with a larger molecular size, meaning it penetrates slowly and is less irritating. Great for sensitive skin and targeting fine lines and pigmentation under the eyes. This makes it the safest acid choice for individuals with deeper skin tones, as it minimizes the risk of triggering rebound pigmentation.
Glycolic Acid (low concentration only)Effective for fine lines and dullness, but only at very low percentages (5% or less) near the eye area. Higher concentrations are too harsh here .A small-molecule AHA that penetrates deep and fast. While effective at boosting collagen and fading stubborn spots, its concentration must be strictly monitored to prevent irritation.
TCA (trichloroacetic acid)Used by dermatologists for deeper concerns like creepy skin or persistent dark circles. never DIY around the eyes.
❖ FRACTIONAL CO2 LASER FOR WRINKLES
The Fractional CO2 laser is a powerful, ablative skin resurfacing treatment that uses targeted light energy to vaporize the top layer of skin. It triggers the body’s natural healing process, stimulating collagen production to smooth fine lines, reduce scars, and even out skin tone and texture with less downtime than traditional lasers. it works by
The laser divides its energy into thousands of tiny, microscopic beams
It treats a fraction of the skin at a time, leaving surrounding healthy tissue intact to promote rapid healing.
Heat penetrates the deeper skin layers, tightening the skin and encouraging new, healthy cell turnover
CO2 laser is one of the most widely used lasers in the dermatology field. With its wavelength in the mid-infrared at 10,600 nm
CO2 laser energy is well absorbed in water. As skin contains a very high water percentage, this makes the CO2 laser ideal for precise, safe ablation with good hemostasis
pmc.ncbi.nlm.nih.gov
The laser divides its energy into thousands of tiny, microscopic beams
It treats a fraction of the skin at a time, leaving surrounding healthy tissue intact to promote rapid healing.
Heat penetrates the deeper skin layers, tightening the skin and encouraging new, healthy cell turnover
CO2 laser is one of the most widely used lasers in the dermatology field. With its wavelength in the mid-infrared at 10,600 nm
CO2 laser energy is well absorbed in water. As skin contains a very high water percentage, this makes the CO2 laser ideal for precise, safe ablation with good hemostasis
The Role of the CO2 Laser and Fractional CO2 Laser in Dermatology - PMC
Background: Tremendous advances have been made in the medical application of the laser in the past few decades. Many diseases in the dermatological field are now indications for laser treatment that qualify for reimbursement by many national health ...
pmc.ncbi.nlm.nih.gov
❖ERBIUM YAG LASER WRINKLES
The Er:YAG laser (Erbium-doped Yttrium Aluminum Garnet) is a solid-state laser that emits light at a wavelength of 2,940 nm (mid-infrared range). This wavelength coincides almost exactly with the peak absorption of water in biological tissue, making it exceptionally precise for ablation.
Photon absorption — Tissue water molecules absorb the 2,940 nm photon with extreme efficiency (highest of any medical laser)
Rapid vaporization — The absorbed energy causes near-instantaneous water superheating, leading to microexplosive ablation.
Minimal thermal spread — Because energy is consumed by ablation rather than heat conduction, the thermal damage zone is extremely thin (typically 5–50 µm), far less than CO₂ lasers.
Minimal hemostasis — poor coagulation ability due to low thermal effect (a disadvantage vs. CO₂ or Nd:YAG for bleeding tissue)
Higher cost than many alternatives
Slower ablation rate per pulse compared to CO₂ laserRequires water spray for cooling during hard tissue use
requires protective eyewear (mid-IR radi) but doing on lower eye is possible
Ablation is a medical and scientific procedure that involves the removal or destruction of targeted body tissue, a tumor, or a specific system component.
Photon absorption — Tissue water molecules absorb the 2,940 nm photon with extreme efficiency (highest of any medical laser)
Rapid vaporization — The absorbed energy causes near-instantaneous water superheating, leading to microexplosive ablation.
Minimal thermal spread — Because energy is consumed by ablation rather than heat conduction, the thermal damage zone is extremely thin (typically 5–50 µm), far less than CO₂ lasers.
Minimal hemostasis — poor coagulation ability due to low thermal effect (a disadvantage vs. CO₂ or Nd:YAG for bleeding tissue)
Higher cost than many alternatives
Slower ablation rate per pulse compared to CO₂ laserRequires water spray for cooling during hard tissue use
requires protective eyewear (mid-IR radi) but doing on lower eye is possible
SINCE MOST OF TREATMENT AND COMPOUND ARE ALREADY EXPLAINED STUFF LIKE KOJIC ACID AZELAIC ACID WILL BE EXPLAINED IN SPECIFIC PART THAT SHIT AINT HARD AND THIS PART WILL BE TOO LONG THATS WHY AND WE WILL USE THIS FIX ANY SPECIFIC ISSUES
AND APPLICTION WILL ALSO BE TOLD BELOW
◈ CANTHAL TILT
Angle formation between lateral and medial canthus
❖PCT( POSITIVE CANTHAL TILT ): FORMS WHEN MEDIAL CANTHUS IS BELOW LATERAL CANTHUS 2 DEGREE PLUS ANGLE FORMATION
❖NCT( NEGATIVE CANTHAL TILT ): WHEN MEDIAL CANTHUS IS ABOVE LATERAL CANTHUS -1 DEGREE PLUS ANGLE FORMATION
❖NCT( NEUTRAL CANTHAL TILT ): WHEN MEDIAL CANTHUS IS AT SAME POSITION AS LATERAL CANTHUS SO 0 TO 1 DEGREE ANGLE FORMATION
IDEAL RANGE : 3 DEGREE TO 6.5 OR 7 DEGREE
❖ NCT DISADVANTAGES
Sad or Fatigued Appearance
It is perceived as prey eyes
This type of eye look more aged as you age more
Give bad face aesthetics
MORE TYPES OF CANTHAL TILT
❖ MASCULINE PCT
When a neutral lateral canthus is combined swung medial canthus ( downturned medial canthus ) this will give PCT and create a angular looking eye area and it will look masculine it looks straight and appears sharp .Also men are closer to neutral tilt due to higher nasal bridges.
❖ FEMININE PCT
PCT caused by swung up lateral canthus. lower eye on women is curved and roundish. rounder lower eyes are feminine and it is not for men even though PCT it self is ideal and women also tends to have sharp infra orbital rims
CANTHAL TILT SPECIFIC SURGERIES
❖ CANTHOPLASTY
First you get either local anesthesia or general, depending on the surgeon and whether it's being combined with other work. The surgeon makes a small incision right at the lateral canthus. They then cut the lower limb of the tendon, which releases the outer corner completely. From there they can either shorten the tendon tightening it or redirect its attachment point upward on the orbital rim using permanent sutures drilled or anchored into the bone. The incision is closed with very fine sutures, usually dissolvable inside and a few external ones.
The procedure generally takes between 30 minutes to two hour, or up to three hours depending on complexity
Significant swelling, bruising, and the eye will look very tight and pulled in the 1st week . Many people look overcorrected at first which is intentional because the tissue relaxes as it heals. You'll have dry eye symptoms because the tear film gets disrupted. External sutures come out around day 5-7. Most of the obvious swelling resolves in 3-4 weeks but the final result takes 3-6 months to fully settle. You can't rub your eyes or wear contacts, or do anything high impact for at least a month.
❖ POSSIBLE COMPLICATION
All surgical procedures come with possible risks. Your surgeon will explain these risks before your procedure.
Scars
Bleeding
Swelling and bruising
Pain
Dry eyes
Difficulty closing your eyes
An infection
Canthoplasty surgery is safe and effective when performed by a highly trained and experienced surgeon so choose yo surgeon wisely
❖ COST
Usa : avg cost 3k to 8k $
South korea : avg cost 2k to 4k $
Turkey: avg cost 1.5 to 3k $
This is also gonna be surgeon dependent
❖ BEFORE AND AFTER
CITATION
[/SPOILER]
❖ CANTHOPEXY
canthopexy is just a gentle version of canthoplasty .Canthopexy does NOT fully detach the tendon. Instead the surgeon places sutures that tighten and reposition the existing tendon without releasing it from its original attachment.. Because the tendon stays attached, the correction is more limited but the procedure is gentler and recovery is faster.
You'll get a modest tightening and slight upward shift of the outer corner. Excellent for people whose tilt is already neutral or mildly negative and want a small improvement, or for people having lower blepharoplasty who need the outer corner supported so the lid doesn't round out post surgery. The downside is that sutures can loosen over time, especially in younger patients with more elastic tissue. Some people see partial regression within a few years. It's not as reliably permanent as true canthoplasty.
Recovery is Noticeably easier than canthoplasty. Swelling and bruising still happen but is less intense. Most people look pretty normal by 2 weeks. Dry eye symptoms are usually milder and shorter-lived. Same restrictions apply no rubbing, no contacts, no impact activity for a few weeks.
❖ POSSIBLE COMPLICATION
Same as canthoplasty but usually at low risk
❖ COST
Usa : avg cost1.5k to 4k $
South korea : avg cost 800 to 2k $
Turkey : avg cost 700 to 1.5k $
This is also gonna be surgeon dependent
❖ BEFORE AND AFTER
❖ FOX EYE THREAD LIFT
A minimally invasive procedure where barbed threads are inserted under the skin of the temple area and used to physically pull the outer corner of the eye upward and laterally. No incisions no cutting of tendons and no permanent changes. are done in here
The threads pull on the skin and soft tissue surrounding the outer canthus the skin of the lateral orbital area, the tail of the eyebrow, and the upper cheek. This creates an upward tension that lifts the outer corner visually.
This means the result is genuinely visible but fundamentally different from canthoplasty. thread lift creates more of an overall pulled, elongated tension across the outer eye area.
NO RECOVERY TIME FOR THIS WORKS DIRECTLY
❖ POSSIBLE COMPLICATION
Swelling and Bruising
Infection
Thread Migration
Asymmetry and Distortion If threads are inserted unevenly or too tightly, it can create unnatural look
internal scarring
loses skin texture and elasticity at application area if we keep doing it again and again
Thread lift is genuinely useful if you want to preview what a more positive canthal tilt would look like on your face before committing to
surgery
❖ COST
Usa : avg cost1.5k to 3.5k $
South korea : avg cost 800 to 2k $
Turkey : avg cost 500 to 1.5k $
❖ BEFORE AND AFTER
❖ FRAUDINGS
1. Improving your eyebrows to make it more sharper and positively tilted to compensate negative tilt best eg are jason momoa and ian somerhalder .Groom your brow tail .1st grow your brow and do it if not you will not have much density in brow after grooming
This wont totally compensate but still a thing to focus on
2.Applying tape .using transparent tape and putting make up over it to hide the tape . Use tape to apply it from lower eye lid and pull to up or apply from lateral canthus and pull to up but it looks uncanny tho i have a video watch it to timestamp 1:13. This will work same as fox eye thread but more temporary
3.Trim the inner corner of lashes slightly for the illusion of a higher canthal tilt
Yeah nothing much for your canthal tilt frauding
❖ BOTOX
injecting botox into the outer eye area muscle relaxes the fibers pulling your corner downward. Creates a real mechanical lift of the outer corner tissue. Not permanent
One to three units of botox injected into the lateral orbicularis oculi at the outer corner area. the injection takes about 10 seconds per side. Some injectors place it in one spot and some split it across two points depending on your anatomy. Total appointment including consultation is maybe 20 minutes.
Results are around fully at around 10-14 days. and lasts around 3 to 4 month
❖ POSSIBLE COMPLICATION
Asymmetry . one side responding better than other
Bruising
Difficulty in squinting
Ptosis. you can search it yourself
❖ COST
2-4 units per side, so 4-8 units total. At $12-20 per unit that's $50-160 for the product itself. Most places don't sell it this cheap per unit
though unless you're at a high volume clinic.
US : avg cost $150 to 400 per session
South Korea : avg cost $80 to 200
Turkey : avg cost $60 to 15
❖ BEFORE AND AFTER
This is after and before
❖ EXTRA TIPS
1.using lower concentrated retinoids to promote cell turn over and improve collagen at the eye area and retain the structural itergrity
0.025% to 0.05% is fine tretinoin
2.Elastiderm: promotes collagen contains 0.1 retinol .it relies on a proprietary Bi-Mineral Contour Complex ( blend of zinc, copper, and malonate) to support the three vital stages of healthy elastin production
3.using argireline which will work 30 % of botox
Apply it to the orbital bone area the skin sitting on the bone around the eye, not the eyelid itself. Use a tiny amount, a grain of rice size for the whole eye area. Apply it over a moisturizer, not on bare skin this is called buffering and significantly reduces irritation while still getting results. apply two times a day every day for all three dont apply at same time tho
❖UPPER EYE
Eye brow - the hair above the eyes no need to explain The outer end of the brow should not sit lower than the inner end. Neutral or a slight upward angle toward the outer end is ideal. Negatively tilted brows is unideal. and give prey like l
Superior orbital -The superior orbital bone generally refers to the supraorbital margin (the upper rim of the eye socket) and the orbital roof (the upper wall this bone bone generally formed by frontal lobe also know as brow bone brow ridge or supra orbital
Upper eye lid -The upper lid crease is the single most defining feature of upper eyelid aesthetics. Its position, depth, and symmetry determine almost everything about how the eye looks
Brow fat pad — sits between frontalis and the orbital rim. Deflates and descends. Critical for youthful brow position and upper lid fullness.
WILL EXPLAIN IN DEPTH EACH
❖EYE BROW A PART OF UPPER EYE AREA
❖ WHY IT MATTERS ?
Eyebrows matter significantly for your looks because they act as the primary frame for your entire face. They balance facial proportions, bring symmetry to your features shaving your eye brow will always look off people recognizes you with your eyebrow it is a really important facial feature
❖ WHAT SHOULD BE SHAPE OF EYE BROW AND DENSITY
Eye brow should be dense and thick as a man this will be a symbol of masculinity for you the shape of eye brow should always be flat to slightly positive this is really important you need to make your eye brow compact and give a slight angular arch at corner rounder eyebrow doesnt look good at men jfl + your eye brow should always be long it should be
❖ EYE BROW SETNESS
Your eye brow should be as low set as possible this will show how masculine your eye area will look this is really important and the more close set your eye brow the better it is yeah but not too much as making a unibrow this can be achieved with few surgeries
the difference is there as you can see
Using volufiline or voluplus in the fat pad for maximum result use this thing like 2 times a day apply a really small amount and use it every day and wait for 2 months wont change completely but works ig
❖ FILLERS AND FAT GRAFTING UNDER BROW BONE
I think you all already know how fat grafting works so the fat is harvested and injected at eye brow fat pad and same way ha filler goes which is not your body tissue or compound ofc but it has a good job to achieve eye brow hooding and increase brow bone projection this is a good thing to go and for recovery time is same as other which i mention earlier and permanent to semi permanent if fat survives which 40 % doesnt and ha filler go in 9 to 8 months
❖ POSSIBLE COMPLICATION
Not adding enough fat/filler undercorrection
Adding too much fat/filler cells overcorrection
20 to 50% fat are reabsorbed so you will lose some in over time
prolonged swelling
and may cause asymmetry cause they can inject more at one part but not at another
same as other fat grafting which i mentioned
❖ BEFORE AND AFTER
for brow bone
❖ TILT OF EYE BROW
TAKING THIS IMAGE FROM OLD THREAD IN HERE
IG i have already explained it the tilt of eye brow should be neutral to slightly positive ok negative are a flaw and we achieve this by grooming as i explained in canthal tilt part your negative eye canthal tilt can be neutralized with positive eyebrow tilt and if you have high set eye brow make sure its not too much positive tilted
❖ EYE BROW COLOUR
The eye brow color should always be darker than your skin tone but the ideal eye brow color is black or brown
as you can see in this pic the darker it it the more contrast it brings
You can achieve this by eye brow dyeing with something dark color eyebrow pencil and eyebrow gel
❖ EYE BROW MICROBLADING
Microblading is a semi-permanent cosmetic tattooing procedure used to enhance the appearance of the eyebrows. A technician uses a handheld tool with tiny, ultrafine needles to etch hair-like strokes into the skin, depositing pigment to create a fuller, natural-looking brow that typically lasts 1 to 3 years
❖ BEFORE AND AFTER
❖ GROWING YOUR EYE BROW
1.Using minoxidil topical : foam > gel > liquid -> apply minoxidil 2 times a day every day for 2 month to get max result
2. Using oral minoxidil : Oral > topical -> Take 2.5 mg to 5mg a day for everyday to see result
3. Castor oil : cope + placebo -> apply it two times a day every day if you wanna use it
4. 0.025% Tretinoin + topical Minoxidil -> apply tret 2 times at eyebrow after minoxidil drying or use it before Tret thins out stratum corneum which makes minoxidil to do it work
5. Micro needling with minoxidil -> Use sum derma roller 3 times a day 2 min at a part
GHK- CU ->1 mg - 2 mg per day . Cycles range from 30 days to 12weeks, followed by a mandatory 4 to 6 week break to prevent the accumulation of excess free copper in your system.
Using bimatoprost -> use 0.03 % conc bimatoprost use it 2 times a day every day apply it via cotton buds in eye brow you can use it with minoxidil but don't use it at same time
❖ EYE BROW IMPLANTS
So at first the hair is taken from nape of neck area or behind the ears the hair follicles are individually placed into tiny incisions in the eyebrow area aligned to match the natural direction and angle of brow growth.
The procedure takes a few hours under local anesthesia
within 3 to 6 months the eye brow grow back
❖ COST ON BROWS
USA : 3k to 8k $ on avg
Turkey : 1 to 1.8k $ on avg
Korea : 1.5 to 3k $ on avg
❖ BEFORE AND AFTER
❖EYE LASHES
❖ WHY IT MATTERS ?
Long, thick lashes naturally frame the eye, making them appear larger and more expressive. This creates a stronger, more magnetic gaze.
eye brow matters a lot you can fraud pfl and create a high amount of contrast and give face a youthful appearance
❖ EYE LASH SHAPE AND DENSITY
Eye lash should be thick and dense for men it should not be extremely large but long enough for men the eye lash should be curled upward and the end corner of eye lash should be trimmed to make perceived canthal tilt positive so to say
HOW TO SHAPE IT
take scissors and start trimming out the outer corner
take vaseline and apply it on lower and upper eye lash use a lash curler and start curling your lash in upward direction and downward lash in down ward direction
by this you will get more volume too but too shape it at 1st you need to have good amount of lash to have it
❖ EYELASH COLOUR
more defined and dark looks good
Just as eye brow darker than your natural skin tone or natural eye lash color while black and brown is the ideal eyelash color
HOW TO GET GOOD LASH COLOR
Take your moms mascara and start curling your eye lash with it but yeah make sure its water proof .Place the wand at the base of the eyelashes and gently wiggle upward to the tips. you can also get like men's mascara but your moms mascara is also ok apply light and a gentle amount of it you don't wanna make it look gay + use a cotton bud to remove any excess mascara off skin
❖ EYE LASH TATOO OR LASH LINE INHANCER
An "eyelash tattoo," often called a lash line enhancement or invisible eyeliner, is a semi-permanent cosmetic procedure. It involves depositing pigment directly between the roots of your eyelashes to create the illusion of a fuller, darker lash line without a harsh, traditional eyeliner look
Results typically last 1 to 3 years,
❖ BEFORE AND AFTER
❖ GROWING
1.Using minoxidil topical : foam > gel > liquid -> apply minoxidil 2 times a day every day for 2 month to get max result use foam or gel
specifically for lash apply with cotton bud don't let get inside your eye
2. Using oral minoxidil : Oral > topical -> Take 2.5 mg to 5mg a day for everyday to see result
GHK- CU ->1 mg - 2 mg per day . Cycles range from 30 days to 12weeks, followed by a mandatory 4 to 6 week break to prevent the accumulation of excess free copper in your system.
Using bimatoprost -> use 0.03 % conc bimatoprost use it 2 times a day every day apply it via cotton buds in eye lash you can use it with minoxidil but don't use it at same time
❖ EYE LASH IMPLANTS
same as brow so at first the hair is taken from nape of neck area or behind the ears the hair follicles are individually placed into tiny incisions in the eyelash area aligned to match the natural direction and angle of brow growth.
The procedure takes a few hours under local anesthesia
within 3 to 6 months the eye lash grow back
❖ COST ON LASHES
USA : 3.5 to 10k $ on avg
Turkey : 1K to 2.4k $ on avg
Korea : 3.5to 6.2k $ on avg
❖ BEFORE AND AFTER
❖SUPRA ORBITAL / BROW RIDGE
❖ANATOMY
Supraorbital anatomy encompasses the bony brow ridge (superciliary arch), the eye socket's upper rim, and the key structures that exit the skull to supply the forehead. Visually, it dictates eyebrow shape, facial expressions, and the prominence of the upper eye contour.
The Supraorbital Margin: This is the sharp, upper boundary of the eye socket. It sits directly beneath your eyebrows and frames the upper part of your eye.
The Supraorbital Notch/Foramen: Located along the upper rim (about midway between the center of your nose and the outer edge of your eye socket) is a small indentation or hole. In some people, it is a small notch. In others, a bridge of bone creates a complete ring (foramen). It is easily felt by gently pressing over the eyebrow in line with your pupil
The height of the supraorbital margin and brow ridge defines facial masculinity or femininity
Men need to have prominent supra orbital this really important
❖WHY IT MATTERS ?
The supraorbital ridge (brow bone) is a major marker of male sexual dimorphism. It dictates how deep-set the eyes appear, influences the angle of the forehead, and establishes a rugged, striking, and structurally mature aesthetic.
Testosterone Signaling: During puberty, higher levels of testosterone and growth hormones lead to thicker, more robust facial bones. A well-defined, prominent brow bone subconsciously signals high androgen levels and genetic masculinity.
A forward-set supraorbital rim creates a prominent brow with a lower, straighter eyebrow position. This frames the eyes tightly and causes the upper eyelid to be hooded or deep-set, conveying a confident, intense, and predatory gaze.
Facial Depth & Proportion: Women typically have flatter, more vertical foreheads and higher, more arched brows. In men, a sloping frontal bone with noticeable supraorbital projection creates a strong "brow break"—a definitive shadow that adds dimension and angles to the upper third of the face.
DAMM
❖HOW TO ADRESS IT ?
Brow-Nasal Angle: A prominent brow bone creates a sharp, 90 degree angle with your nose bridge. A flat projection creates a much wider, flatter angle around 120 degree
No Shadow Casting: A prominent brow causes the superciliary arches (the arches of bone right above your eyes) to cast distinct shadows, especially under overhead lighting. A flat projection does not cast these shadows,
❖SUPRA ORBITAL SHARPNESS
This thing really matters it creates a sharp and angular look in the face even projected supra orbital can be blunt but and Unlike the thin, sharpness of the female supraorbital rim, the male margin is typically thicker, more rounded, and blends seamlessly into the glabella (the bone between the eyebrows)
This will make your eye area really good and balance out your facial feature
❖HOW TO GET GOOD SUPRA ORBITAL SHARPNESS
❖FILLERS
❖PRODUCT CHOICE
Thick, high-G' HA fillers are preferred — they resist compression and hold shape over bone:
Juvederm Voluma
Restylane Lyft / Defyne
Belotero Volume
Radiesse (calcium hydroxyapatite) — also used, gives more lift and stimulates collagen
❖INJECTION TECHIQUE
Zone | Purpose |
|---|---|
Supraorbital ridge (lateral) | Creates the angular lateral brow projection |
Glabella / central brow | Adds forward projection between the brows |
Lateral brow tail | Flattens and extends the brow horizontally |
Temple (optional) | Fills temporal hollowing for a fuller frame |
❖VOLUME
Typically 0.5–1.5ml per side depending on baseline bone structure
Can be done asymmetrically if natural ridge is uneven
❖RISKS TO KNOW
Supratrochlear / supraorbital vessels run through this zone → vascular occlusion risk
Bruising and swelling common for 3–7 days
Tyndall effect if placed too superficially
Experienced injector essential — ideally one familiar with male anatomy
❖FAT GRAFTING VS HA FILLER
HA Filler | Fat Grafting | |
|---|---|---|
Reversible | Yes (hyaluronidase) | No |
Precision | High | Moderate |
Timline | 12–18 months | Permanent (if survives) |
Projection | Good | Limited |
Survival rate | 100% | ~30–60% unpredictable |
Risk of irregularity | Low | Higher |
❖ BEFORE AND AFTER
❖ IMPLANTS
brow bone implant (also known as a supraorbital ridge implant) is a permanent surgical procedure used to increase the projection, definition, and prominence of the brow ridge.
This procedure is highly sought after for facial masculinization, balancing forehead-to-nose ratios
so they do a 3d ct scan at 1st check your skull and add a medical grade silicon implant according to it or they do a custom implant it also comes in many time like In some cases surgeons may use Gore Tex or intraoperative bone cements like PMMA (acrylic) or hydroxyapatite.
Performed under general anesthesia, the implant is typically inserted through small, hidden endoscopic incisions located behind or right at the hairline. If only the outer tail of the brow needs enhancement, it can sometimes be placed via an upper eyelid crease incision
Once positioned precisely over the lower frontal bone, the implant is typically secured in place using tiny titanium micro-screws to prevent shifting or sliding over time
Once positioned precisely over the lower frontal bone, the implant is typically secured in place using tiny titanium micro-screws to prevent shifting or sliding over time
months to heal but sets in like 1 to 2 weeks
better than fat grafting it is permanent
❖ POSSIBLE COMPLICATION
Forehead & Scalp Numbness
Motor Nerve Risk nerve damage may occur man
Implant Shifting
Bruising
Permanent scars
❖ COST
USA : 12k to 22k $ on avg
Turkey : 5.5 to 9k $ on avg
Korea : 7 to 12k $ on avg
❖ BEFORE AND AFTER
❖ILLUSIONS
Add Volume: Use a tinted brow gel or a fine-tipped brow pen to fill in sparse areas. Thicker, darker brows visually pull the entire brow area forward.
Create Shadow Below: Apply a matte contour powder or eyeshadow that matches your skin's shadow tone directly under the brow bone (in the eye crease). This deepens the eye socket, making the bone above it project more.
Highlight the Ridge: Place a tiny amount of matte concealer which should be one shade lighter than your skin directly on the highest point of your brow bone hair.
Pluck hairs only from the top of your brows. This shifts the entire brow downward, closer to your eyes,
Straighten the Arch: Remove the hairs that create a sharp upward peak. A straight, flat brow shape naturally mimics a masculine ridge.
Do not over-pluck the space between your eyebrows. Keeping the brows closer together makes the bridge of your nose and the brow ridge look more forward-facing.
Volufiline or Voluplus -> cope mostly may be will work. idk
❖UPPER EYE LID EXPOSURE
❖WHY IT MATTERS
Low upper eyelid exposure in men is considered highly attractive because it creates a deeper-set eye shape that signifies masculinity and sexual maturity .By partially covering the upper lid, the eye appears more focused, intense, and predatory, which is traditionally favored in masculine aesthetic archetypes. This is a also a biological reason cause hgh testosterone levels during male puberty drive forward growth of the supraorbital ridge .forward bone growth pulls the brow forward and down, recessing the eyeballs deeper into the skull socket.: As the brow bone projects outward, the skin naturally hoods over the upper eyelid, hiding the crease.
as you can already see why it matters
❖HOW IT HAPPENS
High upper eyelid exposure occurs when a large portion of the skin between your eyelashes and your eyebrow is visible when looking straight ahead. This look is often associated with a tired, surprised, or hollow appearance and is primarily caused by genetics, skeletal structure, and age-related volume loss
Fat Pad Atrophy: The natural pockets of orbital fat that keep the upper eyelids looking plump and youthful begin to shrink or shift.
Receding Orbital Rim: A flat or weak brow bone provides very little physical projection. Without a prominent brow bone to naturally overhang and hood" the eye, the upper eyelid remains completely uncovered and fully visible
❖HOW TO ADRESS IT
So we can address this by putting fat in the fat pad below the orbital bone Situated between the orbicularis oculi muscle and the orbital septum
WILL TELL YOU ONLY THE BEST OPTION HA FILLERS AND FAT GRAFTING
1. USING FILLERS HA FILLERS
Strategic HA fillers are directly placed in fat pad to get minimal upper eyelid exposure this can be addressed into two ways as i said earlier
The filler is placed directly along the inferior margin of the supraorbital rim, sitting on the periosteum (bone) and deep underneath the orbicularis oculi muscle. This pushes the entire brow structure forward, building a heavy, prominent brow ridge.
Tiny micro-droplets are sometimes feathered into the lower subcutaneous layer just above the upper eyelid crease to force the skin to fold over.
Results are instantly visible. Swelling peaks within 48 hours and subsides over a week.
Results typically last 12 to 18 months.
❖INJECTION TECHIQUE
Entry Point: A tiny pilot hole is made with a needle at the outer edge of the eyebrow (lateral brow).
Cannula Insertion: A blunt-tipped cannula (typically 22G to 25G) is inserted through the hole. A cannula is used instead of a needle to significantly lower the risk of piercing a major blood vessel.
Fanning Injection: The injector moves the cannula in a slow, precise, fan-shaped pattern deep underneath the muscle, gently depositing threads of filler.
Molding: The provider manually molds the gel to ensure a flat, heavy, uniform hood without lumps
❖ BEFORE AND AFTER
FAT GRAFT
❖FAT GRAFTING VS HA FILLER
Feature | Fat Grafting (Autologous Fat) | Dermal Fillers (Hyaluronic Acid) |
|---|---|---|
Material Source | Your own living fat tissue. | Synthetic hyaluronic acid gel. |
Preparation Needed | Requires minor liposuction from thighs or abdomen. | Comes pre-packaged in a sterile syringe. |
Anesthesia Type | Local anesthesia with sedation or general anesthesia. | Topical numbing cream or local injection. |
Procedure Time | 1.5 to 3 hours total. | 15 to 30 minutes total. |
Initial Downtime | 7 to 14 days. Significant bruising. | 2 to 5 days. Minor swelling. |
Final Result Timeline | 3 months (after cell survival stabilizes). | 1 to 2 weeks (after swelling drops). |
Permanence | Permanent once blood supply is established. | Temporary. Absorbs naturally over time. |
Average Longevity | Lifetime duration. | 12 to 18 months. |
Weight Fluctuations | Grafts grow or shrink if you gain/lose weight. | Unaffected by your body weight changes. |
How It Fails | Can form hard, permanent fat lumps. | Can migrate or look lumpy if shallow. |
Correction Method | Requires complex surgical excision to remove. | Instantly dissolved with an enzyme injection. |
Average Cost | Higher upfront cost ($3,000 – $6,000+). | Lower per-session cost ($600 – $1,200). |
NOTE : fat graft and filler add volume through injection but are different why ?
Feature , | Dermal Filler Injection | Fat Grafting Injection |
|---|---|---|
Preparation | Ready-made gel; taken straight from a sterile manufactured syringe. | Multi-step; fat must be gently liposuctioned, washed, and purified first. |
Tools Used | Ultra-fine needles or thin, flexible cannulas. | Specialized, blunt-tipped grafting cannulas. |
Precision Level | High; allows for superficial placement in lips or fine lines. | Deep; injected in structural micro-layers near muscles and tissue. |
Predictability | What is injected is exactly the volume you keep instantly. | Over-injection is often required because 30% to 50% of cells naturally dissolve |
https://looksmax.org/threads/fix-upper-eyelid-exposure-ha-upper-eye-lid-filler-simple.2067621/ @Sayori covered in depth how to diy inject
❖BROW LIFT AND UPPER BLEPHAROPLASTY
its useless unless if you have extreme hooding where the skin sags down this surgery aims increase high set eye brow if you aint a girl not needed . this will be achieved by many things like cutting skin below supra orbital or using thread to lift or using botox so kinda useless oldcel do this . really bad for asians
❖ SOFTMAXXES
COPES MOSTLY
Use volufiline and voluplus in fat pad may be cope
increase collagen with tret and tazarotene
ghk cu
❖ILLUSIONS
light-colored or straight lashes highlight the upper lid. Darkening your eyelashes and curling them upward can create an open, structured frame without exposing the actual eyelid crease.
Matte Shadows: Applying a very subtle matte brown eyeshadow directly in the crease adds depth, giving the illusion of a deeper-set eye
❖ INFRA ORBITAL
The zone directly below the orbital rim the bony edge of the eye socket down to the top of the cheek. Its the part where your fat pads your lower eye lid and skin sits. its the part that will make or break your eye area so you know how important it is
❖ UNDER EYE SUPPORT OR DEVELOPED INFRA ORBITAL
Developed infra orbital its is kind of oblique shaped it will make your eye look prominent and will make you look like you have sharp under eyes fat pads and skin settles properly and its a reason for positive orbital vector
❖ RECESSED INFRA ORBITAL DISADVANTAGES
Tired appearance a hollow look
Due to lack of fat support on the bone a dark shadow is casted and it will give dark under eyes
Causes midface flattening or bad midface it makes midface look flat and sunken causing nose to project forward or nose appears larger
Accentuation of eye bags because of recessed infra the fat or skin cannot stay or hold under eye properly so it sags down this will look worse with age
AS you can see a direct comparison between recessed infra and good under eye support before the orbital rim implant it looked hollow and shallow total looks killer
❖ ORBITAL VECTOR
The relationship between the most anterior (forward) projection of the eyeball and the infraorbital rim.
neutral and positive looks good and wont have much more complications and you can see the bone sits further and provides structure
in positive vector neutral vector sits on same plane so its also chillin
❖ NEGATIVE ORBITAL VECTOR
Eyeball projects further forward than the infraorbital rim. The eye is essentially unsupported. .Negative vector patients age faster because
Less anterior bony support means soft tissue descends with less resistance
Lid cheek junction drops earlier
Orbital fat herniates more visibly because rim isn't containing it
Cheek volume loss creates more hollow because there was less projection to begin with
if you have a recessed infraorbital rim .meaning the bone underneath the eye socket sits back rather than projecting forward canthopexy is likely to relapse over time cause Canthopexy just tightens and repositions the existing tendon with sutures without fully releasing it. The tendon is being held in a new position against the gravity and tissue tension. When the underlying bone doesn't provide adequate support and projection for the soft tissue to rest against, the sutures slowly lose to tension and the tissue creeps back down toward its original position. The bone structure isn't there to properly anchor everything in place long term.
Canthoplasty is significantly more stable in because the tendon is fully released trimmed and then anchored directly into the orbital rim bone with a permanent suture anchor so it has much more fixation point and wont have to fight back the tension
LOWER EYE SPECIFIC SURGERIES
❖ ACEHIVING REVERSE NEGATIVE ORBITAL VECTOR
❖ IMPLANTS
Infraorbital-malar implants are surgically placed, biocompatible devices designed to permanently build up the deficient bone under the eyes and along the cheekbones. They change the skeletal foundation of the face, pushing the lower eyelid area forward to match or exceed the projection of the eyeball.
few types are used like Solid Silicone Smooth and highly customizable. It does not integrate with the tissue, making it the easiest type to remove or adjust if needed.
Porous Polyethylene (Medpor) : Features microscopic pores that allow your natural blood vessels and tissues to grow into the implant. This locks it firmly in place but makes it highly complex to remove.
PEEK (Polyetheretherketone) : A strong material used almost exclusively for 3D-printed custom implants. It mimics the density of natural bone.
The procedure is performed under general anesthesia by an ocular plastic or ophthalmic surgeon.
Incisions are hidden inside the mouth (under the upper lip) or inside the lower eyelid . This ensures there are no visible external scars Then the surgeon creates a precise pocket directly over the bone, slides the implant in, and positions it over the lower orbital rim and cheekbone.
Then the implants are securely screwed directly into the facial bone using tiny titanium micro-screws to prevent shifting or migration.
Safe surgery done under a good doctor
The initial recovery period for orbital bone implant surgery typically lasts 2 to 3 weeks, while full internal tissue healing and final results can take 3 to 6 months
❖ POSSIBLE COMPLICATION
Complications of orbital implants: a review of 542 patients who have undergone orbital implantation and 275 subsequent PEG placements - PubMed
The majority of orbital implantations involve complications, these being largely minor ones which resolve spontaneously or are easily treated. Secondary implant procedures involve a higher likelihood of complications. Silicone implants have the smallest amount of complications. Should patients...
share.google
❖ COST
US : avg cost $6,500 – $9,500 standard implant and $15,000– $30,000+for custom
South Korea : avg cost $3,500– $5,500 standard implant $5,500 – $9,500+ for custom
Turkey : avg cost $3,000 – $4,500 standard implant $5,000– $7,500+ for custom
❖ BEFORE AND AFTER
❖ FAT GRAFTING
As you can see fat grafting is done for to give lower eye area volume to remove the sunken eyes it is a cosmetic procedure it is done by a surgeon taking fat from a part of your own body like thigh abdomen or flanks for eye they only take like small amount and they like purify the fat by leaving out like sum dead cells oils and fluid then the fat is injected layer by layer and it should be precise cause lower eye is a thin region
once the fat survives the results are long lasting and it also uses your own tissue so no risk of allergy so chill but its not as potent as implant it works but not on a level as implant
plus fat can be gain or loosed and it actually goes away with time so its repetitive
people with lot of volume loss can go with this
POSSIBLE COMPLICATION
Not adding enough fat undercorrection
Adding too much fat cells overcorrection
20 to 50% fat are reabsorbed so you will lose some in over time
prolonged swelling
and may cause asymmetry cause they can inject more at one part but not at another
❖ COST
US : avg cost $3,500 to $5,500
South Korea : avg cost $920 to $1,530
Turkey : avg cost $1,400 to $4,000
❖ BEFORE AND AFTER
❖ LOWER BLEPHAROPLASTY
Ofc surgery to fix your lower eye area blepharoplasty aims to fix puffiness hollowness and dark circles by reducing saggy and extra skin its done by 1st putting the patient into anesthesia general or local anesthesia then a extra skin which is saggy to be removed is marked and using few techniques it is cut and removed the result will be no saggy skin it will take 2 weeks to recover and in almost 3 months the scars will completely wears off
the total surgery time is around 1hr with waiting and all that shit but is done with in 10 to 20 mins 20 to 40 on both eyes it is safe but has limitation like you can not cut the skin too much or remove it too much
❖ POSSIBLE COMPLICATION
Swelling and bruising ofc
Blurry vision for a few days yeah might be a problem cause of stitches and cut
Sensitivity to light
Temporary numbness around the eye
Hollowness if excess skin was removed
Infection
❖ COST
US : avg cost $3,500 to $8,500
South Korea : avg cost $1,500 to $3,500
Turkey : avg cost $2,000 to $4,500
❖ BEFORE AND AFTER
❖ ORBITAL DECOMPRESSION
O this is done for live people who have thyroid eye problem so reactive thyroid causes bug eyes and to fix this this surgery is done this is a total medical surgery and can be used for looksmaxx some people do this to get hunter eye which is utter cope so do this surgery if you have this bug eyes
this is the surgery which botched frank tufano
so they do this by cutting or grinding orbital bone area to create space so eyes can fit there this is a risky surgery and you can get botched
it requires highly skilled surgeon
❖ BEFORE AND AFTER
❖ FILLERS AT LOWER EYE
The results are promising fillers are used for to get lost volume around eyes HA(Hyaluronic acid) fillers are mostly used the filler is mostly semi permanent lasting around 9 to 18 months this will fill any mild class volume loss and dark circle caused by lacking volume under eye this is done in around in 30 mins the amount of filler injected is dependent on how much deep your eyes are or hollow
so they inject by applying numbness cream at 1st
if u don't like it, it can be completely dissolved with an enzyme called hyaluronidase. Unlike fat grafting, fully reversible.
❖ POSSIBLE COMPLICATION
Bruising and swelling
Lumps if placed wrong
Tyndall effect bluish tint if filler placed too shallow, looks worse than before
❖ COST
USA : $800 to $1,800 on avg
Turkey : $300 to $700 on avg
Korea : $400 to $900 on avg
❖ BEFORE AND AFTER
❖ OTHER TREATMENTS
Using tretinoin use the 0.025% low conc this will increase cell turnover evens out skin surface improves collagen production and exfoliates skin cells. really good but if you go higher conc it will actually starts to thin out stratum corneum and will make it more thin which you dont wanna have
apply it like 1 to 2 time a day can apply every day and apply a small amount use with moisturizer this also improve skin pigmentation
then move to tazarotene lower conc
GHK CU
Chemical peels
Fractional Co2 laser
Ebrium yag laser
Use matrixyl 3000 every day 2 time a day
using kojic acid soap this worked for me this also blocks melanocytes works use it two times a day
RLT ( redlight therapy ) also works it will take 8 to 12 weeks to work use it 2 times a day every day works increases collagen wont let lower eye to sag too much
Using hydroquinone to achieve depigmentation might sound crazy but it will inhibit tyrosinase this is the enzyme for melanin production monobenzone also works but its risky need a specific guide use hydroquinone 0.5 % or 1% on under eye use it for 3 to 4 month and cycle it use it everyday 1 time a day if you dont have lower conc hydroquinone i have a way to lower its conc let me know if you want
Using sunscreen
NOTE : these are for lower eye hyper pigmentation not for structure for volume also to preserve volume as you age
❖SCLERA
the white part of your eye important for colouring affected by health the more white the more it looks good
Sclera is a important part it becomes dull to various factor and whiteness shows how healthy and good your eye looks the reason for its dullness are
.jaundice it can cause your eyes to be yellow
Liver, Gallbladder, and Bile Duct Issues When the liver is inflamed, scarred (cirrhosis), or blocked by gallstones or tumors, it struggles to process bilirubin into bile. This backup spills into the bloodstream and tissues, including the eyes
.Blood Disorders (Hemolysis)
. Localized Eye Conditions
.Vitamin Deficiencies like b 12
Lack of sleep
SO ITS ALL DIET AND LIFE STYLE AT THE END THE OTHER SOLUTION IS BRIMONIDINE
Use brimonidine 0.03% 2 times a day every day really good for sclera whitening it has the less rebound effect as possible and will clear your sclera
❖IRIS
the coloured part of your eye its genetic the lighter the eye colour the good the contrast and colouring
What i say is wear contact lens and be healthy. rule for contact lens is the iris colour should be lighter than hair and darker than skin
always go for 1 to 2 shade lighter than your natural eye colour
but try everything if you are black try blue contacts too cause it may look good to you rather than uncanny
LEGIT SOFTMAX EYE COLOR CHANGE (GTFIH)
Introduction I’m a darkeyecel, and I’ve been looking for methods to brighten my eyes. I’ve been searching through BotB, but the only thread about eye color changing is this one by @Alexanderr https://looksmax.org/threads/stroma-eye-color-change-explained-mega-thread.228789/ it’s pretty good with...
looksmax.org
The Science Behind: STRŌMA
Introduction Throughout history, eye color has fascinated us, sparking tales of mystique and beauty. While blue contacts let you play pretend, the dream of actually changing your eye color seemed as likely as growing wings. But science has been busy, and that far-fetched idea? It's here. Well...
looksmax.org
Limbal ring : the dark ring between iris and sclera this looks good and matters this cant be gained wear contact lens for this and will fade as you will age so mange your health
So the general rule of thumb is that your iris color should carry as much as contrast as possible so the eye colouring should be lighter than hair colour but skin should be lighter than eye colour and brightness of sclera also matters the white part of your eyes
your eye colour actually depends on melanin production while every colour has its own benefit blue or lighter colours like green amber still look good and is highly admired by females cause modern hypergamy is based on sexual appeal of men not on survival so you get it .go for contact lens
PFL AND PFW : visible opening of the eye. Measured horizontally (PFL = length) and vertically (PFW = width/height). The PFL: PFW ratio is a major driver of whether eyes appear "hunter" or "prey" wider vertically = more open, rounded, and feminized
The PFL: PFW ratio measures the horizontal length of the eye against its vertical height. This ratio is one of the most important determinants of whether eyes appear masculine or feminine.
3.5:1 or higher, Very long horizontally relative to height, almond-shaped. Ideal for males.
3:1, Good horizontal to vertical ratio, compact appearance. Good.
2.5:1 to 3:1, Average range, acceptable. Neutral.
Below 2.5:1, Round, wide-open eyes, prey-looking, feminized appearance. Suboptimal for males.
Average PFL (horizontal length) is approximately 28 to 31mm. The ratio matters more than raw PFL length. A short but compact eye can look more masculine than a long but tall one.
SURGERY TO FIX THEM
Lateral Canthoplasty
Medial Epicanthoplasty
Double Eyelid Surgery (Blepharoplasty)
Ptosis Surgery
https://looksmax.org/threads/how-to...gtfih-yes-all-of-them-its-never-over.1948605/ TALKED ABOUT ESR AND IPD WITH PFL AND ALL IM WAY TO LAZY TO DO IT RN
❖EYE AREA WRINKLES
a problem which will you get as you age depleting via in collagen this really isnt much of a failo if you are old but as a Young guy how to never have them i will tell you
❖WHY IT OCCURS
Natural Aging & Collagen Loss: As you get older, your skin produces less collagen and elastin .the proteins responsible for keeping skin firm and plump. This biological breakdown is accelerated by genetics, oxidative stress, and lifestyle factors.
Repetitive Muscle Movements: Smiling, laughing, frowning, and blinking contract the underlying muscles. Because the skin is closely attached to these muscles, the continuous micro-folds eventually etch into the skin as permanent wrinkle
Sun Exposure: Ultraviolet (UV) radiation from the sun penetrates the skin and breaks down existing collagen networks faster than natural aging alone. UV damage is a primary contributor to premature eye wrinkles and hyperpigmentation.
Dehydration: The eye area has very few sebaceous glands, which produce the natural oils that create a protective barrier. This makes the skin prone to water loss, causing it to shrink and form tiny "dehydration lines" on the surface.
Mechanical Stress (Squinting & Eye Strain): Constantly squinting from uncorrected vision, bright sunlight, or prolonged screen use causes continuous mechanical stress on the delicate eye-area muscles
❖TREATMENTS
1.BOTOX-->IT CAN DO
Crow's feet — the lines that fan out from the outer corners when you smile or squint
Bunny lines — fine lines on the upper nose bridge that appear when you scrunch your face.
Undereye crinkling — small, careful doses can reduce the crepe-like texture under the eye when smiling (though this is more advanced and provider-dependent).
Brow lift — injecting just above the outer brow can give a subtle lift, opening the eye area
WHAT IT CANT
Static under-eye wrinkles at rest (filler works better there)
Loose or sagging skin (laser/RF or surgery)
Hollowness or dark circles
HOW IT WORKS
a good provider maps your muscle movement first.
The area is cleaned; a topical numbing cream may or may not be used
Several small injections are made around the eye area — typically 3–5 injection points per side for crow's feet.
The whole thing takes 10–15 minutes.
RESULT
Starts working in 3–5 days
Full effect visible at 10–14 days
Your provider will often schedule a 2-week follow-up to assess and touch up if needed
RISKS
Small bruising or swelling at injection site
Mild headache after first session
Asymmetry if one side metabolizes faster
Eyelid drooping (ptosis) — rare (~1–5%), happens if toxin migrates. Resolves on its own in weeks
BEFORE AND AFTER
2.LASER TREATMENTs
CO2 --> THIS IS THE GOOD ONE FOR THIS EBRIUM YAG ISNT BETTER THAN CO2
Botox only works on wrinkles caused by muscle movement. CO2 laser treats
Static wrinkles — lines visible even when your face is completely relaxed
Creepy, thin under-eye skin — the crinkly texture Botox cannot touch
Skin laxity — loose, sagging skin around the eye area
Sun damage and pigmentation around the eyes
Texture and tone overall
HOW IT WORKS
Numbing cream applied 30–60 minutes before
Eyes protected with metal shields
The laser passes over the skin in precise patterns
Takes 15–45 minutes depending on the area
RESULT
Days 1–3: Red, swollenLooks intense. You stay home
Days 4–7: Skin starts crusting and peeling. Still not public-ready
Days 7–10: New pink skin emerges. You can go out with mineral makeup.
Weeks 2–4: Pinkness/redness fades gradually.
Months 1–6: Collagen continues building results keep improving for up to 6 months.
| Botox | CO2 Laser |
|---|---|---|
Best for | Dynamic wrinkles (from movement) | Static wrinkles, crepey skin, laxity |
Results | Temporary (3–4 months) | Long-lasting (3–5 years) |
Downtime | Zero | 1–2 weeks |
Pain | Minimal | Moderate (numbed) |
Cost per session | Lower | Higher |
Long-term cost | Higher (repeat forever) | Lower (rarely repeat) |
Skin improvement | No tissue change | Actual skin rebuilding |
Risk level | Low | Moderate |
BEFORE AND AFTER
SOFT MAXXES
we need to improve our collagen so
1. .using argireline which will work 30 % of botox
2.Using tretinoin 0.025 % to improve collagen over time
3. red light therapy
4. matrixyl 3000
5.Using volufiline and voluplus
all have same application apply it to the wrinkle area t Use a tiny amount, a grain of rice size for the whole eye area. Apply it over a moisturizer, not on bare skin this is called buffering and significantly reduces irritation while still getting results. apply two times a day every day for all three dont apply at same time tho yeah same for this really
6. goo diet sleep and all
GHK- CU ->1 mg - 2 mg per day . Cycles range from 30 days to 12weeks, followed by a mandatory 4 to 6 week break to prevent the accumulation of excess free copper in your system.
SOFT MAXXES
we need to improve our collagen so
1. .using argireline which will work 30 % of botox
2.Using tretinoin 0.025 % to improve collagen over time
3. red light therapy
4. matrixyl 3000
5.Using volufiline and voluplus
all have same application apply it to the wrinkle area t Use a tiny amount, a grain of rice size for the whole eye area. Apply it over a moisturizer, not on bare skin this is called buffering and significantly reduces irritation while still getting results. apply two times a day every day for all three dont apply at same time tho yeah same for this really
6. goo diet sleep and all
GHK- CU ->1 mg - 2 mg per day . Cycles range from 30 days to 12weeks, followed by a mandatory 4 to 6 week break to prevent the accumulation of excess free copper in your system.
@Sycophant @Navity @Nodal
@☄ 𝐎𝐑𝐈𝐂𝐇𝐀𝐋𝐂𝐎𝐍 ☄ @iterallytaxidriver
Last edited:
